Journal of Dietary Supplements最新文献

{"title":"Effect of Vitamin E on Serum Adiponectin and Leptin in Adults: A Systematic Review and Meta-analysis.","authors":"Mehdi Karimi, Sara Alipour, Samira Pirzad, Sajad Ahmadizad, Minoo Bassami, Omid Asbaghi","doi":"10.1080/19390211.2025.2561143","DOIUrl":"https://doi.org/10.1080/19390211.2025.2561143","url":null,"abstract":"<p><p>Adiponectin and leptin are pivotal adipokines regulating metabolic homeostasis, with dysregulation linked to obesity, insulin resistance, and related metabolic disorders. Vitamin E, a potent antioxidant, has been proposed to modulate adipokine secretion, but existing studies report inconsistent findings. This systematic review and meta-analysis aimed to evaluate the impact of vitamin E oral supplementation on serum adiponectin and leptin levels in adults. Systematic searches were performed in major electronic databases up to August 2025 to identify eligible randomized controlled trials (RCTs). Extracted data were analyzed using STATA, and pooled effect estimates were calculated as weighted mean differences (WMDs) with 95% confidence intervals (CIs). The pooled analysis of 10 RCTs (14 effect sizes) showed that vitamin E supplementation did not significantly alter serum adiponectin (WMD: 0.67 ng/mL; 95% CI: [-0.11 - 1.44]; <i>p</i> = 0.093) or leptin levels (WMD: -3.60 ng/mL; 95% CI: [-7.45 - 0.25]; <i>p</i> = 0.067). Subgroup analyses revealed that long-term supplementation (>12 wk) significantly increased adiponectin (WMD: 1.60 ng/mL; <i>p</i> = 0.039), particularly in patients with nonalcoholic fatty liver disease (NAFLD) (WMD: 4.28 ng/mL; <i>p</i> < 0.001). Additionally, vitamin E significantly reduced leptin levels in NAFLD patients (WMD: -5.45 ng/mL; <i>p</i> < 0.001). This meta-analysis found no significant overall effect of vitamin E on adiponectin and leptin levels; however, long-term supplementation appears beneficial, particularly in patients with NAFLD. Heterogeneity in study design, dosage, and duration highlights the need for further well-designed RCTs to clarify the metabolic and therapeutic roles of vitamin E.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"1-19"},"PeriodicalIF":2.3,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a Novel Probiotic Supplement with Weight Gain Intervention on Anthropometry, Body Composition, and Appetite in Underweight Adults: A Randomized Controlled Trial.","authors":"Alireza Hatami, Maryam Ahmadi-Khorram, Reza Rahmanian, Ali Jafarzadeh Esfehani, Elyas Nattagh-Eshtivani, Asma Afshari, Mohsen Nematy","doi":"10.1080/19390211.2025.2561132","DOIUrl":"https://doi.org/10.1080/19390211.2025.2561132","url":null,"abstract":"<p><p>Undernutrition in adults increases mortality and impairs immunity and quality of life. Gut microbiota influences metabolism, suggesting potential for probiotic-based weight-gain strategies. This study aimed to assess the efficacy of a probiotic supplement combined with a weight-gain diet on anthropometric indices, appetite, and calorie intake in underweight adults. In this 8-week, double-blind, randomized, placebo-controlled trial, 95 underweight adults (aged 18-60 years) from Mashhad, Iran, were randomized to receive a probiotic supplement (Lacticaseibacillus rhamnosus GG, Lactobacillus acidophilus, Lacticaseibacillus casei; 10⁹ CFU/capsule) or placebo with a 500-kcal surplus diet. Primary outcomes included anthropometric measures, including body weight and BMI. Secondary outcomes included appetite (via visual analog scales), caloric intake, and stool consistency. The probiotic group (n = 47) showed greater increases than the placebo group (n = 48) in body weight (2.41 vs 0.44 kg, p < 0.001), BMI (0.83 vs 0.24 kg/m², p < 0.001), body fat percentage (3.23% vs 1.03%, p < 0.001), fat mass (1.90 vs 0.89 kg, p = 0.002), and caloric intake (263.55 vs 30.75 kcal/day, p < 0.001). The probiotic group showed significant increases in hunger (p < 0.001) and desire to eat (p < 0.001), with reduced satiety and fullness before meals (p < 0.001), as assessed by VAS. Stool consistency in the probiotic group shifted significantly toward softer, more regular stools, as evidenced by a one-unit increase in the Bristol Stool Score (p = 0.01), compared to no change in the control group (p = 0.97). Probiotic supplementation with a weight-gain diet significantly enhances anthropometric measures, appetite, and calorie intake in underweight adults, offering a novel strategy for managing undernutrition.</p><p><p><b>Clinical trial registration:</b> Iranian Registry of Clinical Trials, IRCT20230310057667N1 (Issue date 30 March 2023), https://irct.behdasht.gov.ir/trial/69130.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"1-19"},"PeriodicalIF":2.3,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemicals in <i>Ginkgo biloba</i> for Age-Related Eye Disease - A Review.","authors":"John Osilama Thomas, Ifeoluwa Margaret Idowu","doi":"10.1080/19390211.2025.2560365","DOIUrl":"https://doi.org/10.1080/19390211.2025.2560365","url":null,"abstract":"<p><p><i>Ginkgo biloba</i> is a rich source of phytochemicals and antioxidants derived from plant extracts, and its therapeutic potential is increasingly recognized in ocular health. Eye diseases such as glaucoma, diabetic retinopathy (DR), and age-related macular degeneration (AMD) are among the leading causes of vision impairment worldwide, with current therapies often failing to counteract oxidative stress and retinal neurodegeneration. <i>Ginkgo biloba</i>, a medicinal plant used for centuries in Traditional Chinese Medicine (TCM), contains diverse flavonoids and terpenoids with potent antioxidant, anti-inflammatory, and neuroprotective properties. However, the specific contributions of these phytochemicals to ocular protection and the optimization of delivery strategies for standardized plant extracts remain insufficiently explored.</p><p><p>This review examines evidence on standardized <i>Ginkgo biloba</i> extracts (GBEs) for ocular health, highlighting their ability to reduce oxidative damage, regulate inflammation, and protect retinal cells in major eye diseases. We hypothesize that standardized GBEs, when formulated <i>via</i> advanced ocular drug delivery systems, could enhance retinal bioavailability and efficacy, serving as viable adjunct or alternative therapies for glaucoma, DR, and AMD. The objectives are to summarize current knowledge on the phytochemical composition of <i>Ginkgo biloba</i> and its mechanisms of ocular protection, critically evaluate preclinical and clinical evidence of its use in eye diseases, and explore novel formulation and delivery strategies to overcome the bioavailability challenges of these plant extracts.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"1-32"},"PeriodicalIF":2.3,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling Origins of N-Acetylcysteine (NAC): A Critical Review.","authors":"Ahmed G Osman, Bharathi Avula, Ikhlas A Khan, Amar G Chittiboyina","doi":"10.1080/19390211.2025.2555015","DOIUrl":"https://doi.org/10.1080/19390211.2025.2555015","url":null,"abstract":"<p><p>The controversial status of <i>N</i>-acetylcysteine (NAC) as a dietary supplement ingredient has renewed interest in its origin. This opinion article critically examines the scientific literature to investigate whether NAC is a naturally occurring compound, with a particular focus on its potential presence in plants. The primary objective of this opinion is to determine the natural occurrence of NAC, specifically within herbal matter. The classification of NAC as a dietary ingredient falls outside the scope of this analysis. We will rigorously evaluate the methodologies implemented in establishing NAC's presence in plant or herbal sources, specifically in <i>Allium</i> species which are often touted to contain NAC. By analyzing the strengths and weaknesses of prior research, we aim to clarify the evidence supporting the origin of NAC.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"1-11"},"PeriodicalIF":2.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamins and Iron-Deficiency Gestational Anemia - A Review.","authors":"Dinesh Venkatesan Yadav, Tridip Mitra, Deeksha Punniyamoorthy, Anuradha Murugesan, Sajeetha Kumari Raveendran, Rajiv Janardhanan","doi":"10.1080/19390211.2025.2555013","DOIUrl":"https://doi.org/10.1080/19390211.2025.2555013","url":null,"abstract":"<p><p>Vitamins, as essential m icronutrients, are vital for numerous cellular functions and play a key role in maintaining hematological parameter s during pregnancy, including erythropoiesis and processes affecting iron status. Iron-Deficient Gestational Anemia (IDGA), the most common clinicopathological condition in obstetrics and highly prevalent in developing countries, significantly contributes to complications such as hypertensive disorders of pregnancy and gestational diabetes. While it is recognized that vitamin deficiencies impact iron metabolism and erythropoiesis, a complete understanding of their specific roles in preventing and managing IDGA is lacking. Insights into how vitamin deficiencies influence gene expression and cellular signaling are crucial. With rising IDGA prevalence, ensuring adequate vitamin intake during pregnancy is essential for improving hematological health. Mobile health-based literacy tools can effectively promote patient education to achieve this. This review underscores the critical role of vitamins in regulating hemoglobin levels in IDGA.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"1-20"},"PeriodicalIF":2.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the Flavonoid Diosmin on Post Exercise Muscle Soreness - A Randomized Controlled Trial.","authors":"Fabiana Cristina Barreiros da Cunha, Giovana Bobato Cortez, Isabela Mayer Pucci, Mariana Martins Silva, Jayne Maria Borim, Mariana M Bertozzi, Jeferson L Jacinto, Thacyana T Carvalho, Andreo F Aguiar, Juliano Casonatto, Eros de Oliveira Júnior, Waldiceu Aparecido Verri, Sergio Marques Borghi","doi":"10.1080/19390211.2025.2547167","DOIUrl":"10.1080/19390211.2025.2547167","url":null,"abstract":"<p><p>Delayed-onset muscle soreness (DOMS) is hypothesized to be due to reversible damage at the cellular level, affecting both recreational and professional athletes. For elite athletes, the prevalence of DOMS is more pronounced during the beginning of the sports season, when they return to the reality of exercise training after a period of inactivity, thus potentially having a negative impact on performance. Era evaluate the effects of supplementation with the flavonoid diosmin (DSM) on athletic performance and DOMS-related symptoms in the pre-season of a futsal team from the Brazilian women's league. A randomized, double‑blind and placebo‑controlled crossover trial was conducted in 15 professional futsal female athletes. They received one daily capsule of DSM or placebo (750 mg) for 3 days as a preventive regimen, and an intense dynamic exercise protocol (concentric/eccentric actions) was applied to the lower limbs. Evaluations on the effects of DSM on athletic performance and DOMS‑related muscle soreness, blood oxidative stress, recovery of strength capacity, and postural balance were performed during a 48 h‑period. Although DSM had no greater effect than placebo on athletic performance, it presented trivial‑to‑moderate effects in other parameters without statistical significance, with the best effects including containing oxidative damage (through reduction in lipid peroxidation) (<i>p</i> = 0.3857, EF = 0.72) and muscle soreness upon climbing stairs (<i>p</i> = 0.7136, EF = 0.50) at the 48^th hour, and in preventing the reduction of muscle strength (<i>p</i> = 0.6784, EF = 0.61) and improving unipedal postural balance in contralateral leg (<i>p</i> = 0.7446, EF = 0.69) at the 24th hour. Althought not significant in the ANOVA, the flavonoid DSM seems effective for futsal athletes as a dietary supplement for some variables evaluated. These include preventing muscle soreness, oxidative stress, impairment of muscle strength, and postural balance postexercise, which is desirable to promote better results in sporting terms. Clinical trial registry number: NCT06125002.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"1-22"},"PeriodicalIF":2.3,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144862271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Fatty Acids as Modulators of Sperm Quality - From Molecular Pathways to Nutritional Interventions.","authors":"Xin-Yu Yang, Si-Qi Wei, Peng-Sheng Zheng","doi":"10.1080/19390211.2025.2539882","DOIUrl":"https://doi.org/10.1080/19390211.2025.2539882","url":null,"abstract":"<p><p>Infertility affects a growing number of families worldwide. Male factors contribute to 20-50% of infertility cases, and their improvement can help reduce the rising infertility rates. Recent studies have increasingly shown that fatty acids (FAs) can modulate sperm quality and significantly impact male fertility. This review investigates recent studies on the role of FAs in infertility, including their impact on sperm quality, FA profiles in infertility-related conditions, and the therapeutic potential of dietary and supplemental FAs. Our review reveals that omega-3 polyunsaturated fatty acids (PUFAs) are crucial for spermatogenesis and sperm function, and their imbalance with omega-6 PUFAs is associated with oxidative stress. FA metabolism is a promising target for infertility management. Precision nutrition strategies may complement conventional therapies, but further RCTs are needed to standardize protocols.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"1-17"},"PeriodicalIF":2.3,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144847069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creatine Supplementation in Combat Sport Athletes: A Narrative Systematic Review.","authors":"Damoon Ashtary-Larky, Darren G Candow, Scott C Forbes, Leila Hajizadeh, Corey A Peacock, Douglas Kalman, Tony Ricci, Jose Antonio","doi":"10.1080/19390211.2025.2539880","DOIUrl":"https://doi.org/10.1080/19390211.2025.2539880","url":null,"abstract":"<p><p>Creatine is a widely studied ergogenic aid known for its effects on muscle performance and body composition. However, its impact or utility for athletes involved in combat sports, who often aim to reduce body mass to meet a specific weight class, remains unclear. To conduct a narrative systematic review of peer-reviewed published studies that examined the effects of creatine supplementation on body mass, body composition, muscular strength, power, endurance, fatigue, recovery, and cognitive performance in combat sport athletes. A comprehensive search was conducted in multiple public databases up to March 2025. Databases searched included PubMed, Scopus, Web of Science, and Google Scholar. Studies evaluating creatine supplementation in combat sports (eg wrestling, judo, taekwondo, boxing) were included. Outcomes assessed included changes in body mass and body composition, performance metrics, and markers of fatigue and recovery. Nineteen studies met the inclusion criteria. Creatine supplementation increased body mass, especially during longer-term interventions (≥6 wk) or when combined with structured resistance training. Creatine supplementation also increased measures of body mass and fat-free mass (FFM). Muscular power and maximal strength outcomes improved significantly after creatine supplementation, particularly in studies utilizing short-duration, high-intensity exercise protocols. Creatine supplementation did not influence measures of sport-specific endurance, recovery or fatigue. No serious adverse effects were reported across studies for creatine supplementation. Creatine supplementation enhances body mass, FFM, muscle strength and power in combat sport athletes. Given its safety and efficacy profile, creatine supplementation remains a promising supplement for supporting some aspects of athletic performance in combat sports.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"1-26"},"PeriodicalIF":2.3,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Ketone Ester Supplementation on Cognition and Appetite in Individuals with and Without Metabolic syndrome: A Randomized Trial.","authors":"Austin J Graybeal, Ryan S Aultman, Caleb F Brandner, Anabelle Vallecillo-Bustos, Abby T Compton, Sydney H Swafford, Ta'Quoris A Newsome, Jon Stavres","doi":"10.1080/19390211.2025.2473371","DOIUrl":"10.1080/19390211.2025.2473371","url":null,"abstract":"<p><p>There are currently no non-pharmacological solutions to combat the appetite and cognitive dysfunctions associated with metabolic syndrome (MetS). Ketosis may be a potential solution, though the restrictive nature of dietary ketosis limits its long-term utility. Oral administration of exogenous ketone esters (KE) independently induces ketosis, eliciting hyperketonemia without the need for prolonged dietary restrictions. However, the acute effects of oral KEs on appetite and cognition have not been evaluated in individuals with MetS. For this randomized, single-blind, placebo-controlled, matched-pairs crossover study, 10 individuals with MetS and 10 without (non-MetS) matched for age, sex, and race/ethnicity completed a cardiometabolic screening/familiarization visit and two experimental trials. During the experimental trials, cognitive function, subjective appetite, and respiratory gases were measured at baseline and for 2h following the ingestion of a randomly assigned KE or placebo drink. Post-trial food intake was also collected. Independent of MetS group, indices of working memory significantly improved (<i>p</i> ≤ .035), and blood glucose significantly decreased (<i>p</i> < .001), following KE ingestion. However, after the KE condition, markers of subjective appetite (<i>p</i> ≤ .048) only decreased in the non-MetS group. Post-trial relative fat intake was higher in the MetS group than the non-MetS group following the KE (<i>p</i> = .002), and lower after the KE than the placebo for the non-MetS group (<i>p</i> = .028). Our findings indicate that while cognitive function may increase following KE ingestion independent of MetS, appetite may only decrease in those without MetS; providing further insight to our understanding of the behavioral and metabolic responses to exogenous ketosis.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"382-400"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary Supplement-Induced Hepatotoxicity: A Clinical Perspective.","authors":"Jordan Carty, Victor J Navarro","doi":"10.1080/19390211.2024.2327546","DOIUrl":"10.1080/19390211.2024.2327546","url":null,"abstract":"<p><p>The consumption of dietary supplements (DS) has resulted in a significant and escalating number of cases involving liver injury. It is crucial for clinicians and consumers to be well informed about the adverse effects of such products, leading to their discontinuation and timely reporting of any harmful cases. This article delves into the clinical perspective of DS-related hepatotoxicity, highlighting key concepts such as a systematic diagnostic approach. The discussion extends to notable examples of both currently popular and potential future dietary supplements, such as garcinia cambogia, turmeric, and ashwagandha, accompanied by an overview of recent findings. Causality assessment tools play a crucial role in establishing a connection between these products and instances of liver injury, with consideration of the advantages and disadvantages associated with their use. Fostering a comprehensive understanding of regulatory standards, coupled with a solid foundation of knowledge of DS, will prove instrumental in preventing DS-related hepatotoxicity. Achieving this goal requires collaborative efforts from both consumers and clinicians.</p>","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"58-77"},"PeriodicalIF":1.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}