血糖状态和骨骼健康:研究糖基化血红蛋白对南印度成年人骨密度的影响。

IF 1.8 Q4 ENDOCRINOLOGY & METABOLISM
Journal of Diabetes and Metabolic Disorders Pub Date : 2024-08-20 eCollection Date: 2024-12-01 DOI:10.1007/s40200-024-01473-9
Rohini Bhadra, Sumithra Selvam, Sucharita Sambashivaiah
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引用次数: 0

摘要

目的:探讨糖化血红蛋白(HbA1c)水平与不同血糖状态个体(包括糖尿病、糖尿病前期和对照组)骨密度(BMD)之间的关系。方法:这项横断面研究在印度班加罗尔进行,包括336名年龄在20至60岁之间的参与者。采集血样评估空腹血糖、糖化血红蛋白和血脂。参与者根据HbA1c水平分为低(HbA1c≤5.5%)、中(HbA1c bb0 5.5-6.0%)和高(HbA1c≥6.1%)三组。双能x线骨密度仪(DXA)测量髋部、脊柱和总骨密度作为骨骼健康指标。结果:与低HbA1c水平的患者相比,中等和高HbA1c水平的患者髋部和总骨密度明显更高(髋部和总骨密度p = 0.006)。三组间脊柱骨密度具有可比性。在调整了年龄、性别和BMI后,观察到血糖控制对髋部骨密度的潜在独立影响(低、中、高血糖状态:β: 0.041, 95% ci: 0.003, 0.078, p = 0.034)。结论:通过DXA观察到,HbA1c升高可能与髋关节和总体骨密度升高有关。然而,这并不一定意味着更好的骨骼健康;建议进一步评估以防止骨折。补充资料:在线版本提供补充资料,网址为10.1007/s40200-024-01473-9。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Glycemic status and bone health: investigating the impact of glycosylated hemoglobin on bone density in South Indian adults.

Objective: To investigate the relationship between glycosylated Hemoglobin (HbA1c) levels and bone mineral density (BMD) in individuals with varying glycemic statuses, including diabetes, prediabetes, and controls.

Methods: This cross-sectional study conducted in Bengaluru, India, included 336 participants aged 20 to 60. Blood samples were taken to assess fasting blood glucose, HbA1c, and lipid profile. Participants were divided into tertiles based on HbA1c levels: low(HbA1c ≤ 5.5%), moderate(HbA1c > 5.5-6.0%), and high(HbA1c ≥ 6.1%).Dual energy-X-ray absorptiometry(DXA) measured hip, spine, and total BMD as indicators of bone health.

Results: Intermediate and high HbA1c tertiles had a significantly higher hip and total BMD compared to low HbA1c tertiles (p < 0.001 and p = 0.006 for hip and total BMD). Spine BMD was comparable between the three groups. After adjusting for age, gender and BMI, a potential independent effect of glycemic control on hip BMD was observed (Low vs. intermediate and high glycemic status: β: 0.041, 95% C.I.: 0.003, 0.078, p = 0.034).

Conclusion: Elevated HbA1c might be associated with higher hip and overall BMD as observed through DXA. Nonetheless, this doesn't necessarily imply better bone health; further evaluation is advised to prevent fractures.

Supplementary information: The online version contains supplementary material available at 10.1007/s40200-024-01473-9.

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来源期刊
Journal of Diabetes and Metabolic Disorders
Journal of Diabetes and Metabolic Disorders Medicine-Internal Medicine
CiteScore
4.80
自引率
3.60%
发文量
210
期刊介绍: Journal of Diabetes & Metabolic Disorders is a peer reviewed journal which publishes original clinical and translational articles and reviews in the field of endocrinology and provides a forum of debate of the highest quality on these issues. Topics of interest include, but are not limited to, diabetes, lipid disorders, metabolic disorders, osteoporosis, interdisciplinary practices in endocrinology, cardiovascular and metabolic risk, aging research, obesity, traditional medicine, pychosomatic research, behavioral medicine, ethics and evidence-based practices.As of Jan 2018 the journal is published by Springer as a hybrid journal with no article processing charges. All articles published before 2018 are available free of charge on springerlink.Unofficial 2017 2-year Impact Factor: 1.816.
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