Mehdi Koushki, Amir Hossein Doustimotlagh, Nasrin Amiri-Dashatan, Masoumeh Farahani, Hossein Chiti, Razieh Vanda, Shahintaj Aramesh
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引用次数: 0
摘要
目的：越来越多的证据已经评估了双酚A （BPA）作为内分泌干扰剂与妊娠糖尿病（GDM）风险之间的关系。本荟萃分析旨在重新评估与对照组相比，GDM女性双酚a水平相关的数据。方法：综合检索Medline、Embase、Scopus、Web of Science等数据库，提取截至2024年5月的相关已发表研究。meta分析纳入了12篇文章。采用DerSimonian和Liard随机效应模型估计合并优势比（OR）。通过从合并效应大小中删除每个研究，进行敏感性分析以评估合并结果的稳健性。根据胎龄、GDM妊娠期、BMI、研究设计和地理区域等亚组进行亚组分析。结果：结果显示，循环和尿中BPA浓度与GDM风险无显著相关性(OR: 0.79；95% ci 0.60-1.04；p = 0.095)。研究间未发现显著的异质性。采用Begg相关检验（P = 0.95）和Egger线性回归检验（P = 0.86），未观察到发表偏倚。敏感性分析表明，我们的发现是完全稳健和稳定的。meta回归显示BPA水平与研究设计和几何平均作为GDM风险指标之间存在显著关联。结论：目前的荟萃分析表明，BPA暴露与GDM风险降低有关。要获得可靠的结果，还需要进一步的研究。图形化的简介:
Impact of bisphenol A exposure on the risk of gestational diabetes: a meta-analysis of observational studies.
Purpose: A growing number of evidence have assessed the association between bisphenol A (BPA) as an endocrine-disrupting agent and the risk of gestational diabetes (GDM). This meta-analysis aimed to reassess the data on the association of BPA levels in women with GDM compared to the control.
Methods: A comprehensive literature search was conducted in Medline, Embase, Scopus, and Web of Science to extract relevant published studies up to May 2024. 12 articles were included in the meta-analysis. DerSimonian and Liard random-effects model was used to estimate the pooled odds ratio (OR). Sensitivity analysis was conducted to assess the robustness of the pooled results by removing each study from the pooled effect size. Subgroup analyses were performed depending on the subgroups of gestational age, GDM trimester, BMI, study design and geographical area.
Results: The results showed that there was no significant association between circulating and urinary BPA concentrations with the risk of GDM (OR: 0.79; 95% CI 0.60-1.04; P = 0.095). No significant heterogeneity was found among the studies. Using Begg's correlation (P = 0.95) and Egger's linear regression (P = 0.86) tests, no publication bias was observed. The sensitivity analysis shows that our findings were completely robust and stable. Meta-regression indicated a significant association between BPA levels and study design and geometric mean as an index of the risk of GDM.
Conclusion: The present meta-analysis demonstrates exposure to BPA was associated with a reduced risk of GDM. Further studies are needed for obtain the reliable results.
期刊介绍：
Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.
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