Journal of Cutaneous Immunology and Allergy最新文献

{"title":"Allergic contact dermatitis caused by Dermabond® Advanced: The role of temperature as a potential risk factor","authors":"Mai Hasegawa MD,&nbsp;Takasuke Ogawa MD,&nbsp;Yumi Ogawa MD,&nbsp;Shigaku Ikeda PhD","doi":"10.1002/cia2.12328","DOIUrl":"10.1002/cia2.12328","url":null,"abstract":"<p>We herein report a case of allergic contact dermatitis (ACD) caused by Dermabond® Advanced, which was diagnosed by a patch test using SurgiSeal® (Nitcho Kogyo, Tokyo, Japan) as a control. A difference in the temperature increase at the time of application suggested that temperature may be a risk factor for sensitization.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":"6 6","pages":"258-259"},"PeriodicalIF":1.0,"publicationDate":"2023-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12328","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135719660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two cases of acute-onset cystoid macular edema and serous retinal detachment associated with combined use of encorafenib and binimetinib for advanced melanoma: A possible confounding risk for drug intolerance","authors":"Takumi Hasegawa MD,&nbsp;Shiro Iino MD, PhD,&nbsp;Misako Fujisaki MD,&nbsp;Sayuri Okamura MD,&nbsp;Natsuki Baba MD, PhD,&nbsp;Nami Tanaka MD,&nbsp;Yuko Takeuchi MD,&nbsp;Noritaka Oyama MD, PhD,&nbsp;Minoru Hasegawa MD, PhD","doi":"10.1002/cia2.12325","DOIUrl":"10.1002/cia2.12325","url":null,"abstract":"<p>While combined use of BRAF/MEK inhibitors has elicited dramatic clinical efficacy in incurable melanoma, drug-associated retinopathy has become an emerging adverse event. We present two Japanese men with advanced melanoma who developed visual impairment due to serous retinal detachments (SRDs) with cystoid macular edema (CME) immediately after initial administration of encorafenib/binimetinib, a BRAF and MEK inhibitor. One case had drug-intolerable retinopathy on repeat dosing. Both cases were switched to another BRAF/MEK inhibitors, dabrafenib/trametinib, with no recurrence of SRDs. Co-existing CME may be a confounding risk for the early development of SRDs with encorafenib/binimetinib therapy, providing attention during drug administration.</p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":"6 6","pages":"231-233"},"PeriodicalIF":1.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136310933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of methotrexate-related lymphoproliferative disorder resolved with discontinuation of the drug: A literature review for clinical characteristics in 105 Japanese cases","authors":"Shintaro Higashida MD,&nbsp;Erina Kodaka MD,&nbsp;Hiromichi Iwasaki MD, PhD,&nbsp;Hideaki Sakai MD,&nbsp;Noritaka Oyama MD, PhD,&nbsp;Minoru Hasegawa MD, PhD","doi":"10.1002/cia2.12324","DOIUrl":"10.1002/cia2.12324","url":null,"abstract":"<p>We report a case of rheumatoid arthritis who developed cutaneous diffuse large B-cell lymphoma during methotrexate (MTX) monotherapy with prompt resolution after discontinuation of the drug. Our literature review of over 100 reported Japanese cases revisited the potential risk of treatment resistance and/or repeated recurrence of lymphomas, particularly in cases that were unresponsive to the withdrawal of MTX or received a higher cumulative dose.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":"6 6","pages":"255-257"},"PeriodicalIF":1.0,"publicationDate":"2023-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12324","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135938589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stevens-Johnson syndrome without skin lesions extensively involving the digestive tract","authors":"Yuto Ishikawa MD,&nbsp;Sayaka Ajima MD,&nbsp;Hideo Hashizume MD, PhD","doi":"10.1002/cia2.12323","DOIUrl":"10.1002/cia2.12323","url":null,"abstract":"<p>We have experienced a case of SWSL involving significant gastrointestinal erosion that occurred after TMP-SMX medication. For accurate diagnosis and prompt treatment of complications, it is essential to be aware of the possibility of this phenomenon.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":"6 6","pages":"249-250"},"PeriodicalIF":1.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48911943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decreased epidermal AXL expression and increased infiltration of AXL-expressing dendritic cells in psoriasis","authors":"Yukiko Ito MD,&nbsp;Sayaka Shibata MD, PhD,&nbsp;Asumi Koyama MD,&nbsp;Lixin Li MD,&nbsp;Eiki Sugimoto MD,&nbsp;Haruka Taira MD,&nbsp;Yuka Mizuno MD,&nbsp;Kentaro Awaji MD, PhD,&nbsp;Shinichi Sato MD, PhD","doi":"10.1002/cia2.12319","DOIUrl":"10.1002/cia2.12319","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Psoriasis is a chronic skin inflammatory disease characterized by epidermal proliferation and inflammatory cell infiltration. AXL is a tyrosine kinase receptor that promotes cell proliferation and invasion in cancer cells, and its expression is elevated in multiple tumors. However, less is known about its expression and function in inflammatory diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim of this study is to examine AXL expression in psoriasis and investigate the biological function of AXL under psoriatic conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>AXL mRNA expression was decreased in psoriatic skin compared to healthy skin, and an inverse correlation with neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio was observed. Immunohistochemical staining of psoriatic skin revealed decreased AXL expression of the epidermis and an increased number of AXL-positive dendritic cells in the dermis. Stimulation of epidermal keratinocytes with antimicrobial peptide LL37, but not with IL-17A, resulted in decreased AXL expression. Knockdown of AXL in epidermal keratinocytes did not affect cell proliferation or expression of psoriasis-associated cytokines and chemokines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Decreased epidermal AXL expression and increased infiltration of AXL-expressing dendritic cells were revealed in psoriasis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":"6 6","pages":"208-218"},"PeriodicalIF":1.0,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12319","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48617135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normocomplementemic urticarial vasculitis with laryngeal and intestinal tract edema","authors":"Daisuke Kawakami MD,&nbsp;Yoshiko Oda MD, PhD,&nbsp;Yumi Oka MD,&nbsp;Anri Morita MD,&nbsp;Keiko Kuroda MD,&nbsp;Yoji Hirai MD, PhD,&nbsp;Chikako Nishigori MD, PhD,&nbsp;Atsushi Fukunaga MD, PhD","doi":"10.1002/cia2.12312","DOIUrl":"10.1002/cia2.12312","url":null,"abstract":"<p>An 81-year-old Japanese man presented with a history of recurrent eyelid swelling and purpura on the face, neck, and limbs. Because the initial clinical presentation was angioedema alone, the patient was treated with an H1-receptor antagonist and tranexamic acid as for an idiopathic angioedema. The patient also experienced dyspnea simultaneously with edema on the face and limbs and was thus taken to the emergency room, where laryngeal edema was confirmed on laryngeal fiber. A good response to hydrocortisone injection was observed in the patient. ACE inhibitors were never prescribed for the patient, and there was no family history of angioedema. Laboratory data indicated normocomplementemia, and skin biopsies revealed leukocytoclastic vasculitis. Therefore, the patient was diagnosed with NUV. Following hospitalization, the patient experienced appetite loss and the CRP level increased, presenting with thickening and stranding around colon tissues on abdominal CT. These symptoms responded well to prednisone treatment. Given that the initial clinical manifestation of the current case was mainly angioedema, physicians should consider that angioedema may in rare cases be diagnostic for UV.</p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":"6 5","pages":"172-174"},"PeriodicalIF":1.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42427882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of disseminated erythematous drug eruption caused by favipiravir in a patient with COVID-19","authors":"Aki Honda MD,&nbsp;Toshiyuki Yamamoto MD, PhD","doi":"10.1002/cia2.12321","DOIUrl":"10.1002/cia2.12321","url":null,"abstract":"<p>The case of a widespread erythematous drug eruption brought on by favipiravir is described here. Patch tests and the drug lymphocyte transformation test (LTT) both indicated a positive reaction. Since COVID-19 patients take many medications, the potential for a drug eruption must be taken into account when diagnosing a rash.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":"6 5","pages":"201-202"},"PeriodicalIF":1.0,"publicationDate":"2023-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12321","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42624162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of IL36RN mutation analysis in an elderly patient with generalized pustular psoriasis patient treated with secukinumab","authors":"Satoko Minakawa MD, PhD,&nbsp;Yasushi Matsuzaki MD, PhD,&nbsp;Soichiro Watanabe MD, PhD,&nbsp;Kazumitsu Sugiura MD, PhD,&nbsp;Daisuke Sawamura MD, PhD","doi":"10.1002/cia2.12318","DOIUrl":"10.1002/cia2.12318","url":null,"abstract":"<p>We present a case of Generalized pustular psoriasis (GPP) presented with SARS-CoV-2 infection under the control of secukinumab. Mutation analysis revealed a heterogeneous c.28C&gt;T (p.Arg10X) mutation in IL36RN. Mutation analysis should be considered to enable preparation for biologic therapy to treat intractable flare-ups.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":"6 5","pages":"198-200"},"PeriodicalIF":1.0,"publicationDate":"2023-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12318","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44872302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contact dermatitis syndrome to poison ivy","authors":"Marina Seki MD,&nbsp;Marie Suzuki MD,&nbsp;Takehiro Okusa MD,&nbsp;Yuta Ito MD,&nbsp;Tokio Nakada MD","doi":"10.1002/cia2.12320","DOIUrl":"10.1002/cia2.12320","url":null,"abstract":"&lt;p&gt;A 7-year-old, otherwise healthy Japanese boy, who lived in Wisconsin State, the United States, developed pruritic rash on his lower extremities 10 days earlier. Since lesions increased in number, he was treated with triamcinolone ointment as eczema at a dermatology clinic in the United States. He then returned to Japan temporarily for a legal matter and was treated with olopatadine hydrochloride, an antihistamine drug, and betamethasone butyrate propionate ointment at a dermatology clinic. Since lesions were not improved despite the treatments described above, the patient was introduced to our department. Figure 1A–D shows a physical examination on his initial visit: We noted vesicles and serous papules and edematous swelling on the left lower thigh (A), papules on the lower back (B), tense blisters on edematous erythema on the right forearm (C), and edematous erythema with papules on left gluteal and femoral regions (D). We suspected contact dermatitis to plants, paint, or resin of bench based on morphology, and those lesions improved by administration of prednisolone, 10 mg for 3 days, and betamethasone butyrate propionate ointment for 7 days. During the interview, we could confirm that poison ivy was growing wild in the yard of the patient's house. As his mother wanted to identify the course, patch testing was performed with Japanese standard series 2015: Patch Test Panel® (S) (the trade name of T.R.U.E. TEST in Japan, Sato Pharmaceutical Co.) and 0.002% urushiol and 0.05% mercuric chloride (Torii Pharmaceutical Co.) 1 month after the initial visit. These were applied on the back for 2 days, and the results read utilizing the International Contact Dermatitis Research Group (ICDRG) scoring system 2 and 6 days after application.&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; Extremely positive reactions to urushiol were recorded on Days 2 and 6 (Figure 1E). Hence, we diagnosed it as contact dermatitis to poison ivy.&lt;/p&gt;&lt;p&gt;In Wisconsin State, where the patient lives, poison ivy is considered a typical noxious plant.&lt;span&gt;&lt;sup&gt;2&lt;/sup&gt;&lt;/span&gt; It is widely known that urushiol is the causative agent in allergic reactions to poison ivy. Urushiol is a typical causative agent of contact dermatitis in Japan, too. According to the Japanese contact dermatitis research group's tally in 2021, the positive rate to it was 8.7%: The fifth highest rate after gold thiosulfate, nickel sulfate, cobalt chloride, paraphenylenediamine among 24 allergens of the Japanese standard series.&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; Hence, the Ministry of Foreign Affairs of Japan has issued a warning to travelers to the United States against poison ivy on its website.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; In this case, lesions developed not only at contact sites to poison ivy but at noncontact sites like the back and gluteal region. This is a condition that should be called contact dermatitis syndrome&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; or stage 3A of allergic contact dermatitis syndrome: It is considered that the causative allergen","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":"6 5","pages":"203-204"},"PeriodicalIF":1.0,"publicationDate":"2023-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12320","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44831853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory hypersensitivity reaction related to ingestion of raspberry","authors":"Yuki Akamatsu MD,&nbsp;Yoshio Kawakami MD, PhD,&nbsp;Shusaku Fujita MD,&nbsp;Tomoko Kawamoto MD,&nbsp;Tomoko Miyake MD, PhD,&nbsp;Yoji Hirai MD, PhD,&nbsp;Shin Morizane MD, PhD","doi":"10.1002/cia2.12317","DOIUrl":"10.1002/cia2.12317","url":null,"abstract":"&lt;p&gt;A 27-year-old woman developed dyspnea and wheezing within 10 min after eating a piece of raspberry walnut cake, and visited an emergency hospital. Based on a presumptive diagnosis of anaphylaxis, she was successfully treated with intravenous corticosteroid and intramuscular injection of adrenaline. She was referred for further investigation. Her medical history included mild asthma, cat allergy, and bipolar disorder, being treated with pranlukast, quetiapine, lamotrigine, and lorazepam. She could eat bread containing wheat and heated eggs without problem after this attack. Laboratory tests showed normal serum level of immunoglobulin (Ig) E 44 IU/mL. Multiple antigen simultaneous test (MAST)-36 (BML Inc) to examine allergen-specific IgE showed 15.2 lumicount (LC) (class 3) of cat dander and 4.89 LC (class 2) of dog dander, whereas the other results were negative. Specific IgE antibodies to strawberry, peach, apple, walnut, Jug r1, egg yolk, egg white, ovomucoid, gluten, ω-5 gliadin, birch pollen tested by CAP fluoro-enzyme immunoassay (CAP-FEIA) and prick-to-prick tests with ingredients of the cake and their related foods, including raspberry, strawberry, blackberry, blueberry, apple, walnut, almond, peanut, wheat, egg yolk, and egg white, were all negative. Then, an open oral provocation test was performed on admission initially with raspberry. Twenty minutes after eating 1.5 pieces of raspberry (about 4.5 g), she developed discomfort of the throat, dyspnea, repetitive cough, audible wheezing, and tachycardia (145 beats/min). Cutaneous symptoms were absent except for mild pruritus of the neck. Her blood pressure and percutaneous oxygen saturation (SpO2) levels were normal. She was treated with intravenous administration of 4 mg betamethasone and 5 mg chlorpheniramine, followed by an intramuscular injection of 0.3 mg adrenaline. Within 10 min, the patient's dyspnea and tachycardia subsided without sequelae. Further investigation with CD203c expression-based basophil activation test (BAT) to raspberry was negative. After avoiding raspberry and all the other berries, as well as still unchallenged walnuts, she has not experienced any episode of acute respiratory reactions for 3 years.&lt;/p&gt;&lt;p&gt;Raspberry (&lt;i&gt;Rubus idaeus&lt;/i&gt;) is a small fruit belonging to the &lt;i&gt;Rosaceae&lt;/i&gt; family: subfamily &lt;i&gt;Rosoideae&lt;/i&gt; along with strawberry. To the best of our knowledge, there have been only five reported cases of hypersensitivity reactions related to raspberry including our case (Table 1).&lt;span&gt;&lt;sup&gt;1-4&lt;/sup&gt;&lt;/span&gt; Three cases had evidence of cross-reactivities with other fruits belonging to &lt;i&gt;Rosaceae&lt;/i&gt; family, such as strawberry (&lt;i&gt;n&lt;/i&gt; = 2), and/or rPru p 3 (&lt;i&gt;n&lt;/i&gt; = 2) from peach.&lt;span&gt;&lt;sup&gt;2-4&lt;/sup&gt;&lt;/span&gt; Our case demonstrated negative results on the skin-prick test, which is reliable but not infallible, exhibiting an 85% sensitivity rate.&lt;span&gt;&lt;sup&gt;5&lt;/sup&gt;&lt;/span&gt; Despite a lack of cutaneous or mucosal involvement, our case demonstrated the acute","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":"6 5","pages":"196-197"},"PeriodicalIF":1.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12317","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41408158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}