Journal of Dietary Supplements最新文献

{"title":"Statement of Retraction: Taurine supplementation improves functional capacity, myocardial oxygen consumption and electrical activity in heart failure.","authors":"","doi":"10.1080/19390211.2026.2656044","DOIUrl":"10.1080/19390211.2026.2656044","url":null,"abstract":"","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"441"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Latent Magnesium Deficiency and an Unbalanced Calcium-to-Magnesium Ratio Impact Fetal Development and Maternal Health.","authors":"Deanna J Nelson, Laura J Sommerville","doi":"10.1080/19390211.2026.2624107","DOIUrl":"10.1080/19390211.2026.2624107","url":null,"abstract":"<p><p>During pregnancy, a mother experiences increased metabolic demands to meet the needs of the fetus. A mismatch between these demands and nutrient intake can result in a host of developmental abnormalities to the fetus and health risks to the mother. Several studies have reported strong correlations between deficiency of the essential mineral, magnesium (Mg), and many pregnancy complications, including intrauterine growth restriction, preeclampsia, gestational diabetes, and preterm delivery. Mg also impacts fetal programming and disease presentation in childhood and adulthood, showing that aberrant Mg levels <i>in utero</i> have far-reaching consequences. In this narrative review and commentary, we evaluated recently published data to identify a range of serum Mg concentrations that may reflect chronic latent Mg deficiency (0.7-0.85 mmol/L). We then evaluated independent studies that reported on the relationship between Mg levels and pregnancy outcomes to assess whether this cutoff may help identify patients at risk for adverse events and inform therapeutic strategies. Our analysis showed that chronic latent Mg deficiency coupled with a molar ratio of serum calcium to serum Mg >3 may indicate increased risk to mother or fetus. Given the high social and economic burdens of pregnancy complications, nutritional supplementation that includes Mg at all stages of pregnancy may be a safe and cost-effective way to mitigate the risk of adverse outcomes for mother and child.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"268-289"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of <i>in Vitro</i> Cytotoxicity and Induction Potential of Açaí (<i>Euterpe oleracea)</i> Extracts in Human Hepatocytes.","authors":"Zarna Raichura, Kelli L McDonald, Savanna DePriest, Madison Dupre, Meredith Almy, Kristen Hansen, Julia M Salamat, Satyanarayana R Pondugula, Angela I Calderón","doi":"10.1080/19390211.2026.2615924","DOIUrl":"10.1080/19390211.2026.2615924","url":null,"abstract":"<p><p><i>Euterpe oleracea</i> Mart. (açaí) is a widely consumed botanical supplement marketed for antioxidant, anti-inflammatory, and antiproliferative properties. Despite its popularity, limited data exist on its ability to modulate drug-metabolizing enzymes and transporters-critical determinants of pharmacokinetic botanical-drug interactions. This study evaluated the cytotoxicity and induction potential of açaí extracts on cytochrome P450 (CYP450) enzymes and drug transporters using physiologically relevant <i>in vitro</i> models. Test samples included aqueous, acidic methanol, methanol, and ethanol extracts of açaí berry powder (Mountain Rose) and commercial capsules (Nature's Way, Natrol), selected to reflect consumer products and enhance translational relevance. Cytotoxicity was assessed using CellTiter-Glo^® luminescent assay in sandwich-cultured human hepatocytes. Induction of CYP1A2, CYP2B6, CYP3A4, P-glycoprotein (P-gp), and organic anion transporting polypeptides (OATP1B1/B3) was evaluated at the mRNA level <i>via</i> RT-qPCR in the same hepatocyte model. Functional transporter activity was assessed using intracellular probe accumulation assays in LS174T human colon carcinoma cells, a complementary model for preliminary screening. A time- and dose-dependent reduction in hepatocyte viability occurred with specific extracts, notably MRAC (acidic methanol), MRME (methanol), MRET (ethanol), and F4AC (acidic methanol, Natrol). However, none significantly induced CYP450 or transporter expression. Preliminary functional assays also showed minimal impact on P-gp and OATP activity. While preliminary, this study provides a comprehensive evaluation of açaí-mediated modulation of key pharmacokinetic pathways and underscores the need for rigorous assessment of botanical extracts to better predict potential botanical-drug interactions.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"217-239"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13008539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Shatavari Root Extract in Managing Peri-Menopausal Symptoms-A Randomized, Double-Blind, Placebo Controlled Clinical Trial.","authors":"Gurunath Surampalli, Madhuchander S, Mounika Mudhigonda","doi":"10.1080/19390211.2026.2689348","DOIUrl":"10.1080/19390211.2026.2689348","url":null,"abstract":"<p><strong>Clinical trial registry of india (ctri): </strong>CTRI/2025/06/088470 (https://ctri.nic.in).</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":"23 4","pages":"490-518"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Antarctic Krill Oil Extract (FJH-KO) on Platelet Aggregation and Arterial Stiffness in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"Hyungyung Chai, Miae Yoo, In-Kee Hong, Eun-Ryoung Kim, Hyeon Gyu Lee, Yu-Jin Paek","doi":"10.1080/19390211.2026.2691816","DOIUrl":"10.1080/19390211.2026.2691816","url":null,"abstract":"<p><strong>Background: </strong>Impaired platelet function, endothelial activation, and vascular stiffness contribute to cardiovascular disease risk. Antarctic krill oil contains bioactive compounds that may support vascular function. This randomized, double-blind, placebo-controlled trial aimed to evaluate the efficacy and safety of Antarctic krill oil extract (FJH-KO) on platelet function and arterial stiffness in healthy adults.</p><p><strong>Methods: </strong>A total of 120 adults aged 19 to 70 years were randomized to receive low-dose FJH-KO (375 mg/day), high-dose FJH-KO (750 mg/day), or placebo for twelve weeks. The functional efficacy analysis was performed on a per-protocol (PP) basis. The primary outcome was platelet aggregation time. Secondary outcomes included brachial-ankle pulse wave velocity (ba-PWV), blood pressure, platelet-related and endothelial biomarkers, inflammatory markers, and fibrinolytic parameters.</p><p><strong>Results: </strong>Overall, 115 participants completed the study. FJH-KO supplementation showed significant between-group differences in platelet aggregation time and ba-PWV. Notably, the high-dose group demonstrated a significant reduction in ba-PWV compared to the placebo group (<i>p</i> = 0.006), reflecting reduced arterial stiffness. High-dose FJH-KO was also associated with a within-group reduction in P-selectin, while intercellular adhesion molecule-1 (ICAM-1) decreased in the low-dose and placebo groups.</p><p><strong>Conclusions: </strong>Twelve-weeks supplementation with high-dose FJH-KO was well tolerated and was associated with favorable between-group differences in PFA-200 closure time and ba-PWV in healthy adults. These findings suggest potential effects on platelet and vascular function.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"535-552"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148404769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astaxanthin Supplementation Lowers Respiratory Exchange Ratio During Submaximal Cycling in Females: A Randomized, Double-Blind, Placebo-Controlled Crossover Trial.","authors":"Gaven A Barker, Jenna N Starkey, Eric K O'Neal, Hunter S Waldman","doi":"10.1080/19390211.2026.2705844","DOIUrl":"10.1080/19390211.2026.2705844","url":null,"abstract":"<p><p>Astaxanthin (AX) is a lipid-soluble carotenoid that has produced mixed results in increasing fat oxidation during submaximal exercise in male cohorts. Females exhibit a higher reliance on fat oxidation, potentially making them a demographic more likely to benefit from AX supplementation. Following an initial VO_2max test to determine maximum power (W_max), twenty recreationally active females (age: 22 ± 2 y) participated in a two-arm double-blind, counterbalanced, crossover design study with a 2-week supplementation period of either AX (12 mg·day^-1) or placebo (PLA) separated by a 2-week washout period. Participants cycled continuously for 30 min for six, 5-min stages with data collected over the last minute of each stage. The initial and final stages were 40 and 65% of W_max, respectively with 5% increment increases between stages. There were no differences between AX or PLA for heart rate, blood lactate, or rate of perceived exertion at any intensity (all <i>p</i> > 0.05). For RER, there was no significant supplement × intensity interaction (<i>p</i> = 0.14), but a significant main effect was observed for both intensity (<i>p</i> < 0.001) and supplement (<i>p</i> = 0.04), with overall RER being significantly lower during the cycling bout following AX supplementation compared to PLA. Two weeks of AX supplementation lowered RER values in an active female cohort, indicating a shift toward a greater reliance on lipid-dominant substrate preference at specific submaximal intensities. The lack of change in cardiovascular or perceptual markers suggests that these shifts in RER occur independently of systemic physiological or psychological stress, though the exact underlying cellular mechanisms remain to be elucidated.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"639-652"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148470934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blackcurrant Anthocyanin Supplementation Alters Exercise-Induced Substrate Utilization - A Systematic Review and Meta-Analysis.","authors":"Matthew D Cook, James J Bateman, Mark E T Willems","doi":"10.1080/19390211.2026.2624114","DOIUrl":"10.1080/19390211.2026.2624114","url":null,"abstract":"<p><p>Blackcurrant anthocyanins have been investigated for their effects on exercise‑induced substrate utilisation. Previous research has examined the influence of supplementation dose, duration, and exercise modality, with mixed findings. This systematic review and meta-analysis examined the effect of blackcurrant supplementation on exercising substrate utilisation. Electronic searches were conducted in PubMed, Web of Science, and EBSCOhost between the 1st May and 14th November 2025 using a predefined search strategy. Controlled trials investigating the effects of blackcurrant supplementation on fat and carbohydrate oxidation during exercise in physically active adults (18-65 years) were included. All forms, doses, and supplementation durations were eligible, provided outcomes were reported as absolute rates of substrate utilisation during exercise. Two authors independently extracted data and assessed for risk of bias using the Cochrane RoB 2 tool, with a random-effects meta-analysis undertaken on the mean difference between control or placebo and consumption of blackcurrant extract on exercise substrate utilisation. Searches returned 263 articles, with 15 studies included with 226 participants after full-text screening. Meta-analysis demonstrated blackcurrant extract to increase fat oxidation (0.042 g·min-1, <i>P</i> < 0.001) and decrease carbohydrate oxidation (-0.099 g·min-1, <i>P</i> = 0.012). Blackcurrant can increase fat oxidation and decrease carbohydrate oxidation during exercise. However, this finding is not consistent for individuals and factors such as training status, sex, dosage, duration of intake may determine responses. The review was registered on the 28th April 2025 in PROSPERO (CRD420251030222).</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"290-305"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146112818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of a Multi-Ingredient Liquid-Based Botanical Nutraceutical for Improving Markers of Metabolic Health: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.","authors":"Helen Messier, Christopher R D'Adamo, Niranjankumar Panchal, Ghanashyam Patel","doi":"10.1080/19390211.2026.2691821","DOIUrl":"10.1080/19390211.2026.2691821","url":null,"abstract":"<p><p>Many individuals aiming to improve or maintain markers of metabolic and cardiovascular health seek non-pharmacological options with demonstrated efficacy and safety. This study evaluated the efficacy and safety of a multi-ingredient liquid botanical nutraceutical containing organic herbal extracts of turmeric, pomegranate, amla, ginger, and black pepper, as well as niacinamide, CoQ10, folic acid, and lycopene on biomarkers related to cardiovascular health. This was a randomized, double-blind, placebo-controlled clinical trial with a duration of 90 days. The study was conducted at a single center. Participants were healthy adults with normal lipid profiles and were randomized 1:1 to receive the nutraceutical treatment or placebo using simple randomization. Participants received 60 mL of the nutraceutical treatment or placebo twice daily for 90 days, which was orally self-administered. The primary outcome was mean change in low-density lipoprotein (LDL) from baseline to endline. Secondary outcomes were mean changes in high-density lipoprotein, very low-density lipoprotein (VLDL), total cholesterol, triglycerides, adiponectin, apolipoprotein A1, and apolipoprotein B. Outcomes were compared between the treatment and placebo groups using analysis of covariance. Safety was evaluated with liver and kidney function markers and adverse event comparison. Eighty-six participants were randomized (<i>n</i> = 43 per group). From baseline to endline, significant differences between study groups favoring the treatment arm were observed in LDL (treatment vs placebo: -19.21 vs +21.07 mg/dL; <i>p</i> < 0.001). Between-group comparisons also favored the treatment arm for all secondary outcomes (<i>p</i> < 0.05 to <i>p</i> < 0.001). No adverse events were reported. The liquid nutraceutical formula was associated with favorable changes in lipid cardiometabolic markers in healthy adults, suggesting a potential role in supporting lipid homeostasis and attenuating unfavorable lipid trends that typically occur over time.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"519-534"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148338788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Plant Sterols on Cholesterol Oxidation Products in Statin-Treated Hypercholesterolemic Individuals: A Pilot Study.","authors":"Diego Miedes, Dario Mercatante, Sonia Broseta, Antonio Cilla, Maria Teresa Rodriguez-Estrada, Amparo Alegría","doi":"10.1080/19390211.2026.2695120","DOIUrl":"10.1080/19390211.2026.2695120","url":null,"abstract":"<p><p>Cholesterol oxidation products (COPs) have been linked to inflammation, endothelial dysfunction, and atherosclerosis. COPs levels in hypercholesterolemic individuals are up to 50% higher than in healthy people. Although statins lower cholesterol synthesis, research demonstrates that they do not prevent an increase in COPs levels and the damage on endothelial cells. We hypothesized that plant sterols (PS) could reduce COPs concentrations, potentially offering a synergistic effect with statin treatment. This randomized, double-blind, parallel clinical trial investigates the effects of a PS-food supplement (2 g PS/d) on plasma COPs levels in statin-treated hypercholesterolemic individuals (ClinicalTrials.gov ID: NCT05901246). Twenty-six volunteers were randomly assigned to two groups and given either a PS supplement or a placebo for six weeks. Blood samples were taken before and after the treatment, and plasma was isolated. After sterol extraction and purification, COPs and cholesterol levels were analyzed by gas chromatography/mass spectrometry. There were no significant differences (<i>p</i> > 0.05) in plasma cholesterol (2276 ± 480 in control and 2169 ± 735 μg/mL in PS-treated subjects), total (1.12 ± 0.26 in control and 1.47 ± 0.48 μg/mL in PS-treated subjects) and single (α-epoxy-cholesterol, <i>β</i>-epoxy-cholesterol, cholestanetriol, 7α-hydroxy-cholesterol, 7<i>β</i>-hydroxy-cholesterol, and 7-keto-cholesterol) COPs levels between the two groups after the intervention; moreover, these levels were not associated with physical or dietary habits. These findings suggest that PS supplementation did not measurably reduce COPs concentrations over six weeks in this small sample of statin-treated individuals with relatively stable cholesterol levels. Future studies should explore the mechanisms underlying the interaction between statins, PS, and cholesterol oxidation to improve strategies for managing CVD risk.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"623-638"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycine Bioavailability and Sleep-Related Outcomes Following Oral Glycine and Collagen Supplementation-A Scoping Review.","authors":"Zhongqi Fan, John M Nelson, Taylor C Wallace","doi":"10.1080/19390211.2026.2726197","DOIUrl":"10.1080/19390211.2026.2726197","url":null,"abstract":"<p><p>Glycine is a conditionally essential amino acid with plausible roles in sleep regulation through thermoregulatory and glycinergic/N-methyl-D-aspartate signaling pathways. Collagen is rich in glycine and thus, collagen-based supplements may represent a practical dietary source of glycine and could plausibly influence sleep-related outcomes. We conducted a scoping review to map the clinical literature on glycine bioavailability from dietary supplements and to evaluate whether available evidence supports glycine as a biologically plausible candidate mechanism underlying sleep-related effects of glycine- and collagen-containing supplements. Following Joanna Briggs Institute guidance and PRISMA-ScR reporting standards, we searched PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials from inception through July 9, 2026. A total of 21 records comprising 22 unique trials met the inclusion criteria. Of these, 14 trials examined pharmacokinetic glycine availability from glycine-, collagen-, or other glycine-containing supplements, 3 investigated supplemental glycine and sleep-related outcomes, and 5 studies reported across 4 records evaluated collagen or collagen peptides and sleep-related, fatigue, or recovery-related outcomes. Across pharmacokinetic trials, glycine-containing supplement interventions generally increased circulating glycine concentrations, with some evidence of dose dependence. All 3 glycine sleep trials reported benefits on at least 1 sleep-related outcome. Among collagen peptide trials, 1 placebo-controlled trial reported fewer polysomnographic awakenings, 1 placebo-controlled trial reported lower fatigue scores, and active-comparator studies with alpha-lactalbumin did not show superiority of collagen peptides for sleep-related outcomes. Overall, current evidence supports biological plausibility for glycine as a candidate mechanism that may contribute to collagen-related sleep effects, but mediation has not been directly tested. Larger mechanistic trials with standardized sleep outcomes are needed.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"602-622"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}