Personal care products exposure patterns and prostate cancer: evidence from a case-control study in Mexico City.

IF 4.7 3区 医学 Q2 ENVIRONMENTAL SCIENCES
Luisa Torres-Sánchez, Jesús Gibran Hernández-Pérez, David S Lopez, Sara Romero-Romero, Lizbeth López-Carrillo, Mauricio Rodríguez-Dorantes, Ruth Argelia Vázquez-Salas
{"title":"Personal care products exposure patterns and prostate cancer: evidence from a case-control study in Mexico City.","authors":"Luisa Torres-Sánchez, Jesús Gibran Hernández-Pérez, David S Lopez, Sara Romero-Romero, Lizbeth López-Carrillo, Mauricio Rodríguez-Dorantes, Ruth Argelia Vázquez-Salas","doi":"10.1038/s41370-025-00772-4","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Personal care products (PCPs) use has been associated with a high risk of hormone-sensitive cancers in women. However, this association is poorly understood in hormone-sensitive cancers in men.</p><p><strong>Objective: </strong>To investigate the association between PCPs use and prostate cancer (PC) and PC histological differentiation in men from Mexico City.</p><p><strong>Methods: </strong>We analyzed the information from 400 histologically confirmed incident PC cases and 801 population controls matched by age (±5 y). The usage frequency (daily, weekly, or less, and non-use) of deodorant, body lotion, shampoo, perfume, and shaving or after-shaving products was evaluated based on a structured questionnaire. Using the K-means approach, we selected three patterns according to the usage frequency and number of PCPs used: high, intermediate, and low. Multivariable non-conditional logistic regression models adjusted by selected confounders were conducted to estimate the association between the use of PCPs (patterns, individual products, and number of products used daily) and PC, as well as PC histological differentiation.</p><p><strong>Results: </strong>Compared to the low exposure pattern, the high (OR: 2.6 95% CI: 1.8-3.8) and intermediate (OR: 1.3 95% CI: 1.0-1.8) PCPs patterns were associated with higher odds of PC. Similarly, the intermediate exposure pattern was significantly associated with poorly differentiated PC (OR: 1.8 95% CI: 1.1-2.9). The daily use of perfume was the most consistent PCP associated with PC (OR <sub>high vs. low</sub>: 1.9 95% CI: 1.3-2.8; p for trend = 0.001) and PC poor differentiation (OR: 2.0, 95% CI: 1.1-3.6; p for trend = 0.013). In addition, a dose-response relationship was observed with the number of personal care products used daily.</p><p><strong>Impact statement: </strong>This study provided evidence that high exposure to personal care products (PCPs) is associated with prostate cancer. Our findings are consistent with those observed regarding hormone-sensitive female cancer and suggest the potential contribution of PCPs to prostatic carcinogenesis.</p>","PeriodicalId":15684,"journal":{"name":"Journal of Exposure Science and Environmental Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.7000,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Exposure Science and Environmental Epidemiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41370-025-00772-4","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Personal care products (PCPs) use has been associated with a high risk of hormone-sensitive cancers in women. However, this association is poorly understood in hormone-sensitive cancers in men.

Objective: To investigate the association between PCPs use and prostate cancer (PC) and PC histological differentiation in men from Mexico City.

Methods: We analyzed the information from 400 histologically confirmed incident PC cases and 801 population controls matched by age (±5 y). The usage frequency (daily, weekly, or less, and non-use) of deodorant, body lotion, shampoo, perfume, and shaving or after-shaving products was evaluated based on a structured questionnaire. Using the K-means approach, we selected three patterns according to the usage frequency and number of PCPs used: high, intermediate, and low. Multivariable non-conditional logistic regression models adjusted by selected confounders were conducted to estimate the association between the use of PCPs (patterns, individual products, and number of products used daily) and PC, as well as PC histological differentiation.

Results: Compared to the low exposure pattern, the high (OR: 2.6 95% CI: 1.8-3.8) and intermediate (OR: 1.3 95% CI: 1.0-1.8) PCPs patterns were associated with higher odds of PC. Similarly, the intermediate exposure pattern was significantly associated with poorly differentiated PC (OR: 1.8 95% CI: 1.1-2.9). The daily use of perfume was the most consistent PCP associated with PC (OR high vs. low: 1.9 95% CI: 1.3-2.8; p for trend = 0.001) and PC poor differentiation (OR: 2.0, 95% CI: 1.1-3.6; p for trend = 0.013). In addition, a dose-response relationship was observed with the number of personal care products used daily.

Impact statement: This study provided evidence that high exposure to personal care products (PCPs) is associated with prostate cancer. Our findings are consistent with those observed regarding hormone-sensitive female cancer and suggest the potential contribution of PCPs to prostatic carcinogenesis.

个人护理产品暴露模式与前列腺癌:来自墨西哥城病例对照研究的证据。
背景:个人护理产品(pcp)的使用与女性激素敏感性癌症的高风险相关。然而,在男性激素敏感型癌症中,人们对这种关联知之甚少。目的:探讨墨西哥城男性前列腺癌(PC)及组织学分化与pcp使用的关系。方法:我们分析了400例组织学证实的PC病例和801例年龄匹配的人群对照。使用频率(每天,每周,或更少,不使用)除臭剂,身体乳液,洗发水,香水,剃须或剃须后产品基于结构化问卷进行评估。使用K-means方法,我们根据使用的pcp的使用频率和数量选择了三种模式:高、中、低。采用经选定混杂因素调整的多变量非条件逻辑回归模型来估计pcp(模式、单个产品和每天使用的产品数量)的使用与PC以及PC组织学分化之间的关联。结果:与低暴露模式相比,高暴露模式(OR: 2.6 95% CI: 1.8-3.8)和中等暴露模式(OR: 1.3 95% CI: 1.0-1.8)与较高的PC发生率相关。同样,中等暴露模式与低分化PC显著相关(OR: 1.8 95% CI: 1.1-2.9)。日常使用香水是PCP与PC最一致的相关性(OR高vs低:1.9 95% CI: 1.3-2.8;p为趋势值= 0.001)和PC差分化(OR: 2.0, 95% CI: 1.1-3.6;P代表趋势= 0.013)。此外,剂量-反应关系被观察到与个人护理产品的数量每天使用。影响声明:本研究提供了高暴露于个人护理产品(pcp)与前列腺癌相关的证据。我们的研究结果与对激素敏感的女性癌症的观察结果一致,并提示pcp对前列腺癌的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
8.90
自引率
6.70%
发文量
93
审稿时长
3 months
期刊介绍: Journal of Exposure Science and Environmental Epidemiology (JESEE) aims to be the premier and authoritative source of information on advances in exposure science for professionals in a wide range of environmental and public health disciplines. JESEE publishes original peer-reviewed research presenting significant advances in exposure science and exposure analysis, including development and application of the latest technologies for measuring exposures, and innovative computational approaches for translating novel data streams to characterize and predict exposures. The types of papers published in the research section of JESEE are original research articles, translation studies, and correspondence. Reported results should further understanding of the relationship between environmental exposure and human health, describe evaluated novel exposure science tools, or demonstrate potential of exposure science to enable decisions and actions that promote and protect human health.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信