Journal of Clinical Medicine最新文献

{"title":"Orbital Implant Surgery with Costal Cartilage Graft Is Associated with Better Symmetry and Improved Cosmetic Appearance.","authors":"Ushio Hanai, Yotaro Tsunoda, Hitoshi Nemoto, Yoshihiro Nakagawa, Takahiro Suzuki, Tadashi Akamatsu","doi":"10.3390/jcm14062052","DOIUrl":"10.3390/jcm14062052","url":null,"abstract":"<p><p><b>Background/Objectives</b>: In Japan, artificial orbital implants are not approved as medical materials, limiting the number of facilities that perform orbital implant surgery. However, this procedure is crucial for improving the quality of life of ocular prosthesis users by enhancing cosmetic outcomes. This study aimed to evaluate the short-term outcomes of orbital implant surgery using costal cartilage grafts and assess the cosmetic impact by comparing upper eyelid positions between patients who underwent the procedure and those who did not. <b>Methods</b>: Patients were divided into two groups: those who underwent evisceration and orbital implant grafting with costal cartilage (Group 1) and those who used a prosthetic eye without an orbital implant (Group 2). In Group 1 cases, following evisceration, a spherical implant was created using the sixth autologous costal cartilage and covered with four pedicled scleral flaps. The incidence of complications and the necessity for additional surgery were investigated through medical records, and both complications and upper eyelid symmetry were assessed at least 12 months after the final surgical procedure. <b>Results</b>: A total of 23 patients were included: 13 in Group 1 and 10 in Group 2. Group 1 had a significantly lower median age (52 vs. 68 years, <i>p</i> = 0.002) and a higher proportion of females (76.9% vs. 30%, <i>p</i> = 0.024). Upper eyelid asymmetry was significantly greater in Group 2 than in Group 1 (<i>p</i> < 0.05). Orbital fracture was associated with a higher risk of requiring additional surgery (100% vs. 37.5%, <i>p</i> = 0.075), though not statistically significant. <b>Conclusions</b>: Orbital implant surgery with costal cartilage grafts improves eyelid symmetry and cosmetic appearance. Early and accurate orbital volume repair is essential for preventing enophthalmos.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping Psychological Well-Being in Morbid Obesity: A Network Analysis Approach.","authors":"Giada Pietrabissa, Anna Guerrini-Usubini, Valentina Villa, Alessandro Sartorio, Gianluca Castelnuovo, Amelia Brunani","doi":"10.3390/jcm14062076","DOIUrl":"10.3390/jcm14062076","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Identifying key psychological well-being factors in morbid obesity is crucial for designing effective mental health and weight management interventions. This study explores the interconnections between the dimensions of psychological well-being in a large sample of adults with morbid obesity enrolled in an inpatient nutritional rehabilitation program. <b>Methods</b>: A sample of 3212 participants (F = 58%; mean age = 57.18 years; mean Body Mass Index = 43.40 kg/m²) completed the Psychological General Well-Being Index (PGWBI) upon admission to the clinic. A network analysis approach examined the relationships among the PGWBI dimensions (anxiety, depression, positive well-being, self-control, vitality, and general health). <b>Results</b>: Network analysis revealed that vitality and positive well-being exhibited the highest values across closeness (1.432; 0.353), strength (0.853; 0.917), and expected influence (0.853; 0917), indicating their key role in psychological well-being. Depression also demonstrated moderate relevance, suggesting its connection to other well-being factors, though it was not the primary determinant. In contrast, self-control and general health had negative strength and expected influence values (-0.660; -1.641), indicating a less central role in the network. Additionally, anxiety and depression displayed negative betweenness (-0.645), reinforcing their more peripheral position. Conversely, positive well-being and vitality showed the highest betweenness (1.291), highlighting their role as key connecting nodes within the well-being network. <b>Conclusions</b>: Findings suggest interventions targeting positive well-being and vitality may most effectively enhance psychological well-being in morbid obesity, emphasizing strength-based approaches that foster positive affect, motivation, and resilience rather than focusing solely on reducing distress or weight-related concerns.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942673/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum Desmosine Levels Might Be Associated with the Size of Ruptured Cerebral Aneurysms in Patients with Aneurysmal Subarachnoid Hemorrhage-A Preliminary Study.","authors":"Peter Csecsei, Agnes Bogdan, Tihamer Molnar, Laszlo Zavori, Attila Schwarcz, Gabor Lenzser","doi":"10.3390/jcm14062056","DOIUrl":"10.3390/jcm14062056","url":null,"abstract":"<p><p><b>Background:</b> Aneurysmal subarachnoid hemorrhage (aSAH) is a disease associated with high mortality, caused by the rupture of a cerebral aneurysm. Decision-support scoring systems used for managing unruptured aneurysms (UIAs) include only radiological parameters related to the size and configuration of the aneurysm, without incorporating blood-based markers. Our aim is to identify a serum marker that shows a correlation with aneurysm size in patients with ruptured aneurysms. <b>Methods</b>: Arterial blood samples were collected from patients who experienced aSAH within 24 h of the ictus, and serum desmosine levels were determined using ELISA. The morphological parameters of the aneurysms were assessed during 3D DSA. A favorable outcome was defined as a 3-month mRS score of 0-3. <b>Results</b>: This study included 135 aSAH patients and 25 controls. (i) The desmosine level in serum collected within 24 h after aneurysm rupture in patients with aSAH was significantly higher compared to the serum level in the control group (aSAH: 0.737 ng/mL [IQR: 0.401-1.214], vs. control: 0.365 ng/mL [IQR: 0.251-0.531], <i>p</i> < 0.001); (ii) examining the size of ruptured aneurysms, patients with aneurysms larger than 7 mm had significantly higher serum desmosine levels than those with aneurysms smaller than 7 mm; (iii) in the group with aneurysms smaller than 7 mm, serum desmosine levels correlated with the aneurysm neck width and the size ratio. <b>Conclusions</b>: Serum desmosine shows a strong correlation with the size of ruptured aneurysms in aSAH patients.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thermal and Non-Thermal Energies for Atrial Fibrillation Ablation.","authors":"Francesco M Brasca, Emanuele Curti, Giovanni B Perego","doi":"10.3390/jcm14062071","DOIUrl":"10.3390/jcm14062071","url":null,"abstract":"<p><p>The cornerstone of ablative therapy for atrial fibrillation (AF) is pulmonary vein isolation (PVI). Whether PVI should be added with additional lesions in persistent atrial fibrillation (PerAF) or for any post-ablative recurrent AF is a matter of debate. Whatever the ablative strategy, it must determine the choice of energy source to achieve the most durable lesion sets with the least likelihood of complications. Radiofrequency (RF) is the most studied thermal ablation technique. It can be combined with high-density electroanatomic mapping and can be used for both pulmonary and extrapulmonary atrial ablation. Cryoenergy is at least as effective as radiofrequency for PVI; it is rapid, relatively safe, and has a steep learning curve. Therefore, it has been proposed as a first-line approach for PVI-only procedures. More recently, a non-thermal technique based on the application of pulsed direct current (Pulsed Field Ablation-PFA) has been introduced. PFA causes cell death by opening cell membrane pores (electroporation) without a significant increase in tissue temperature. It is fast and does not alter the extracellular matrix as thermal techniques do, although it ends up causing long-lasting, transmural lesions. Most importantly, it is relatively selective on cardiac myocytes and therefore potentially safer than thermal techniques. Some PFA systems can be combined with electroanatomic mapping systems. However, as of now, it appears that these ablation technologies should be considered complementary rather than alternative for a number of practical and theoretical reasons.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Parkinson's Rest Tremor from the Wrist with Accelerometry and Gyroscope Signals in Patients with Deep Brain Stimulation: An Observational Study.","authors":"Martin Keba, Maie Bachmann, Jaanus Lass, Tõnu Rätsep","doi":"10.3390/jcm14062073","DOIUrl":"10.3390/jcm14062073","url":null,"abstract":"<p><p><b>Background:</b> Wearable sensors are mainly used in Parkinson's disease (PD) to assess motor symptoms and to aid clinicians in patient management. Inertial measurement units that simultaneously register accelerometric and gyroscope signals have been one of the most studied and practicable methods. The heterogeneity of described methods and clinical settings studied can discourage wearable device use and highlight the need for standardization. This study compares previously proposed accelerometry and gyroscope signal features for tremor assessment measured at the wrist. <b>Methods</b>: An inertial measurement unit registered accelerometry and gyroscope signals at the wrist from 18 PD patients treated with deep brain stimulation (DBS). Measurements were made in DBS on and off states. Signal features for both accelerometry and gyroscope were calculated-mean linear acceleration, mean angular velocity, root mean square, maximal amplitude and power of the 3-7 Hz frequency band. The outcome features were log-transformed and correlated to the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) item 3.17 using linear regression. Intraclass correlation coefficient (ICC) values were calculated for the signal features. <b>Results</b>: A total of 108 tremor episodes were investigated. All signal features exhibited a strong correlation with the MDS-UPDRS tremor amplitude scale. Tremor ratings showed a stronger correlation with accelerometry (r = 0.964-0.970) than with gyroscope-derived features (r = 0.942-0.956). The best-performing feature was the mean linear acceleration (r = 0.970, R² = 0.940), which also showed high reliability (ICC = 0.921). <b>Conclusions</b>: Different accelerometry and gyroscope signal features are viable in characterizing rest tremor at the wrist. Simpler accelerometry signal features can be preferred in conducting the MDS-UPDRS item 3.17 examination in PD patients with DBS using a wrist-worn inertial measurement unit. Future research to expand the validity and usefulness of wearable technologies in PD is warranted.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Affecting Recurrence in 165 Patients with Serous Borderline Ovarian Tumours: The Pattern of Micro-Invasion Is Main Prognostic Factor.","authors":"Zehra Ozturk Basarır, Tufan Arslanca, Yesim Ozkaya Ucar, Sevgi Ayhan, Bülent Ozdal","doi":"10.3390/jcm14062050","DOIUrl":"10.3390/jcm14062050","url":null,"abstract":"<p><p><b>Background</b>: The aim of this study was to evaluate the serous borderline ovarian tumours (BOTs), the recurrence rates, and the factors affecting recurrence. <b>Methods</b>: A total of 165 patients diagnosed with serous BOT between 2004 and 2019 were included. The patients were evaluated in respect of age, preoperative CA125 levels, FIGO stage, tumour size, stromal micro-invasion, the presence of non-invasive implants, surgical procedures, and lymphadenectomy performed, or all that affects disease-free survival. <b>Results</b>: Early-stage BOT (stage I-II) was determined in 149 (90.3%) patients. Conservative surgery was performed in 57 (34.5%) patients. The non-invasive implantation was detected in 19 (11.5%) patients, and micro-invasion was determined in 31 (18.8%) patients. The median follow-up was 120 months, and recurrence was observed in 8 (4.8%) patients. The 5-year disease-free survival rate was 95.2%, and the 10-year disease-free survival rate was also 95.2%. Univariate analysis showed that elevated preoperative CA125 levels and the presence of micro-invasion were associated with poor disease-free survival outcomes. In the multivariate analysis, the presence of micro-invasion was the only independent poor prognostic factor (HR: 8.944, 95%CI: 2.060-38.833; p:0.003). <b>Conclusions</b>: The micro-invasion was the main factor for recurrence in patients with serous BOT.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Respiratory Distress Syndrome and Fluid Management: Finding the Perfect Balance.","authors":"Irene Sbaraini Zernini, Domenico Nocera, Rosanna D'Albo, Tommaso Tonetti","doi":"10.3390/jcm14062067","DOIUrl":"10.3390/jcm14062067","url":null,"abstract":"<p><p>ARDS is a challenging syndrome in which the hallmark is alveolar epithelium damage, with the consequent extravasation of fluids into the interstitium and alveolar space. Patients with severe ARDS almost always require mechanical ventilation and aggressive fluid resuscitation, at least in the initial phases. The increased intrathoracic pressure during positive pressure ventilation reduces cardiac output, worsening the circulatory status of these patients even more. In this pathological context, fluid therapies serve as a means to restore intravascular volume but can simultaneously play a detrimental role, increasing the amount of liquid in the lungs and worsening gas exchange and lung mechanics. Indeed, clinical research suggests that fluid overload leads to worsening outcomes, mostly in terms of gas exchange, days of mechanical ventilation, and ICU stay duration. For these reasons, this review aims to provide basic information about ARDS pathophysiology and heart-lung interactions, the understanding of which is essential to guide fluid therapy, together with the close monitoring of hemodynamics and fluid responsiveness.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukins in the Pathogenesis of Warts: Insight from the Last Decade-A Narrative Review.","authors":"Clara Matei, Laura Sorina Diaconu, Mircea Tampa","doi":"10.3390/jcm14062057","DOIUrl":"10.3390/jcm14062057","url":null,"abstract":"<p><p>Human papillomavirus (HPV) is the etiological agent of a wide spectrum of diseases, from benign lesions to neoplasms. In most cases, in the first few years after infection, viral clearance occurs; however, in some cases, the infection remains persistent, allowing the progression of the lesions. The host immune response plays a key role in the resolution of the infection. The immune response to HPV is regulated by the dynamic interaction between numerous interleukins that exert pro- or anti-inflammatory effects. The role of interleukins in malignant lesions caused by HPV has been intensively studied, but in the case of benign lesions including warts, data are limited. This review compiles data from the last 10 years on the involvement of interleukins in the pathogenesis of warts, with the aim of providing new perspectives on this topic. Elucidating the role of interleukins will not only increase our knowledge of the pathogenesis of HPV infection but will also provide the foundation for the development of new therapies.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Temperature Variations Following Sympathetic Blocks in Warm and Cold Subtypes of Complex Regional Pain Syndrome (CRPS): A Retrospective Cohort Study.","authors":"Burcu Candan, Semih Gungor","doi":"10.3390/jcm14062060","DOIUrl":"10.3390/jcm14062060","url":null,"abstract":"<p><p><b>Background/Objectives</b>: The pathophysiological mechanisms of temperature asymmetry differ between patients with warm and cold subtypes of Complex Regional Pain Syndrome (CRPS). Consequently, the response to lumbar sympathetic blocks (LSBs) and the resulting temperature improvement may vary between these two subtypes. We aimed to evaluate whether there was a significant difference in temperature elevation following sympathetic blocks in warm versus cold subtypes of CRPS. <b>Methods</b>: We calculated the temperature difference by analyzing forward-looking infrared (FLIR) thermal camera images of the affected extremity at pre-block and 5-min post-block time points. The primary outcome measure was that the mean temperature increase following LSB would be higher in the cold CRPS group than in the warm CRPS group. The secondary outcome measure was that the mean temperature elevation following the sympathetic block in the cold CRPS subtype would be at least 50% higher than in the warm CRPS subtype. <b>Results</b>: The study assessed warm and cold CRPS subtypes by analyzing temperature profiles from 90 lumbar sympathetic blocks performed on 34 patients. The temperature change in the affected extremity following LSB varied widely, with the highest increase observed in one patient at 10.99 °C. The cold CRPS patients demonstrated a higher mean temperature increase at the 5 min time point following LSB, averaging 3.37 °C in initial cases and 2.67 °C across all cases. In comparison, warm CRPS patients had lower mean increases of 0.58 °C in initial cases and 1.23 °C across all cases. Notably, the mean temperature rise in the cold CRPS group exceeded that of the warm CRPS group by more than 50%, meeting the secondary outcome goal. <b>Conclusions</b>: Our results indicated that patients with the cold subtype of CRPS tend to experience greater temperature improvements compared to those with the warm subtype after undergoing a sympathetic block. Therefore, our findings suggest that the criteria for determining the success of a sympathetic block should be revised to account for the cold and warm subtypes of CRPS.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Clinical Remission on Benralizumab Treatment in Severe Eosinophilic Asthma: A Four-Year Real-Life Study.","authors":"Carla Maria Irene Quarato, Pasquale Tondo, Donato Lacedonia, Piera Soccio, Dalila Pescatore, Maria Lisa Baccellieri, Giorgia Lepore, Maria Pia Foschino Barbaro, Giulia Scioscia","doi":"10.3390/jcm14062075","DOIUrl":"10.3390/jcm14062075","url":null,"abstract":"<p><p><b>Background:</b> The current availability of monoclonal antibodies against key mediators of type-2 (T2) inflammation has led to a redefinition of the ultimate objectives of severe asthma treatment to a more composite concept of disease remission. <b>Objectives:</b> The aim of this real-life study was to estimate the percentage of patients who achieved clinical remission over 4 years of treatment with benralizumab, and to identify baseline predictors for the achievement of such a composite outcome in the long term. <b>Methods:</b> Data from a 4-year follow-up of 23 patients who were prescribed benralizumab as an add-on therapy because of uncontrolled severe eosinophilic asthma were retrospectively analyzed and compared. Clinical remission was considered to be \"complete\" if oral corticosteroid (OCS) use was not required, there were no exacerbations, an asthma control test (ACT) score ≥ 20 was achieved and a pre-bronchodilation percent predicted a forced expiratory volume in 1 s (FEV₁%) ≥ 80%. Clinical remission was considered to be \"partial\" if OCS use was not required, plus at least two of the other three aforementioned criteria. <b>Results:</b> The overall percentage of patients who achieved clinical remission was 86.9% after 12 months, and 91.3% after 24 and 48 months of treatment. The rate of complete remission over partial remission increased over time. After 12 months of treatment, 65% of patients fulfilled the criteria for complete remission and 35.0% for partial remission. After 48 months of treatment, 71.4% of patients were in a status of complete remission and 28.6% in a status of partial remission. A long-term composite outcome of complete clinical remission was more likely to be achieved by severe eosinophilic asthma patients with comorbid nasal polyposis, bronchiectasis and osteoporosis, and with OCS dependency, a predicted pre-bronchodilation FEV₁% ≥ 80% and a predicted FEF_25-75% < 65% at baseline. <b>Conclusions:</b> Our real-life experience suggests that treatment with benralizumab may allow the achievement and long-term maintenance of clinical remission in a high percentage of severe eosinophilic asthma patients, up to 4 years of follow-up.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}