Journal of Diabetes and Metabolic Disorders最新文献

{"title":"Effectiveness of a three-month yoga protocol on glycemic control in type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.","authors":"A Vijay, G Sathiyavathi, S Suganthi, L Nivethitha, N Manavalan, A Mooventhan","doi":"10.1007/s40200-025-01807-1","DOIUrl":"10.1007/s40200-025-01807-1","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a major global health challenge, characterized by insulin resistance, progressive β-cell dysfunction, and persistent hyperglycemia. Yoga is a mind-body practice that has been studied as a potential complementary therapy for T2DM. However, no systematic review has specifically synthesized evidence on the effects of a three-month yoga intervention on glycemic control.</p><p><strong>Methods: </strong>A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted in accordance with PRISMA guidelines (PROSPERO: CRD42024599832). Three electronic databases (PubMed, Science Direct, Cochrane Library) were searched from inception to October 2024. Eligible studies included participants with T2DM who had undergone yoga for three months. The primary outcome was glycated hemoglobin (HbA1c), secondary outcomes were fasting blood glucose (FBG) and postprandial blood glucose (PPBG).</p><p><strong>Results: </strong>Fourteen RCTs comprising 1876 participants with T2DM met the eligibility criteria. Pooled analysis showed a significant reduction in HbA1c (Mean difference [MD] = - 0.55; 95% Confidence interval [CI]: - 1.02 to - 0.08; I² = 97%), FBG (MD = - 24.72 mg/dL; 95% CI: - 34.10 to - 15.34; I² = 80%), and PPBG (MD = - 26.01 mg/dL; 95% CI: - 40.91 to - 11.12; I² = 51%) after three months of yoga. Most trials had a high overall risk of bias.</p><p><strong>Conclusion: </strong>A three-month yoga practice significantly reduces HbA1c, FBG, and PPBG in participants with T2DM without adverse effects, supporting its role as a safe, low-cost adjunct to standard care. However, high heterogeneity restricts certainty. High-quality, multicenter RCTs with standardized yoga protocols are warranted to confirm these findings.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"281"},"PeriodicalIF":1.6,"publicationDate":"2025-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12664867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145654577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation and clinical usefulness of the SCORE2 cardiovascular risk prediction algorithms in an Iranian population.","authors":"Ehsan Shahrestanaki, Masoud Solaymani-Dodaran, Morteza Mohammadzadeh, Farzad Masoudkabir, Fereidoun Azizi, Farzad Hadaegh, Davood Khalili","doi":"10.1007/s40200-025-01730-5","DOIUrl":"https://doi.org/10.1007/s40200-025-01730-5","url":null,"abstract":"<p><strong>Purpose: </strong>SCORE2 is a 10-year CVD risk prediction model developed for use in European populations. This study aimed to externally validate the SCORE2 model and assess its clinical usefulness in an Iranian adult population using data from the TLGS cohort.</p><p><strong>Methods: </strong>A total of 4,942 individuals aged 40-69 years participated in the TLGS cohort, which was randomly sampled from the population. A Fine and Gray competing risk model was fitted to estimate sex-specific regression coefficients in the TLGS cohort for comparison with the original SCORE2 model. The outcome was first fatal or non-fatal CVD event (myocardial infarction, stroke, or CVD death), considering non-CVD mortality as a competing event. The predictors included age, sex, smoking status, history of diabetes, SBP, total cholesterol, and HDL cholesterol. Model performance was evaluated as statistical performance (discrimination using Harrell's C-index , calibration via plots and O/E ratio) and clinical performance (sensitivity, specificity, decision curve analysis, and net benefit fraction) across different SCORE2 risk thresholds.</p><p><strong>Results: </strong>A total of 4,579 adults without a history of CVD were included in this study. During the follow-up period, CVD events occurred in 211 (11.05%) men and 151 (5.70%) women. The 10-year cumulative incidence of CVD was 8.00% (95% CI: 6.90-9.40) in men and 3.70% (3.00-4.50) in women. The validated SCORE2 model showed higher discrimination in women (C-index: 0.80; 0.76-0.83) than in men (0.70; 0.67-0.74), but it underestimated the CVD risk in both sexes (men: O/E: 2.05; 2.02-2.08, women: O/E: 1.50; 1.40-1.50). At the risk threshold of ≤ 2.5% for individuals under 50 years and ≤ 5% for those aged 50 years and older, sensitivity in men was 0.65 (0.57-0.73) and specificity was 0.63 (0.60-0.65). In women, sensitivity was 0.54 (0.44-0.64) and specificity was 0.88 (0.87-0.89). Decision curve analysis supported its clinical usefulness, particularly at intermediate risk levels (7.5-15%) in both sexes. The net benefit fraction ranged from 0.13 to 0.49 in men and 0.07-0.42 in women.</p><p><strong>Conclusion: </strong>The validated SCORE2 model demonstrated good discriminatory performance, particularly in women, but calibration tended to underestimate risk. Although net benefit indicated that the model provides meaningful clinical usefulness in identifying individuals who may benefit from preventive interventions, recalibration and updating the model according to national data is recommended.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-025-01730-5.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"280"},"PeriodicalIF":1.6,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12660526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145648672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of metabolic syndrome and its components with brain volumes and structural connections: a systematic review and meta-analysis of observational studies.","authors":"Yunus Soleymani, Ramin Heshmat, Ata Pourabbasi","doi":"10.1007/s40200-025-01800-8","DOIUrl":"https://doi.org/10.1007/s40200-025-01800-8","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review and meta-analysis aimed to synthesize the current evidence on the associations of metabolic syndrome (MetS) and its components, central obesity, hypertension, dyslipidemia, and elevated fasting plasma glucose (FPG) with brain volumes and structural connectivities.</p><p><strong>Methods: </strong>We conducted a comprehensive literature search in major databases (PubMed, Web of Science, Scopus, and ScienceDirect) up to December 2024. Studies were included if they reported quantitative data on the association between MetS or its components and brain volumetric or white matter (WM) integrity outcomes in adults. Two independent reviewers screened titles, abstracts, and full texts, extracted data, and assessed study quality using established tools. Random-effects meta-analyses were performed to pool effect sizes (ESs) for key outcomes. Heterogeneity was assessed using I² statistics, and sensitivity analyses were conducted to evaluate the robustness of findings.</p><p><strong>Results: </strong>A total of 38 studies (<i>n</i> = 27 to 37395 participants) met the inclusion criteria. Central obesity and hypertension were robustly associated with reduced total brain volume and increased WM hyperintensity volume, respectively (<i>n</i> = 4677, ES = -0.15, 95% CI: -0.24, -0.05 and <i>n</i> = 36135, ES = 0.22, 95% CI: 0.13, 0.31, respectively). Hypertension also demonstrated a significant negative association with WM fractional anisotropy (FA) (<i>n</i> = 31167, ES = -0.20, 95% CI: -0.35, -0.05). Elevated FPG and low HDL cholesterol were linked to adverse brain changes, though the evidence was less consistent. High triglyceride levels did not consistently predict brain structural alterations. Heterogeneity was high for the analyses (I² >80%), and results remained significant in sensitivity analyses.</p><p><strong>Conclusions: </strong>MetS and its key components are associated with detrimental effects on brain structure and connectivity. These findings underscore the importance of early detection and management of metabolic risk factors for preserving brain health and reducing the risk of cognitive decline and dementia.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-025-01800-8.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"279"},"PeriodicalIF":1.6,"publicationDate":"2025-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12647414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145634317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of pectin from various sources against diabetes mellitus in rats: AKT/PI3K/GSK-3β/CREB signaling pathways, inflammation, oxidative stress and genotoxicity crosstalk.","authors":"Yomna R Ahmed, Rehab M Abdel-Megeed, Samar M Gooda, Nahla N Kamel, Gehan F Abdel Raoof, Entesar E S Hassan, Ayman A Farghaly, Mohamed A El-Saied, Nagy S El-Rigal, Maha Z Rizk, Manal A Hamed","doi":"10.1007/s40200-025-01776-5","DOIUrl":"https://doi.org/10.1007/s40200-025-01776-5","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus type 2 (DMT2) is a chronic metabolic disorder caused by a disruption or resistance in insulin secretion. AKT /PI3K, GSK-3β and CREB signaling pathways influence insulin sensitivity and glucose metabolism.</p><p><strong>Purpose: </strong>This study aimed to compare the therapeutic impact of pectin extracted from different sources (lemon, orange and grapefruit peels) against diabetic rats.</p><p><strong>Methods: </strong>Fourier transform infrared spectroscopy (FT-RI) and Proton Nuclear Magnetic Resonance (¹H-NMR) analysis of pectin were done. Treatments were administered daily for one month (500 mg/kg) post diabetes induction <i>via</i> a single dose of streptozotocin (STZ) (40 mg/kg) considering Metformin as a reference drug (250 mg/kg). Biochemical, mutagenicity and genotoxicity analyses were assessed.</p><p><strong>Results: </strong>The FT-IR and¹H-NMR revealed that lemon pectin had a strong peak at ≈3.7 ppm. Orange pectin showed a moderate peak at ≈3.7 ppm, and grapefruit pectin showed a weak peak at ≈3.7 ppm. Diabetic rats showed alterations in glucose, insulin, liver function enzymes, urea, oxidative stress indices, IL-6, TNF-α, AKT, PI3K levels and GSK-3β and cAMP responsive element binding protein 1(CREB) genes expression. Changes in micronuclei of polychromatic erythrocytes, chromosomal aberrations, sperm abnormalities and the histopathology of liver and pancreas were also observed. Pectin treatments declared a notable amelioration in glucose and insulin levels as well as the other selected parameters.</p><p><strong>Conclusion: </strong>Pectin extracted from lemon, orange and grapefruit peels showed a promising therapeutic impact against DMT2. High degree of esterification in lemon pectin may explore its potent effect <i>via</i> regulating glucose, α-amylase and the metabolic genes expression pathways. Orange pectin exhibits the strongest anti-mutagenic properties. Together, citrus pectin may be considered as a nutraceutical agent against diabetes.</p><p><strong>Graphical abstract: </strong></p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"278"},"PeriodicalIF":1.6,"publicationDate":"2025-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12644379/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145634360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Overbasalization and glycemic control: longitudinal analysis in people with type 2 diabetes in Peru.","authors":"Sandra Analí Vadillo-Saravia, Antonio Bernabé-Ortiz","doi":"10.1007/s40200-025-01786-3","DOIUrl":"10.1007/s40200-025-01786-3","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s40200-025-01756-9.].</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"263"},"PeriodicalIF":1.6,"publicationDate":"2025-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12595193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145481822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global prevalence and factors associated with overweight and obesity in children and adolescents with type 1 diabetes: a systematic review and meta-analysis.","authors":"Eric Peprah Osei, Emmanuel Ekpor, Gideon Yaw Osei, Samuel Akyirem","doi":"10.1007/s40200-025-01774-7","DOIUrl":"10.1007/s40200-025-01774-7","url":null,"abstract":"<p><strong>Objective: </strong>To determine the global prevalence and factors associated with overweight and obesity in children and adolescents with type 1 diabetes (T1D).</p><p><strong>Methods: </strong>A systematic database search was conducted in PubMed, CINAHL, EMBASE, MEDLINE, and Web of Science from 2000 to October 2024. Studies were included if they: (1) used observational designs (2) reported the prevalence of overweight and/or obesity among children with TID (< 20 years) (3) were published in English Language. Studies with both T1D and T2D participants that lacked separate T1D findings were excluded. The DerSimonian-Laird random-effects model was used to estimate the pooled prevalence, with heterogeneity assessed using I² statistics. Publication bias was assessed using funnel plots, Egger's and Begg's tests.</p><p><strong>Results: </strong>Out of 10,491 references, 21 articles met the inclusion criteria. The overall pooled prevalence of obesity and overweight among children and adolescents was 30.0%, with substantial geographical and gender differences. The pooled prevalence of obesity alone was 8.8% and overweight prevalence was higher at 20.0%. Key factors such as female gender, increasing age, lower household income, and lower parental education, increased insulin doses, reduced physical activity, lower self-monitoring of blood glucose, perceived stress, poor diabetes care activities, and poor quality of life were associated with higher overweight and obesity risk.</p><p><strong>Conclusion: </strong>Obesity and overweight in children with T1D stem from a complex interplay of sociodemographic, clinical, and behavioral factors. Data from underrepresented areas, especially Africa, highlight the need for further research to guide global policies for managing and preventing obesity.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-025-01774-7.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"257"},"PeriodicalIF":2.1,"publicationDate":"2025-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12586262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145458858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Systematic review and meta-analysis of health outcomes following diabetes risk reduction diet (DRRD).","authors":"Farzam Kamrani, Amirhossein Ataei Kachouei, Mobina Imannezhad, Sana Farzam, Masoumeh Sadeghi","doi":"10.1007/s40200-025-01777-4","DOIUrl":"10.1007/s40200-025-01777-4","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s40200-025-01687-5.].</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"255"},"PeriodicalIF":1.6,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12579088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145431832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body composition measurement and diabetes - A new perspective on development of antibodies after SARS-CoV-2 booster vaccination.","authors":"Lukas Van Baal, Susanne Tan, Dagmar Fuhrer, Johanna Reinold, Ulf Dittmer, Melanie Fiedler","doi":"10.1007/s40200-025-01699-1","DOIUrl":"10.1007/s40200-025-01699-1","url":null,"abstract":"<p><strong>Purpose: </strong>In patients with SARS-CoV-2 infection overweight and diabetes are associated with poor prognosis. Therefore, effectiveness and tolerance of booster vaccination against SARS-CoV-2 has to be ensured. We examined the impact of overweight and diabetes on anti-SARS-CoV-2-titers and the incidence of side effects after booster vaccination.</p><p><strong>Methods: </strong>We performed a cross-sectional study with consecutive recruitment and convenience sampling of 100 participants vaccinated three times against SARS-CoV-2. Anti-SARS-CoV-2-titers, immunological parameters and biochemical markers of glucose metabolism were measured. Prevalence of vaccination side effects was assessed by personal interview. Moreover, metabolic status was assessed by performance of body composition measurement and body impedance analysis. The glycemic and metabolic parameters were correlated with the anti-SARS-CoV-2-titers and the incidence of side effects. The results were compared between patient with and without overweight and diabetes.</p><p><strong>Results: </strong>Levels of anti-SARS-CoV-2-titers did not differ between participants with and without overweight (5756.6 ± 6848.9 vs. 4997.0 ± 5050.3, p.83) or participants with and without diabetes (6681.0 ± 6795.2 vs. 5124.0 ± 5070.4 BAU/ml, <i>p</i> = .28). Moreover, the investigated glycemic parameters and parameters of the body composition measurement and body impedance analysis did not present any correlation with the antibody levels. Furthermore, we could reveal that vaccination side effects are more likely to occur in participants without diabetes (OR 2.9 (95%-CI: 0.5-4.3, p.04)).</p><p><strong>Conclusions: </strong>Overweight and diabetes are not associated with lower anti-SARS-CoV-2-titers after booster vaccination. Parameters of the body composition and body impedance analysis did not reveal any further association regarding development of anti-SARS-CoV-2-titers. Vaccination side effects are more likely to occur in participants without diabetes.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-025-01699-1.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"250"},"PeriodicalIF":2.1,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12553712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145376749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of probiotic supplementation on anthropometric indices and body composition in unprofessional bodybuilders: a randomized, double-blind,: Placebo-Controlled clinical trial.","authors":"Nastaran Mahmoudi Shirkoohi, Alireza Chegol, Hamed Mohammadi, Sakineh Shab-Bidar, Siroos Choobineh, Kurosh Djafarian","doi":"10.1007/s40200-025-01766-7","DOIUrl":"10.1007/s40200-025-01766-7","url":null,"abstract":"<p><strong>Background: </strong>Probiotics may help bodybuilders by improving gut health, nutrient absorption, and reducing inflammation, potentially supporting muscle growth and fat loss. While research is promising, more studies are needed. This study explores the effects of probiotic supplementation on body composition and anthropometrics key measurements, aiming to see if they can support muscle building and fat management in unprofessional bodybuilders.</p><p><strong>Methods: </strong>The research was conducted as a randomized, parallel, placebo-controlled clinical trial with a 12-week follow-up period. Participants were randomly assigned to one of the probiotic supplementations (<i>n</i> = 18), or placebo supplementation (<i>n</i> = 18). At the beginning and 12 weeks of the intervention, anthropometric indices and body composition were evaluated.</p><p><strong>Results: </strong>A total of 80 participants (mean age, 29 years and mean weight, 74 kg) were enrolled in this trial. After 12-week intervention, we observed WC, ABSI, BRI, BAI, AVI, and ConI significantly decreased in the probiotic group and BAI significantly decreased placebo group, with no significant differences observed between groups. Moreover, BMI, AVI, and ConI were significantly reduced in probiotic group in compare with the placebo group. No significant results were observed in other anthropometric and body composition indicators.</p><p><strong>Conclusions: </strong>Probiotic supplementation improved anthropometric indices in unprofessional bodybuilders. However, these results need to be validated in a larger sample size.</p><p><strong>Trial registration: </strong>Iranian Registry of Clinical Trials IRCT20240424061562N1, Registration date 20,240,730, Trial Id 77,722.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s40200-025-01766-7.</p>","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"249"},"PeriodicalIF":2.1,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12552195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145377287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neck circumference is Associated with Hypertriglysceridemia in Adults.","authors":"Ülkügül Yıldırım, Özlem Güç Suvak","doi":"10.1007/s40200-025-01761-y","DOIUrl":"10.1007/s40200-025-01761-y","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Anthropometric measurements are considered a applicable and cost-effective indicator in primary healthcare settings for identifying the risk of obesity and related chronic diseases. This study aimed to elucidate the association between hypertriglyceridemia and neck circumference in adults.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The participants diagnosed with hypertriglyceridemia (HTG) (&lt;i&gt;n&lt;/i&gt; = 65) and those without HTG (&lt;i&gt;n&lt;/i&gt; = 65) were assessed in this prospective case-control study. Measurements included body mass index, neck circumference (NC), waist circumference, hip circumference, and various metabolic laboratory parameters.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The case group exhibited significantly higher anthropometric indices (body mass index, NC, waist circumference, and hip circumference) as well as higher age, fasting blood glucose, HbA1c, uric acid, hematocrit, hemoglobin, white blood cell count (WBC), low density lipid cholesterol, and triglyceride (TG) compared to the control group (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). In the HTGsubgroup, the mean neck circumference was 38.1 ± 4.1 cm, whereas in the control subgroup it was 35.7 ± 3.8 cm, with a statistically significant difference between the two groups (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). NC demonstrated statistically significant positive correlations with waist, hip circumference, and TG (&lt;i&gt;r&lt;/i&gt; = 0.593, &lt;i&gt;r&lt;/i&gt; = 0.461, &lt;i&gt;r&lt;/i&gt; = 0.330, and &lt;i&gt;r&lt;/i&gt; = 0.243, respectively; &lt;i&gt;p&lt;/i&gt; &lt; 0.001 for all). The regression analysis between NC and TG levels yielded a statistically significant model (&lt;i&gt;p&lt;/i&gt; &lt; 0.001), with the equation log(y) = 1.3423 + 0.02146x (R² = 0.150), suggesting that for each unit increase in NC, triglyceride concentration increases by approximately 2.1%.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;NC is closely associated with hypertriglyceridaemia in adults, while BMI, waist and hip circumference demonstrated a moderate positive correlation. Furthermore, a positive correlation with LDL-c and a negative correlation with HDL were also observed. What is already known about this topic? Anthropometric indices are simpleand low-cost quantitative measurements well positioned in primary health care, as they facilitate the early diagnosis of cardiometabolic diseases.Neck circumference is a simple, cost-effective and time-saving method to ascertain upper body obesity.Numerous studies have focused on the association between BMI, simple antropometric measurements and hypertension, or metabolic syndrome. However, there is little research investigating the primary effect of high triglycerides. However, few studies have investigated the primary effects of high triglyceride concentrations. 2.What this paper adds: This study demostrated an association between NC and non-HDL cholesterol levels esp. tryglicerid in adults. The study is expected to encourage clinicians using this cost-effective and easily applicable measurement method in clinical practice and to contribute to further research in th","PeriodicalId":15635,"journal":{"name":"Journal of Diabetes and Metabolic Disorders","volume":"24 2","pages":"248"},"PeriodicalIF":2.1,"publicationDate":"2025-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12552213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145377307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}