Journal of Clinical Medicine最新文献

{"title":"Clinical Personality Patterns in Alcohol Use Disorder: A Study Focused on Sex Differences.","authors":"Armando L Morera-Fumero, Maria Natividad García-Gómez, Alejandro Jiménez-Sosa","doi":"10.3390/jcm14145062","DOIUrl":"10.3390/jcm14145062","url":null,"abstract":"<p><p><b>Background:</b> Research on sex differences in personality disorders profiles among individuals with Alcohol Use Disorder (AUD) remains limited. This study aimed to examine sex differences in personality disorders in AUD individuals attending to an outpatient alcohol and drugs treatment unit. <b>Methods:</b> Persons seeking alcohol detoxification treatment were assessed with the Millon Clinical Multiaxial Inventory-III (MCMI-III) after abstinence. Both dimensional trait scores and cluster personality disorders types distribution were analyzed. A total of 216 subjects, 114 women (53%) and 102 men (47%), participated in the study. <b>Results:</b> No sex differences were found for paranoid, schizoid or schizotypal traits scores of Cluster A types. Women exhibited higher scores on the Cluster B histrionic trait (48 ± 22 vs. 39 ± 23, <i>p</i> = 0.012), with no differences in antisocial, borderline, or narcissistic trait scores. Narcissistic personality disorder was more prevalent in men than women (44% vs. 20%, <i>p</i> = 0.012). Cluster C dependent (52 ± 24 vs. 46 ± 20, <i>p</i> = 0.025) and obsessive-compulsive (54 ± 20 vs. 43 ± 19, <i>p</i> = 0.012) traits scores were elevated in women, but only dependent personality disorder prevalence differed categorically (38% women vs. 15% men, <i>p</i> = 0.012). <b>Conclusions:</b> Employing both dimensional and cluster approaches enriches personality disorder research in AUD. Dependent personality disorder in Cluster C robustly differentiates sexes, while personality disorder patterns in Clusters A and B show minimal sex differences when both approaches are considered.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 14","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295018/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Obstructive Sleep Apnea in Surgical Patients: A Systematic Review.","authors":"Ioana-Medeea Titu, Damiana Maria Vulturar, Ana Florica Chis, Alexandru Oprea, Alexandru Manea, Doina Adina Todea","doi":"10.3390/jcm14145095","DOIUrl":"10.3390/jcm14145095","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Obstructive sleep apnea is a prevalent, yet often underdiagnosed, condition characterized by recurrent upper airway obstruction during sleep, leading to significant perioperative risks in surgical patients. This systematic review aims to evaluate the incidence and impact of objectively diagnosed obstructive sleep apnea on postoperative outcomes across various surgical specialties-including bariatric, orthopedic, cardiac, and otorhinolaryngologic surgeries-and to assess the effectiveness of preoperative screening and perioperative management strategies. <b>Methods</b>: A comprehensive literature search of PubMed was conducted for studies published between January 2013 and December 2024, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Included studies involved adult surgical patients with OSA confirmed by polysomnography or respiratory polygraphy. Studies were assessed for methodological quality using the Oxford Centre for Evidence-Based Medicine Levels of Evidence framework. <b>Results</b>: The findings consistently indicated that obstructive sleep apnea significantly increases the risk of postoperative complications, such as respiratory depression, atrial fibrillation, acute kidney injury, delirium, and prolonged hospital stay. Continuous positive airway pressure therapy demonstrated a protective effect in bariatric and cardiac surgeries, though its effectiveness in orthopedic and otorhinolaryngologic contexts was inconsistent, largely due to adherence variability and limited implementation. Preoperative screening tools such as the STOP-BANG questionnaire were widely used, but their utility depended on integration with confirmatory diagnostics. <b>Conclusions</b>: Obstructive sleep apnea represents a significant, modifiable risk factor in surgical populations. Preoperative identification and risk-adapted perioperative management, including CPAP therapy and multimodal analgesia, may substantially reduce postoperative morbidity. However, further randomized trials and cost-effectiveness studies are needed to optimize care pathways and ensure consistent implementation across surgical disciplines.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 14","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Perception and Dietary Impact in Fixed Orthodontic Appliances vs. Clear Aligners: An Observational Study.","authors":"Bianca Maria Negruțiu, Cristina Paula Costea, Alexandru Nicolae Pîrvan, Diana-Ioana Gavra, Claudia Judea Pusta, Ligia Luminița Vaida, Abel Emanuel Moca, Raluca Iurcov, Claudia Elena Staniș","doi":"10.3390/jcm14145060","DOIUrl":"10.3390/jcm14145060","url":null,"abstract":"<p><p><b>Background and Objectives:</b> Orthodontic treatment, whether fixed or removable, offers several benefits, including improved aesthetics, enhanced oral function, and increased self-confidence. However, it may also cause discomfort and pain, particularly following adjustment visits. This study aimed to assess pain characteristics (latency and continuity), food impairment, weight loss, and analgesic use in relation to treatment duration and appliance type. <b>Methods:</b> This observational study included 160 orthodontic patients who completed a structured questionnaire comprising 13 single-choice items. The questionnaire assessed age, gender, residential environment, educational status, type and duration of orthodontic treatment, pain characteristics (duration, latency, continuity), food impairment, and analgesic use. Inclusion criteria specified patients with moderate anterior crowding undergoing fixed orthodontic treatment or treatment with clear aligners on both arches, for at least one month. All fixed appliance cases involved 0.022-inch-slot Roth prescription brackets. <b>Results:</b> Patients undergoing fixed orthodontic treatment reported a higher frequency of pain (91.4%), greater need for analgesics (95.2%), and more food impairment compared to those with clear aligners. Patients treated for less than 6 months more frequently reported pain lasting 1 week (57.1%), while those treated for 1-2 years more commonly reported pain lasting several days (43.8%). <b>Conclusions:</b> Fixed orthodontic appliances are associated with greater discomfort, longer pain latency, more frequent analgesic use, and higher dietary impact compared to clear aligners. These findings emphasize the importance of personalized patient counseling and proactive pain management to improve compliance, enhance quality of life, and support informed decision-making in orthodontic care.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 14","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PET and SPECT Imaging of Macrophages in the Tumor Stroma: An Update.","authors":"Shaobo Li, Alex Maes, Tijl Vermassen, Justine Maes, Chabi Sathekge, Sylvie Rottey, Christophe Van de Wiele","doi":"10.3390/jcm14145075","DOIUrl":"10.3390/jcm14145075","url":null,"abstract":"<p><p>Tumor-associated macrophages (TAMs) are pivotal immune cells within the tumor stroma, whose dynamic alterations significantly impact tumor progression and therapeutic responses. Conventional methods for TAM detection, such as biopsy, are invasive and incapable of whole-body dynamic monitoring. In contrast, positron emission tomography (PET) and single-photon emission computed tomography (SPECT) offer a non-invasive imaging approach by targeting TAM-specific biomarkers like CD206, TSPO, and CCR2. This review comprehensively summarizes the advancements in TAM-targeted imaging probes, including cell surface markers, metabolic/functional markers, and multifunctional nanoprobe, while assessing their potential in tumor immune surveillance and tumor targeting therapeutic applications. While current probes, including ⁶⁸Ga-NOTA-anti-CD206 and ⁶⁴Cu-Macrin, have exhibited high specificity and theragnostic potential in preclinical and early clinical trials, challenges such as target heterogeneity, off-target effects, and clinical translation persist. Moving forward, the advancement of multi-target probes, optimization of pharmacokinetics, and incorporation of multimodal imaging technologies are anticipated to further enhance the impact of TAM-targeted imaging in precision medicine and tumor immunotherapy, fostering the refinement of personalized treatment strategies and improving patient outcomes.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 14","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12294810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical, Emotional, and Stress-Related Dynamics over Six Months in Newly Diagnosed Epithelial Ovarian Cancer Survivors.","authors":"Camelia Budisan, Razvan Betea, Maria Cezara Muresan, Zoran Laurentiu Popa, Cosmin Citu, Ioan Sas, Veronica Daniela Chiriac","doi":"10.3390/jcm14145087","DOIUrl":"10.3390/jcm14145087","url":null,"abstract":"<p><p><b>Background and Objectives:</b> Epithelial ovarian cancer (EOC) remains the deadliest gynecologic malignancy, yet the psychosocial dynamics of early survivorship are inadequately described. We prospectively quantified six-month trajectories in the quality of life in a consecutive cohort of 88 women newly diagnosed with EOC and explored clinical moderators of change. <b>Methods:</b> Eighty-eight consecutive patients (mean age 59.1 ± 10.7 years) completed the SF-36, WHOQOL-BREF, EORTC QLQ-C30, and 10-item Perceived Stress Scale (PSS-10) at baseline (pre-therapy) and six months after cytoreductive surgery ± platinum-based chemotherapy. Stage (FIGO I-II vs. III-IV) and treatment pathway (primary debulking surgery, neoadjuvant chemotherapy plus interval debulking, chemotherapy only) data were recorded. <b>Results:</b> Global QoL improved significantly (EORTC Global Health +5.9 ± 7.7 points; <i>p</i> < 0.001) while perceived stress declined (ΔPSS -3.6 ± 5.1; <i>p</i> < 0.001). SF-36 Physical Functioning rose 4.7 ± 7.9 points (<i>p</i> < 0.001) and Mental Health 4.4 ± 7.9 points (<i>p</i> = 0.004). The WHOQOL Physical and Psychological domains gained 4.7 ± 7.1 and 4.3 ± 7.4 points, respectively (both <i>p</i> < 0.01). Advanced-stage patients experienced larger stress reductions than early-stage patients (-4.1 ± 2.7 vs. -2.9 ± 2.2; <i>p</i> = 0.028) but comparable QoL gains. Greater stress relief correlated with greater mental-health improvement (r = -0.51) and global-health gains (r = -0.45) (all <i>p</i> < 0.001). Treatment pathway did not significantly influence trajectories. <b>Conclusions:</b> Early survivorship after first-line ovarian-cancer therapy was characterized by the clinically meaningful recovery of physical and emotional functioning together with the moderate alleviation of perceived stress. Improvements were observed irrespective of stage and treatment strategy, suggesting that contemporary multimodal regimens do not inevitably compromise patient-reported outcomes. Our estimates provide preliminary effect sizes that should be validated in multi-center cohorts with longer follow-up.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 14","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long Non-Coding RNAs in Psoriasis and Cutaneous Squamous Cell Carcinoma.","authors":"Ioana Irina Trufin, Loredana Ungureanu, Salomea-Ruth Halmágyi, Adina Patricia Apostu, Simona Corina Șenilă","doi":"10.3390/jcm14145081","DOIUrl":"10.3390/jcm14145081","url":null,"abstract":"<p><p><b>Background:</b> Long non-coding RNAs (lncRNAs) are increasingly recognized as pivotal regulators in both inflammatory and neoplastic skin disorders. Their implications in numerous biological processes, including gene expression, immune responses, and epidermal homeostasis, suggest potential applications as diagnostic and prognostic markers, as well as therapeutic targets. <b>Methods:</b> We conducted a literature search on lncRNAs involved in both psoriasis and cutaneous squamous cell carcinoma (cSCC), highlighting overlapping pathogenic mechanisms. <b>Results:</b> Several lncRNAs, such as <i>HOTAIR, MALAT-1</i>, <i>H19</i>, and <i>uc.291</i>, display dysregulated expression in both psoriasis and cSCC, influencing keratinocyte proliferation and apoptosis, immune modulation, cytokine signaling, and the synthesis of epidermal proteins. <b>Conclusions:</b> The intersection of lncRNA function in chronic inflammation and skin carcinogenesis underscores their role in mediating the transition from psoriatic inflammation to tumorigenesis, offering new insights into disease susceptibility; further investigation through functional studies and clinical validation are required. The study of lncRNA-mediated molecular pathways is particularly relevant given the increased risk of non-melanoma skin cancers and lymphoproliferative disorders among patients with chronic and severe forms of psoriasis.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 14","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Potential of Normobaric Oxygen Therapy to Enhance Erythropoiesis, Reduce Oxidative Stress, and Modulate Immune Function in Colorectal Cancer Patients Undergoing Chemotherapy: Study Protocol for a Prospective, Randomized, Double-Blind, Placebo-Controlled Trial (NBO-ONCO).","authors":"Jacek Polański, Beata Jankowska-Polańska, Robert Dymarek, Olga Zajączkowska, Sebastian Makuch, Beata Freier, Dorota Kamińska, Edyta Pawlak, Adam Busławski, Jerzy Zwoździak","doi":"10.3390/jcm14145057","DOIUrl":"10.3390/jcm14145057","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Colorectal cancer (CRC) patients undergoing chemotherapy often experience anemia, oxidative stress, and immune suppression, significantly impacting their quality of life and treatment outcomes. Normobaric oxygen (NBO) therapy, which delivers oxygen at atmospheric pressure with an elevated oxygen concentration, has shown the potential to enhance erythropoiesis, reduce oxidative stress, and modulate immune function. However, its efficacy in CRC patients remains underexplored. This study aims to evaluate the effects of NBO exposures on (1) supporting erythropoiesis by measuring erythropoietin (EPO) levels and hypoxia-inducible factor 1-alpha (HIF-1α), (2) reducing oxidative stress and improving stress and emotional well-being, and (3) modulating immune function by assessing cytokine profiles. Secondary objectives include assessing the impact of NBO on patient-reported outcome measures (PROMs) such as stress, anxiety, depression, and quality of life. <b>Methods:</b> This is a prospective, randomized, double-blind, placebo-controlled clinical trial. A total of 254 CRC patients undergoing chemotherapy will be randomized 1:1 to receive either active NBO therapy (n = 127, study group) or placebo NBO therapy (n = 127, control group). The intervention will consist of 10 NBO sessions over five weeks. Primary outcomes include biomarkers of erythropoiesis, oxidative stress, and immune response. Secondary outcomes assess quality of life and psychological well-being. Data will be collected at baseline, mid-intervention, post-intervention, and during two follow-up visits (3 and 6 months post-intervention). <b>Results:</b> The study hypothesizes that NBO therapy will improve erythropoiesis, reduce oxidative stress, and enhance immune function in CRC patients, leading to improved quality of life and clinical outcomes. <b>Conclusions:</b> Findings from this trial may establish NBO as a novel supportive therapy for CRC patients undergoing chemotherapy.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 14","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulation in Obstetric and Gynecologic Ultrasound Training: Design and Implementation Considerations.","authors":"Sheldon Bailey, Christoph F Dietrich, Jacqueline Matthew, Michael Bachmann Nielsen, Malene Roland Vils Pedersen","doi":"10.3390/jcm14145064","DOIUrl":"10.3390/jcm14145064","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The use of simulation has become more popular in healthcare settings, and simulation is also very popular in ultrasound training, allowing the learners to virtually practice and improve clinical skills. Obstetric pathology and gynecologic lesions can have a large range of sonographic features, and the detection rates for these can be increased by using ultrasound simulation systems to train users. In the following paper, we provide insight into the application of simulation tools in obstetric and gynecologic ultrasound training. <b>Methods</b>: We present different ultrasound models for GYN/OB ultrasound training. <b>Results</b>: Ultrasound simulation is a key component of obstetrics and gynecology (OB/Gyn) ultrasound education. <b>Conclusions</b>: By examining the best practices, we highlight the diverse simulation options available to help learners technical and non-technical skills in a controlled learning environment.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 14","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are There Benefits of Total Hip Arthroplasty with Dual-Mobility Cups Compared to Bipolar Hemiarthroplasty for Femoral Neck Fractures in the Geriatric Population? A Systematic Review and Meta-Analysis of Comparative Studies.","authors":"Dimitrios Grammatikopoulos, Vasileios F Pegios, Stavros Tsotsolis, Eustathios Kenanidis, Eleftherios Tsiridis","doi":"10.3390/jcm14145076","DOIUrl":"10.3390/jcm14145076","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The optimal treatment for femoral neck fractures (FNFs) in the elderly remains unclear. Internal fixation, bipolar hip hemiarthroplasty (BH), standard total hip arthroplasty (THA), or dual mobility (DM-THA) cups have been employed, each presenting various advantages and disadvantages. This systematic review and meta-analysis evaluated comparative studies of BH and DM-THA in FNFs among the elderly, aiming to ascertain differences in outcomes, including functional recovery, patient-reported outcome measures, implant survival, complications, and mortality rates. <b>Methods</b>: This meta-analysis followed PRISMA 2020 guidelines with a pre-registered PROSPERO protocol (CRD420251065762). A comprehensive search of electronic databases and grey literature included only comparative studies of BH and DM-THA in patients over 65 years with FNFs. <b>Results</b>: Sixteen studies were eligible, comprising four randomised controlled trials and twelve retrospective comparative studies involving 11,460 patients (10,036 BH; 1424 DM-THA). Patients with DM-THA exhibited a higher postoperative Harris Hip Score (4.55, <i>p</i> < 0.0001), alongside a lower dislocation risk ([OR] 2.77, <i>p</i> < 0.0001), a reduced revision rate ([OR] 2.36, <i>p</i> < 0.0001), and decreased mortality ([OR] 1.94, <i>p</i> < 0.0001). The operative time was somewhat longer in the DM-THA group, by 12.71 min, and blood loss was greater by 121 mL, indicating significant heterogeneity across the studies. <b>Conclusions</b>: DM-THA for FNFs in elderly patients results in improved functional recovery and lower dislocation, reoperation, and mortality risk. However, longer operative times and increased blood loss remain significant considerations. Further, well-designed comparative studies are required to evaluate overall cost-effectiveness and define the optimal age threshold, beyond which the limitations of DM-THA may outweigh its benefits.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 14","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12295041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining Laboratory and Imaging Evaluation for Cardiovascular Risk Stratification in Systemic Lupus Erythematosus.","authors":"Chrysanthi Staveri, Vassiliki Vartela, Sophie I Mavrogeni, Stamatis-Nick C Liossis","doi":"10.3390/jcm14145085","DOIUrl":"10.3390/jcm14145085","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is a multisystem auto-immune disease that may affect any organ/system, including the cardiovascular system. Several studies have shown that SLE is associated with an increased risk of cardiovascular disease (CVD), even though most of the patients who have lupus are young women. In this review, we present that apart from the traditional risk factors, there are more appropriate SLE-related indices such as imaging parameters, auto-antibodies, disease manifestations, medications, and genetic factors that might represent useful tools to create an algorithm for early identification of SLE patients at increased risk of CVD. Early recognition and appropriate treatment of patients at increased CVD risk might reduce morbidity/mortality and improve the quality of life of patients with SLE.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 14","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12296132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144731278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}