Effects of a Novel Probiotic Supplement with Weight Gain Intervention on Anthropometry, Body Composition, and Appetite in Underweight Adults: A Randomized Controlled Trial.

IF 2.3 Q3 NUTRITION & DIETETICS
Alireza Hatami, Maryam Ahmadi-Khorram, Reza Rahmanian, Ali Jafarzadeh Esfehani, Elyas Nattagh-Eshtivani, Asma Afshari, Mohsen Nematy
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引用次数: 0

Abstract

Undernutrition in adults increases mortality and impairs immunity and quality of life. Gut microbiota influences metabolism, suggesting potential for probiotic-based weight-gain strategies. This study aimed to assess the efficacy of a probiotic supplement combined with a weight-gain diet on anthropometric indices, appetite, and calorie intake in underweight adults. In this 8-week, double-blind, randomized, placebo-controlled trial, 95 underweight adults (aged 18-60 years) from Mashhad, Iran, were randomized to receive a probiotic supplement (Lacticaseibacillus rhamnosus GG, Lactobacillus acidophilus, Lacticaseibacillus casei; 109 CFU/capsule) or placebo with a 500-kcal surplus diet. Primary outcomes included anthropometric measures, including body weight and BMI. Secondary outcomes included appetite (via visual analog scales), caloric intake, and stool consistency. The probiotic group (n = 47) showed greater increases than the placebo group (n = 48) in body weight (2.41 vs 0.44 kg, p < 0.001), BMI (0.83 vs 0.24 kg/m², p < 0.001), body fat percentage (3.23% vs 1.03%, p < 0.001), fat mass (1.90 vs 0.89 kg, p = 0.002), and caloric intake (263.55 vs 30.75 kcal/day, p < 0.001). The probiotic group showed significant increases in hunger (p < 0.001) and desire to eat (p < 0.001), with reduced satiety and fullness before meals (p < 0.001), as assessed by VAS. Stool consistency in the probiotic group shifted significantly toward softer, more regular stools, as evidenced by a one-unit increase in the Bristol Stool Score (p = 0.01), compared to no change in the control group (p = 0.97). Probiotic supplementation with a weight-gain diet significantly enhances anthropometric measures, appetite, and calorie intake in underweight adults, offering a novel strategy for managing undernutrition.

Clinical trial registration: Iranian Registry of Clinical Trials, IRCT20230310057667N1 (Issue date 30 March 2023), https://irct.behdasht.gov.ir/trial/69130.

一种新型益生菌补充剂与体重增加干预对体重过轻成人人体测量、身体组成和食欲的影响:一项随机对照试验。
成人营养不良会增加死亡率,损害免疫力和生活质量。肠道菌群影响新陈代谢,提示基于益生菌的增重策略的潜力。本研究旨在评估益生菌补充剂结合增重饮食对体重过轻成人人体测量指标、食欲和卡路里摄入的影响。在这项为期8周的双盲、随机、安慰剂对照试验中,来自伊朗马什哈德的95名体重不足的成年人(18-60岁)被随机分为两组,一组接受益生菌补充剂(鼠李糖乳杆菌GG、嗜酸乳杆菌、干酪乳杆菌;109 CFU/胶囊),另一组接受500千卡剩余饮食的安慰剂。主要结局包括人体测量指标,包括体重和BMI。次要结果包括食欲(通过视觉模拟量表)、热量摄入和大便一致性。益生菌组(n = 47)在体重(2.41 vs 0.44 kg, p < 0.001)、BMI (0.83 vs 0.24 kg/m²,p < 0.001)、体脂率(3.23% vs 1.03%, p < 0.001)、脂肪量(1.90 vs 0.89 kg, p = 0.002)和热量摄入(263.55 vs 30.75 kcal/d, p < 0.001)方面均比安慰剂组(n = 48)有更大的增加。根据VAS评估,益生菌组的饥饿感(p < 0.001)和食欲(p < 0.001)显著增加,餐前饱腹感和饱腹感降低(p < 0.001)。与对照组没有变化(p = 0.97)相比,益生菌组的粪便稠度明显转向更柔软、更规律的粪便,布里斯托尔粪便评分增加了一个单位(p = 0.01)就是证据。在体重增加的饮食中补充益生菌可以显著提高体重不足的成年人的人体测量、食欲和卡路里摄入量,为治疗营养不良提供了一种新的策略。临床试验注册:伊朗临床试验注册中心,IRCT20230310057667N1(发布日期2023年3月30日),https://irct.behdasht.gov.ir/trial/69130。
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来源期刊
Journal of Dietary Supplements
Journal of Dietary Supplements Agricultural and Biological Sciences-Food Science
CiteScore
6.10
自引率
0.00%
发文量
34
期刊介绍: The Journal of Dietary Supplements (formerly the Journal of Nutraceuticals, Functional & Medical Foods) has been retitled to reflect the bold departure from a traditional scientific journal presentation to a leading voice for anyone with a stake in dietary supplements. The journal addresses important issues that meet the broad range of interests from researchers, regulators, marketers, educators, and health professionals from academic, governmental, industry, healthcare, public health, and consumer education sectors. This vital tool not only presents scientific information but interprets it - helping you more readily pass it on to your students, patients, clients, or company.
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