Journal of diabetes & metabolism最新文献

{"title":"Nordic walking nations exercise rehabilitation program: Medicine of the 21st century","authors":"pDennis P Meloneyp","doi":"10.4172/2155-6156-C7-095","DOIUrl":"https://doi.org/10.4172/2155-6156-C7-095","url":null,"abstract":"","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78837371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low carbohydrate diet research by glucose variability with various medical care such as physiotherapy and music therapy","authors":"B. Hiroshi","doi":"10.4172/2155-6156-C3-084","DOIUrl":"https://doi.org/10.4172/2155-6156-C3-084","url":null,"abstract":"Background: DM type-2 is characterized by gradual decrease in insulin sensitivity within the peripheral tissues and liver (insulin resistance), followed by gradual decline in β-cell function and insulin secretion. Thus, patients with poor glycemic control require the utilization of insulin therapy to realize the target of yank Diabetes Association, recommending HbA1c to be but 7% (≥8% despite of optimal doses of anti-diabetic drugs). Aim: This study aimed to guage and addressing the barriers to be used of insulin in type-2 DM patients, where their glycemic control is poor, i.e., HbA1c is ≥8% despite of optimal doses of anti-diabetic drugs. Research Design & Method: We surveyed 200 patients with type-2 diabetes mellitus, i.e., cross-sectional quantitative study; patients showed poor glycemic control HbA1c≥8%, already treated with one or more oral agents, who recently prescribed insulin to regulate their metabolic status. Data were obtained by patient’s interview employing a validated questionnaire. The place of the study was in DM clinic in Farwaniyah Primary Health Care Center in Kuwait. Result: Patients with type-2 diabetes failing to initiate the prescribed insulin therapy have reported misconception regarding fear of hypoglycemia in 49% of the entire sample, pain from injections in 68% and self-blame about need for insulin i.e., sense of failure in 61% of total sample of study. Other factors were addressed like sensation by getting more severity of the disease, weight gain fear and other negative self-perceptions and attitudinal barriers were studied. Conclusion: Reducing the negative influence of psychological insulin resistance (PIR) on treatment outcomes should be a clinical priority. The position statement of the ADA and thus the EASD quotes the Committee on Quality of Health Care in America of the Institute of medicine in defining patient-centered care as an approach “to providing care that's respectful of and aware of individual patient preferences, needs, and values and ensuring that patient values guide all clinical decisions.”17 This position statement acknowledges that glycemic management in patients with T2DM has become increasingly complex and, to some extent, controversial, considering the increasing number and type of pharmacologic agents now available. I truly believe in a patient-centered approach. The patient possesses to be a neighborhood of the decision-making process. I ask all of my new patients, and that i explain every different medication that's available. I tell them about the risks and benefits of the medications, and that I allow them to decide which medication to require . T2DM consists of interventions designed to affect the physical activity levels and food intake of a private . However, current treatment recommendations now also include initiation of pharmacotherapy at the time of diagnosis, partially as a of Metformin therapy has been shown to scale back the danger of microvascular complications related to T2DM.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"45 1","pages":"24-24"},"PeriodicalIF":0.0,"publicationDate":"2018-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73714028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pattern of Lipid Profile of Type 2 Diabetes Patients in Tertiary Hospital South-West Region of Cameroon","authors":"Mboh Epanda Achille, N. Michel, Sama Leonard Fonkeng, Wam Elvis Chongsi, Panni Asongwed Patrice, Mouladje Maurice, Mouliom Njikam Réné, T. C. Bonglavnyuy","doi":"10.4172/2155-6156.1000795","DOIUrl":"https://doi.org/10.4172/2155-6156.1000795","url":null,"abstract":"Diabetes mellitus (DM) is recognized as a serious global health problem and frequently associated with disabling and life-threatening complications related to some modifiable risk factors. One of the modifiable factors is dyslipidemia. Because detection and treatment of dyslipidemia is one means of reducing cardiovascular disease (CVD) risk, determination of serum lipid levels in people with diabetes is now considered a standard of care. Lipid profile and fasting blood sugar (FBS) of 108 diabetic subjects were assessed. Dyslipidaemia was defined using the national cholesterol education programme–adult treatment panel III (NCEP-ATP III) criteria. BMI and waist circumferences were measured. The mean of the body mass index was 29.85 ± 6.32 kg/m2 with the males having 27. 23 ± 5.29 kg/m2 while the females had 30. 90 ± 6.43 kg/m2. The mean duration of DM was 57.80 ±13.72 month for males while for females it was 6.58 ± 7.11 month. Also 23(74.19%) of the male patients had a waist circumference ≥ 120 cm and 8(25.81%) had a waist circumference A‹Â‚120 cm while for female patients, 64(83.12%) had waist circumference ≥ 88 cm and 13(16.88%) had a waist circumference A‹Â‚88 cm. The mean TC (4.77 ± 1.13 vs 5.13 ± 1.24 P=0.1711) and LDL-C (2.79 ± 0.95 vs 2.98 ± 1.25 P=0.4016) were slightly higher among the female subjects but the differences were not significant from males, while HDL-C (1.53 ± 0.50 vs 1.40 ± 0.42 P=0.2006) and TG (1.35 ± 0.66 vs 0.61 ± 0.18 P=0.3424) were higher among the male subjects but were not statistically different from the females. Ninety-eight diabetic patients had at-least one lipid value or the other outside of the clinical target giving it a prevalence of 88.89%. The most frequent lipid combination was ↑TC+↑LDLc. There was no significant correlations between the anthropometric indices and the lipid profile. It is important to realise that hyperlipidaemia and the resultant macro vascular disease can develop even in the 'prediabetic phase' of type 2 DM. Hence, early detection and correction of dyslipidaemic state is essential in the management of diabetic patients.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"54 46 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2018-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83266949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Growth among Children with Type 1 Diabetes Mellitus: A Cross-Sectional Study of Factors Contributing to Stunting","authors":"Anabelle Kayirangwa, F. Rutagarama, D. Stafford, N. McCall","doi":"10.4172/2155-6156.1000793","DOIUrl":"https://doi.org/10.4172/2155-6156.1000793","url":null,"abstract":"Introduction: Diabetes is a worldwide health challenge. Research done among diabetic children concluded that the abnormalities in growth associated with diabetes are due to reduced insulin use and are reversible with adequate insulin therapy. A diabetic child who is on appropriate treatment should have no impairment of growth. In this study, we assessed the prevalence of stunting among a population of pediatric patients with diabetes. \u0000Methods: It is a descriptive cross-sectional study done from September to December 2015 in Rwanda. 136 children from 23 districts were included. Patients aged 1 to 18 years old were enrolled. Weight, height and Glycated hemoglobin were our study parameters. Stunting was defined as height for age below -2SD. Previous HbA1c readings were obtained from patient files. Interviews were used to code demographic, socio-economic factors, access to and affordability of food and clinical data information. Data entry was done in Epidata and analyzed by Stata 13. \u0000Result: 136 children were enrolled, aged 2 to 18 years with a mean age of 15.5. 39.7% were male and 60.3% were female. The prevalence of stunting was 30.9%. The mean HbA1c was 9.7%; 28% were well controlled with an HBA1c <7.5, whereas 41.2% had a poor glycemic control with HbA1c of 10% or above. Those with lower socioeconomic status were better controlled. The mean daily Insulin dose was 0.8 IU/kg/day. Regarding availability of meals, 4.4% reported to have only one meal per day. 34.6% admitted their nutrition was inadequate. No secondary school education for parents was associated with stunting. Districts Huye and Rusizi were the most affected with stunting. Insufficiently fed children were likely to be stunted. \u0000Conclusion: The prevalence of stunting among children with diabetes was high. There was no association between stunting and glycemic control, but there was an association between stunting and poor socio-economic condition.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"26 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2018-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79903502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysregulated inflammatory responses lead to enhanced infection and impaired healing in diabetic wound","authors":"S. Shafikhani","doi":"10.4172/2155-6156-C1-077","DOIUrl":"https://doi.org/10.4172/2155-6156-C1-077","url":null,"abstract":"Citation: Alexandr V Dreval. (2020). IVGTT in Diagnosing of Glucose Kinetics Dis-balance in Diabetic Patients. Archives of Endocrinology and Diabetes 2(1). Currently, there are two approaches that are used during the clinical diagnostics of diabetes: (a) according to the results of a static study of glycemia (in a fasting state and/or at a random point within 24 hours), and diabetes is diagnosed when the glycemia level exceeds a certain threshold value; (b) using a dynamic stress test, or OGTT (2 hours after taking 75g glucose), which also sets threshold values for normal glycemia at the 2-hour test point. But as early as 1943, another dynamic method for diagnosing diabetes, IVGTT (Greville), was proposed, in addition to OGTT. The advantages of the IVGTT method over the OGTT method in the accuracy of diagnosing diabetes are obvious. First of all, this is due to the fact that insulin has no influence on the absorption of glucose, but only on the rate of glucose elimination from blood. And, in the OGTT, not only the elimination of glucose from blood is reflected, but also the processes of glucose absorption from the gastrointestinal tract, which have nothing to do with insulin deficiency. On this basis, in 1943, Greville suggested using IVGTT for diagnosing diabetes and, as stated in this study, was quite successful. Moreover, to calculate the rate of glucose elimination from the blood, Greville proposed a simple kinetic model where the rate of glucose decreases in blood (dC(t)/dt) after an intravenous bolus injection (approximately 20g, IV push for a few minutes) was considered proportional to the concentration of blood glucose (C) with a proportionality factor of k: As a result, it was impossible to definitely determine the factor, and, moreover, if we ignore this systematic deviation and draw a direct regression line through the glycemic logarithm points, some patients with clinical findings of diabetes mellitus will have a normal k factor.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"114 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76936460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Insulin Resistance and Beta-Cell Function Using Homeostatic Model Assessment in Type 2 Diabetic Patients at Diagnosis","authors":"P. Basukala, B. Jha, B. Yadav, P. Shrestha","doi":"10.4172/2155-6156.1000790","DOIUrl":"https://doi.org/10.4172/2155-6156.1000790","url":null,"abstract":"Objective: Despite the increasing incidence of type 2 diabetes mellitus (T2DM) in South Asian countries, there have been no studies related to insulin resistance (IR) and beta-cell function (BCF) in Nepal. Measurement of both of these parameters at T2DM diagnosis can be a potential tool in evaluation, risk stratification and monitoring treatment. In this study, we used C-peptide modified homeostatic model assessment (both HOMA1 and HOMA2) and correlated the obtained IR with cardiovascular risk factors. We also intended to find out whether reduced insulin sensitivity or beta-cell failure predominates in new T2DM cases. Also there has been some dilemma in using either body mass index (BMI) or waist-hip ratio (WHR) as a better predictor of IR in our population. Lipoprotein ratios TC/ HDL and TG/HDL also needed evaluation in this regard.Results: Participants were sixty newly diagnosed T2DM patients visiting Tribhuvan University Teaching Hospital (TUTH), Nepal. The mean IR and beta-cell function were HOMA1IR=4.91 ± 1.62; HOMA2IR=2.61 ± 1.06 and HOMA1%B=40.28 ± 23.64; HOMA2%B=47.10 ± 24.67 respectively. Both HOMA1 and HOMA2 showed greater reduction in insulin sensitivity than beta-cell function at diagnosis. ROC curves analysis showed WHR and TC/HDL ratio as better predictors of IR.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"27 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2018-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78007697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18bp Fragment Insertion/Deletion Polymorphism of Vascular Endothelial Growth Factor (VEGF) Gene with Diabetes Mellitus Type 2 and Diabetic Retinopathy Patients of Quetta, Balochistan, Pakistan","authors":"Sanam Zeib Khan, Rozeena Shaikh, M. Azhar, A. Wali, J. Ahmad","doi":"10.4172/2155-6156.1000789","DOIUrl":"https://doi.org/10.4172/2155-6156.1000789","url":null,"abstract":"Background: An important candidate gene for diabetic retinopathy (DR) is vascular endothelial growth factor (VEGF). The VEGF gene is extremely polymorphic. The 18 base pairs (bp) segment (I/D) polymorphism at -2549 position of the promoter region is of great importance. \u0000Aim: The present study aimed to identify VEGF (I/D) polymorphism in DM and DR patients. \u0000Materials and Methods: This cross section study involved 100 healthy control subjects, 100 diabetes mellitus (DM) subjects and 100 DR subjects. Blood samples were collected after informed consent of study subjects, DNA extraction was performed using inorganic method, VEGF gene promoter region that was confirmed using 2% agarose gel. Polymerase Chain Reaction (PCR) was used to identify (I/D) polymorphism of 18 bp fragment at position -2549, DNA Sequencing was done commercially to confirm the presence of 18bp I/D polymorphism. The allele (I/D) and genotypes (DD, I/D, II) frequencies of VEGF gene were compared among all the study subjects. \u0000Results: The frequency of DD genotype in DR was 52% while in DM was 40% and in control was 2%. The significant differences (p<0.05) were observed when genotypes were compared among control and DM, DM and DR, Control and DR. The significant differences (p<0.05) were observed in Control and DM Control and DR, DM and DR at 95% CI. \u0000Conclusion: These findings suggest that the DD genotype is possible risk factor for development and progression of retinopathy as compared to uncomplicated subject II genotype in local population.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"63 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72633905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Type 2 Diabetes Mellitus and Risk of Prostate Cancer: Literature Review and Critical Appraisal","authors":"T. Chu","doi":"10.4172/2155-6156.1000787","DOIUrl":"https://doi.org/10.4172/2155-6156.1000787","url":null,"abstract":"Background: Type 2 Diabetes Mellitus and Prostate Cancer are two common illnesses. However, there was not extensive research done to determine the relationship between the two diseases. \u0000Objective: This article aims to investigate the relationship between Type 2 Diabetes Mellitus and the risk of Prostate Cancer, and some possible underlying mechanisms. \u0000Method: Several papers published within 5 years in this area are critically appraised and reviewed, including meta-analyses with large scale cohorts. \u0000Results: Type 2 Diabetes Mellitus is linked to a moderately decreased risk of Prostate Cancer, as seen in recent evidences. Possible underlying mechanisms include changes in hormonal profiles, genetics, and use of diabetic drugs (Metformin). \u0000Conclusion: While Type 2 Diabetes Mellitus might be protective against Prostate Cancer risk, more evidence as to how confounding variables such as ethnicity, lifestyle, and co-morbidities modify the overall risk is needed, as related information in this area is scarce.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"120 3 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84053263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities of the Akabane Test for Diagnosis and Monitoring of Patients with Type 2 Diabetes","authors":"V. Muzhikov, E. Vershinina, Ruslan Muzhikov","doi":"10.4172/2155-6156.1000785","DOIUrl":"https://doi.org/10.4172/2155-6156.1000785","url":null,"abstract":"Background: In view of its prevalence, type 2 diabetes (T2D) is a socially significant disease, which affects millions of patients. Despite the significant advances in modern medicine, there are problems with early diagnosis and effective treatment of this disease, especially at home. In this regard, it would be interesting to pay attention to the possibility of diagnosing and treating this disease from reverse the viewpoint of traditional Chinese medicine (TCM).Methods/Design: In order to assess patterns of heat sensitivity thresholds of acupuncture channels (AC) in patients with T2D, the Akabane test was carried out on with 116 men and 190 women. For comparison, a group of healthy subjects made up of 112 men and 277 women was also used.Results: Simple effects of paired comparisons between healthy subjects and T2D in groups of men and women, showed significant differences. The most significant differences are seen in the AC connected with the digestive system. In this case, the greatest diagnostic value is the level of asymmetry between the right and left branches of these AC, which varies in proportion to the level of glycaemia. Changes in the AC are stable and precede the manifestation of the functional and organic disorders inherent in this disease. This dependence allows for early T2D diagnostics and individual monitoring.Conclusion: The combination of the Akabane test with the use of mathematical analysis in patients with T2D makes it possible to trace the entire chain of carbohydrate metabolism at an individual level and to identify regulatory violation and the compensatory mechanisms for more effective therapeutic effects.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"1 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2018-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90893791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Study of the Effect of a 16-Week Program of Resistance-Aerobic Training on BDNF, Hba1c, Pain, and Michigan Neuropathy Score Among Type 2 Diabetic Patients with Peripheral Neuropathy","authors":"Tayebeh Amiriparsa, S. A. Hosseini, N. Bijeh, M. R. H. Nia","doi":"10.4172/2155-6156.1000811","DOIUrl":"https://doi.org/10.4172/2155-6156.1000811","url":null,"abstract":"","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84530983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}