Journal of Diabetes and Metabolic Disorders最新文献

{"title":"Glycemic status and bone health: investigating the impact of glycosylated hemoglobin on bone density in South Indian adults.","authors":"Rohini Bhadra, Sumithra Selvam, Sucharita Sambashivaiah","doi":"10.1007/s40200-024-01473-9","DOIUrl":"10.1007/s40200-024-01473-9","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the relationship between glycosylated Hemoglobin (HbA1c) levels and bone mineral density (BMD) in individuals with varying glycemic statuses, including diabetes, prediabetes, and controls.</p><p><strong>Methods: </strong>This cross-sectional study conducted in Bengaluru, India, included 336 participants aged 20 to 60. Blood samples were taken to assess fasting blood glucose, HbA1c, and lipid profile. Participants were divided into tertiles based on HbA1c levels: low(HbA1c ≤ 5.5%), moderate(HbA1c > 5.5-6.0%), and high(HbA1c ≥ 6.1%).Dual energy-X-ray absorptiometry(DXA) measured hip, spine, and total BMD as indicators of bone health.</p><p><strong>Results: </strong>Intermediate and high HbA1c tertiles had a significantly higher hip and total BMD compared to low HbA1c tertiles (<i>p</i> < 0.001 and <i>p</i> = 0.006 for hip and total BMD). Spine BMD was comparable between the three groups. After adjusting for age, gender and BMI, a potential independent effect of glycemic control on hip BMD was observed (Low vs. intermediate and high glycemic status: <i>β</i>: 0.041, 95% C.I.: 0.003, 0.078, <i>p</i> = 0.034).</p><p><strong>Conclusion: </strong>Elevated HbA1c might be associated with higher hip and overall BMD as observed through DXA. Nonetheless, this doesn't necessarily imply better bone health; further evaluation is advised to prevent fractures.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-024-01473-9.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2115-2121"},"PeriodicalIF":1.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incretin-based therapy: a new horizon in diabetes management.","authors":"Malek Zarei, Navideh Sahebi Vaighan, Mohammad Hadi Farjoo, Soosan Talebi, Mohammad Zarei","doi":"10.1007/s40200-024-01479-3","DOIUrl":"10.1007/s40200-024-01479-3","url":null,"abstract":"<p><p>Diabetes mellitus, a metabolic syndrome characterized by hyperglycemia and insulin dysfunction, often leads to serious complications such as neuropathy, nephropathy, retinopathy, and cardiovascular disease. Incretins, gut peptide hormones released post-nutrient intake, have shown promising therapeutic effects on these complications due to their wide-ranging biological impacts on various body systems. This review focuses on the role of incretin-based therapies, particularly Glucagon-like peptide-1 (GLP-1) agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors, in managing diabetes and its complications. We also discuss the potential of novel agents like semaglutide, a recently approved oral compound, and dual/triple agonists targeting GLP-1/GIP, GLP-1/glucagon, and GLP-1/GIP/glucagon receptors, which are currently under investigation. The review aims to provide a comprehensive understanding of the beneficial impacts of natural incretins and the therapeutic potential of incretin-based therapies in diabetes management.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"1665-1686"},"PeriodicalIF":1.8,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Material needs security and mental health outcomes in adults with type 2 Diabetes in Lebanon: A cross-sectional study.","authors":"Ola Sukkarieh, Maya Bassil, Leonard E Egede","doi":"10.1007/s40200-024-01484-6","DOIUrl":"10.1007/s40200-024-01484-6","url":null,"abstract":"<p><strong>Objectives: </strong>Despite their documented significance in type 2 diabetes (T2DM) management, social determinants of health (SDOHs) including material needs security and mental health outcomes are understudied in the Middle East and North Africa (MENA) region. This study aims to assess the relation between material needs security and mental health outcomes in Lebanese adults with T2DM.</p><p><strong>Methods: </strong>Subjects with T2DM (<i>N</i> = 300) were recruited from primary health care centers in Lebanon. Sociodemographic, material need variables, depression measured by Patient Health Questionnaire (PHQ-9), and diabetes fatalism measured by Diabetes Fatalism Scale (DFS) were collected.</p><p><strong>Results: </strong>Most of the participants were men, married and with lower educational levels. Multivariate analyses revealed that having material needs security was associated with diabetes fatalism (β = -0.63(-1.13; -0.12)), and depression (β = -0.46(-0.78; -0.13)). Also, higher age (β = 3.49(0.91; 6.06)) and education (β = 3.42(1.18; 5.66)), and lower income (β = 3.25(0.62; 5.88)) were independently associated with diabetes fatalism. Being male was the only independent variable associated with less depression (β = -1.56(-2.97; -0.14)).</p><p><strong>Conclusion: </strong>Our study highlights the importance of material needs security on mental health outcomes for adults with T2DM in the MENA region. Clinicians are encouraged to assess the impact of material needs on mental health outcomes. Further research is needed to understand potential pathways/mechanisms and options for effective interventions and policymaking.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2165-2171"},"PeriodicalIF":1.8,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599642/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of fracture risk in diabetic patients.","authors":"Zhenpeng Wang, Mei Zhang, Dan Jia","doi":"10.1007/s40200-024-01474-8","DOIUrl":"10.1007/s40200-024-01474-8","url":null,"abstract":"<p><p>Patients with diabetes often experience reduced bone strength, resulting in a higher fracture risk. This decline and increased susceptibility stem from intricate interactions within the bone microstructure. However, current gold standard methods for assessing bone strength, such as bone mineral density, and widely-used fracture risk assessment tools do not accurately predict fracture risk in diabetic patients. Therefore, it is crucial to incorporate additional indicators that evaluate bone quality and specific markers relevant to diabetes to enhance the accuracy of predictive models. Moreover, the selection of appropriate algorithms for model construction is essential. This review aims to introduce indicators from both imaging examinations and laboratory indicators that hold significant value for inclusion in fracture risk prediction models for diabetic patients. Additionally, this study provides an overview of the research progress in fracture risk prediction models for diabetic patients, serving as a valuable reference for clinical practice.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"1653-1663"},"PeriodicalIF":1.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of diabetes care parameters in patients with diabetes: A population-based cross-sectional study in Khuzestan province (southwest of Iran).","authors":"Leila Yazdanpanah, Hajieh Shahbazian, Ali Akbar Shayesteh, Hossein Poustchi, Saeed Ghanbari, Bahman Cheraghian, Zeinab Masoumipoya, Behnam Ahmadi, Amir Mohammad Zamani","doi":"10.1007/s40200-024-01483-7","DOIUrl":"10.1007/s40200-024-01483-7","url":null,"abstract":"<p><strong>Background: </strong>Diabetes is becoming a worldwide concern. Optimal diabetes control reduces diabetes complications.</p><p><strong>Objectives: </strong>We aimed to measure the principal diabetes care parameters to recognize the main deficits in care for patients with diabetes in the region.</p><p><strong>Methods: </strong>This cross-sectional study is based on the Khuzestan Comprehensive Health Study (KCHS) data. Of all participants, 4673 (15.3%) were identified to have diabetes. We invited the known cases of diabetes to complete a checklist about their diabetes through face-to-face interviews, and we obtained a blood sample to measure their HbA1c.</p><p><strong>Results: </strong>Of all participants of the KCHS study, 312 patients with diabetes who met the inclusion criteria were identified. Mean (± SD) HbA1c was 8.5% (± 1.8), and 225 (72.1%) of the participants had poor glycemic control. About 45.2% had blood pressure less than 130/80 mmHg, and 24% had FBS lower than 130 mg/dl. Nearly 37.8% of the participants had LDL < 100 mg/dl and 40% TG < 150 mg/dl. Of all participants, 38.5% had undergone retinal examination, 13.8% had their foot examined, and 39.4% had done urine micro-albumin /Cr test. HbA1c level had a statistically significant relationship with gender (P = 0.012), occupation (P = 0.007), nephropathy (P = 0.004) and retinopathy (P < 0.001).</p><p><strong>Conclusions: </strong>This study showed that less than half of the participants achieved the optimal ADA goals for diabetes care, therefore it is necessary to revise the basic protocols of diabetes care in the region to improve diabetes management.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2151-2163"},"PeriodicalIF":1.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating mannose-binding lectin in diabetic patients and risk of vascular complications: a systematic review and meta-analysis.","authors":"Mohammad Sedghi, Ali Ranjbaran, Mahtab Forouhi, Mahdi Nejatianfar, Nazanin Azmi-Naei, Parian Pourmoafi Esfahani, Mahdi Tavakoli, Fatemeh Sadat Hashemi Javaheri, Nazanin Shakibi, Elham Mirzaee, Akram Mirzaee, Hannaneh Nejati, Mansoureh Makarem, Tahereh Parishan Kordiani, Gita Pourshahikhaneh, Rasoul Shavaleh, Kazem Rahmani, Molood Foogerdi","doi":"10.1007/s40200-024-01478-4","DOIUrl":"10.1007/s40200-024-01478-4","url":null,"abstract":"<p><strong>Objectives: </strong>Recent studies have confirmed the involvement of mannose-binding lectin (MBL) in the pathogenesis of vascular complications in individuals with diabetes. Due to the discrepancy between the results of studies, a meta-analysis was conducted to evaluate MBL levels in patients with diabetes and its vascular complications.</p><p><strong>Methods: </strong>We reviewed all observational studies published in PubMed/Medline, Scopus, EMBASE, and Web of Science Core Collection databases to identify relevant studies up to 1 April 2024. To account for describing heterogeneity among the studies, I² and χ² statistics were utilized. Also, a random-effects model was employed to combine the studies. The Newcastle Ottawa Scale (NOS) checklist was applied for quality assessment of each study.</p><p><strong>Results: </strong>Twenty-eight papers were encompassed in this meta-analysis. The mean difference in MBL levels between patients with diabetic nephropathy and diabetic retinopathy differed significantly compared with the healthy control group and the diabetic group without vascular complications (P-value < 0.05). Moreover, the pooled results revealed a significant relationship between MBL levels and the incidence of vascular complications (pooled HR = 1.44, 95% CI: 1.07-1.95, P-value < 0.05) and disease-related mortality (pooled HR = 1.52, 95% CI: 1.07-2.16, P-value < 0.05) among diabetic patients. Also, there was a direct association between incidence of nephropathy in diabetics and higher levels of MBL (pooled HR = 2.16, 95% CI: 1.52-3.08, P-value < 0.05).</p><p><strong>Conclusion: </strong>Diabetic patients with elevated MBL levels are potentially at increased risk of vascular complications such as nephropathy and retinopathy. Therefore, by determining MBL status in diabetic patients, it is possible to predict the progress and possible consequences of the disease.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2131-2142"},"PeriodicalIF":1.8,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recognition of GCK Homozygote missense (His424Tyr) variant in a female patient with neonatal hyperglycemia.","authors":"Amirreza Pashapour Yeganeh, Marjan Rahimi Farahani, Nekoo Panahi, Mahsa Mohammad Amoli, Zeynab Nickhah Klashami, Hamid Reza Aghaei Meybodi, Akbar Soltani","doi":"10.1007/s40200-024-01480-w","DOIUrl":"10.1007/s40200-024-01480-w","url":null,"abstract":"<p><strong>Introduction: </strong>Heterozygous mutations in the GCK gene result in mildly elevated glucose levels from birth, and the homozygous loss-of-function mutations leads to permanent neonatal diabetes. In the present study we aim to investigate the cause of diabetes in an adult female patient with unusual course of diabetes.</p><p><strong>Case presentation: </strong>We evaluate a female patient who previously encountered significant hyperglycemia during the infancy and subsequently experienced a relatively uneventful childhood. In later years, she faced significant hyperglycemia and retinopathy that required laser photocoagulation. Her treatment history included periods of oral hypoglycemic agents or insulin, which occasionally led to hypoglycemia, as well as extended intervals without treatment. However, she never required hospitalization for diabetic ketoacidosis. The patient's family history was significant, with her parents being cousins and having a history of prediabetes and gestational diabetes in several family members. Autoantibody tests for type 1 diabetes were negative. Next-generation sequencing analysis of the coding regions and conserved splice sites of several genes identified a homozygous GCK (T/T) missense (His424Tyr) variant, which was validated by Sanger sequencing. Heterozygous C/T mutations were revealed in the parents.</p><p><strong>Discussion and conclusion: </strong>This case highlights the importance of considering homozygous GCK mutations as a potential cause of persistent neonatal diabetes, especially in patients with a history of elevated glucose levels from infancy, a family history of early-onset non-progressive diabetes and gestational diabetes, and parental consanguinity. Genetic testing can help identify the underlying genetic etiology in such cases. Early diagnosis is crucial to guide appropriate treatment and management strategies.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2401-2405"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Alpha-glucosidase and α-amylase inhibitory activity of Pistacia atlantica Desf. Gall extracts and identification of putative bioactives using a combined UPLC fingerprinting and molecular docking approach.","authors":"Ziyad Ben Ahmed, Toufik Hadj Mahammed, Taha Chegma, Veronique Seidel, Mohamed Yousfi","doi":"10.1007/s40200-024-01476-6","DOIUrl":"https://doi.org/10.1007/s40200-024-01476-6","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s40200-024-01470-y.].</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2419"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Enhancing childhood obesity management: implementing an obesity registry for Iranian children and adolescents.","authors":"Pejman Rohani, Hanieh-Sadat Ejtahed, Shima Shojaie, Mohammad Hassan Sohouli, Shirin Hasani-Ranjbar, Bagher Larijani, Afshin Ostovar","doi":"10.1007/s40200-024-01477-5","DOIUrl":"https://doi.org/10.1007/s40200-024-01477-5","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s40200-024-01467-7.].</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2421"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between patient portal use and electronic health record (EHR) data timeliness in type 2 diabetes mellitus care.","authors":"Kevin Wiley, Justin Blackburn, Eneida Mendonca, Nir Menachemi, Mary De Groot, Joshua R Vest","doi":"10.1007/s40200-024-01468-6","DOIUrl":"10.1007/s40200-024-01468-6","url":null,"abstract":"<p><strong>Objective: </strong>Patient data is subject to missingness and errors. Patient portals enable patients managing type 2 diabetes mellitus (T2DM) to review and correct data to avoid retesting, medication errors, and diagnostic mistakes. We examined whether patient portal use was associated with electronic health record (EHR) data timeliness in T2DM care.</p><p><strong>Research design and methods: </strong>We analyzed EHR data from a panel of adult patients to determine whether portal use improved data timeliness. EHR data timeliness is measured as the number of days between patient encounters, accounting for mean attribute update periods, where available EHR attribute updates for T2DM measurements were present, including body mass, weight, glycated hemoglobin A1c, cholesterol, blood pressure, serum creatinine, and smoking status. We performed negative binomial regressions with fixed effects to estimate the association between patient portal use and EHR data timeliness. Sensitivity analyses were conducted using Poisson regressions.</p><p><strong>Results: </strong>Nearly a third (31.3%) of patients in our sample actively used the health portal. There were fewer days (111.9 days vs. 136.7 days; <i>p</i> < 0.001) between EHR attribute updates for patients who used health portals compared to patients who did not. Data timeliness was lower among female, non-Hispanic White Medicare beneficiaries. Based on regression analyses, portal use was associated with an expected 3.6 (<i>p</i> < 0.001) percentage point decrease in days between attribute updates, indicating improved EHR timeliness.</p><p><strong>Conclusion: </strong>Improving the quality of health information may streamline decision-making in partnership with patients who produce data points across clinical settings. Active use of patient portals and digital health tools in chronic disease care are critical for care management and clinical decision-making, especially for patients managing type 2 diabetes across clinical settings.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-024-01468-6.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"23 2","pages":"2073-2080"},"PeriodicalIF":1.8,"publicationDate":"2024-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}