Journal of Clinical Medicine最新文献

{"title":"Exploring Coronavirus Disease 2019 Risk Factors: A Text Network Analysis Approach.","authors":"Min-Ah Kang, Soo-Kyoung Lee","doi":"10.3390/jcm14062084","DOIUrl":"10.3390/jcm14062084","url":null,"abstract":"<p><p><b>Background/Objectives:</b> The coronavirus disease 2019 (COVID-19) pandemic has significantly affected global health, economies, and societies, necessitating a deeper understanding of the factors influencing its spread and severity. <b>Methods:</b> This study employed text network analysis to examine relationships among various risk factors associated with severe COVID-19. Analyzing a dataset of published studies from January 2020 to December 2021, this study identifies key determinants, including age, hypertension, and pre-existing health conditions, while uncovering their interconnections. <b>Results:</b> The analysis reveals five thematic clusters: biomedical, occupational, demographic, behavioral, and complication-related factors. Temporal trend analysis reveals distinct shifts in research focus over time. In early 2020, studies primarily addressed immediate clinical characteristics and acute complications of COVID-19. By mid-2021, research increasingly emphasized long COVID, highlighting its prolonged symptoms and impact on quality of life. Concurrently, vaccine efficacy became a dominant topic, with studies assessing protection rates against emerging viral variants, such as Alpha, Delta, and Omicron. This evolving landscape underscores the dynamic nature of COVID-19 research and the adaptation of public health strategies accordingly. <b>Conclusions:</b> These findings offer valuable insights for targeted public health interventions, emphasizing the need for tailored strategies to mitigate severe outcomes in high-risk groups. This study demonstrates the potential of text network analysis as a robust tool for synthesizing complex datasets and informing evidence-based decision-making in pandemic preparedness and response.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abatacept, Golimumab, and Sarilumab as Selected Bio-Originator Disease-Modifying Antirheumatic Drugs with Diverse Mechanisms of Action in Their Current Use in Treatment.","authors":"Piotr Kawczak, Igor Jarosław Feszak, Tomasz Bączek","doi":"10.3390/jcm14062107","DOIUrl":"10.3390/jcm14062107","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Arthritis encompasses a range of joint-related conditions, including osteoarthritis and rheumatoid arthritis, along with inflammatory diseases such as gout and lupus. This research study explores the underlying causes, challenges, and treatment options for arthritis, aiming to enhance the effectiveness of therapies. <b>Methods</b>: This research study evaluated current treatment strategies and examined the effectiveness of selected biological disease-modifying antirheumatic drugs (bDMARDs), i.e., abatacept, golimumab, and sarilumab, with a focus on emerging drug classes and their distinct mechanisms of action. <b>Results</b>: Biologic DMARDs like abatacept, golimumab, and sarilumab offer hopeful treatment alternatives for patients who fail to respond to conventional therapies. However, individual outcomes differ because of the disease's complexity and the influence of accompanying health conditions. <b>Conclusions</b>: Treating arthritis continues to be challenging due to its numerous underlying causes and the varied ways in which patients respond to treatment. Although biologics and targeted therapies have brought progress, additional research is needed to identify new treatment targets and enhance patient results.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney Transplant: More than Immunological Problems.","authors":"Rosana Gelpi, Angela Casas, Omar Taco, Maya Sanchez-Baya, Mohamed Nassiri, Mónica Bolufer, Javier Paul, Maria Molina, Laura Cañas, Anna Vila, Jordi Ara, Jordi Bover","doi":"10.3390/jcm14062101","DOIUrl":"10.3390/jcm14062101","url":null,"abstract":"<p><p>Kidney transplantation (KT) represents a pivotal intervention for patients with chronic kidney disease (CKD), significantly improving survival and quality of life. However, KT recipients face an array of non-immunological complications, collectively amplifying cardiovascular (CV) and metabolic risks. This review explores the intersection of cardio-metabolic syndrome and KT, emphasizing the recently introduced cardiovascular-kidney-metabolic (CKM) syndrome. CKM syndrome integrates metabolic risk factors, CKD, and CV disease, with KT recipients uniquely predisposed due to immunosuppressive therapies and pre-existing CKD-related risks. Key issues include post-transplant hypertension, obesity, dyslipidemia, post-transplant diabetes mellitus (PTDM), and anemia. Immunosuppressive agents such as corticosteroids, calcineurin inhibitors, and mTOR inhibitors contribute significantly to these complications, exacerbating metabolic dysfunction, insulin resistance, and lipid abnormalities. For instance, corticosteroids and calcineurin inhibitors heighten the risk of PTDM, while mTOR inhibitors are strongly associated with dyslipidemia. These pharmacologic effects underscore the need for tailored immunosuppressive strategies. The management of these conditions requires a multifaceted approach, including lifestyle interventions, pharmacological therapies like SGLT2 inhibitors and GLP-1 receptor agonists, and close monitoring. Additionally, emerging therapies hold promise in addressing metabolic complications in KT recipients. Proactive risk stratification and early intervention are essential to mitigating CKM syndrome and improving outcomes. This comprehensive review highlights the importance of integrating cardio-metabolic considerations into KT management, offering insights into optimizing long-term recipient health and graft survival.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Audiological Disorders in Cochlear Implants: Outcomes in Demanding Listening Situations and Future Perspectives.","authors":"Matthias Hey, Ulrich Hoppe","doi":"10.3390/jcm14062089","DOIUrl":"10.3390/jcm14062089","url":null,"abstract":"<p><p>Severe to profound sensorineural hearing loss can nowadays successfully be treated by cochlear implantation [...].</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of the Periodontal Breakdown over the Amount of Orthodontic Force Reaching the Dental Pulp and NVB During Orthodontic Movements-A Biomechanical Finite Element Analysis.","authors":"Radu-Andrei Moga, Cristian Doru Olteanu, Ada Gabriela Delean","doi":"10.3390/jcm14062094","DOIUrl":"10.3390/jcm14062094","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Most orthodontic forces are absorbed-dissipated before reaching the dental pulp and its neuro-vascular bundle (NVB); nonetheless, no data are available about this issue during the periodontal breakdown. The current study's objective was to investigate how much orthodontic force reaches the dental pulp and NVB during the orthodontic movements in periodontal breakdown. <b>Methods</b>: Herein, an assessment was performed on the second lower premolar of nine patients (72 3D models) and included 1440 numerical simulations. A gradual horizontal periodontal breakdown (1-8 mm loss) was simulated. Five orthodontic movements (intrusion, extrusion, rotation, translation, and tipping) under 0.5 N/5 KPa and 4 N/40 KPa were assessed. The numerical methods used were Von Mises/VM (overall homogenous) and Tresca (shear non-homogenous), suitable for the ductile resemblance of dental tissues. <b>Results</b>: Both methods showed similar color-coded projections for the two forces. Quantitatively, Tresca was 1.14 times higher than VM and lower than the maximum physiological hydrostatic circulatory pressure. During the bone loss simulation, the NVB stress was 5.7-10.7 times higher than the pulpal stress. A gradual tissue stress increase was seen, strictly correlated with the bone loss level. For 1 mm bone loss, only 2-3% of the applied force manifested at the NVB level (0.27-0.5% for pulp), while for 8 mm loss, the received stress was 4-10% for the NVB (0.6-0.9% for pulp) when compared to the applied force. Only translation displayed pulpal stress. <b>Conclusions</b>: When assessing NVB stress, the tooth absorption-dissipation ability of dental tissues varied between 90 and 93% (8 mm loss) and 97% (1 mm bone loss) and 99% when assessing pulpal stress.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolving Landscape of Infective Endocarditis: Difficult-to-Treat Resistance Bacteria and Novel Diagnostics at the Foreground.","authors":"Vasiliki Rapti, Efthymia Giannitsioti, Nikolaos Spernovasilis, Anna-Pelagia Magiorakos, Garyfallia Poulakou","doi":"10.3390/jcm14062087","DOIUrl":"10.3390/jcm14062087","url":null,"abstract":"<p><p>Infective endocarditis (IE) is a relatively rare but potentially life-threatening disease characterized by substantial mortality and long-term sequelae among the survivors. In recent decades, a dramatic change in the profile of patients diagnosed with IE has been observed primarily in developed countries, most likely due to an aging population and a recent increase in invasive medical procedures. Nowadays, the typical IE patient is usually older, with complex comorbidities, and a history significant for cardiac disease, including degenerative heart valve disease, prosthetic valves, or cardiovascular implantable electronic devices (CIEDs). Moreover, as patient risk factors change, predisposing them to more healthcare-associated IE, the microbiology of IE is also shifting; there are growing concerns regarding the rise in the incidence of IE caused by difficult-to-treat resistance (DTR) bacteria in at-risk patients with frequent healthcare contact. The present review aims to explore the evolving landscape of IE and summarize the current knowledge on novel diagnostics to ensure timely diagnosis and outline optimal therapy for DTR bacterial IE.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of the Mayo Risk Score in Predicting Transplant and Mortality in a Single-Center U.S. Cohort of Primary Sclerosing Cholangitis.","authors":"Tamara Kahan, Ana Marenco-Flores, Natalia Rojas Amaris, Romelia Barba, Daniela Goyes, Esli Medina-Morales, Leandro Sierra, Vilas R Patwardhan, Alan Bonder","doi":"10.3390/jcm14062098","DOIUrl":"10.3390/jcm14062098","url":null,"abstract":"<p><p><b>Background:</b> The Mayo Risk Score (MRS) predicts short-term mortality in primary sclerosing cholangitis (PSC) using the age, bilirubin, albumin, aspartate aminotransferase (AST), and variceal bleeding history. While the MRS has been validated in end-stage PSC, its ability to predict liver transplantation (LT) and outcomes in newly diagnosed patients without advanced disease remains unclear. This study evaluated the effectiveness of the MRS in predicting LT and mortality in this patient population. <b>Methods:</b> We analyzed data from 109 adults with PSC enrolled in a prospective registry (2018-2024) with ≥4 years of follow-up. Logistic regression identified the predictors of LT or death, and the model performance was assessed using the area under the receiver operating characteristic curve (AUROC). Multicollinearity was evaluated using the variance inflation factor (VIF). <b>Results:</b> Among the 109 patients (mean age 45 ± 15 years, 51% female), 85% remained alive without LT, 12% underwent LT, and 3% died over a median follow-up of 4.63 years. The MRS was significantly associated with LT or death (OR 3.08, <i>p</i> < 0.001) and demonstrated excellent predictive performance (AUROC 0.99, <i>p</i> < 0.001). The model achieved 95.45% sensitivity, 98.85% specificity, and a correct classification rate of 98.17%, supporting its clinical utility. <b>Conclusion:</b> The MRS is a robust tool for risk stratification in PSC, predicting LT and mortality. These findings highlight its broader applicability beyond end-stage PSC and underscore its potential for guiding clinical management and early intervention strategies.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Transcranial Direct Current Stimulation on Memory and Emotional Recovery in Patients with Stroke and Traumatic Brain Injury: A Prospective, Multicenter, Interventional Pilot Study.","authors":"Marta Szczepańska, Zofia Twardochleb, Maciej Miś, Marcin Miś, Adam Druszcz, Małgorzata Paprocka-Borowicz, Joanna Rosińczuk","doi":"10.3390/jcm14062083","DOIUrl":"10.3390/jcm14062083","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Emotional and cognitive impairments are prevalent in patients with acute ischemic stroke (AIS) and traumatic brain injury (TBI), significantly affecting their quality of life and recovery potential. Transcranial direct current stimulation (tDCS) has emerged as a promising non-invasive method to enhance neurorehabilitation outcomes by modulating neural activity. <b>Methods:</b> This prospective, open-label, multicenter interventional study included 100 participants (50 AIS, 50 TBI) who underwent 10 sessions of tDCS. Emotional states, depression levels, and memory and learning outcomes were assessed pre- and post-intervention using the UWIST Mood Adjective Checklist (UMACL), Depression Measurement Questionnaire (DMQ), Benton Visual Retention Test (BVRT), and Brain Damage Diagnostic Test (BDDT). <b>Results:</b> Significant improvements in emotional states were observed post-tDCS. Hedonic tone increased (AIS: 2.5 to 5 stens; TBI: 1.5 to 4 stens), while tension arousal decreased (AIS: 8 to 6 stens; TBI: 8 to 6 stens; all <i>p</i> < 0.001). Depression levels dropped significantly, with the overall depression index decreasing from 131 to 100 points in AIS and from 126 to 104 points in TBI (both <i>p</i> < 0.001). Memory and learning scores improved significantly, evidenced by increased correct responses and reduced errors in BVRT and BDDT tests (all <i>p</i> < 0.001). <b>Conclusions:</b> tDCS effectively improved emotional states, reduced depression levels, and enhanced cognitive functions in AIS and TBI patients. These findings support the integration of tDCS into neurorehabilitation protocols, with further research needed to explore long-term benefits and individualized treatment strategies.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visceral Adiposity, Anthropometric and Liver Function Indexes for Identifying Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) in Adolescents with Obesity: Which Performs Better?","authors":"Lara Mari, Stefano Lazzer, Alessandro Gatti, Mattia D'Alleva, Simone Zaccaron, Jacopo Stafuzza, Enrico Rejc, Matteo Vandoni, Adele Bondesan, Diana Caroli, Francesca Frigerio, Laura Abbruzzese, Enrica Ventura, Alessandro Sartorio","doi":"10.3390/jcm14062085","DOIUrl":"10.3390/jcm14062085","url":null,"abstract":"<p><p><b>Background:</b> Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD) is the accumulation of fat in the liver without excessive alcohol consumption or other known liver diseases. MASLD is the most common liver disease in adolescents with obesity. The aims of this study were as follows: (i) to determine which index (waist circumference BMI, WHtR, VAI, METS-IR, METS-VF, HSI, FLI, or MetS_zscore) best explains the prevalence of MASLD in adolescents with obesity; (ii) to determine whether there was a specific index that was most strongly associated with MASLD; (iii) to assess which liver function indexes were most strongly correlated with MASLD. <b>Methods:</b> A total of 758 adolescents with severe obesity (BMI z-score > 2) admitted at the Division of Auxology, Istituto Auxologico Italiano, IRCCS, Piancavallo-Verbania for a 3-week multidisciplinary body weight reduction program were selected. Anthropometric parameters (stature, body mass, BMI, and waist and hip circumference) were collected, and body composition (lean and fat mass) was determined using the tetrapolar bioimpedance analysis (BIA) technique. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (gamma GT), alkaline phosphatase (ALP), bilirubin, glucose, total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglycerides (TG), and C-reactive protein (CRP) were measured using standard techniques. MASLD was diagnosed based on abdominal ultrasound results. <b>Results:</b> WHtR (65.76%) was the most sensitive compared with other indexes. The HSI (AUC: 0.67 (0.63-0.71, 95% CI), <i>p</i>-value < 0.05) showed the best performance in predicting MASLD, with the threshold for having MASLD considered at 48.22. The indexes that showed the worst performance in predicting MASLD were the MetS z-score (AUC: 0.56 (0.52-0.60)) and the VAI (AUC: 0.57 (0.52-0.61)). ALT (OR: 2.92 (2.29-3.77); 95% CI) and AST (OR: 2.52 (2.03-3.20)) were the parameters with a stronger correlation with MASLD. <b>Conclusions:</b> The most sensitive index for diagnosing MASLD was the WHtR, based exclusively on anthropometric parameters. HSI was the index that correlated the most with MASLD, while the parameters of liver function (ALT and AST) were the most strongly correlated with the disease and its severity.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11943388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distal Intersection Tenosynovitis: Surgical Insights From Five Cases.","authors":"Julie Mercier, Agata Durdzinska Timoteo, Romain Baillot, Sébastien Durand","doi":"10.3390/jcm14062110","DOIUrl":"10.3390/jcm14062110","url":null,"abstract":"<p><p><b>Background:</b> Distal intersection tenosynovitis (DIT) is a rare and recently described condition that affects the extensor pollicis longus (EPL), extensor carpi radialis brevis (ECRB), and longus (ECRL). Based on surgical observations, this study aimed to provide new insights into its physiopathology. <b>Methods:</b> This was a retrospective study of all patients who underwent surgery for DIT at our institution from 2015 to 2024. Five patients were included in the study. <b>Results:</b> Wrist joint issues clearly explained the occurrence of DIT in three cases. Tendon lesions were observed either on the extensor carpi radialis brevis or extensor pollicis longus. <b>Conclusions</b>: These additional data complement the existing literature, which primarily focuses on the anatomical mechanisms of DIT without fully explaining its causes. Our observations suggest that wrist joint or bone disorders may play a significant role in its occurrence. Lesions in different tendons suggest the involvement of distinct pathological mechanisms.</p>","PeriodicalId":15533,"journal":{"name":"Journal of Clinical Medicine","volume":"14 6","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11942923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}