Physician awareness and understanding of hereditary angioedema: A web-based study in Japan

IF 1.1 Q4 ALLERGY
Atsushi Fukunaga MD, PhD, Miwa Kishimoto MD, PhD, Akinori Oh PhD, Takeshi Akiyama MBA, Ippei Kotera PhD, Yoichi Inoue MD, JD, Junichi Maehara MD
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引用次数: 1

Abstract

Objectives

Hereditary angioedema (HAE) is a rare disease with acute attacks in the skin and mucosa throughout the body including life-threatening laryngeal edema and abdominal attacks with severe pain. Physicians, regardless of specialty, may encounter HAE patients in their daily practice; however, low disease awareness may attribute to a considerable number of undiagnosed HAE patients in Japan. This study aims to identify issues associated with the diagnosis processes of HAE and to determine levels of HAE awareness among Japanese physicians from various specialties.

Methods

A web-based quantitative survey was conducted using a physicians panel. Physicians from the following departments were included in the survey: internal medicine, dermatology, pediatrics, emergency medicine, and gastroenterological surgery.

Results

The proportions of physicians in dermatology, pediatrics, emergency medicine, internal medicine, and gastroenterological surgery who were able to select the C1-INH activity test as a diagnosis test for potential HAE patients were 71.8%, 59.7%, 57.1%, 40.3%, and 25.7%, respectively. Multivariate analysis showed significant association between physicians who selected “strongly suspected” AE based on the case-scenario and physicians who had knowledge of the essential HAE symptoms (laryngeal edema, swelling after tooth extraction, swelling of the tongue, and abdominal pain).

Conclusions

This study showed that disease awareness of HAE varied among medical specialties, suggesting the importance of educational activities in academic societies and specialist accreditation in raising HAE awareness. Proper knowledge of complement testing and HAE symptoms may help not only to diagnose patients with AE-like symptoms as AE but also to differentially diagnose HAE from AE.

Abstract Image

医生对遗传性血管性水肿的认识和理解:日本一项基于网络的研究
遗传性血管性水肿(HAE)是一种罕见的疾病,全身皮肤和粘膜急性发作,包括危及生命的喉水肿和伴有剧烈疼痛的腹部发作。医生,无论专业如何,都可能在日常实践中遇到HAE患者;然而,低疾病意识可能归因于日本大量未确诊的HAE患者。本研究旨在确定与HAE诊断过程相关的问题,并确定不同专业的日本医生对HAE的认识水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
0.60
自引率
10.00%
发文量
69
审稿时长
12 weeks
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