Journal of Clinical Medicine最新文献

{"title":"Feasibility Testing of the Automatic Design of Three-Unit Implant Fixed Dental Prostheses with Different Dental CAD Software: A Pre-Clinical Pilot Trial.","authors":"Selina A Bernauer, Philipp Wieland, Nicola U Zitzmann, Tim Joda","doi":"10.3390/jcm14010233","DOIUrl":"10.3390/jcm14010233","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The technical development of implant-supported fixed dental prostheses (iFDP) initially concentrated on the computer-aided manufacturing of prosthetic restorations (CAM). Advances in information technologies have shifted the focus for optimizing digital workflows to AI-based processes for design (CAD). This pre-clinical pilot trial investigated the feasibility of the automatic design of three-unit iFDPs using CAD software (Dental Manger 2021, 3Shape; DentalCAD 3.1 Rijeka, exocad GmbH). <b>Methods:</b> Two clinical scenarios based on a full dentition were created virtually. Physical models were produced and digitized using two intraoral scanners applying quadrant or full-arch scans (Trios3, 3Shape, Copenhagen, Denmark; and Primescan AC, Dentsply Sirona, Bensheim, Germany). For each scenario, iFDP designs were generated automatically using two laboratory software systems (Dental Manger 2021, 3Shape; DentalCAD 3.1 Rijeka, exocad GmbH), resulting in 80 STL datasets (2 scenarios × 2 scan strategies × 2 IOS systems × 5 scan repetitions × 2 software). The files were analyzed clinically for the contact schemes and pontic area. One of the automated designs for each scenario was manually post-processed and one iFDP design for each scenario was manually created by experienced dental technicians (control). The time required for all the design processes was recorded. <b>Results:</b> The automatic design of iFDPs without manual adjustment did not lead to clinically acceptable restorations. The time required for the automatically generated/manually adjusted iFDPs designs was not significantly different to that for the manually designed restorations. <b>Conclusions:</b> Current laboratory software can not automatically generate three-unit iFDPs with clinically acceptable results in terms of the interproximal and occlusal contacts and the pontic design. The automatic iFDP design process currently requires manual adjustment, which means there is no benefit in terms of the working time compared with manually created restorations.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-Related Quality of Life in Juvenile Idiopathic Arthritis: A Systematic Review of Phase III Clinical Trials.","authors":"Federica Romano, Federica Di Scipio, Giacomo Baima, Francesco Franco, Mario Aimetti, Giovanni Nicolao Berta","doi":"10.3390/jcm14010254","DOIUrl":"10.3390/jcm14010254","url":null,"abstract":"<p><p><b>Background/objectives:</b> Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood, leading to severe disability and negatively affecting patients' health-related quality of life (HRQoL). The aim of this systematic review was to evaluate the adoption, reporting and assessment methodology of HRQoL in phase III clinical trials involving children with JIA. <b>Methods:</b> An electronic and manual search was conducted to identify primary and secondary publications of pharmacological trials conducted between 2012 and 2023. Data were extracted and recorded in duplicate. <b>Results:</b> A total of 222 studies were screened and 24 articles (22 primary and 2 secondary publications) were included in the review. HRQoL was not listed among the endpoints in 10 trials (45.5%), while it was a secondary endpoint in 12 trials (54.5%). The proportion of trials that did not consider HRQoL was equally relevant in both for-profit and no-profit settings (44.4% versus 50.0%), but it was higher in studies on systemic JIA compared to other JIA subtypes (62.5%), and on IL inhibitor treatment (72.7%) with respect to other disease-modifying antirheumatic drugs. Information on HRQoL was usually collected from parents/caregivers, and only three studies were categorized as \"probably robust\" with regard to HRQoL assessment. <b>Conclusions:</b> Systematic incorporation of HRQoL measures represents an urgent need in pediatric rheumatology, aiding clinicians in their decision-making in relation to treatment effectiveness and considering the children's perspective.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Reported Outcomes After Arthroscopic Single-Row Rotator Cuff Repair: A Monocentric Retrospective Study at Minimum 12 Years Follow-Up.","authors":"Alessandro Castagna, Tommaso Campeggi, Marco Maria Minelli, Mario Borroni, Marco Conti, Giacomo Delle Rose, Raffaele Garofalo, Riccardo Ranieri","doi":"10.3390/jcm14010235","DOIUrl":"10.3390/jcm14010235","url":null,"abstract":"<p><p><b>Background:</b> Arthroscopic rotator cuff repair (RCR) is a common procedure, yet long-term patient-centered outcome studies remain limited. This study aims to evaluate the outcomes of arthroscopic RCR using a single-row metallic anchor technique over a 12-year follow-up, focusing on patient-reported outcomes and potential risk factors. <b>Methods:</b> A monocentric cohort study was conducted on patients who underwent complete arthroscopic RCR with a single-row metallic anchor technique from January 2007 to July 2011. A total of 628 patients completed three standardized questionnaires: Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH), American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form (ASES), and the Simple Shoulder Test (SST). They were also asked for their overall satisfaction on the procedure with a single direct question. Outcomes were analyzed by gender, age at surgery, lesion pattern, and follow-up duration. <b>Results:</b> The mean follow-up period was 12.9 ± 1.3 years. Overall satisfaction was 96.5%. The mean scores for QuickDASH, ASES, and SST were 7.2 ± 15.7, 83.8 ± 23.9, and 89.9 ± 22.3, respectively. Female patients reported significantly lower QuickDASH (<i>p</i> < 0.001), ASES (<i>p</i> < 0.001), and SST (<i>p</i> = 0.004) than male patients, but overall satisfaction did not differ by gender. Age, number of tendons repaired, anterior tear, and follow-up length were not significantly associated with differences in outcome measures. <b>Conclusions:</b> Single-row arthroscopic RCR provides excellent long-term patient-reported outcomes and high patient satisfaction. Female gender may be associated with slightly lower functional scores, yet satisfaction remains unaffected. This study supports the single-row technique as a reliable, efficient, and cost-effective option for long-term success in RCR, challenging the need for more complex multi-anchor approaches.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Family Shopping Basket Intervention: A Strategy to Reduce Obesity in Prepubertal Children.","authors":"Rocío Escartín, Beatriz de Peray, Yolanda Couto, Abel Martínez-Mejias, Raquel Corripio","doi":"10.3390/jcm14010227","DOIUrl":"10.3390/jcm14010227","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The goal of childhood obesity treatment is to benefit the physical and mental health of children who suffer from it and to prevent complications, improving their quality of life and ensuring adequate development. Family-based interventions are demonstrating positive results, especially in prepubertal children. The aim of our study was to evaluate the effectiveness of a family grocery basket intervention for the treatment of childhood obesity in a Spanish primary care office. <b>Methods:</b> A randomized controlled trial comparing a family grocery basket intervention through the analysis of unhealthy products included in the grocery receipts that families bring to the primary care office, in comparison with the usual interventions. <b>Results:</b> Ninety-one children participated in the study (intervention group: <i>n</i> = 60, control group: <i>n</i> = 31). After one year of follow-up, a relevant weight loss with a decrease of ≥0.5 SDS in the z-IMC was obtained in 60.6% of the total sample. In the intervention group, there was a significant decrease in the number of unhealthy products in the family grocery basket and a lower percentage of hypertension and severe obesity than in the control group. In families in which there was a significant decrease in the consumption of unhealthy products, a higher percentage of weight loss was observed. <b>Conclusions:</b> Intervention in the family grocery basket through receipts is an original, simple and effective tool for family-based treatment in childhood obesity.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Displacement Following Vitrectomy for Rhegmatogenous Retinal Detachment: A Systematic Review of Surgical Techniques, Tamponade Agents, and Outcomes.","authors":"Paulina Siwik, Tomasz Chudoba, Sławomir Cisiecki","doi":"10.3390/jcm14010250","DOIUrl":"10.3390/jcm14010250","url":null,"abstract":"<p><p><b>Background:</b> Rhegmatogenous retinal detachment (RRD) is a severe condition that may lead to permanent vision loss if untreated. Pars plana vitrectomy (PPV) has become a preferred surgical intervention, particularly in complex cases. Objective: Retinal displacement (RD) following PPV for RRD can lead to visual distortions and can negatively impact patient quality of life. This review examines surgical techniques, tamponade choices, and postoperative strategies to mitigate displacement risks and their clinical implications. <b>Methods:</b> A systemic review of studies from 2010 to 2024 was conducted using PubMed, MEDLINE, and Ovid. The search included terms such as \"retinal displacement, \"tamponade agents\", and postoperative positioning\". Inclusion criteria focused on studies addressing PPV outcomes, retinal alignment, and visual distortions. Methodological quality was assessed using PRISMA guidelines. <b>Results:</b> Gas tamponades were associated with lower RD rates compared to silicone oil. Intraoperative use of perfluorocarbon liquid (PFCL) improved retinal stability. Postoperative positioning strategies significantly reduced visual distortions. <b>Conclusions:</b> Surgical and postoperative techniques substantially influence RD risk. Advances in imaging and tamponade agents offer promising avenues to improve patient outcomes and minimize RD.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of Endovascular Aortic Repair with Parallel Chimney or Periscope Stent Grafts for Ruptured Complex Abdominal Aortic Aneurysms.","authors":"Reinhard Kopp, Lukas Stachowski, Gilbert Puippe, Alexander Zimmermann, Anna-Leonie Menges","doi":"10.3390/jcm14010234","DOIUrl":"10.3390/jcm14010234","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Background&lt;/b&gt;: The parallel stent graft endovascular aortic repair (PGEVAR) technique is an off-the-shelf option used for elective complex abdominal aortic aneurysm repair with acceptable outcome results, as reported so far. The PGEVAR technique, using chimney or periscope parallel grafts, can also be used for patients with ruptured complex abdominal aortic aneurysms. However, only few data about the mid- to long-term outcomes are available. &lt;b&gt;Methods&lt;/b&gt;: Data from patients treated between August 2009 and July 2023 with the PGEVAR technique for ruptured complex abdominal aortic aneurysms were analyzed. The endpoints of this study were primary and secondary technical success, perioperative mortality, rate of proximal type 1a (gutter) endoleaks (T1aEL), and overall and aneurysm-related survival. Secondary endpoints were major adverse events, durability of parallel grafts, and factors associated with overall survival. &lt;b&gt;Results&lt;/b&gt;: Twenty patients (mean age: 77 ± 9 y; 18 male) with ruptured complex abdominal aortic aneurysm were treated, receiving PGEVAR for ruptured juxtarenal (n = 11), suprarenal (n = 7), or distal thoracoabdominal Crawford IV aortic aneurysms (n = 2) with a mean diameter of 82 ± 18 mm (range 59-120). The patients had PGEVAR with implantation of 39 parallel grafts (1.95 PGs per patient; 23 chimney and 16 periscope) for revascularization of the celiac artery (n = 3), superior mesenteric artery (n = 9), and renal arteries (n = 27). Three patients had delayed PG implantation within 10 days. Primary technical success was 15/20 (75%) with five patients having an early proximal T1aEL, three of them having successful reintervention (secondary success rate: 18/20; 90%), with no persistent bleeding. Two patients had late T1aELs. The presence of an early T1aEL was related to the number of PGs (≥2) implanted (&lt;i&gt;p&lt;/i&gt; = 0.038) or insufficient aortic SG oversizing (&lt;i&gt;p&lt;/i&gt; = 0.038). In-hospital mortality was 1/20 (5%). Perioperative mortality up to 32 days was 3/20 (15%), with two further late aneurysm-related deaths and eight late aneurysm-unrelated deaths (overall mortality 13/20; 65%) during follow-up (median 34 months; range 1-115). Major adverse events were observed in 11 (55%) patients. Secondary parallel stent graft patency at 1 and 3 years was 97.4 and 94.1%. During follow-up, aneurysm sac behavior was determined in 19 patients, which showed diameter progression (n = 3), stable aneurysm disease (n = 3), and aneurysm diameter regression in 13 (68.4%) patients. Overall survival was 75% after 1 year, and 53% and 22% after 3 and 5 years. Factors associated with overall long-term survival were age &lt; 80 years (&lt;i&gt;p&lt;/i&gt; = 0.037), juxtarenal aneurysms (&lt;i&gt;p&lt;/i&gt; = 0.023), the absence of major adverse events (&lt;i&gt;p&lt;/i&gt; = 0.025), and aneurysm sac regression (&lt;i&gt;p&lt;/i&gt; = 0.003). &lt;b&gt;Conclusions&lt;/b&gt;: Treatment of ruptured complex abdominal aortic aneurysm with the PGEVAR technique is associated with acceptable perioperative and long-te","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Combined Proteinuria and Increased Renal Resistive Index on Chronic Kidney Disease Progression: A Retrospective Longitudinal Study.","authors":"Giulio Romano, Nicholas Fiorini, Martina Bertoni, Stefania Rondinella, Laura Di Pietra, Marco F Cola, Paolo De Martin, Maurizio Tonizzo, Lorenzo Desinan, Benedetta Boari, Roberto Manfredini, GianLuca Colussi","doi":"10.3390/jcm14010228","DOIUrl":"10.3390/jcm14010228","url":null,"abstract":"<p><p><b>Introduction:</b> An increased renal resistive index (RRI) and proteinuria can predict an estimated glomerular filtration rate (eGFR) decline in patients with chronic kidney disease (CKD) of various causes. This study hypothesized that the RRI and proteinuria interact to determine disease progression in patients with CKDs of unknown origin. <b>Patients and Methods</b>: One hundred and fifty six patients (age 76.0 ± 8.1 years, 63.5% males) were analyzed for anthropometric, kidney morphology, blood pressure, 24 h urinary protein excretion, and RRI. The CKD-EPI equation was used to calculate the eGFR at baseline and after a two-year follow-up. Patients with an elevated (≥0.80) or normal (<0.80) RRI and significant (≥150 mg/day) or physiological (<150 mg/day) proteinuria were evaluated for the likelihood of at least a 30% drop in the eGFR or the onset of end-stage kidney disease (endpoint). <b>Results</b>: Hypertension and diabetes were the predominant cardiovascular risk factors (90.4%). Fifty patients (32%) met the endpoint. Elevated RRIs (odds ratio, OR, 4.28; 95% confidence interval, CI, 1.82-10.6; <i>p</i> = 0.001) and significant proteinuria (OR 3.59, 95% CI 1.59-8.48, <i>p</i> = 0.003) were independent predictors of the endpoint in a multivariate logistic model. Patients with an elevated RRI and significant proteinuria were more likely to meet the endpoint (R1P1: 65.2%) compared to those with only proteinuria (R0P1: 39.5%, <i>p</i> = 0.043) or both normal factors (R0P0: 10.9%, <i>p</i> < 0.001) but not to those with only an elevated RRI (R1P0: 42.3%, <i>p</i> = 0.094). Continuous RRIs (partial correlation r = -0.245, <i>p</i> < 0.001) and 24 h urinary protein excretion (partial r = -0.226, <i>p</i> = 0.003) were inversely and independently correlated with eGFR% change. R1P1 showed a higher eGFR% reduction (-38.0% ± 20.4%) compared to R0P1 (-25.3% ± 19.0%, <i>p</i> = 0.043) and R0P0 (-8.8% ± 25.1%, <i>p</i> < 0.001) but not to R1P0 (-29.6% ± 21.0%, <i>p</i> = 0.192). <b>Conclusions</b>: An increased RRI and proteinuria were independent predictors of disease progression. When interaction was considered, the negative effect of an elevated RRI on CKD progression was evident in both proteinuric and non-proteinuric patients, whereas the negative effect of proteinuria on disease progression was only significant in patients with no elevated RRIs.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11721810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Subcutaneous Negative-Suction Drain on Surgical Site Infection After Ileostomy Reversal: A Propensity Score Matching Analysis.","authors":"Ju Myung Song, Ji Hoon Kim, Moon Jin Kim, Chae Dong Lim, Yoon Suk Lee","doi":"10.3390/jcm14010236","DOIUrl":"10.3390/jcm14010236","url":null,"abstract":"<p><p><b>Background/Objective:</b> Surgical site infection (SSI) is a leading common condition after ileostomy reversal (IR). However, evidence is unclear that subcutaneous negative-suction drainage (SND) reduces the incidence of SSI. This study aimed to investigate whether SND effectively reduced the incidence of SSI. <b>Methods:</b> We retrospectively analyzed the records of 531 patients who underwent IR at Incheon St. Mary's Hospital between June 2005 and December 2020. SND was classified into two groups based on its presence or absence. The estimated risk of SSI was calculated using the surgical risk calculator of the American College of Surgeons National Surgical Quality Improvement Program (ACS NSQIP). After 1:1 propensity score matching (PSM) using the estimated risk of SSI, we analyzed the two group's postoperative outcomes, including SSI rates. <b>Results:</b> After PSM, there was no difference in demographics between the two groups; however, the reversal interval was longer in the SND group than in the no SND group (193.3 ± 151.6 vs. 151.5 ± 141.0 days, <i>p</i> = 0.005). The incidence of SSI was lower in the SND group than in the no SND group (5.2% vs. 13.0%, <i>p</i> = 0.013). <b>Conclusions:</b> SND insertion can reduce the incidence of SSI during IR. Therefore, SND insertion should be considered as a basic technique for reducing SSI after IR.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720836/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Triple Inhaler Therapy on COPD Patients with Non-Small Cell Lung Cancer After Radical Surgery: A Single-Centre Retrospective Analysis.","authors":"Francesco Rocco Bertuccio, Vito D'Agnano, Simone Cordoni, Mitela Tafa, Cristina Novy, Nicola Baio, Klodjana Mucaj, Chandra Bortolotto, Giulio Melloni, Andrea Bianco, Angelo Guido Corsico, Fabio Perrotta, Giulia Maria Stella","doi":"10.3390/jcm14010249","DOIUrl":"10.3390/jcm14010249","url":null,"abstract":"<p><p><b>Background:</b> Chronic obstructive pulmonary disease (COPD) is among the most relevant comorbidity associated with lung cancer. The advent of innovative triple treatment approaches for COPD has significantly improved patients' quality of life and outcomes. Few data are available regarding the impact of triple inhaler therapy on patients featuring COPD and lung cancer. <b>Methods:</b> We retrospectively evaluated the impact of triple inhale bronchodilators in a cohort of 56 patients with treated COPD who underwent lung surgery for primary cancer. <b>Results:</b> Triple bronchodilation can help to relieve the symptoms of the disease and improve lung function, allowing people with lung cancer to reduce the risk of serious exacerbations and improve their quality of life. <b>Conclusions:</b> Within the limits of the study, it should be underlined that bronchodilators can effectively affect the outcome and performance status after thoracic surgery.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11722558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the Long-Term Effectiveness of Fractional CO₂ Laser Treatment in Perimenopausal Women with Genitourinary Syndrome of Menopause-Single Center Preliminary Study.","authors":"Sławomir Woźniak, Andrzej Woźniak","doi":"10.3390/jcm14010242","DOIUrl":"10.3390/jcm14010242","url":null,"abstract":"<p><p><b>Background:</b> Genitourinary Syndrome of Menopause (GSM) is a prevalent condition in postmenopausal women characterized by symptoms such as vaginal dryness, itching, and urinary tract issues due to declining estrogen levels. Despite its widespread impact on quality of life, GSM often remains underdiagnosed and without effective treatment. <b>Methods:</b> This study assessed the long-term efficacy of fractional CO₂ laser treatment in alleviating GSM symptoms in perimenopausal women. The study involved 125 participants, with clinical evaluations conducted using vaginal pH, the Vaginal Health Index Score (VHIS), the Vaginal Maturation Index (VMI), and the Female Sexual Function Index (FSFI). <b>Results:</b> Results indicated significant improvements in these parameters, with pH levels decreasing, VHIS scores rising, and notable gains in VMI and FSFI observed up to 12 months post-treatment. This improvement has been validated through both subjective and objective assessments of GSM. <b>Conclusions:</b> The findings indicate that this method is effective and safe, with no significant side effects reported. However, conducting a long-term observational study on eventual longer protocol for maintaining the positive effect of this therapy should be conducted.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 1","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11722030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142965396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}