Journal of Cutaneous Immunology and Allergy最新文献

{"title":"Sustained Release Theophylline (SRT): An Older Drug for COPD which Still Retains its Edge in the Management of this Chronic Disease","authors":"Amit Sharma","doi":"10.37191/mapsci-2582-6549-3(1)-031","DOIUrl":"https://doi.org/10.37191/mapsci-2582-6549-3(1)-031","url":null,"abstract":"Sustained release theophylline (SRT) has been an important component in the Pharmacotherapy of Chronic Obstructive Pulmonary Disease (COPD). Recent years have witnessed a dynamic change in the treatment of this disease. Several new drugs, especially inhaled ones, have largely supplanted the oral drugs used in COPD. SRT has also been relegated to such a position that it is an option which may be used in very severe cases only on the Clinician’s discretion. The axiom that development of new drugs does not belittle the clinical edge of the previous used one is in our opinion applicable to SRT. In this abstract, we attempt to underline the importance of Sustained-Released Theophylline (SRT) in the management of COPD.The endeavour is to systematically emphasize the myriad actions of SRT which provide relief by multiple means to patients in Acute exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD).","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89027171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of PcsB as Potential Vaccine Candidate Using Computational Tools","authors":"Sakshi Jain","doi":"10.37191/mapsci-2582-6549-3(1)-030","DOIUrl":"https://doi.org/10.37191/mapsci-2582-6549-3(1)-030","url":null,"abstract":"Streptococcus agalactiae/GBS is an organism that is responsible for many severe infections in infants as well as in adults. Streptococcus Agalactiae is a gram-positive bacterium that causes pneumonia, sepsis, and meningitis in newborns, as well as infections of the bones and joints [1]. Subclinical mastitis in dairy cattle is commonly caused by Streptococcus Agalactiae. It's a mammary parasite that can be treated with a variety of antibiotics. In this study a bioinformatics tool was used to find out if PcsB can be a good vaccine candidate to combat the disease. If according to results the desired protein can be a good vaccine candidate then it can be studied further.","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77628214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physician awareness and understanding of hereditary angioedema: A web-based study in Japan","authors":"Atsushi Fukunaga MD, PhD,&nbsp;Miwa Kishimoto MD, PhD,&nbsp;Akinori Oh PhD,&nbsp;Takeshi Akiyama MBA,&nbsp;Ippei Kotera PhD,&nbsp;Yoichi Inoue MD, JD,&nbsp;Junichi Maehara MD","doi":"10.1002/cia2.12265","DOIUrl":"10.1002/cia2.12265","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Hereditary angioedema (HAE) is a rare disease with acute attacks in the skin and mucosa throughout the body including life-threatening laryngeal edema and abdominal attacks with severe pain. Physicians, regardless of specialty, may encounter HAE patients in their daily practice; however, low disease awareness may attribute to a considerable number of undiagnosed HAE patients in Japan. This study aims to identify issues associated with the diagnosis processes of HAE and to determine levels of HAE awareness among Japanese physicians from various specialties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A web-based quantitative survey was conducted using a physicians panel. Physicians from the following departments were included in the survey: internal medicine, dermatology, pediatrics, emergency medicine, and gastroenterological surgery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The proportions of physicians in dermatology, pediatrics, emergency medicine, internal medicine, and gastroenterological surgery who were able to select the C1-INH activity test as a diagnosis test for potential HAE patients were 71.8%, 59.7%, 57.1%, 40.3%, and 25.7%, respectively. Multivariate analysis showed significant association between physicians who selected “strongly suspected” AE based on the case-scenario and physicians who had knowledge of the essential HAE symptoms (laryngeal edema, swelling after tooth extraction, swelling of the tongue, and abdominal pain).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study showed that disease awareness of HAE varied among medical specialties, suggesting the importance of educational activities in academic societies and specialist accreditation in raising HAE awareness. Proper knowledge of complement testing and HAE symptoms may help not only to diagnose patients with AE-like symptoms as AE but also to differentially diagnose HAE from AE.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12265","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41714951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent advanced rectal malignant melanoma that discontinued anti-PD-1 antibody after complete response and was refractory to rechallenge","authors":"Shintaro Saito MD,&nbsp;Masahito Yasuda MD, PhD,&nbsp;Takeshi Araki MD,&nbsp;Azusa Ida MD,&nbsp;Yuko Kuriyama MD, PhD,&nbsp;Akihito Uehara MD, PhD,&nbsp;Chikako Kishi MD, PhD,&nbsp;Yukie Endo MD, PhD,&nbsp;Hiroomi Ogawa MD, PhD,&nbsp;Sei-ichiro Motegi MD, PhD","doi":"10.1002/cia2.12264","DOIUrl":"10.1002/cia2.12264","url":null,"abstract":"<p>We report a case of 70-year-old woman with rectal malignant melanoma that recurred in the pelvic lymph node one year after surgery. Nivolumab was initiated and she achieved complete response after one year, but she discontinued nivolumab at her instance. At a follow-up 21 months after the discontinuation of nivolumab, a pelvic lymph node metastasis recurrence and a lung metastasis discovered. Nivolumab rechallenge was initiated, but it was not successful.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48713231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of patients with erythema exudativum multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis treated at our department during the previous 9-year period","authors":"Midori Kawasaki-Nagano MD,&nbsp;Risa Tamagawa-Mineoka MD, PhD,&nbsp;Koji Masuda MD, PhD,&nbsp;Mayumi Ueta MD, PhD,&nbsp;Chie Sotozono MD, PhD,&nbsp;Norito Katoh MD, PhD","doi":"10.1002/cia2.12259","DOIUrl":"10.1002/cia2.12259","url":null,"abstract":"<p>Erythema exudativum multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) are acute inflammatory diseases of the skin and mucous membranes. EM with mucosal eruptions is sometimes difficult to differentiate from SJS or TEN. This study aimed to understand the characteristics of these diseases by evaluating the backgrounds, clinical symptoms, and disease courses of EM/SJS/TEN patients treated at our hospital. It shows that persistent fevers and erosion are common in SJS/TEN. Therefore, we must pay attention to whether they become more severe.</p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12259","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47257295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate hypersensitivity reaction to carboxymethylcellulose in lidocaine jelly and dimethicone drops: A case report and mini-review","authors":"Eri Hotta MD, PhD,&nbsp;Risa Tamagawa-Mineoka MD, PhD,&nbsp;Yuri Onishi MD,&nbsp;Ayaka Sotozono MD,&nbsp;Megumi Kusunoki MD,&nbsp;Junko Hattori MD,&nbsp;Natsue Ioka MD,&nbsp;Hiromi Mizutani MD, PhD,&nbsp;Koji Masuda MD, PhD,&nbsp;Norito Katoh MD, PhD","doi":"10.1002/cia2.12261","DOIUrl":"10.1002/cia2.12261","url":null,"abstract":"<p>Excipient allergies are rare and difficult to diagnose. Carboxymethylcellulose (CMC, carmellose sodium) is an anionic water-soluble polymer derived from native cellulose, that is, used as an excipient. Here, we report a case of urticaria caused by the CMC in lidocaine jelly and dimethicone drops, which had used for upper gastrointestinal endoscopy. CMC is widely used in pharmaceutical preparations, food additives, and other pharmaceuticals, and its use is increasing. However, there are few reports on immediate hypersensitivity reactions because substances containing CMC. Previous reports and our case suggest that excipients, such as CMC, can be potential hidden allergens.</p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12261","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43820491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of the spinal trigeminal nucleus secondary to herpes zoster in a patient with hemifacial redness and swelling","authors":"Satoshi Yoshida MD,&nbsp;Kazuki Yatsuzuka MD,&nbsp;Yuta Kuroo MD,&nbsp;Ryo Utsunomiya MD, PhD,&nbsp;Rina Ando MD, PhD,&nbsp;Jun Muto MD, PhD,&nbsp;Koji Sayama MD, PhD","doi":"10.1002/cia2.12262","DOIUrl":"10.1002/cia2.12262","url":null,"abstract":"<p>We describe a 73-year-old patient who presented with marked hemifacial swelling secondary to herpes zoster. Magnetic resonance imaging (MRI) revealed hyperintensity of the spinal trigeminal nucleus. In the case presented here, stimulation of the spinal trigeminal nucleus owing to herpes zoster can cause vasodilation of the facial skin.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45476763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exacerbation of pre-existence psoriasis following immune checkpoint inhibitor treatment","authors":"Yoko Minokawa MD,&nbsp;Yu Sawada MD, PhD","doi":"10.1002/cia2.12244","DOIUrl":"10.1002/cia2.12244","url":null,"abstract":"<p>Immune checkpoint inhibitors are currently developed for the treatment of cancers showing high efficacy even in the cases of advanced and persistent malignancies. Psoriasis has been reported as a rare irAE in both the exacerbation of preexisting psoriasis and the novel onset psoriasis during immunotherapy. Herein, we report a case of pre-existence psoriasis, which was exacerbated following the administration of immune checkpoint inhibitors. We also summarize case reports and conducted a review of the literature.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12244","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47432443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention Risks of Post Covid-19 Infection and Rebound Symptoms","authors":"H. B. Reinfeld","doi":"10.37191/mapsci-2582-6549-3(1)-029","DOIUrl":"https://doi.org/10.37191/mapsci-2582-6549-3(1)-029","url":null,"abstract":"The novel coronavirus of 2019 has been present among us for decades, mainly confined to cattle and livestock where it is harmless and up until the end of 2019, did not infect human cells. Once it did, it produced a combination of mild to severe manifestations that guaranteed its spread across the globe. The combination of aerosol transmission alongside barely detectible and nonspecific symptoms allowed it to spread unmanageable. Finally, the ultimate onslaught of respiratory distress in a small proportion of unfortunate individuals solidified its deadliness. By the time a decent understanding of the situation was achieved, its already too late to contain it.","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73939795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory nummular eczema in child successfully treated with NB-UVB and topical delgocitinib","authors":"Ichiro Kurokawa MD,&nbsp;Jun-Ichiro Ono MD","doi":"10.1002/cia2.12250","DOIUrl":"10.1002/cia2.12250","url":null,"abstract":"<p>A 4-year-old girl with refractory nummular eczema with atopic dermatitis (AD) was reported successfully treated with narrowband ultraviolet B (NB-UVB) once a week (400 mJ/cm²) and topical delgocitinib for 8 weeks. The treatment of NB-UVB and topical delgocitinib improved the severe nummular lesions and strong pruritus, resulting in only brown postinflammatory hyperpigmentation without pruritus. The combination of NB-UVB and topical delgocitinib can be an alternative treatment for refractory nummular eczema in children.</p><p>A 4-year-old girl presented with a 2-year history of AD. She had impetigo contagiosum throughout her body due to methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infection. Subsequently, nummular eczema with elevated erythema, erosion, and brown pigmentation occurred over the former impetigo lesions on the shoulders, buttocks (Figure 1A), and thighs with severe pruritus. She was treated with topical steroids, oral antihistamines, and antimicrobials. However, the patient did not respond to these treatments. Thus, NB-UVB therapy (400 mJ/cm²) once a week and topical delgocitinib twice a day were administered. After 8 weeks, the nummular eczema remarkably improved, resulting in flat brown pigmentation (Figure 1B). Laboratory findings showed eosinophilia (22%) and high immunoglobulin (Ig) E levels (853 IU/ml). Radioallergosorbent test (RAST) had a score of 6 (House dust 1 and dust mite). Bacterial culture from nummular eczema was negative.</p><p>Topical corticosteroids, antihistamines, and antimicrobials were ineffective in our case. NB-UVB therapy is a tolerant and effective treatment for children with AD.<span>¹</span> NB-UVB inhibits immunological reactions and has anti-inflammatory and anti-bacterial effects. It also recovers skin barrier defects.<span>²</span> Therefore, NB-UVB therapy is a tolerant and economical treatment for children with AD. Moreover, it inhibits immune reactions, cytotoxic effects, cis-urocanic induction, and decreases Langerhans cells, antigen presentation, NK cell activity, and apoptosis of T cells and keratinocytes.<span>³</span> However, the side effects of NB-UVB include erythema, reactivation of herpes simplex, and polymorphous light eruption.</p><p>Delgocitinib, a Janus kinase (JAK) inhibitor, is useful for treating AD.<span>⁴</span> It is available for children with AD with ages more than 2 years old.<span>⁵</span> It inhibits IL-4, IL-13, and IL-31,<span>⁶</span> resulting in the relief of pruritus.</p><p>In our case, the patient did not respond to topical corticosteroids, antihistamines, or oral antimicrobials. We preferred NB-UVB and topical delgocitinib treatments. We speculated that the synergistic effects of NB-UVB and delgocitinib improved the refractory nummular eczema.</p><p>In our case, to reduce the risk, we should have tried to use topical delgocitinib alone at first. Additionally, the ","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12250","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"51154501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}