Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering最新文献_第9页

Overview of microplastic pollution and its influence on the health of organisms. 微塑料污染综述及其对生物健康的影响。

IF 2.1 4区环境科学与生态学

Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering Pub Date : 2023-01-01 DOI: 10.1080/10934529.2023.2190715

Yingling Deng, Jiang Wu, Jinjun Chen, Kai Kang

引用次数: 6

Synthesis of the MnO₂-Fe₃O₄ catalyst support on amorphous silica: a new Fenton's reagent in the degradation of the reactive blue-19 in aqueous solution. 无定形二氧化硅载体MnO2-Fe3O4催化剂的合成:一种降解水中活性蓝-19的Fenton试剂。

IF 2.1 4区环境科学与生态学

Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering Pub Date : 2023-01-01 DOI: 10.1080/10934529.2023.2198477

Nguyen Manh Ha, Tran Thi Huong, Ninh The Son

{"title":"Synthesis of the MnO2-Fe3O4 catalyst support on amorphous silica: a new Fenton's reagent in the degradation of the reactive blue-19 in aqueous solution.","authors":"Nguyen Manh Ha, Tran Thi Huong, Ninh The Son","doi":"10.1080/10934529.2023.2198477","DOIUrl":"https://doi.org/10.1080/10934529.2023.2198477","url":null,"abstract":"In this study, a new Fenton's reagent was synthesized via two steps: (1) the dispersed Fe3O4 nanoparticles were immobilized on the surface of the SiO2 carrier via the precipitation process, and (2) the MnO2 nano-sheets were coated on the surface of Fe3O4/SiO2 via hydrothermal method. The SiO2 carrier has been synthetically utilized from Vietnamese rice husk. The successful formation of the MnO2-Fe3O4/SiO2 composite has been analytically characterized by the XRD (X-ray diffraction), SEM (scanning electron microscope), EDS (energy dispersive spectrometry)-mapping, FTIR (Fourier transform infrared), SBET (Brunauer-Emmett-Teller specific surface area), and adsorption/desorption isotherms. This Fenton system was employed to catalyze degradation process of the reactive-blue 19 (RB19) with approximately 100% of removal efficiency after 25 min at the optimal condition of 0.15 g/100 mL of catalyst dosage, pH = 3, and the H2O2 concentration of 3 mL/100 mL. Moreover, the catalyst could be reused at least six times with high catalytic activity that was more than 90%. In conclusion, this study showed that the mesoporous MnO2-Fe3O4/SiO2 composite has a great potential for the removal application of dyes from wastewater, and the application of Vietnam rice husk in environmental treatment was developed.","PeriodicalId":15671,"journal":{"name":"Journal of Environmental Science and Health Part A-toxic\\/hazardous Substances & Environmental Engineering","volume":"58 5","pages":"506-514"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9348929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sub-ppm determination of perfluorinated carboxylic acids in solution by UV-vis high-performance liquid chromatography through solid phase extraction. 固相萃取紫外可见高效液相色谱法测定溶液中亚ppm的全氟羧酸。

IF 2.1 4区环境科学与生态学

Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering Pub Date : 2023-01-01 DOI: 10.1080/10934529.2023.2204801

Hongjiao Pang, Mayumi Allinson, Peter J Scales

{"title":"Sub-ppm determination of perfluorinated carboxylic acids in solution by UV-vis high-performance liquid chromatography through solid phase extraction.","authors":"Hongjiao Pang, Mayumi Allinson, Peter J Scales","doi":"10.1080/10934529.2023.2204801","DOIUrl":"https://doi.org/10.1080/10934529.2023.2204801","url":null,"abstract":"This study investigated a novel and sensitive analytical method based on a simple heat-based derivatization using 3-bromoacetyl coumarin as the reagent and analysis with a HPLC-UV system or just a UV-vis spectrometer to allow the sub-ppm determination of PFCAs in water solution with the potential for utilization in simple laboratories and field laboratory scenarios. A Strata-X-AW cartridge was used for the solid phase extraction (SPE) procedure and higher than 98% recoveries were obtained. The derivatization condition showed that a high efficiency of peak separation was obtained with obviously different retention time among various PFCAs derivatives using HPLC-UV analysis. The derivatization stability and repeatability showed favorable results with stable derivatized analytes for ≤12 h and a relative standard deviation (RSD) of <2% for all repetitions. The limit of detection for the HPLC-UV analysis was between 0.1 ppm and 0.5 ppm. A satisfactory linearity response was found with R2 >0.998 for all individual PFCA compounds. The limit of detection for simple UV-Vis analysis was <0.0003 ppm to measure the presence of PFCAs. Contamination of standards with humic substances and measurement of industrial samples in a complex wastewater matrix showed no adverse effects on the accuracy of PFCA determination by using the developed methodology.","PeriodicalId":15671,"journal":{"name":"Journal of Environmental Science and Health Part A-toxic\\/hazardous Substances & Environmental Engineering","volume":"58 6","pages":"605-616"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9466487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Membrane separation of antibiotics predicted with the back propagation neural network. 应用反向传播神经网络预测抗生素的膜分离。

IF 2.1 4区环境科学与生态学

Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering Pub Date : 2023-01-01 Epub Date: 2023-04-18 DOI: 10.1080/10934529.2023.2200719

Mixuan Ye, Haidong Zhou, Xinxuan Xu, Lidan Pang, Yunjia Xu, Jingyuan Zhang, Danyan Li

{"title":"Membrane separation of antibiotics predicted with the back propagation neural network.","authors":"Mixuan Ye, Haidong Zhou, Xinxuan Xu, Lidan Pang, Yunjia Xu, Jingyuan Zhang, Danyan Li","doi":"10.1080/10934529.2023.2200719","DOIUrl":"10.1080/10934529.2023.2200719","url":null,"abstract":"Antibiotics and antibiotic resistance genes (ARGs) have been frequently detected in the aquatic environment and are regarded as emerging pollutants. The prediction models for the removal effect of four target antibiotics by membrane separation technology were constructed based on back propagation neural network (BPNN) through training the input and output. The membrane separation tests of antibiotics showed that the removal effect of microfiltration on azithromycin and ciprofloxacin was better, basically above 80%. For sulfamethoxazole (SMZ) and tetracycline (TC), ultrafiltration and nanofiltration had better removal effects. There was a strong correlation between the concentrations of SMZ and TC in the permeate, and the R2 of the training and validation processes exceeded 0.9. The stronger the correlation between the input layer variables and the prediction target was, the better the prediction performances of the BPNN model than the nonlinear model and the unscented Kalman filter model were. These results showed that the established BPNN prediction model could better simulate the removal of target antibiotics by membrane separation technology. The model could be used to predict and explore the influence of external conditions on membrane separation technology and provide a certain basis for the application of the BPNN model in environmental protection.","PeriodicalId":15671,"journal":{"name":"Journal of Environmental Science and Health Part A-toxic\\/hazardous Substances & Environmental Engineering","volume":"58 6","pages":"538-549"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9467831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accumulation and distribution of heavy metals in soil and food crops in the Pb-Zn mine environ. Case study: Region of Probištip, North Macedonia. 铅锌矿环境中重金属在土壤和粮食作物中的积累和分布。案例研究：北马其顿普罗比什蒂普地区。

IF 2.1 4区环境科学与生态学

Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering Pub Date : 2023-01-01 DOI: 10.1080/10934529.2023.2174331

Trajče Stafilov, Katerina Stojanova, Krste Таšev, Katerina Bačeva Andonovska

{"title":"Accumulation and distribution of heavy metals in soil and food crops in the Pb-Zn mine environ. Case study: Region of Probištip, North Macedonia.","authors":"Trajče Stafilov, Katerina Stojanova, Krste Таšev, Katerina Bačeva Andonovska","doi":"10.1080/10934529.2023.2174331","DOIUrl":"https://doi.org/10.1080/10934529.2023.2174331","url":null,"abstract":"The aim of the study was to investigate the exploration and distribution of various chemical elements in soils and vegetables from gardens in the region of Probištip, North Macedonia. This region was exposed to heavy metals pollution from Pb-Zn mining and flotation tailings landfill near the town of Probištip for 70 years. A total of 38 samples of various crops and vegetable products from 19 gardens were analyzed. The analyzes were carried out by ICP-AES (Al, Ba, Ca, Cr, Cu, Fe, K, Li, Mg, Mn, Na, Ni, P, Pb, Sr, V, and Zn) and by ICP-MS (As, Cd, Co, Cr, and Pb). It was found that the content of some potentially toxic elements (As, Cd, Cu, Pb, and Zn) in the soil samples from the gardens, exceeded the target values. From these results, it is clear that the contamination of the soils in this area is due to mining activities and the distribution of flotation wastes from the nearby flotation dump. It was also found that the contaminated soils lead to elevated levels of these elements in some vegetables from the gardens, especially those near the Zletovska River and the flotation waste landfill, exceeding the nationally permissible food content.","PeriodicalId":15671,"journal":{"name":"Journal of Environmental Science and Health Part A-toxic\\/hazardous Substances & Environmental Engineering","volume":"58 3","pages":"171-182"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9162363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biosorption of cadmium from aqueous solution by combination of microorganisms and chitosan: response surface methodology for optimization of removal conditions. 微生物与壳聚糖联合吸附镉的研究:响应面法优化去除条件。

IF 2.1 4区环境科学与生态学

Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering Pub Date : 2023-01-01 DOI: 10.1080/10934529.2023.2188023

Elham Khanniri, Mojtaba Yousefi, Amir Mohammad Mortazavian, Nasim Khorshidian, Sara Sohrabvandi, Mohammad Reza Koushki, Saeideh Esmaeili

{"title":"Biosorption of cadmium from aqueous solution by combination of microorganisms and chitosan: response surface methodology for optimization of removal conditions.","authors":"Elham Khanniri, Mojtaba Yousefi, Amir Mohammad Mortazavian, Nasim Khorshidian, Sara Sohrabvandi, Mohammad Reza Koushki, Saeideh Esmaeili","doi":"10.1080/10934529.2023.2188023","DOIUrl":"https://doi.org/10.1080/10934529.2023.2188023","url":null,"abstract":"The food-grade adsorbents of Saccharomyces cerevisiae (108 CFU/mL), Bifidobacterium longum (108 CFU/mL) and chitosan (1%w/v) alone or in combination were used for biosorption of cadmium (Cd) from aqueous solution. Among the tested adsorbents, combination of B. longum and chitosan had the highest efficiency. Therefore, biosorption process with B. longum/chitosan as the most efficient biosorbent was optimized by variables of pH (3-6), temperature (4-37 °C), contact time (5-180 min) and Cd concentrations (0.01-5 mg/L) using RSM. Twenty-seven tests were carried out and the data fitted to the second-order polynomial models. Results revealed that 99.11% of Cd was reduced within 180 min at concentration of 2.5 mg/L, pH 6 and temperature of 20.5 °C that were considered as the optimal conditions for Cd removal. The trend of isotherm was more fitted to the Langmuir model and maximum biosorption capacity was obtained about 3.61 mg/g. The pseudo-second-order fitted the biosorption kinetics for Cd ions. The B. longum/chitosan biosorbent exhibited the high affinity to Cd ion in the presence of coexisting metal ions. It could remove 81.18% of Cd from simulated gastrointestinal tract. Thus, B. longum/chitosan can have good potential as an effective adsorbent for Cd biosorption from aqueous solutions and human body.","PeriodicalId":15671,"journal":{"name":"Journal of Environmental Science and Health Part A-toxic\\/hazardous Substances & Environmental Engineering","volume":"58 5","pages":"433-446"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9400255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evaluation of ciprofloxacin (CIP) and clarithromycin (CLA) adsorption with weathered PVC microplastics. 风化聚氯乙烯微塑料吸附环丙沙星(CIP)和克拉霉素(CLA)的性能评价。

IF 2.1 4区环境科学与生态学

Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering Pub Date : 2023-01-01 DOI: 10.1080/10934529.2023.2198475

Duygu Osman, İbrahim Uyanık, Hamdi Mıhçıokur, Oktay Özkan

{"title":"Evaluation of ciprofloxacin (CIP) and clarithromycin (CLA) adsorption with weathered PVC microplastics.","authors":"Duygu Osman, İbrahim Uyanık, Hamdi Mıhçıokur, Oktay Özkan","doi":"10.1080/10934529.2023.2198475","DOIUrl":"https://doi.org/10.1080/10934529.2023.2198475","url":null,"abstract":"The sorption kinetics of two of the most frequently used antibiotics onto recycled (weathered) polyvinyl chloride (PVC) was investigated, using Freundlich and Langmuir isotherm models. Various experimental conditions were set, including pH, contact time, rotational speed, temperature, and initial concentration. The batch experimental results indicated that Freundlich model was better fitted than Langmuir (R2: 98.7 and 84.7, for CIP and CLA respectively). Maximum adsorption capacity is 45.9 mg/g and 22.0 mg/g for CIP and CLA, respectively. Enthalpy (ΔH), and entropy (ΔS) values were negative for CIP, indicating that the reaction was exothermic and spontaneous, respectively. It was vice versa for CLA. Field emission scanning electron microscope (FESEM) and Fourier transform infrared spectrometer (FT-IR) analysis confirmed the physical adsorption mechanism. The results demonstrated that the recycled PVC microplastic has a good capacity for adsorption for both antibiotics.","PeriodicalId":15671,"journal":{"name":"Journal of Environmental Science and Health Part A-toxic\\/hazardous Substances & Environmental Engineering","volume":"58 5","pages":"498-505"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9440248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation of the research trends on perfluorinated compounds using bibliometric analysis: knowledge gap and future perspectives. 利用文献计量学分析评价全氟化合物的研究趋势:知识差距和未来展望。

IF 2.1 4区环境科学与生态学

Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering Pub Date : 2023-01-01 DOI: 10.1080/10934529.2023.2203639

Cecilia Y Ojemaye, Mike O Ojemaye, Anthony I Okoh, Omobola O Okoh

{"title":"Evaluation of the research trends on perfluorinated compounds using bibliometric analysis: knowledge gap and future perspectives.","authors":"Cecilia Y Ojemaye, Mike O Ojemaye, Anthony I Okoh, Omobola O Okoh","doi":"10.1080/10934529.2023.2203639","DOIUrl":"https://doi.org/10.1080/10934529.2023.2203639","url":null,"abstract":"Detection of perfluorinated compounds (PFCs) in the environment has been a global concern because of the risk they pose due to their endocrine-disruptive properties. This study analyzed the global trends and research productivity of PFCs from 1990 to 2021. A total number of 3256 articles on PFCs were retrieved from the Web of Science focusing on different environmental and biological matrices. An increase in the productivity of research on PFCs was observed during the survey period which indicates that more research and publications on this class of contaminants are expected in the future. Evaluating the most productive countries and the number of citations per country on PFCs research shows that China and the United States of America were ranked in first and second places. It was also observed that research on PFCs received the most attention from scientists in developed countries, with little research emerging from Africa. Hence, research on PFCs in developing countries, especially low-income countries should be promoted. Consequently, more research programs should be implemented to investigate PFCs in countries and regions where research on these contaminants is low. The study will help researchers, government agencies and policymakers to tailor future research, allocation of funds to PFCs research and countries' collaboration.","PeriodicalId":15671,"journal":{"name":"Journal of Environmental Science and Health Part A-toxic\\/hazardous Substances & Environmental Engineering","volume":"58 6","pages":"570-595"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9521615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health risk study of cadmium, chromium, lead and arsenic in reservoir water of Changzhou, China. 常州市水库水中镉、铬、铅、砷的健康风险研究

IF 2.1 4区环境科学与生态学

Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering Pub Date : 2023-01-01 DOI: 10.1080/10934529.2023.2206772

Yue-Fang Chen, Meng-Xue He, Hui-Min Feng, Qian Liu, Jin-Xiu Chen, Tong Li

{"title":"Health risk study of cadmium, chromium, lead and arsenic in reservoir water of Changzhou, China.","authors":"Yue-Fang Chen, Meng-Xue He, Hui-Min Feng, Qian Liu, Jin-Xiu Chen, Tong Li","doi":"10.1080/10934529.2023.2206772","DOIUrl":"https://doi.org/10.1080/10934529.2023.2206772","url":null,"abstract":"Accurately assessing the health risks of human exposure to heavy metals via water is of great importance for performing targeted health risk prevention measures. To better understand the concentration characteristics and potential harm to human health of cadmium, chromium, lead and arsenic in the main drinking water-type reservoirs of Changzhou city, we collected samples from the Haidi Reservoir, Dongjin Reservoir, Xinfushan Reservoir, Maodong Reservoir and Xiangyang Reservoir of Changzhou in the summer of 2019. The results showed that the daily average comprehensive exposure level of metals was much lower than the provisional tolerated daily intake (PTDI), i.e., Cd: 1 µg kg-1 d-1; Cr: 3 µg kg-1 d-1; Pb: 3.57 µg kg-1 d-1; and As: 2.14 µg kg-1 d-1. The comprehensive non-carcinogenic risk levels of four metals under water-drinking exposure and water-skin exposure routes ranged from 4.68E - 3 to 1.69E - 1, and the carcinogenic risk ranged from 2.09E - 5 to 7.30E - 5, which were all at acceptable risk levels. Although lead and chromium were present at acceptable health risk levels, they still represented the main pollutants of potential health risk in the local water environment from a non-carcinogenic or carcinogenic perspective, and they should be listed as the primary targets for water environmental risk management.","PeriodicalId":15671,"journal":{"name":"Journal of Environmental Science and Health Part A-toxic\\/hazardous Substances & Environmental Engineering","volume":"58 7","pages":"680-693"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9660592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuro-protective potentials of N-acetylcysteine and zinc against di(2-ethylhexyl)-phthalate-induced neuro-histopathology and dys-regulations of Dopamine and Glutamate in rat brain. n -乙酰半胱氨酸和锌对邻苯二甲酸二(2-乙基己基)-邻苯二甲酸酯诱导的大鼠脑神经组织病理学和多巴胺和谷氨酸调节异常的神经保护作用

IF 2.1 4区环境科学与生态学

Journal of Environmental Science and Health Part A-toxic\/hazardous Substances & Environmental Engineering Pub Date : 2023-01-01 DOI: 10.1080/10934529.2023.2177449

Adelaja Akinlolu, Victor Emejovwe, Raphael Uwejigho, Juliet Ilesanmi, Rokibat Owolabi, Abimbola Igandan

{"title":"Neuro-protective potentials of N-acetylcysteine and zinc against di(2-ethylhexyl)-phthalate-induced neuro-histopathology and dys-regulations of Dopamine and Glutamate in rat brain.","authors":"Adelaja Akinlolu, Victor Emejovwe, Raphael Uwejigho, Juliet Ilesanmi, Rokibat Owolabi, Abimbola Igandan","doi":"10.1080/10934529.2023.2177449","DOIUrl":"https://doi.org/10.1080/10934529.2023.2177449","url":null,"abstract":"This study examined neuro-protective potentials of N-acetyl-cysteine (NAC) and Zinc on expression levels of Dopamine and Glutamate in the Cerebrum, Hypothalami and Pituitary Glands in Di(2-ethylhexyl)-phthalate (DEHP)-induced neurotoxicity in rats. Thirty-six adult male Wistar rats were randomly divided into 6 groups (n = 6). Group 1 was control. Groups 2-6 received oral administrations of 100 mg/kg NAC, 0.5 mg/kg Zinc, 750 mg/kg DEHP, DEHP + NAC doses and DEHP + Zinc doses respectively for 21 days. Brain histology (Heamatoxyline and Eosine technique), histochemical and enzyme-linked-immunosorbent assays of Dopamine and Glutamate in homogenates of Cerebrum, Hypothalami and Pituitary Glands were evaluated. Data were statistically analyzed using One-way-ANOVA with Tukey-post-hoc test at p ≤ 0.05. Histo-pathological evaluations of Cerebrum, Hypothalami and Pituitary Glands showed gross histo-alterations and neurodegenerative changes (Group 4), mild histo- and neuro-degenerative changes (Groups 5 and 6) and normal histology (Group 1). Histochemical analyses showed higher Dopamine levels in Hypothalami (Group 5) and Pituitary Glands (Groups 5 and 6), compared with Group 4. Furthermore, results showed lower Glutamate levels in Cerebrum, Hypothalami and Pituitary Glands of Groups 5 and 6, compared with Group 4. Overall, NAC and Zinc conferred neuro-protection and histo-protection against DEHP-induced neuro-toxicity, neuro-histopathology, decreased Dopamine levels and increased Glutamate levels.","PeriodicalId":15671,"journal":{"name":"Journal of Environmental Science and Health Part A-toxic\\/hazardous Substances & Environmental Engineering","volume":"58 1","pages":"81-90"},"PeriodicalIF":2.1,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9127484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1