The role of branched chain aminotransferase in the interrelated pathways of type 2 diabetes mellitus and Alzheimer's disease.

IF 1.6 Q4 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes and Metabolic Disorders Pub Date : 2025-03-25 eCollection Date: 2025-06-01 DOI:10.1007/s40200-025-01597-6

Haya Majid, Sunil Kohli, Sajad Ul Islam, Nidhi

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引用次数: 0

Abstract

Objectives: This review assessed the role of Branched-Chain Amino Acid Transaminase (BCAT) enzymes in human metabolism, and their involvement in the catabolism of branched-chain amino acids (BCAAs) and exploring the association between Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD) through insulin resistance.

Methods: The analysis involves a comprehensive literature review of recent research findings related to BCAT enzymes, BCAA metabolism, T2DM, and AD. Relevant studies and articles were identified through systematic searches in databases such as PubMed, ScienceDirect, and other scholarly resources. Inclusion criteria encompassed research articles, reviews, and studies published in peer-reviewed journals, with a focus on human metabolism, BCAT enzymes, and the interplay between BCAA metabolism, T2DM, and AD.

Results: The association between T2DM and AD suggests a potential metabolic link, particularly through dysregulated BCAA metabolism leading to insulin resistance. The impact of impaired insulin signaling is implicated in brain function and the accumulation of amyloid plaques facilitated by BCAT.

Conclusion: The identified link between BCAT, BCAA metabolism, T2DM, and AD suggests that disruptions in BCAT levels could serve as valuable indicators for early detection of insulin resistance and cognitive impairment as observed in Type 3 Diabetes which may present a promising therapeutic target.

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支链转氨酶在2型糖尿病和阿尔茨海默病相关通路中的作用。

目的：本综述评估了支链氨基酸转氨酶（BCAT）在人体代谢中的作用，及其参与支链氨基酸（BCAAs）的分解代谢，并通过胰岛素抵抗探讨2型糖尿病（T2DM）与阿尔茨海默病（AD）之间的关系。方法：对BCAT酶、BCAA代谢、T2DM和AD相关的最新研究成果进行综合文献综述。通过系统检索PubMed、ScienceDirect等数据库和其他学术资源，确定了相关研究和文章。纳入标准包括发表在同行评审期刊上的研究文章、评论和研究，重点是人体代谢、BCAT酶以及BCAA代谢、2型糖尿病和AD之间的相互作用。结果：T2DM和AD之间的关联提示了潜在的代谢联系，特别是通过BCAA代谢失调导致胰岛素抵抗。胰岛素信号受损的影响涉及脑功能和BCAT促进的淀粉样斑块的积累。结论：BCAT、BCAA代谢、T2DM和AD之间的联系表明，BCAT水平的破坏可以作为早期发现3型糖尿病胰岛素抵抗和认知障碍的有价值的指标，可能是一个有希望的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine

CiteScore

4.80

自引率

3.60%

发文量

210

期刊介绍： Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.