Journal of Diabetes and Metabolic Disorders最新文献

{"title":"Intentional co-ingestion of levothyroxine and insulin in a teenager.","authors":"Sarah El Yaman, Kathryn Swaby, Jeffrey N Bernstein, Janine E Sanchez","doi":"10.1007/s40200-026-01877-9","DOIUrl":"10.1007/s40200-026-01877-9","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of polydrug ingestion involving levothyroxine and insulin in an adolescent, demonstrating potential protective effects of insulin co-ingestion against symptomatic thyrotoxicosis.</p><p><strong>Methods: </strong>A 14-year-old female with type 1 diabetes and Hashimoto thyroiditis presented following intentional ingestion of 6.75 milligrams levothyroxine, 60 units insulin aspart, and 80 units insulin degludec. Laboratory studies revealed severe biochemical thyrotoxicosis with free thyroxine greater than 7.77 nanograms per deciliter and total triiodothyronine 220.5 nanograms per deciliter. She required glucose infusion at 2.3 to 3.7 milligrams per kilogram per minute to maintain normoglycemia, with hypoglycemic episodes lasting up to 17 h post-ingestion. Throughout her 12-day admission, she maintained normal vital signs with no clinical evidence of sympathetic overactivity despite prolonged biochemical thyrotoxicosis.</p><p><strong>Conclusions: </strong>Co-ingestion of insulin and levothyroxine appears to minimize symptomatic thyrotoxicosis risk, potentially through inhibition of thyroxine to triiodothyronine conversion and glucose homeostasis maintenance. This case highlights complex interactions in polydrug ingestions and suggests insulin may provide protection against thyroid storm in mixed overdoses.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"72"},"PeriodicalIF":2.1,"publicationDate":"2026-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12924816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The simplified method for quantifying metabolic syndrome (siMS) score reflects an increased cardiometabolic burden: adiposity, hemodynamics, and HRV findings in young adults.","authors":"Christopher J Kotarsky, Jillian M Lang, Elena S Shostak, William Quinn, Valerie Chervinskaya, Elisa Fioraso, Everett Smith, Justin A DeBlauw, Jennifer Lloyd, Stephen J Ives","doi":"10.1007/s40200-026-01870-2","DOIUrl":"10.1007/s40200-026-01870-2","url":null,"abstract":"<p><strong>Purpose: </strong>Metabolic Syndrome (MetS) increases cardiovascular disease risk, yet early identification of pre-MetS remains challenging. The Simple Method for Quantifying MetS (siMS) score offers potential for detecting cardiometabolic burden in younger and middle-aged, relatively healthy populations.</p><p><strong>Methods: </strong>We stratified 51 healthy adults (aged 18-60 years) into Low siMS (LMS, siMS < 2.085, <i>n</i> = 25) and High siMS (HMS, siMS ≥ 2.085, <i>n</i> = 26) groups based on the median siMS score and compared central hemodynamic parameters, heart rate variability (HRV), and microvascular function as independent predictors of cardiometabolic risk between these groups. Anthropometrics, body composition, hemodynamics (e.g., central blood pressure [BP], mean arterial pressure [MAP]), HRV (e.g., %R-R intervals > 50 msec, pNN50; high-frequency power), microvascular reactivity (near-infrared spectroscopy vascular occlusion test), blood glucose and lipid profiles, and dietary intake were assessed using established protocols.</p><p><strong>Results: </strong>The HMS group exhibited significantly higher body mass, body mass index (BMI), waist and hip circumferences, fat mass, visceral fat, central and peripheral BP, MAP, and augmentation index adjusted to 75 bpm (all <i>p</i> ≤ 0.004), alongside lower HRV metrics (pNN50, high-frequency power, low-frequency power, and total power, <i>p</i> ≤ 0.003), indicating increased cardiometabolic burden. No differences were observed in blood glucose, lipids, dietary intakes, or microvascular reactivity.</p><p><strong>Conclusion: </strong>These findings suggest that higher siMS scores reflect early cardiometabolic risk through adverse hemodynamic and autonomic profiles, even in the absence of overt MetS, metabolic abnormalities, or detectable microvascular dysfunction. The siMS score may serve as a proactive tool for identifying at-risk individuals, supporting targeted interventions to mitigate long-term cardiometabolic risk.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"66"},"PeriodicalIF":2.1,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147271209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuromodulation using Bioelectronics-enabled therapies to combat insulin resistance and its comorbidities.","authors":"Yosra Magdi Mekki, Jeongeun Park, Zeinah Alzaareer, Zaeem Hussain, Ayesha Gulzar, Abdelnaser Elzouki, Amparo Güemes, Susu M Zughaier","doi":"10.1007/s40200-026-01876-w","DOIUrl":"10.1007/s40200-026-01876-w","url":null,"abstract":"<p><strong>Introduction: </strong>Insulin resistance is a complex metabolic disorder that involves multiple molecular pathways to disrupt insulin signaling and is associated with systemic complications.</p><p><strong>Methodology: </strong>We searched through the literature using databases such as PubMed and selected relevant published papers related to the topic of this review.</p><p><strong>Results: </strong>We synthesized this review based on the relevant literature and found that neuromodulation can target neuroendocrine systems responsible for metabolic homeostasis to manage insulin resistance. This involves integrating neural circuit modulation into biological systems. We also found that neuromodulation, particularly vagus nerve stimulation, can reduce inflammation and combat insulin resistance and its associated comorbidities. However, with advancements in closed-loop systems and artificial intelligence, challenges persist in maximizing therapeutic effects, minimizing adverse events, and balancing ethical considerations.</p><p><strong>Conclusion: </strong>Neuromodulation offers novel treatment options for metabolic disorders. An enhanced understanding of neuro-metabolic reflex in insulin resistance is needed to develop more effective and safer neuromodulation therapy.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"59"},"PeriodicalIF":2.1,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12905043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146201884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do insomnia and physical activity mediate the relationship between diabetes and depression in people with type 2 diabetes?","authors":"Sebastian Markvard Petersen, Daniel B Ibsen, Anette Andersen","doi":"10.1007/s40200-026-01875-x","DOIUrl":"10.1007/s40200-026-01875-x","url":null,"abstract":"<p><strong>Purpose: </strong>To examine how self-reported depressive symptoms are affected by type 2 diabetes, and how this relationship may be mediated by insomnia and physical activity.</p><p><strong>Methods: </strong>We used cross-sectional data from the Health In Central Denmark (HICD) cohort including persons with and without type 2 diabetes aged 18 to 75 years. Register-identified diabetes status was used as the exposure and The World Health Organization Five Well-Being Index (WHO-5) was used as the outcome measure for risk of depression. Insomnia severity index level and physical activity level were used as potential mediators. We performed logistic regression analyses and cross-sectional mediation analyses.</p><p><strong>Results: </strong>In total, 45,988 participants were included. Of these, 19,907 had type 2 diabetes of which 1,396 were at risk of depression. Adjusted odds ratio (OR) for risk of depression in people with type 2 diabetes was 1.55 (95% confidence interval (CI): 1.19, 1.59). The strongest risk factor for depression was insomnia at an adjusted OR of 7.43 (CI: 6.63, 8.32). The relationship between diabetes and risk of depression may be mediated by both insomnia and physical activity, the proportion mediated being 42.1% for insomnia and 20.5% for physical activity, in our analyses.</p><p><strong>Conclusion: </strong>Living with type 2 diabetes was associated with higher odds of depression, and insomnia and physical activity may mediate this relationship. Insomnia and physical activity may be important factors for healthcare professionals to consider in their treatment of people with type 2 diabetes.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"50"},"PeriodicalIF":2.1,"publicationDate":"2026-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12882907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory effects of water chestnut (<i>Trapa bispinosa</i> Roxb.) extract plus lutein on the progression of cataract and their impact on the retina and aorta in diabetic rats.","authors":"Hiroshi Mizuno, Gaku Ishigooka, Denan Jin, Shinji Takai, Teruyo Kida","doi":"10.1007/s40200-025-01845-9","DOIUrl":"10.1007/s40200-025-01845-9","url":null,"abstract":"<p><strong>Purpose: </strong><i>Trapa bispinosa</i> Roxb. extract (TBE), combined with lutein, has an inhibitory effect on cataract progression. However, no prior studies evaluated oxidative stress- and antioxidant-related factors simultaneously. This study aimed to investigate TBE plus lutein's potential mechanism to suppress cataract progression and examine its effects on retinal tissue and aorta in spontaneous diabetic Torii (SDT) rats.</p><p><strong>Methods: </strong>Seven-week-old SDT rats (<i>n</i> = 10) and Sprague-Dawley (SD) control rats (<i>n</i> = 5) were divided into three groups: SDT-administered TBE plus lutein (TBE plus lutein), untreated SDT, and control. Blood glucose levels and anterior segment photographs were obtained. Subsequently, polymerase chain reaction (PCR) was used to measure the expression of oxidative stress- and antioxidant-related genes in the lenses, retinas, and aortas. Immunohistochemical staining of the lenses was performed to detect the expression of NOX-1 (an oxidative stress-related factor), 4-HNE (a lipid peroxidation product), and CEL (an advanced glycation end product [AGE]).</p><p><strong>Results: </strong>The progression of diabetic cataract was suppressed in the TBE plus lutein group. PCR results revealed that NOX-1 in lenses was significantly suppressed in the TBE plus lutein group (<i>p</i> < 0.05), whereas antioxidant-related factors, such as SOD, GPX, and Peroxiredoxin 6, were significantly increased (<i>p</i> < 0.01). A similar trend in NOX-1 expression was observed in the retinas and aortas, but the difference was not significant. Immunohistochemical staining of lenses revealed reduced NOX-1, 4-HNE, and CEL expression in the lenses of the TBE plus lutein group.</p><p><strong>Conclusion: </strong>TBE plus lutein may inhibit the progression of diabetic cataract by increasing antioxidant-related factors rather than suppressing oxidative stress-related factors.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"35"},"PeriodicalIF":2.1,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12804548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body mass index mediates the association between serum fibroblast growth factor-19 and diabetes.","authors":"Lin Liu, Shuyun Liu, Juanying Zhen, Lijie Ren, Guoru Zhao, Jianguo Liang, Aimin Xu, Chao Li, Jun Wu, Bernard My Cheung","doi":"10.1007/s40200-025-01850-y","DOIUrl":"10.1007/s40200-025-01850-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the relationship between serum fibroblast growth factor-19 (FGF19) levels and diabetes, as well as the potential mediating role of body mass index (BMI).</p><p><strong>Methods: </strong>Data from 1,018 participants with valid serum FGF19 measurements from the Shenzhen-Hong Kong United Network on Cardiovascular Disease study were analyzed. Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for diabetes risk. Mediation analysis was conducted to assess the extent to which BMI mediated the association between serum FGF19 levels and diabetes.</p><p><strong>Results: </strong>The mean age of participants was 45.1 years, with 77 individuals (7.6%) diagnosed with diabetes. Natural logarithm (ln)-transformed FGF19 levels were inversely associated with BMI [age- and sex-adjusted β (95% CI): -0.30 (-0.58, -0.03)]. Ln-transformed FGF19 levels were also negatively associated with diabetes after adjusting for covariates, including age, sex, smoking status, alcohol consumption, blood pressure, BMI, waist circumference, and lipid profile [OR (95% CI): 0.66 (0.47-0.95)]. No significant interactions were observed between ln-transformed FGF19 levels and age, sex, obesity, or abdominal obesity in relation to diabetes. Mediation analysis revealed that BMI reduction accounted for 10.1% of the association between ln-transformed FGF19 levels and diabetes.</p><p><strong>Conclusion: </strong>Serum FGF19 levels are inversely associated with diabetes risk in the Chinese population, with BMI serving as a partial mediator of this relationship.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-025-01850-y.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"27"},"PeriodicalIF":2.1,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12783406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An integrated design for segmentation and classification of diabetic foot ulcers using thermography images.","authors":"Wan Suhaimizan Bin Wan Zaki, Yamunarani Thanikachalam, Ashok Vajravelu, Prabu Rathinam, E Thangavelu","doi":"10.1007/s40200-025-01813-3","DOIUrl":"10.1007/s40200-025-01813-3","url":null,"abstract":"<p><p>In recent days, diabetics, a chronic disease has risen significantly which leads to more health complications. Among those complications, diabetic foot ulcer (DFU) is much serious. DFU is a wound on the foot of a person who is affected with diabetics. It sometimes leads to fatality if untreated. Diagnosing the DFU in its early stage remains challenging due to medical impediments by the diabetics. Thermography serves as a promising technique in the early prediction of the DFU and aids for an improvised treatment towards the eradication of foot amputations. But still, utilizing thermography images for clinical treatments continues to be underexplored in treating DFU due to its computational complexities and existence of ambiguities in thermal images. To overcome this challenge, this research paper proposes an Intelligent Prediction System (IPS) using the modified swin transformers for an effective segmentation and deep capsule networks for an accurate prediction of DFU. In the segmentation phase, swin transformers can be used as U-NET based architecture to segment the lesions of foot ulcers. Deep features are extracted by the capsule networks and supplied to the deep shallow network which works on the standard of extreme learning networks to achieve the early prediction of DFU. The extensive experimentation is conducted using the thermal foot ulcer images in Python3.20 and Tensorflow -Keras Libraries. To verify the efficiency of the proposed schema, evaluated performances are assessed with other research experiments. Results show that the proposed schema achieves the highest prediction accuracy (99%) with promising segmented performance (98.6%). Moreover, the proposed model excels the varied residing schema and establishes a firm foothold in the early prediction of DFUs.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"17"},"PeriodicalIF":2.1,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12764721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of neddylation in diabetes metabolism: potential therapeutic target.","authors":"Hui Li, Ruiyin Zeng, Jing Liu, Huiwen Wang","doi":"10.1007/s40200-025-01837-9","DOIUrl":"10.1007/s40200-025-01837-9","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to explore the role of neddylation in diabetes metabolism and its potential as a therapeutic target. Given the increasing global diabetes burden and limitations of current treatments, the research question was to determine how neddylation affects diabetes pathophysiology and if targeting it could offer new treatment strategies.</p><p><strong>Methods: </strong>The authors gathered data from a comprehensive review of existing research on neddylation in diabetes, including studies on insulin signaling, glucose and lipid metabolism, and related diseases. Experimental models, including diabetic mice and granulosa cells, and pharmacological interventions like MLN4924 were also thoroughly reviewed. By collating and evaluating these sources of information, the authors analyzed the influence of neddylation on diverse molecules and pathways implicated in diabetes.</p><p><strong>Results: </strong>Neddylation is involved in multiple aspects of diabetes. It affects insulin signaling by modifying insulin receptor substrate (IRS), inositol hexakisphosphate (IP6), phosphoenolpyruvate carboxykinase 1 (PCK1), and other molecules. Inhibiting neddylation with drugs like MLN4924 can reduce hepatic glucose generation, alleviate hyperglycemia, and improve metabolic phenotypes in mouse models. Neddylation is also associated with related diseases such as familial hyperkalemic hypertension, obesity - related metabolic disorders, and nonalcoholic steatohepatitis combined with type 2 diabetes.</p><p><strong>Conclusion: </strong>Neddylation plays a significant role in glucose metabolism regulation and diabetes pathogenesis. Targeting neddylation, especially with inhibitors like MLN4924, shows promise as a new therapeutic strategy for diabetes. Further research on neddylation in diabetes is needed to solidify its potential in treatment and management.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"20"},"PeriodicalIF":2.1,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12764712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145906158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of <i>Toxoplasma gondii</i> seropositivity with type 2 diabetes mellitus: a meta-analysis.","authors":"Raphael Enrique Tiongco, Ralphe Laurenne Arbas, Ian Dave Balanditan, Eliezer John Castro, Michael John Dominguez, Jan Clarence Salinas, Maria Ruth Pineda-Cortel","doi":"10.1007/s40200-025-01822-2","DOIUrl":"https://doi.org/10.1007/s40200-025-01822-2","url":null,"abstract":"<p><strong>Background: </strong><i>Toxoplasma gondii</i> (<i>T. gondii</i>) infection has been associated with type 2 diabetes mellitus (T2DM) through mechanisms involving chronic inflammation and immune dysregulation. However, prior meta-analyses were limited by their inability to distinguish between T2DM and type 1 diabetes, as well as the lack of antibody-based stratification.</p><p><strong>Methods: </strong>A comprehensive search was conducted on PubMed, Google Scholar, and EBSCOhost up to July 4, 2025, for observational studies reporting <i>T. gondii</i> seropositivity among T2DM patients. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Subgroup, sensitivity, and publication bias analyses were also conducted to strengthen the study results further.</p><p><strong>Results: </strong>Eleven case-control studies comprising 1,956 cases and 1,423 controls were included in the analysis. A significant association was found between <i>T. gondii</i> seropositivity and T2DM (OR: 2.21; 95% CI: 1.47-3.33; <i>I²</i> = 82%). IgG seropositivity demonstrated a consistent significant association (OR: 2.26; 95% CI: 1.45-3.53), whereas IgM seropositivity reached significance only in sensitivity analyses (OR: 5.65; 95% CI: 1.61-19.80). No publication bias was identified.</p><p><strong>Conclusion: </strong><i>T. gondii</i> seropositivity is associated with an increased risk of T2DM, which may suggest a potential infectious component in the pathogenesis of diabetes. Further research involving larger, high-quality studies is warranted.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"293"},"PeriodicalIF":1.6,"publicationDate":"2025-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12705505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of curcumin plus piperine co-supplementation on glycemic control in adults: A meta-analysis of randomized controlled trials.","authors":"Mehdi Karimi, Sahar Moshrefi, Ali Daneshmand Bahman, Kimia Kazemi, Arash Jamshidi, Farzad Fayedeh, Meysam Javadi, Fereshteh Bahreini, Omid Asbaghi","doi":"10.1007/s40200-025-01799-y","DOIUrl":"https://doi.org/10.1007/s40200-025-01799-y","url":null,"abstract":"<p><strong>Background and aim: </strong>Poor glycemic control leading to hyperglycemia is a major risk factor for diabetes and its complications. Several primary studies have demonstrated that co-supplementation with curcumin plus piperine (Curc + Pipe) can enhance glycemic control. However, findings across studies are inconsistent. This meta-analysis aims to evaluate the efficacy of Curc + Pipe in glycemic indices in adults.</p><p><strong>Method: </strong>A comprehensive search of major databases was conducted through October 2025 to identify eligible randomized controlled trials (RCTs). Extracted data included fasting blood glucose (FBG), hemoglobin A1c (HbA1c), fasting insulin (FI), and the homeostatic model assessment for insulin resistance (HOMA-IR). Outcomes were pooled using a random-effects model, with weighted mean differences (WMDs) and 95% confidence intervals (CIs).</p><p><strong>Results: </strong>This meta-analysis included 15 RCTs comprising 1,020 participants (514 in the intervention group and 506 in the control group). Pooled analyses demonstrated that Curc + Pipe co-supplementation significantly reduced FBG (WMD: -5.89 mg/dL; 95% CI: [- 9.52, - 2.26], <i>p</i> = 0.001). However, no significant effects were observed for HbA1c (WMD: -0.34%; 95% CI: [- 0.80, 0.11], <i>p</i> = 0.135), FI (WMD: -0.19 mIU/L; 95% CI: [- 1.44, 1.83], <i>p</i> = 0.815), or HOMA-IR (WMD: -0.02; 95% CI: [- 0.67, 0.63], <i>p</i> = 0.957). According to the GRADE assessment, the certainty of evidence was rated as low for FBG, HbA1c, and FI, and moderate for HOMA-IR, indicating limited confidence in the overall findings.</p><p><strong>Conclusion: </strong>Curc + Pipe co-supplementation may modestly improve FBG in adults, particularly in overweight patients with metabolic disorders, but the low-quality evidence, small effect sizes, and non-significant effects on HbA1c, FI, and HOMA-IR limit its clinical relevance. Well-designed, large-scale RCTs are needed to confirm these findings, clarify mechanisms, and determine their potential role in metabolic health management.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-025-01799-y.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"292"},"PeriodicalIF":1.6,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12701184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}