Journal of Diabetes and Metabolic Disorders最新文献

{"title":"Hip geometry, trabecular bone score, and bone mineral density in patients with celiac disease: a multi-center cross-sectional study in Southern Iran.","authors":"Arzhang Naseri, Alireza Keshtkar, Ramina Mofarrah, Amirreza Sabahizadeh, Mostafa Farhadi, Ehsan Shojaeefard, Farnaz Atighi, Pedram Talezadeh, Seyed Taghi Heydari, Marzieh Bakhshayeshkaram, Mohammad Mahdi Dabbaghmanesh, Ramin Niknam, Mohammad Reza Fattahi, Ebrahim Fallahzadeh, Mohammad Hossein Dabbaghmanesh","doi":"10.1007/s40200-026-01972-x","DOIUrl":"https://doi.org/10.1007/s40200-026-01972-x","url":null,"abstract":"<p><strong>Background: </strong>Bone strength is influenced by the stiffness and spatial distribution of mineralized tissue. Bone mineral density (BMD) is used to assess osteoporosis but is limited in evaluating microarchitectural and geometric changes. We investigated Trabecular Bone Score (TBS), BMD, and hip structural analysis (HSA) in celiac disease (CD) patients.</p><p><strong>Methods: </strong>A cross-sectional study compared bone density factors in CD patients with a healthy control group matched for gender, BMI, and age. Dual-energy X-ray absorptiometry (DXA) assessed BMD at the femoral neck, hip, and lumbar spine (L1-L4). TBS was measured at the lumbar spine, and HSA evaluated geometry at the narrow neck (NN), femoral shaft (FS), and intertrochanteric (IT) regions.</p><p><strong>Results: </strong>The study included 73 CD patients and 93 healthy controls. The prevalence of low BMD for age at the lumbar spine, total hip, femoral neck, and at any skeletal site was significantly higher in the CD group compared with controls (<i>P</i> < 0.05). No significant differences were found in TBS between groups (<i>P</i> > 0.05). IT buckling ratio (BR), FS BR, and FS endocortical diameter were significantly higher in the CD group, while IT cortical thickness, FS cross-sectional area, and FS cortical thickness were significantly higher in controls (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>Patients with celiac disease demonstrated adverse DXA-derived structural and densitometric skeletal parameters, which may potentially contribute to increased skeletal fragility, highlighting the importance of assessing both BMD and structural factors.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"160"},"PeriodicalIF":2.1,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13269572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular outcomes of glucagon-like peptide-1 receptor agonists in patients without obesity: a systematic review and meta-analysis of randomized controlled trials.","authors":"Saad Ahmed Waqas, Muhammad Ibrahim, Muhammad Ahmed, Muhammad Waqas, Jazza Aamir, Marat Fudim, Muzammil H Musani, Gregg C Fonarow, Stephen J Greene","doi":"10.1007/s40200-026-01969-6","DOIUrl":"https://doi.org/10.1007/s40200-026-01969-6","url":null,"abstract":"<p><strong>Background: </strong>Glucagon-like peptide-1 receptor agonists (GLP1-RAs) improve cardiometabolic health in patients with obesity and/or type 2 diabetes mellitus. However, their role in cardio protection in individuals without obesity (BMI < 30 kg/m²) remains unclear. This study aimed to determine whether GLP1-RAs reduce cardiovascular events in individuals without obesity.</p><p><strong>Methods: </strong>A systematic review and meta-analysis of RCTs evaluating GLP1-RAs in obese (BMI ≥ 30 kg/m²) and non-obese (BMI < 30 kg/m²) individuals was conducted. The analyzed outcomes included major adverse cardiovascular events (MACE), cardiovascular (CV) death, and heart failure hospitalization (HFH). Hazard ratios (HRs) and 95% confidence intervals (CIs) were pooled using a random-effects model. The study was conducted according to a prespecified protocol registered in PROSPERO (CRD4201287112).</p><p><strong>Results: </strong>Twelve RCTs comprising 91,167 participants were included. BMI subgroup population counts were available in 10 of the 12 included trials. In patients without obesity, GLP1-RAs significantly reduced MACE (HR = 0.81 [0.72-0.90]; <i>p</i> = 0.0002) and CV death (HR = 0.80 [0.70-0.91]). No significant effect was observed in HFH (HR = 1.00 [0.68-1.47]). There was no evidence of effect modification by BMI for MACE (<i>p</i> = 0.53), CV death (<i>p</i> = 0.49), or HFH (<i>p</i> = 0.50).</p><p><strong>Conclusion: </strong>GLP1-RAs reduce MACE and CV death in individuals irrespective of the obesity status. These findings support expanding GLP1-RA use beyond weight management to broader cardiometabolic prevention, though long-term data in healthy weight and lower-risk populations are warranted.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-026-01969-6.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"158"},"PeriodicalIF":1.6,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13264643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of diabetes mellitus on generic health-related quality of life measured by EQ-5D-5L, characterization and disutilities for adverse factors.","authors":"Daniela Mestre, Idoia Castillo-Sintes, Amaia Bilbao-González, Yolanda Ramallo-Fariña, Miguel Paja-Fano, Iñigo Gorostiza","doi":"10.1007/s40200-026-01974-9","DOIUrl":"https://doi.org/10.1007/s40200-026-01974-9","url":null,"abstract":"<p><strong>Purpose: </strong>1) to describe generic health-related quality of life (HRQoL) by EQ-5D-5L in patients with diabetes (DM), 2) to identify adverse variables for HRQoL in DM estimating disutilities and 3) to address the impact of DM on EQ-5D-5L compared to general population (GP).</p><p><strong>Methods: </strong>EQ-5D-5L was characterized according to several clinical and sociodemographic variables in DM patients recruited from two hospitals in the Basque Country (Spain) (n = 133). Disutilities of factors independently reducing HRQoL were estimated by a two-part model. EQ-5D-5L scores in DM patients were compared with those from GP.</p><p><strong>Results: </strong>In DM patients, utility index (mean = 0.823, SD = 0.191) and visual analogue scale (mean = 69.6, SD = 19.1) depended on: sex, age, occupation status, level of studies, BMI, exercising, DM history, glycemic control, comorbidities and presence of severe diabetes, cardiovascular, peripheral vascular disease (PVD), renal and pulmonary diseases. Patients reporting problems were 54.1%, 45.1%, 36.8%, 30.1% and 11.3% for pain/discomfort, mobility, anxiety/depression, usual activities and self-care dimensions, respectively. Disutilities for PVD, ≥ 75-year-old, no exercising and being female were -0.106, -0.104, -0.098 and -0.096, respectively, compared to the corresponding reference. EQ-5D-5L diminished in DM patients compared to GP, overall, in females and males.</p><p><strong>Conclusions: </strong>HRQoL is negatively affected by DM by clinical and sociodemographic factors in this cohort of study. Key determinants impairing HRQoL of DM patients here are being female, ≥ 75-year-old, do not exercising and having PVD.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-026-01974-9.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"159"},"PeriodicalIF":1.6,"publicationDate":"2026-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13264636/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver enzymes as predictors of gestational diabetes: a meta-analysis.","authors":"Angela Mae Cuartelon, John Ashley Flores, Sofia Alexis Dayrit, Raphael Enrique Tiongco","doi":"10.1007/s40200-026-01977-6","DOIUrl":"https://doi.org/10.1007/s40200-026-01977-6","url":null,"abstract":"<p><strong>Purpose: </strong>Gestational diabetes mellitus (GDM) is a metabolic disorder of pregnant women that develops during their second or third trimester. As an important organ in carbohydrate and lipid metabolism, the liver may play a role in GDM pathophysiology. This meta-analysis examined the conflicting relationship between liver enzyme levels and GDM risk while emphasizing the probable use of liver enzymes as a biomarker for early detection and prevention of GDM.</p><p><strong>Methods: </strong>Literature from PubMed, EBSCO, Google Scholar, and ScienceDirect was systematically reviewed through August 2025. A total of seven studies were included after meeting the inclusion criteria. The pooled data were converted to mean and SD, then analyzed with the random-effects model to estimate ORs with 95% CIs. ROC curves were generated to determine the AUC and evaluate the diagnostic performance of liver enzymes. Subgroup analyses were made based on ethnicity and timing of the enzyme test.</p><p><strong>Results: </strong>ALT (SMD = 1.11; 95% CI: 0.72-1.49; <i>p</i> < 0.00001) and GGT (SMD = 0.79; 95% CI: 0.48-1.09; <i>p</i> < 0.00001) levels were markedly elevated in women who developed GDM. AST did not differ significantly between the GDM and non-GDM groups (SMD = -0.15; 95% CI: -0.66-0.37; <i>p</i> = 0.57). However, there is high heterogeneity in all three analyses. Subgroup analyses showed ALT levels to be significantly elevated among Asian women with GDM (SMD = 0.92; 95% CI: 0.49-1.35; <i>p</i> < 0.0001) and among women who were assessed during early pregnancy (SMD = 1.29; 95% CI: 0.88-1.69; <i>p</i> < 0.00001). ROC curve analyses revealed that ALT (AUC = 0.755) and GGT (AUC = 0.778) have a fair ability to differentiate GDM cases.</p><p><strong>Conclusion: </strong>This meta-analysis further elaborated the potential of ALT and GGT enzyme tests during early pregnancy as markers for identifying women at risk. However, AST did not have a significant correlation in this case. These findings further suggest the need to evaluate the connection between hepatic alterations and the onset of GDM.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-026-01977-6.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"157"},"PeriodicalIF":1.6,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13263379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinopathy screening uptake among diabetic patients in Northern Iraq based on the attitude-social influence-self-efficacy model.","authors":"Mehdi Mirzaei-Alavijeh, Hardi Taher Radha, Hassan Gharibnavaz, Shima Khashij, Farzad Jalilian","doi":"10.1007/s40200-026-01971-y","DOIUrl":"https://doi.org/10.1007/s40200-026-01971-y","url":null,"abstract":"<p><strong>Background: </strong>Diabetic Retinopathy (DR) is the leading cause of blindness in middle-aged and elderly individuals in Asia. Screening for retinopathy is a cost-effective method to prevent this condition. This study aims to identify the factors that are associated with the uptake of Diabetic Retinopathy Screening (DRS) among patients with type 2 diabetes in northern Iraq, using the attitude-social influence-self-efficacy (ASE) model.</p><p><strong>Methods: </strong>This cross-sectional study was conducted in 2023 in the city of Sulaymaniyah, northern Iraq, and involved 602 patients with type 2 diabetes. The patients were selected using a simple random sampling method from those who referred to the diabetes clinic in Sulaimaniyah city. Data was collected through written questionnaires including background and demographic information, DRS uptake, and ASE determinants based on patient interviews. The collected data was analyzed using SPSS version 16, as well as, STAT-17 and statistical tests including Independent Samples t Test, Pearson correlation coefficient, and univariate and multivariate logistic regression were used.</p><p><strong>Results: </strong>The mean age of respondents was 53.17 ± 9.38 years, ranged from 30 to 77 years. The mean of diabetes duration was 7.92 ± 4.90 years, ranged from 1 to 24 years. 58.1% (350/602) of the participants had DRS uptake. Social influence (OR: 1.089 and P: 0.039), self-efficacy (OR: 1.502 and <i>P</i> < 0.001), barriers (OR: 0.891 and P: 0.002), and intention (OR: 1.215 and P: 0.012) were found to be significantly associated with the DRS uptake. Goodness of fit model indices included sensitivity, specificity, positive predictive value, negative predictive value and correctly classified were equal to 83.67%, 74.80%, 82.23%, 76.67% and 79.97% respectively.</p><p><strong>Conclusion: </strong>Our findings suggest that in the development of interventions to promote DRS uptake, it should focus on strategies to promote social influences and self-efficacy, along with reducing barriers to DRS uptake.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-026-01971-y.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"156"},"PeriodicalIF":1.6,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13247102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and treatment of mitochondrial diabetes in Southwest Finland.","authors":"Nelli Rindell, Heidi Immonen, Mika H Martikainen","doi":"10.1007/s40200-026-01964-x","DOIUrl":"10.1007/s40200-026-01964-x","url":null,"abstract":"<p><strong>Purpose: </strong>Diabetes mellitus (DM) is a common manifestation of mitochondrial disease, typically associated with the mitochondrial DNA (mtDNA) variant m.3243A>G. We investigated the clinical features, treatment, and epidemiology of mitochondrial DM in the region of Southwest Finland.</p><p><strong>Methods: </strong>Electronic medical records at Turku University Hospital were searched for patients assigned ICD-10 codes E13.0-E13.9 during 2000-2022. Among 1004 screened individuals, nine patients with genetically confirmed mitochondrial diabetes were identified. Eight additional genetically confirmed patients were included from an ongoing mitochondrial disease research project, resulting in a cohort of 17 patients. The clinical characteristics and DM treatment of the patients were obtained from medical records.</p><p><strong>Results: </strong>We identified 17 patients with mitochondrial DM. Mean age at diagnosis of DM was 35 years (range 11 to 60 years). Most patients with mitochondrial DM had hearing impairment (14/17). Insulin treatment was typically initiated 3.5 years after the diagnosis of DM. Only six (35%) patients had HbA1c below 7.0% (53 mmol/mol). The prevalence of mitochondrial DM in the region of Southwest Finland in the end of 2022 was 2.7/100,000 and annual incidence during the study period 0.14/100,000.</p><p><strong>Conclusions: </strong>The onset of non-autoimmune diabetes in young adult age, particularly when associated with hearing impairment, suggests possible mitochondrial DM. Recognition of mitochondrial diabetes is essential for optimal management and complication prevention.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"154"},"PeriodicalIF":2.1,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13241360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Species-specific modulation of serotonin-related gene expression by <i>Akkermansia muciniphila</i>, <i>Faecalibacterium prausnitzii</i>, and their extracellular vesicles in HT-29 cells.","authors":"Rezvan Yaghoubfar, Ehsan Zare Banadkoki, Shohreh Khatami, Seyed Davar Siadat","doi":"10.1007/s40200-026-01967-8","DOIUrl":"https://doi.org/10.1007/s40200-026-01967-8","url":null,"abstract":"<p><strong>Background: </strong>Host-microbiota interactions play a critical role in modulating the serotonin (5-HT) system, which is essential for maintaining intestinal homeostasis. Akkermansia muciniphila and Faecalibacterium prausnitzii are well-recognized commensal bacteria with anti-inflammatory properties and barrier-enhancing functions. However, their effects on the regulation of serotonin-related gene expression in intestinal epithelial cells remain poorly understood. This study investigated the effects of A. muciniphila and F. prausnitzii, as well as their extracellular vesicles (EVs), on the serotonergic system in the human colorectal adenocarcinoma HT-29 cell line.</p><p><strong>Methods and results: </strong>HT-29 cells were exposed to viable bacteria and their corresponding EVs, and serotonin levels were quantified using ELISA. In parallel, the expression of genes involved in serotonin signaling and metabolism was evaluated. Although neither bacterial strain significantly altered serotonin levels, treatment with EVs resulted in a significant increase compared with control cells. Furthermore, both bacterial and EV treatments modulated the mRNA expression of key genes associated with serotonergic signaling and metabolic pathways.</p><p><strong>Conclusions: </strong>Importantly, A. muciniphila and F. prausnitzii exerted distinct effects on serotonin-related pathways, suggesting species-specific regulatory mechanisms. These findings indicate that commensal bacteria and their EVs may represent promising modulators of disorders associated with dysregulated serotonin signaling. Overall, this study provides novel insight into the role of gut microorganisms and their extracellular vesicles in shaping the intestinal serotonergic system.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"152"},"PeriodicalIF":1.6,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal timing and its determinants among Iranian women: findings from the 2021 national STEPS survey.","authors":"Shirin Djalalinia, Yosra Azizpour, Nazila Rezaei, Golaleh Almasi, Sina Azadnajafabad, Ali Golestani, Naser Ahmadi, Yosef Farzi, Ameneh Kazemi, Negar Rezaei, Arezou Dilmaghani-Marand, Moein Yoosefi, Mohammad-Mahdi Rashidi, Erfan Ghasemi, Elham Abdolhamidi, Maryam Nasserinejad, Amirali Hajebi, Rosa Haghshenas, Kamyar Rezaee, Arefeh Alipour Derouei, Sahar Saeedi Moghaddam, Marziyeh Vahid Dastjerdi, Bagher Larijani, Fahimeh Ramezani Tehrani, Farshad Farzadfar","doi":"10.1007/s40200-026-01961-0","DOIUrl":"https://doi.org/10.1007/s40200-026-01961-0","url":null,"abstract":"<p><strong>Background: </strong>Menopausal timing is an important marker of women's long-term health, yet nationally representative evidence on menopause categories and their correlates remains limited in Iran. This study aimed to estimate the prevalence and timing of menopause and to examine sociodemographic, nutritional, cardiometabolic, and geographic factors associated with different menopause categories among Iranian women.</p><p><strong>Methods: </strong>We analyzed data from the 2021 Iran WHO STEPwise approach to non-communicable disease risk factor surveillance (STEPS), including 14,656 women aged ≥ 18 years. Menopause status and age at menopause were self-reported and categorized as premature ovarian insufficiency (POI; <40 years), early menopause (40-44 years), normal menopause (45-54 years), or late menopause (≥ 55 years). Weighted descriptive analyses and multinomial logistic regression models accounting for the complex survey design were used to assess associations with sociodemographic, lifestyle, nutritional, and cardiometabolic factors.</p><p><strong>Results: </strong>Overall, 32.72% (95% CI: 31.87-33.57) of women were postmenopausal, with the majority experiencing menopause between 45 and 54 years. Among menopausal women, 74.37% had normal menopause, 11.15% late menopause, 9.83% early menopause, and 4.65% POI. In adjusted analyses, early menopause was associated with higher educational attainment and poor nutritional status, while moderate and good dietary patterns were protective. Late menopause was negatively associated with education and positively associated with hypertension. Diabetes and dyslipidemia were more prevalent among postmenopausal women but were not independently associated with menopausal timing. No significant predictors of POI were identified. Substantial provincial variation in menopause prevalence and timing was observed.</p><p><strong>Conclusion: </strong>Menopausal timing among Iranian women reflects heterogeneous socioeconomic, nutritional, and cardiometabolic patterns. Incorporating menopause assessment into routine women's health care and strengthening nutrition and hypertension prevention strategies may facilitate earlier risk identification and promote healthier aging, particularly in the context of marked regional disparities.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-026-01961-0.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"153"},"PeriodicalIF":1.6,"publicationDate":"2026-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does chronic kidney disease associated with fall risk in community-dwelling older adults? Data from baseline phase of Birjand longitudinal aging study.","authors":"Alireza Azarboo, Negar Zareshahi, Mitra Moodi, Akam Ramezani, Hossein Fakhrzadeh, Masoumeh Khorashadizadeh, Hanieh-Sadat Ejtahed, Farshad Sharifi","doi":"10.1007/s40200-026-01970-z","DOIUrl":"https://doi.org/10.1007/s40200-026-01970-z","url":null,"abstract":"<p><strong>Background: </strong>Falls represent a significant public health concern, particularly among the elderly. Chronic kidney disease (CKD) is a multifaceted condition associated with frailty, sarcopenia, and polypharmacy, all of which increase the risk of falls. This study aimed to evaluate the association between CKD severity and the risk of falls among elderly individuals in Birjand, Iran.</p><p><strong>Methods: </strong>This prospective cohort study included 1,344 elderly participants from the Birjand Longitudinal Aging Study. CKD severity was classified based on estimated glomerular filtration rate (eGFR), and falls were self-reported at specified intervals. Logistic and Cox regression models were used to examine the association between CKD severity and fall risk.</p><p><strong>Results: </strong>Fallers (<i>n</i> = 82) were older, predominantly female, and had a higher prevalence of comorbidities compared to non-fallers (<i>n</i> = 1,262). The absolute risk of falls was 4.16% in participants with normal GFR, 7.93% in those with mild CKD, and 13.33% in those with severe CKD. Mild CKD was significantly associated with increased odds (OR: 1.98, 95% CI: 1.23-3.18, <i>p</i> = 0.005) and hazard (HR: 2.22, 95% CI: 1.38-3.58, <i>p</i> = 0.001) of falls in crude models. However, after adjusting for confounders, these associations became weaker and even non-significant (OR: 1.39, 95% CI: 0.83-2.31, <i>p</i> = 0.209 and HR: 1.67, 95% CI: 1.01-2.77, <i>p</i> = 0.047). Severe CKD was not consistently associated with fall risk in any models.</p><p><strong>Conclusion: </strong>Mild CKD is associated with an increased risk of falls in older adults; however, this relationship is influenced by confounders such as sex, comorbidities, and anthropometric factors. The findings underscore the importance of addressing fall risk through multifaceted interventions targeting comorbidity management in elderly CKD patients.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"155"},"PeriodicalIF":1.6,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13247004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood pressure in relation to traditional and emerging anthropometric indices: a cross-sectional study of older adults.","authors":"Azin Pakmehr, Zohreh Sajadi Hezaveh, Hossein Fakhrzadeh, Mitra Moodi, Masoumeh Khorashadizadeh, Fateme Ettehad Marvasti, MinaSadat Taghavi, Hanieh-Sadat Ejtahed, Farshad Sharifi","doi":"10.1007/s40200-026-01955-y","DOIUrl":"https://doi.org/10.1007/s40200-026-01955-y","url":null,"abstract":"<p><strong>Purpose: </strong>Due to the increasing trend of hypertension (HTN) prevalence and consequences, investigations in related risk factors including age and obesity has always been of great interest. This study aimed to investigate the association between certain anthropometric indices with HTN in a sample of Iranian older adults.</p><p><strong>Methods: </strong>This cross-sectional study used the data from the first wave of Birjand Longitudinal Aging Study (BLAS) (<i>n</i> = 1364). Body mass index (BMI) and waist circumference (WC) were assessed as old anthropometric indices, and body roundness index (BRI) and a body shape index (ABSI) were assessed as new body composition indices. Analyses were conducted using binary logistic regression and receiver-operating characteristic curves analysis (ROC curve).</p><p><strong>Results: </strong>Among 1,364 participants, 657 (48.2%) were men, with a mean age of 69.77 ± 7.66 years. ROC curve demonstrated poor discriminatory ability for all anthropometric indices, with AUC values ranging from 0.48 to 0.65 across outcomes and sex-stratified analyses. In adjusted regression models, BMI and WC were statistically associated with HTN and elevated blood pressure measures; however, effect sizes were small (ORs ≈ 1.04-1.11 per unit increase). In contrast, ABSI and BRI showed no consistent associations with HTN outcomes. Regression models demonstrated very low explanatory power (pseudo-R² ≤ 0.01), indicating that anthropometric indices explained only a minimal proportion of HTN variability.</p><p><strong>Conclusion: </strong>In this cohort of older adults, neither traditional nor emerging anthropometric indices demonstrated meaningful discriminatory or predictive ability for HTN. Although BMI and WC showed statistically significant associations with blood pressure outcomes, the observed effect sizes and explanatory power were small. These findings suggest that anthropometric measures alone have limited utility for HTN risk stratification in older populations, and that newer indices such as ABSI and BRI do not provide meaningful improvement over conventional measures.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"25 1","pages":"151"},"PeriodicalIF":1.6,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13222151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}