Journal of Dietary Supplements最新文献_第10页

A Double-Blind, Randomized, Placebo-Controlled Pilot Study examining an Oxygen Nanobubble Beverage for 16.1-km Time Trial and Repeated Sprint Cycling Performance. 一项双盲、随机、安慰剂对照试验研究，检验了纳米氧泡泡饮料对 16.1 公里计时赛和重复冲刺自行车赛成绩的影响。

IF 2.5

Journal of Dietary Supplements Pub Date : 2024-01-01 Epub Date: 2023-05-01 DOI: 10.1080/19390211.2023.2203738

David G King, Eleanor Stride, Jeewaka Mendis, William H Gurton, Heather Macrae, Louise Jones, Julie Hunt

{"title":"A Double-Blind, Randomized, Placebo-Controlled Pilot Study examining an Oxygen Nanobubble Beverage for 16.1-km Time Trial and Repeated Sprint Cycling Performance.","authors":"David G King, Eleanor Stride, Jeewaka Mendis, William H Gurton, Heather Macrae, Louise Jones, Julie Hunt","doi":"10.1080/19390211.2023.2203738","DOIUrl":"10.1080/19390211.2023.2203738","url":null,"abstract":"There is growing interest of ergogenic aids that deliver supplemental oxygen during exercise and recovery, however, breathing supplemental oxygen via specialist facemasks is often not feasible. Therefore, this study investigated the effect of an oxygen-nanobubble beverage during submaximal and repeated sprint cycling. In a double-blind, randomized, placebo-controlled study, 10 male cyclists (peak aerobic capacity, 56.9 ± 6.1 mL·kg-1·min-1; maximal aerobic power, 385 ± 25 W) completed submaximal or maximal exercise after consuming an oxygen-nanobubble (O2) or placebo (PLA) beverage. Submaximal trials comprised 30-min of steady-state cycling at 60% peak aerobic capacity and 16.1-km time-trial (TT). Maximal trials involved 4 × 30 s Wingate tests interspersed by 4-min recovery. Time-to-completion during the 16.1-km TT was 2.4% faster after O2 compared with PLA (95% CI = 0.7-4.0%, p = 0.010, d = 0.41). Average power for the 16.1-km TT was 4.1% higher for O2 vs. PLA (95% CI = 2.1-7.3%, p = 0.006, d = 0.28). Average peak power during the repeated Wingate tests increased by 7.1% for O2 compared with PLA (p = 0.002, d = 0.58). An oxygen-nanobubble beverage improves performance during submaximal and repeated sprint cycling, therefore may provide a practical and effective ergogenic aid for competitive cyclists.","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"167-181"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9387645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. PREMEN-CALM® 在经前综合症治疗中的效果：一项随机、双盲、安慰剂对照试验研究。

IF 1.9

Journal of Dietary Supplements Pub Date : 2024-01-01 Epub Date: 2024-01-11 DOI: 10.1080/19390211.2023.2301398

Andrea Herrera, Miriam Al Adib, Ana Beatriz Rodríguez, Cristina Carrasco

{"title":"Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.","authors":"Andrea Herrera, Miriam Al Adib, Ana Beatriz Rodríguez, Cristina Carrasco","doi":"10.1080/19390211.2023.2301398","DOIUrl":"10.1080/19390211.2023.2301398","url":null,"abstract":"Premenstrual syndrome is a common disorder in women of reproductive age characterized by a variety of cyclical symptoms with a great impact on their lifestyle. Available pharmacological options include both antidepressants and oral contraceptives, both of which have side effects, are expensive and not always effective. Vitamins, minerals and plant extracts have been proven to alleviate the symptomatology of the premenstrual syndrome. For this reason, the purpose of this study was to test the effectiveness of a commercial phytotherapeutic dietary supplement (PREMEN-CALM®: γ-aminobutyric acid, Rhodiola rosea L., Vitex agnus-castus, vitamin B6 and melatonin) as an alternative treatment for this condition. A randomized, double-blind, and placebo-controlled pilot study was performed. Participants (n = 42) were assessed before and after 3 months of taking the supplement (n = 21) or the placebo (n = 21). Outcome measures include antioxidant and inflammatory biomarkers, body composition, subjective sleep quality, mood state profile, quality of life, and certain characteristics of the menstrual cycle. The within-group analysis revealed a significant improvement in the total antioxidant status (1.49 ± 0.34 vs reference value 1, p = 0.002), mood state profile (p = 0.02), and affective symptoms (p = 0.01) in the women receiving the commercial phytotherapeutic dietary supplement PREMEN-CALM®. On the contrary, the between-group analysis showed no statistical differences, suggesting a plausible placebo effect. The phytotherapeutic supplement PREMEN-CALM® might be effective in treating or alleviating the symptoms of the premenstrual syndrome without adverse events. Integrative medicine approaches in the clinical practice may help improve the health of women suffering from this and other gynecological conditions.","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"495-511"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139424913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Probiotic Supplementation on Gut Microbiota and Sport Performance in Athletes and Physically Active Individuals: A Systematic Review. 补充益生菌对运动员和体育活跃人士肠道微生物群和运动表现的影响：系统综述

IF 1.9

Journal of Dietary Supplements Pub Date : 2024-01-01 Epub Date: 2023-12-26 DOI: 10.1080/19390211.2023.2293842

Olavo da Silva Carvalho Porepp, Mariana Gonçalves Xavier, Larissa Menezes da Silveira, Isadora Lindenau, Andrine Schmechel Schellin, Raphaela Cassol Piccoli, Gabriel Peres Messenburger, Paula Pastorino da Silva, Pathise Souto Oliveira, Felipe Mendes Delpino, Simone Pieniz

{"title":"Effect of Probiotic Supplementation on Gut Microbiota and Sport Performance in Athletes and Physically Active Individuals: A Systematic Review.","authors":"Olavo da Silva Carvalho Porepp, Mariana Gonçalves Xavier, Larissa Menezes da Silveira, Isadora Lindenau, Andrine Schmechel Schellin, Raphaela Cassol Piccoli, Gabriel Peres Messenburger, Paula Pastorino da Silva, Pathise Souto Oliveira, Felipe Mendes Delpino, Simone Pieniz","doi":"10.1080/19390211.2023.2293842","DOIUrl":"10.1080/19390211.2023.2293842","url":null,"abstract":"The present systematic review aimed to evaluate the effect of probiotic supplementation on gut microbiota and sport performance in athletes and physically active individuals. This review followed the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (P RISMA). The search had no time limits and included the following databases: MEDLINE, LILACS, Scopus, Web of Science, Cochrane, and SP ORT Discus. The risk of bias was assessed through the updated version of the Cochrane tool for assessing the risk of bias in randomized trials (RoB 2). Nine randomized clinical trials (RCTs) were included, accounting for 216 participants. Of these, seven studies found positive results on sport performance. Additionally, some studies showed significant decrease in biochemical parameters linked to inflammation. It was also observed direct results in the microbiota composition of the participants, such as an increase in the abundance of probiotics and a decrease in certain pathogenic bacteria. Therefore, the use of probiotics showed improvement in inflammatory biomarkers and oxidative stress, which indirectly may contribute to the improvement of sport performance. However, the majority of the studies presented a high risk of bias, which impair the reproducibility of the results. While the field of probiotic supplementation and sport performance is emerging, the promising results from this systematic review suggest that further investigation through larger and more robust randomized clinical trials can provide valuable insights for athletes and their performance.","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"660-676"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139040076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Dose-Response Study to Examine Paraxanthine's Impact on Energy Expenditure, Hunger, Appetite, and Lipolysis. 一项剂量反应研究，探讨帕罗沙坦因对能量消耗、饥饿、食欲和脂肪分解的影响。

IF 1.9

Journal of Dietary Supplements Pub Date : 2024-01-01 Epub Date: 2024-05-14 DOI: 10.1080/19390211.2024.2351222

Kristen N Gross, Leah E Allen, Anthony M Hagele, Joesi M Krieger, Paige J Sutton, Esther Duncan, Petey W Mumford, Ralf Jäger, Martin Purpura, Chad M Kerksick

{"title":"A Dose-Response Study to Examine Paraxanthine's Impact on Energy Expenditure, Hunger, Appetite, and Lipolysis.","authors":"Kristen N Gross, Leah E Allen, Anthony M Hagele, Joesi M Krieger, Paige J Sutton, Esther Duncan, Petey W Mumford, Ralf Jäger, Martin Purpura, Chad M Kerksick","doi":"10.1080/19390211.2024.2351222","DOIUrl":"10.1080/19390211.2024.2351222","url":null,"abstract":"This study investigated if paraxanthine (PX) impacts energy expenditure, lipolysis and perceptual responses. In a randomized, double-blind, placebo-controlled, crossover fashion, 21 adults (13 M, 8 F; 26.0 ± 6.4 years, 174.9 ± 11.5 cm, 81.0 ± 15.7 kg body mass, 26.3 ± 3.4 kg/m2) consumed a placebo (PLA), 100 mg (PX100), 200 mg (PX200), and 300 mg of PX (PX300, enfinity®, Ingenious Ingredients, L.P. Lewisville, TX, USA). Venous blood was collected 0, 30, 60, 90, 120 and 180 min (min) after ingestion and analyzed for glycerol and free fatty acids. Resting hemodynamics, metabolic rate and perceptual indicators of hunger, appetite and anxiety were evaluated. Mixed factorial analysis of variance were used to evaluate changes time within and between groups. Heart rate decreased in PX100 compared to PLA 60 (p = .022) and 180 min (p = .001). Blood pressure did not change. Hunger ratings in PLA increased 30 (p = .05), 60 (p = .04), 90 (p = .02), and 180 min (p = .05) after ingestion when compared to PX200. PX200 increased energy expenditure (all p < .05) when compared to PLA. Rates of fat oxidation tended to increase 90 (p = .056) and 120 min (p = .066) in PX200 compared to PLA. Free fatty acids increased in PX300 compared to PLA (p = .002). Glycerol did not change. Ingestion of PX200 augmented energy expenditure and hunger ratings when compared to PLA without impacting hemodynamics or lipolysis.","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"608-632"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and Efficacy of Moderately-High Dose Turmacin® (Turmerosaccharide >10% w/w) Supplementation on Joint Discomfort in Healthy Adults - A Pilot Proof-of-Concept Single Arm Study. 中-高剂量Turmacin®(姜黄糖>10% w/w)对健康成人关节不适的安全性和有效性-一项试点概念验证单臂研究

IF 2.5

Journal of Dietary Supplements Pub Date : 2024-01-01 Epub Date: 2023-02-14 DOI: 10.1080/19390211.2023.2176577

Jeffrey Pradeep Raj, Shreeraam Venkatachalam, Rajkumar S Amaravati

{"title":"Safety and Efficacy of Moderately-High Dose Turmacin® (Turmerosaccharide >10% w/w) Supplementation on Joint Discomfort in Healthy Adults - A Pilot Proof-of-Concept Single Arm Study.","authors":"Jeffrey Pradeep Raj, Shreeraam Venkatachalam, Rajkumar S Amaravati","doi":"10.1080/19390211.2023.2176577","DOIUrl":"10.1080/19390211.2023.2176577","url":null,"abstract":"Turmeric is well-known for its analgesic, anti-inflammatory and anti-arthritic properties but 69.4% of the turmeric rhizome contains Turmerosaccharides whose clinical benefit is still unexplored. Turmacin®/NR-INF-02 is an aqueous extract of Turmeric containing Turmerosaccharides (>10%w/w) with negligible curcuminoids. Previous study with low dose Turmacin® confirmed its safety and efficacy in alleviating induced knee pain in healthy volunteers. Hence, this study aimed to assess the safety and explore the efficacy of moderately high dose Turmacin®. It was an open-label, single-arm interventional trial conducted from August 2018 - January 2019 in a tertiary care teaching hospital. Turmacin® was administered for seven days to 15 healthy volunteers as four capsules of 500 mg each in the morning with food. The stair mill at a speed of 60 steps per minute was used to induce knee pain and Visual Analogue Scale (VAS) was used to measure the pain intensity. Assessments were performed at baseline, Days 5 and 7. One participant reported dyspepsia of mild grade that resolved on its own. When compared to baseline, time to initial discomfort significantly increased on Day-5 (Mean Difference [MD] = 30s, p = 0.016) and Day-7 (MD = 32s, p = 0.007). Whereas the maximum VAS score decreased with time and on Day-7 and it was significantly low when compared with baseline (MD = -0.93, p = 0.008). In summary, Turmacin® supplements given at a dose of 2 g/day was safe and tolerable. Similar to the previous study with low dose Turmacin®, there was a significant increase in pain threshold and decrease in the maximum pain score post intervention.","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"28-37"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9277661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of the Health-Promoting Properties of Spirulina with a Focus on athletes' Performance and Recovery. 螺旋藻促进健康特性综述，重点关注运动员的表现和恢复。

IF 2.5

Journal of Dietary Supplements Pub Date : 2024-01-01 Epub Date: 2023-05-04 DOI: 10.1080/19390211.2023.2208663

Mehdi Chaouachi, Sophie Vincent, Carole Groussard

{"title":"A Review of the Health-Promoting Properties of Spirulina with a Focus on athletes' Performance and Recovery.","authors":"Mehdi Chaouachi, Sophie Vincent, Carole Groussard","doi":"10.1080/19390211.2023.2208663","DOIUrl":"10.1080/19390211.2023.2208663","url":null,"abstract":"Spirulina species are photosynthetic and filamentous bacteria, commonly called 'blue-green microalgae'. Spirulina has a high nutrient content. It contains 60-70% protein with all essential amino acids present, and is rich in several vitamins, minerals, and bioactive compounds. Spirulina is also rich in essential fatty acids, and antioxidants. This rich nutritional content provides to Spirulina several health benefits including antioxidant, anti-inflammatory, immunomodulation, and insulin-sensitizing properties as well as positive effects in various diseases which could be also interesting for athletes. This paper mainly aims to review the interest and effects of Spirulina supplementation in athletes at rest, and in relation to exercise/training. Spirulina's biochemical composition, health properties/effects in humans, and effects in athletes including nutritional status, body composition, physical performance and intense exercise-related disorders were discussed in this review. Literature data showed that Spirulina seems to have positive effects on body composition especially in overweight and obese subjects which could not be the case in other pathologies and athletes. Spirulina appears to be also effective in improving aerobic fitness especially in untrained and moderately trained subjects. Results reported in the literature suggest that Spirulina may improve strength and power performance despite the minor or no significant effects in highly trained subjects. Most studies have shown that Spirulina improves antioxidant status, prevents and accelerates the recovery of exercise-induced lipid peroxidation, muscle damage and inflammation in trained and untrained subjects. Taken together, the results from these studies are encouraging and may demonstrate the potential benefits of Spirulina supplementation in athletes despite methodological differences.","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"210-241"},"PeriodicalIF":2.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9411612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review. 螺旋藻补充剂对心脏代谢风险因素的影响：叙述性综述。

IF 1.9

Journal of Dietary Supplements Pub Date : 2024-01-01 Epub Date: 2024-01-22 DOI: 10.1080/19390211.2023.2301366

Sara Sokary, Hiba Bawadi, Zain Zaki Zakaria, Maha Al-Asmakh

{"title":"The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review.","authors":"Sara Sokary, Hiba Bawadi, Zain Zaki Zakaria, Maha Al-Asmakh","doi":"10.1080/19390211.2023.2301366","DOIUrl":"10.1080/19390211.2023.2301366","url":null,"abstract":"Spirulina (Arthrospira platensis) is a cyanobacterium associated with multiple health benefits. Cardiometabolic diseases such as cardiovascular disease, nonalcoholic fatty liver disease, and diabetes are prevalent yet usually preventable non-communicable diseases. Modifiable risk factors for cardiometabolic diseases include excessive body weight, body inflammation, atherogenic lipid profile, and imbalanced glucose metabolism. This review explores the effects of spirulina on cardiometabolic diseases risk factors. Spirulina was effective in reducing body weight, body mass index, and waist circumference, with a potential dose-dependent effect. It also decreased interleukin 6, an important biomarker of body inflammation, by inhibiting NADPH oxidase enzyme, and lowering insulin resistance. spirulina supplementation also reduced triglycerides, low-density lipoprotein cholesterol, and increased high-density lipoprotein cholesterol. Additionally, spirulina reduced fasting blood sugar and post-prandial blood sugar and increased insulin sensitivity, but no effect was observed on glycated hemoglobin A1c. The diverse nutrients, such as phycocyanin, gamma-linolenic acid, and vitamin B12, present in spirulina contribute to its cardiometabolic benefits. The doses used are heterogeneous for most studies, ranging from 1 to 8 grams daily, but most studies administered spirulina for 3 months to observe an effect. The collective evidence suggests that spirulina supplements may help improve risk factors for cardiometabolic diseases, thus, preventing its development. However, due to the heterogeneity of the results, more randomized clinical trials are needed to draw robust conclusions about spirulina's therapeutic potential in ameliorating risk factors for cardiometabolic diseases and fully elucidate the mechanisms by which it exerts its effects.","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"527-542"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Health-Promoting Opportunities of Hemp Hull: The Potential of Bioactive Compounds. 大麻壳促进健康的机会：生物活性化合物的潜力。

IF 1.9

Journal of Dietary Supplements Pub Date : 2024-01-01 Epub Date: 2024-02-01 DOI: 10.1080/19390211.2024.2308264

B Jan-Willem van Klinken, Maria L Stewart, Swati Kalgaonkar, Lee Chae

{"title":"Health-Promoting Opportunities of Hemp Hull: The Potential of Bioactive Compounds.","authors":"B Jan-Willem van Klinken, Maria L Stewart, Swati Kalgaonkar, Lee Chae","doi":"10.1080/19390211.2024.2308264","DOIUrl":"10.1080/19390211.2024.2308264","url":null,"abstract":"Hemp hull is the outer coat of the hemp seed, derived from the plant Cannabis sativa L., Cannabaceae. While much attention has been paid to hemp seed for its oil, protein and micronutrient content, far less attention has been given to hemp hull, a side stream of hemp processing. Hemp hull is a source of bioactive compounds, dietary fiber, minerals as well as protein, lipids and carbohydrates. Of note, two bioactive compounds, n-trans-caffeoyltyramine and n-trans-feruloyltyramine have been identified in hemp hull as key bioactive compounds that support gut health, liver function and other physiological processes. Both of these compounds were identified as agonists of the transcription factor, hepatic nuclear factor-4 alpha which has been implicated in gene expression that governs gut permeability, factors associated with inflammatory bowel diseases, and hepatic lipid homeostasis. Additionally, the dietary fibers in hemp hull have been demonstrated to be novel prebiotics, which may further amplify hemp hull's effect on gut health and metabolic health. This review article summarizes the nutritional content of hemp hull, explores the physiological effects of bioactive compounds found in hemp hull, and identifies opportunities for further research on hemp hull for human health benefit.","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"543-557"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Caffeic Acid: Numerous Chemoprotective Effects are Mediated via Hormesis. 咖啡酸许多化学保护作用都是通过激素作用介导的

IF 1.9

Journal of Dietary Supplements Pub Date : 2024-01-01 Epub Date: 2024-10-03 DOI: 10.1080/19390211.2024.2410776

Edward J Calabrese, Peter Pressman, A Wallace Hayes, Linda Baldwin, Evgenios Agathokleous, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese

{"title":"Caffeic Acid: Numerous Chemoprotective Effects are Mediated via Hormesis.","authors":"Edward J Calabrese, Peter Pressman, A Wallace Hayes, Linda Baldwin, Evgenios Agathokleous, Gaurav Dhawan, Rachna Kapoor, Vittorio Calabrese","doi":"10.1080/19390211.2024.2410776","DOIUrl":"10.1080/19390211.2024.2410776","url":null,"abstract":"Caffeic acid is a common phenolic acid found in coffee and numerous fruits and vegetables. Known for its antioxidant properties, it is widely used as a dietary supplement as part of a polyphenol mixture or as an extract in the form of a capsule or powder. It is also available in liquid form as a homeopathic supplement. Caffeic acid phenethyl ester (CAPE) is an active component of propolis produced by honey bees. Propolis extract is used as a supplement and is available in various forms. The present paper is a comprehensive review of the biomedical literature, showing that caffeic acid effects are hormetic and occur in numerous biological models and cell types for a broad range of endpoints including many aging-related processes. Hormesis is a biphasic dose/concentration response displaying a low concentration/dose stimulation and a high concentration/dose inhibition. Complex alternative search strategies for caffeic acid were used since publications rarely used the terms hormesis or hormetic. Evaluation of the data provides the first assessment of caffeic acid-induced hormetic concentration/dose responses and their quantitative features. Their mechanistic foundations, extrapolative strengths/limitations, and their biomedical, clinical, and public health implications are discussed. Suggestions for future research are presented.","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"842-867"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation of a Toll-like Receptor (TLR)2/TLR1 Activation Assay for Biological Standardization of Arthrospira/Limnospira Immune-Enhancing Potency. Toll样受体（TLR）2/TLR1激活测定用于关节螺旋体/Limnospira免疫增强能力的生物标准化的验证。

IF 1.9

Journal of Dietary Supplements Pub Date : 2024-01-01 Epub Date: 2023-10-04 DOI: 10.1080/19390211.2023.2263566

Mona H Haron, Jin Zhang, Amar G Chittiboyina, Ikhlas A Khan, Nirmal D Pugh

{"title":"Validation of a Toll-like Receptor (TLR)2/TLR1 Activation Assay for Biological Standardization of Arthrospira/Limnospira Immune-Enhancing Potency.","authors":"Mona H Haron, Jin Zhang, Amar G Chittiboyina, Ikhlas A Khan, Nirmal D Pugh","doi":"10.1080/19390211.2023.2263566","DOIUrl":"10.1080/19390211.2023.2263566","url":null,"abstract":"Arthrospira/Limnospira is a popular botanical dietary supplement throughout the world and has been consumed as a food product for hundreds of years. Ongoing efforts from our research group are focused on evaluating the utility of a Limnospira-derived oral supplement (Immulina) in promoting resilience against influenza viral infection. Like other botanical extracts, Immulina is inherently a complex matrix with variation in the levels of its chemical constituents. Therefore, to ensure therapeutic consistency for future scientific research and clinical studies, we are developing standardization technology using a bioassay and chemical markers. Braun-type lipoproteins, a class of macromolecules that activate the Toll-like receptor (TLR)2/TLR1 signaling pathway, have been identified as a major active component within Immulina. Based on the mechanism of action of the Braun-type lipoproteins, an in vitro bioassay was established using the HEK-Blue hTLR2/TLR1 cell line to quantitate the immune-enhancing potency of Immulina. The objective of the current research was to validate that bioassay for Immulina activity quantification using the U.S. FDA guidance document for botanical drug development and U.S. Pharmacopeia recommendations. System suitability, reference standards and defining potency units were established. Validation of performance parameters included precision, specificity, accuracy, linearity, and range. Validating this bioassay for Immulina activity provides a tool for ensuring product consistency and quantifying the potency of this botanical for use in future research as well as material in the consumer market.","PeriodicalId":15646,"journal":{"name":"Journal of Dietary Supplements","volume":" ","pages":"281-293"},"PeriodicalIF":1.9,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10984802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41146359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0