Journal of Diabetes and Metabolic Disorders最新文献

{"title":"A new glucose monitoring system for the intermittent monitoring of interstitial glucose values in patients with diabetes mellitus.","authors":"Antonio Rossi, Giada Rossi, Laura Montefusco, Vincenzo Cimino, Ida Pastore, Alessandra Gandolfi, Loredana Bucciarelli, Cristian Loretelli, Denisa Boci, Francesca D'Addio, Maria Elena Lunati, Paolo Fiorina","doi":"10.1007/s40200-024-01488-2","DOIUrl":"10.1007/s40200-024-01488-2","url":null,"abstract":"<p><strong>Objectives: </strong>Glucose monitoring in diabetes is changing overtime with a constant development of new devices for continuous glucose monitoring (CGM). Aim of this observational, prospective study was to evaluate the clinical performance of a novel intermittently scanned CGM system, the Glunovo Flash in a cohort of patients with type 1 diabetes.</p><p><strong>Methods: </strong>A total of 45 patients with T1D followed at the Endocrinology Unit of the ASST-FBF-Sacco (Milan) were enrolled. All patients were habitual CGM users and were asked to wear simultaneously the Glunovo Flash system and their habitual CGM device for 14 days. A comparison of CGM glucose metrics was performed. Patients' opinions on the new device were also collected.</p><p><strong>Results: </strong>Thirty-five patients completed the study period of two weeks (7 habitual real time CGM users, 28 habitual intermittently scanned CGM users). Mean Time In Range resulted significantly higher with the novel studied sensor respect to intermittently scanned CGM comparator. No differences were found considering other glucose metrics. A positive correlation was found between the Time In Range recorded by Glunovo Flash and intermittently scanned CGM comparators as well as for Time Above Range, Glucose Management Indicator, Time Below Range and Coefficient of Variation. No correlations were found between glucose metrics recorded by Glunovo Flash and real time CGM comparators. Patients reported a positive experience of use with the new sensor but some elements appeared improvable.</p><p><strong>Conclusions: </strong>The CGM device Glunovo Flash for patients with diabetes shows similar performance to other intermittently scanned CGM systems.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2201-2205"},"PeriodicalIF":1.8,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex disparity in the burden of NCDs and its four main subgroups in Iran 1990-2019: a systematic analysis from the global burden of disease study 2019.","authors":"Mahdie Fatollahzade, Mohammad-Mahdi Bastan, Moez Shaabanian, Ali Golestani, Ozra Tabatabaei-Malazy, MohammadReza Mohajeri-Tehrani, MohammadReza Amini, Sepehr Khosravi, Hamid Pajavand, Bagher Larijani","doi":"10.1007/s40200-024-01489-1","DOIUrl":"10.1007/s40200-024-01489-1","url":null,"abstract":"<p><strong>Objectives: </strong>The significant health differences between sexes in Iran in terms of burden of non-communicable diseases (NCDs) point to the urgency of developing policies. We aim to explore sex disparities in NCDs.</p><p><strong>Methods: </strong>We used Global Burden of Disease 2019 study to compare estimates of incidence, prevalence, disability-adjusted life years (DALYs), years lived with disabilities (YLDs), years of life lost (YLLs), and deaths among sexes for NCDs, and their main subgroups; neoplasms, cardiovascular diseases (CVDs), chronic respiratory diseases (CRDs), diabetes mellitus (DM) during 1990-2019.</p><p><strong>Results: </strong>In 2019, there were 62,476,274 (59517167.5, 65759931) incident NCDs in men and 78758640.6 (75222093.7, 82272935.8) in women. There were 7734064.3 (6744951.2, 8846192) DALYs in men and 7760484.2 (6496609, 9218299.9) in women. Fatal estimates (deaths and YLLs) of NCDs were higher for men, while non-fatal estimates (prevalence, YLDs) were higher for women. Men were superior in all burden indices of NCDs subgroups, except for all indices of DM and YLDs in CVDs. Compared to 1990-2010, the period 2010-2019 confirmed a marked stagnation in decline rates of burden indices, as well as an increase in incidence and prevalence which was more pronounced among men. Despite shrinking sex gaps in NCDs subgroups since 1990, sex gap in DM is widening in 2019.</p><p><strong>Conclusions: </strong>There is a notable sex disparity in NCDs prevalence in Iran, which has become increasingly evident in DM burden. It will be imperative to continue monitoring sexual differences in NCDs burden to determine if disease rates between sexes continue to diverge in the future.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-024-01489-1.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2207-2224"},"PeriodicalIF":1.8,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comment on: \"Risk of nonarteritic anterior ischemic optic neuropathy in patients prescribed semaglutide\".","authors":"Mandana Hasanzad, George P Patrinos, Hamid Reza Aghaei Meybodi, Shekoufeh Nikfar, Bagher Larijani","doi":"10.1007/s40200-024-01493-5","DOIUrl":"10.1007/s40200-024-01493-5","url":null,"abstract":"","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2411-2414"},"PeriodicalIF":1.8,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of closed-loop automated insulin delivery systems on hypoglycaemia awareness in people living with type 1 diabetes: A systematic review and meta-analysis.","authors":"Agathoklis Efthymiadis, Anastasios Bastounis, Linda Liu, Marianthi Bourlaki, Dimitrios Spinos, Konstantinos Tsikopoulos","doi":"10.1007/s40200-024-01492-6","DOIUrl":"10.1007/s40200-024-01492-6","url":null,"abstract":"<p><strong>Objectives: </strong>Impaired awareness of hyperglycaemia (IAH) affects approximately 20-40% of people living with type 1 diabetes (T1D), predisposing them to severe hypoglycaemia. This systematic review evaluated the efficacy of closed-loop automated insulin delivery systems (CL-AID) in restoring IAH compared with standard diabetes care, including other diabetes technologies.</p><p><strong>Methods: </strong>Six electronic databases were searched for published and unpublished observational and randomised-control studies (RCTs) from inception to 29th of May 2024. The results of observational studies and RCTs were meta-analysed separately to calculate the effect of CL-AID on IAH in people living with T1D. Quality assessment of studies was performed using the Joanna-Briggs appraisal tool for cohort studies and the Risk of Bias (Rob-2) tool for RCTs.</p><p><strong>Results: </strong>Meta-analysis of four prospective observations studies (n = 583) demonstrated a statistically significant improvement in hypoglycaemia awareness upon transition to a hybrid closed-loop (HCL) system compared with standard diabetes care in people with T1D, Clarke score mean difference (MD) of -0.45 (-0.69 to -0.22, p = 0.0001). However, this was less than 1 point, which is the minimum clinically important difference (MCID) of Clarke score. Meta-analysis of three RCTs (n = 55) comparing standard diabetes care did not demonstrate any statistically significant effect on hypoglycaemia awareness, Clarke score MD of -0.69 (-1.89 to 0.50, p = 0.26).</p><p><strong>Conclusions: </strong>This systematic review demonstrated that transition from standard diabetes care to HCL has the potential to improve hypoglycaemia awareness in people with T1D and IAH, but this might not be of major clinical significance. Hence, psychoeducational interventions continue to be the cornerstone of IAH management. Novel therapeutic modalities, such as bi-hormonal automated delivery systems, need to be further explored to help restore hypoglycaemia awareness.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-024-01492-6.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2251-2261"},"PeriodicalIF":1.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring genetic signatures of obesity: hub genes and miRNAs unveiled through comprehensive bioinformatic analysis.","authors":"Mahdieh Tamkini, Mitra Nourbakhsh, Monireh Movahedi, Abolfazl Golestani","doi":"10.1007/s40200-024-01490-8","DOIUrl":"10.1007/s40200-024-01490-8","url":null,"abstract":"<p><strong>Objectives: </strong>Adipogenesis, the process of fat accumulation in adipose tissue, is closely linked to obesity, a condition characterized by excessive fat storage. Genetic factors significantly contribute to an individual's susceptibility to adipogenesis and the development of obesity.</p><p><strong>Methods: </strong>In this study, we conducted a comprehensive bioinformatic analysis, including Weighted Gene Co-expression Analysis, differentially expressed gene analysis, and protein-protein interaction analysis, to identify hub genes and miRNAs associated with obesity.</p><p><strong>Results: </strong>Our findings highlight the potential involvement of genes such as ATP5F1A, FN1, CCl2, RPS14, and RPS16, as well as miRNAs including hsa-miR-6844, hsa-miR-4528, hsa-miR-3686, hsa-miR-3124-3p, hsa-miR-381-3p, and hsa-miR-300 in obesity.</p><p><strong>Conclusions: </strong>The findings from this study contribute to the growing knowledge of adipogenesis and obesity genetics, and provide potential biomarkers for further investigation and translation into clinical or research applications.</p><p><strong>Graphical abstract: </strong></p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-024-01490-8.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2225-2232"},"PeriodicalIF":1.8,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of bisphenol A exposure on the risk of gestational diabetes: a meta-analysis of observational studies.","authors":"Mehdi Koushki, Amir Hossein Doustimotlagh, Nasrin Amiri-Dashatan, Masoumeh Farahani, Hossein Chiti, Razieh Vanda, Shahintaj Aramesh","doi":"10.1007/s40200-024-01485-5","DOIUrl":"10.1007/s40200-024-01485-5","url":null,"abstract":"<p><strong>Purpose: </strong>A growing number of evidence have assessed the association between bisphenol A (BPA) as an endocrine-disrupting agent and the risk of gestational diabetes (GDM). This meta-analysis aimed to reassess the data on the association of BPA levels in women with GDM compared to the control.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in Medline, Embase, Scopus, and Web of Science to extract relevant published studies up to May 2024. 12 articles were included in the meta-analysis. DerSimonian and Liard random-effects model was used to estimate the pooled odds ratio (OR). Sensitivity analysis was conducted to assess the robustness of the pooled results by removing each study from the pooled effect size. Subgroup analyses were performed depending on the subgroups of gestational age, GDM trimester, BMI, study design and geographical area.</p><p><strong>Results: </strong>The results showed that there was no significant association between circulating and urinary BPA concentrations with the risk of GDM (OR: 0.79; 95% CI 0.60-1.04; <i>P</i> = 0.095). No significant heterogeneity was found among the studies. Using Begg's correlation (<i>P</i> = 0.95) and Egger's linear regression (<i>P</i> = 0.86) tests, no publication bias was observed. The sensitivity analysis shows that our findings were completely robust and stable. Meta-regression indicated a significant association between BPA levels and study design and geometric mean as an index of the risk of GDM.</p><p><strong>Conclusion: </strong>The present meta-analysis demonstrates exposure to BPA was associated with a reduced risk of GDM. Further studies are needed for obtain the reliable results.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2173-2182"},"PeriodicalIF":1.8,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced 3D-DXA insights into bone density changes in hyperparathyroidism.","authors":"Francesco Saverio Guerra, Nicola Palladino, Renaud Winzenrieth, Giuseppe Guglielmi","doi":"10.1007/s40200-024-01487-3","DOIUrl":"10.1007/s40200-024-01487-3","url":null,"abstract":"<p><strong>Objectives: </strong>Primary hyperparathyroidism (PHPT) is a disorder marked by chronic parathyroid hormone hypersecretion, which affects bone turnover and remodelling processes. With a loss of bone density and an increase in bone porosity, the cortical compartment is most severely impacted. The study's goal is to assess PHPT's effects on the volumetric bone mineral density (vBMD) of the femur's trabecular compartment as well as the vBMD and thickness of the cortical bone.</p><p><strong>Methods: </strong>This is a retrospective case-control study, valuating age, biochemical doses, anthropometric measurements, and bone measurements. Between 2011 and 2016, 74 Caucasian Italian women and men with PHPT were sought out. Biochemical analyses were added to bone mineral density (BMD) values found in the lumbar spine and femoral neck. Proximal femur parameters such as cortical and trabecular volumetric (v) BMD, cortical thickness (CTh) and surface (s) BMD were analyzed by 3D-DXA software (3D-SHAPER Medical, Spain).</p><p><strong>Results: </strong>The findings showed a negative correlation between PHPT patients and controls, which was equally affecting the cortical and trabecular compartments. This correlation was especially evident in the areal BMD (aBMD) and vBMD measurements. Nonetheless, no appreciable correlation was found between the cortical level and the thickness of the cortical bone.</p><p><strong>Conclusions: </strong>Parathormone (PHT) levels had an adverse effect on the cortical, trabecular volumetric density in this investigation, as was expected. Cortical thickness, however, is unaffected significantly. The literature and these findings are consistent.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2191-2199"},"PeriodicalIF":1.8,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599834/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of <i>SLC22A1</i> rs12208357 on therapeutic response to metformin in type 2 diabetes patients.","authors":"Reza Moazzami, Mohammad Yahya Vahidi Mehrjardi, Ali Miri","doi":"10.1007/s40200-024-01486-4","DOIUrl":"10.1007/s40200-024-01486-4","url":null,"abstract":"<p><strong>Introduction: </strong>: Metformin, an oral hypoglycemic agent, is generally used as the first-line treatment in type 2 diabetes mellitus (T2DM) patients. The response to metformin varies between patients, and its mechanisms remain incompletely understood. Genetic variations in proteins involved in the pharmacodynamics and pharmacokinetics of metformin, like OCT1 transporter, are suspected to explain this difference. This study investigated the association of the response to metformin in T2DM patients with the presence of rs12208357 (R61C) variant in the <i>SLC22A1</i> gene.</p><p><strong>Materials and methods: </strong>We selected 100 patients who responded and 100 patients who did not respond to metformin monotherapy after 20 weeks according to their HbA1c level change. We investigated the effect of rs12208357 on the structure, function, and stability of OCT1 protein and its interaction with metformin by in silico tools. To determine the genotype of rs12208357 we used the ARMS-PCR technique.</p><p><strong>Results: </strong>The in silico study indicated that rs12208357 probably changes OCT1 stability, function, interaction site, and binding energy to metformin in the extracellular domain. ARMS-PCR also showed the frequency of T and C alleles were significantly different between responders and non-responders (<i>P-value</i> = 0.014), also there is a significant difference in CC and CT/TT genotype frequency between responders and non-responders (<i>P-value</i> = 0.023).</p><p><strong>Conclusion: </strong>Based on the in silico study and ARMS-PCR experiment results, the CC genotype has a better response to metformin therapy and the carrier of the T allele (CT and TT genotype) probably has complications in glycemic control by metformin.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2183-2190"},"PeriodicalIF":1.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive modelling of metabolic syndrome in Ghanaian diabetic patients: an ensemble machine learning approach.","authors":"Emmanuel Acheampong, Eric Adua, Christian Obirikorang, Enoch Odame Anto, Emmanuel Peprah-Yamoah, Yaa Obirikorang, Evans Adu Asamoah, Victor Opoku-Yamoah, Michael Nyantakyi, John Taylor, Tonnies Abeku Buckman, Maryam Yakubu, Ebenezer Afrifa-Yamoah","doi":"10.1007/s40200-024-01491-7","DOIUrl":"10.1007/s40200-024-01491-7","url":null,"abstract":"<p><strong>Objectives: </strong>The burgeoning prevalence of cardiometabolic disorders, including type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) within Africa is concerning. Machine learning (ML) techniques offer a unique opportunity to leverage data-driven insights and construct predictive models for MetS risk, thereby enhancing the implementation of personalised prevention strategies. In this work, we employed ML techniques to develop predictive models for pre-MetS and MetS among diabetic patients.</p><p><strong>Methods: </strong>This multi-centre cross-sectional study comprised of 919 T2DM patients. Age, gender, novel anthropometric indices along with biochemical measures were analysed using BORUTA feature selection and an ensemble majority voting classification model, which included logistic regression, k-nearest neighbour, Gaussian Naive Bayes, Gradient boosting classification, and support vector machine.</p><p><strong>Results: </strong>Distinct metabolic profiles and phenotype clusters were associated with MetS progression. The BORUTA algorithm identified 10 and 16 significant features for pre-MetS and MetS prediction, respectively. For pre-MetS, the top-ranked features were lipid accumulation product (LAP), triglyceride-glucose index adjusted for waist-to-height ratio (TyG-WHtR), coronary risk (CR), visceral adiposity index (VAI) and abdominal volume index (AVI). For MetS prediction, the most influential features were VAI, LAP, waist triglyceride index (WTI), Very low-density cholesterol (VLDLC) and TyG-WHtR. Majority voting ensemble classifier demonstrated superior performance in predicting pre-MetS (AUC = 0.79) and MetS (AUC = 0.87).</p><p><strong>Conclusion: </strong>Identifying these risk factors reveals the complex interplay between visceral adiposity and metabolic dysregulation in African populations, enabling early detection and treatment. Ethical integration of ML algorithms in clinical decision-making can streamline identification of high-risk individuals, optimize resource allocation, and enable precise, tailored interventions.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-024-01491-7.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2233-2249"},"PeriodicalIF":1.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing high disease burden: a study of medication rationality in diabetes and hypertension in Andhra Pradesh.","authors":"Nagasen Dasari, Nisar Ahmed, Sankhanil Panda, Ayushi Kumari, T Thanmayi Sai Lakshmi, Hema Ratna Sai Lakshmi Vemana","doi":"10.1007/s40200-024-01475-7","DOIUrl":"10.1007/s40200-024-01475-7","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the burden of chronic Non-communicable diseases (NCDs) such as diabetes and hypertension, and evaluate the utilization of drugs for their treatment among the population of Andhra Pradesh, India.</p><p><strong>Methods: </strong>A cross-sectional study was conducted to analyse the prevalence of diabetes and hypertension, as well as the pattern of drug usage for their management. Data were collected through surveys and medical records review.</p><p><strong>Results: </strong>The study revealed a high prevalence of diabetes and hypertension in Andhra Pradesh, with significant proportions of the population remaining untreated despite critical drug utilization. Commonly used antidiabetic drugs included metformin, glipizide, and insulin, while telmisartan, furosemide, and metoprolol were frequently utilized for hypertension treatment. Side effects associated with these drugs were reported, emphasizing the need for better public awareness campaigns, improved access to healthcare, and effective management of side effects.</p><p><strong>Conclusions: </strong>The findings underscore the importance of early detection and preventive measures for hypertension and diabetes. There is a pressing need for tailored interventions addressing social and economic factors contributing to non-adherence to treatment regimens. While the widespread use of medications indicates significant awareness and proactive healthcare among a substantial portion of the population, the presence of individuals not adhering to their treatment suggests significant gaps in awareness and access to healthcare services. This study provides crucial insights into medication patterns for managing diabetes and hypertension in Andhra Pradesh, laying the groundwork for targeted public health interventions.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2123-2129"},"PeriodicalIF":1.8,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}