双酚A暴露对妊娠糖尿病风险的影响:一项观察性研究的荟萃分析

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM
Journal of Diabetes and Metabolic Disorders Pub Date : 2024-09-02 eCollection Date: 2024-12-01 DOI:10.1007/s40200-024-01485-5
Mehdi Koushki, Amir Hossein Doustimotlagh, Nasrin Amiri-Dashatan, Masoumeh Farahani, Hossein Chiti, Razieh Vanda, Shahintaj Aramesh
{"title":"双酚A暴露对妊娠糖尿病风险的影响:一项观察性研究的荟萃分析","authors":"Mehdi Koushki, Amir Hossein Doustimotlagh, Nasrin Amiri-Dashatan, Masoumeh Farahani, Hossein Chiti, Razieh Vanda, Shahintaj Aramesh","doi":"10.1007/s40200-024-01485-5","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>A growing number of evidence have assessed the association between bisphenol A (BPA) as an endocrine-disrupting agent and the risk of gestational diabetes (GDM). This meta-analysis aimed to reassess the data on the association of BPA levels in women with GDM compared to the control.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in Medline, Embase, Scopus, and Web of Science to extract relevant published studies up to May 2024. 12 articles were included in the meta-analysis. DerSimonian and Liard random-effects model was used to estimate the pooled odds ratio (OR). Sensitivity analysis was conducted to assess the robustness of the pooled results by removing each study from the pooled effect size. Subgroup analyses were performed depending on the subgroups of gestational age, GDM trimester, BMI, study design and geographical area.</p><p><strong>Results: </strong>The results showed that there was no significant association between circulating and urinary BPA concentrations with the risk of GDM (OR: 0.79; 95% CI 0.60-1.04; <i>P</i> = 0.095). No significant heterogeneity was found among the studies. Using Begg's correlation (<i>P</i> = 0.95) and Egger's linear regression (<i>P</i> = 0.86) tests, no publication bias was observed. The sensitivity analysis shows that our findings were completely robust and stable. Meta-regression indicated a significant association between BPA levels and study design and geometric mean as an index of the risk of GDM.</p><p><strong>Conclusion: </strong>The present meta-analysis demonstrates exposure to BPA was associated with a reduced risk of GDM. Further studies are needed for obtain the reliable results.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2173-2182"},"PeriodicalIF":1.8000,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599497/pdf/","citationCount":"0","resultStr":"{\"title\":\"Impact of bisphenol A exposure on the risk of gestational diabetes: a meta-analysis of observational studies.\",\"authors\":\"Mehdi Koushki, Amir Hossein Doustimotlagh, Nasrin Amiri-Dashatan, Masoumeh Farahani, Hossein Chiti, Razieh Vanda, Shahintaj Aramesh\",\"doi\":\"10.1007/s40200-024-01485-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>A growing number of evidence have assessed the association between bisphenol A (BPA) as an endocrine-disrupting agent and the risk of gestational diabetes (GDM). This meta-analysis aimed to reassess the data on the association of BPA levels in women with GDM compared to the control.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in Medline, Embase, Scopus, and Web of Science to extract relevant published studies up to May 2024. 12 articles were included in the meta-analysis. DerSimonian and Liard random-effects model was used to estimate the pooled odds ratio (OR). Sensitivity analysis was conducted to assess the robustness of the pooled results by removing each study from the pooled effect size. Subgroup analyses were performed depending on the subgroups of gestational age, GDM trimester, BMI, study design and geographical area.</p><p><strong>Results: </strong>The results showed that there was no significant association between circulating and urinary BPA concentrations with the risk of GDM (OR: 0.79; 95% CI 0.60-1.04; <i>P</i> = 0.095). No significant heterogeneity was found among the studies. Using Begg's correlation (<i>P</i> = 0.95) and Egger's linear regression (<i>P</i> = 0.86) tests, no publication bias was observed. The sensitivity analysis shows that our findings were completely robust and stable. Meta-regression indicated a significant association between BPA levels and study design and geometric mean as an index of the risk of GDM.</p><p><strong>Conclusion: </strong>The present meta-analysis demonstrates exposure to BPA was associated with a reduced risk of GDM. Further studies are needed for obtain the reliable results.</p><p><strong>Graphical abstract: </strong></p>\",\"PeriodicalId\":15635,\"journal\":{\"name\":\"Journal of Diabetes and Metabolic Disorders\",\"volume\":\"23 2\",\"pages\":\"2173-2182\"},\"PeriodicalIF\":1.8000,\"publicationDate\":\"2024-09-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599497/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Diabetes and Metabolic Disorders\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s40200-024-01485-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/12/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q4\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Diabetes and Metabolic Disorders","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40200-024-01485-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/12/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0

摘要

目的:越来越多的证据已经评估了双酚A (BPA)作为内分泌干扰剂与妊娠糖尿病(GDM)风险之间的关系。本荟萃分析旨在重新评估与对照组相比,GDM女性双酚a水平相关的数据。方法:综合检索Medline、Embase、Scopus、Web of Science等数据库,提取截至2024年5月的相关已发表研究。meta分析纳入了12篇文章。采用DerSimonian和Liard随机效应模型估计合并优势比(OR)。通过从合并效应大小中删除每个研究,进行敏感性分析以评估合并结果的稳健性。根据胎龄、GDM妊娠期、BMI、研究设计和地理区域等亚组进行亚组分析。结果:结果显示,循环和尿中BPA浓度与GDM风险无显著相关性(OR: 0.79;95% ci 0.60-1.04;p = 0.095)。研究间未发现显著的异质性。采用Begg相关检验(P = 0.95)和Egger线性回归检验(P = 0.86),未观察到发表偏倚。敏感性分析表明,我们的发现是完全稳健和稳定的。meta回归显示BPA水平与研究设计和几何平均作为GDM风险指标之间存在显著关联。结论:目前的荟萃分析表明,BPA暴露与GDM风险降低有关。要获得可靠的结果,还需要进一步的研究。图形化的简介:
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of bisphenol A exposure on the risk of gestational diabetes: a meta-analysis of observational studies.

Purpose: A growing number of evidence have assessed the association between bisphenol A (BPA) as an endocrine-disrupting agent and the risk of gestational diabetes (GDM). This meta-analysis aimed to reassess the data on the association of BPA levels in women with GDM compared to the control.

Methods: A comprehensive literature search was conducted in Medline, Embase, Scopus, and Web of Science to extract relevant published studies up to May 2024. 12 articles were included in the meta-analysis. DerSimonian and Liard random-effects model was used to estimate the pooled odds ratio (OR). Sensitivity analysis was conducted to assess the robustness of the pooled results by removing each study from the pooled effect size. Subgroup analyses were performed depending on the subgroups of gestational age, GDM trimester, BMI, study design and geographical area.

Results: The results showed that there was no significant association between circulating and urinary BPA concentrations with the risk of GDM (OR: 0.79; 95% CI 0.60-1.04; P = 0.095). No significant heterogeneity was found among the studies. Using Begg's correlation (P = 0.95) and Egger's linear regression (P = 0.86) tests, no publication bias was observed. The sensitivity analysis shows that our findings were completely robust and stable. Meta-regression indicated a significant association between BPA levels and study design and geometric mean as an index of the risk of GDM.

Conclusion: The present meta-analysis demonstrates exposure to BPA was associated with a reduced risk of GDM. Further studies are needed for obtain the reliable results.

Graphical abstract:

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of Diabetes and Metabolic Disorders
Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine
CiteScore
4.80
自引率
3.60%
发文量
210
期刊介绍: Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信