Journal of Clinical and Translational Science最新文献

{"title":"Community-engaged COVID-19 contact tracing initiative in Chicago.","authors":"Sage J Kim, Noah McWhirter, Sangeun Lee, Ajanta Patel, Jeni Hebert-Beirne, Ronald Hershow, Emily Stiehl","doi":"10.1017/cts.2026.10744","DOIUrl":"10.1017/cts.2026.10744","url":null,"abstract":"<p><strong>Introduction: </strong>During the early days of the COVID-19 pandemic, the Chicago Department of Public Health (CDPH) partnered with 31 community-based organizations (CBOs) to implement contact tracing to identify and manage potential COVID-19 infection cases in the city of Chicago.</p><p><strong>Methods: </strong>To evaluate the performance of the COVID-19 contact tracing, we utilized data between September 16, 2020, and December 31, 2021. Contact tracers collected data through phone interviews with potentially affected individuals. The level of initiation, timeliness, and completion of the contact tracing process were examined.</p><p><strong>Results: </strong>A total of 38,086 unique individuals were included in the analysis. Compared to White contacts, Blacks were more likely to refuse contact tracing, and Hispanics were less likely to be contacted within 7 days of exposure. Community areas with a greater number of contact tracing cases had a lower proportion of call completion.</p><p><strong>Conclusions: </strong>There was significant difficulty conducting contact tracing in the early months of COVID-19 due to the high volume of infected individuals. Contact tracing efforts were less successful among racial/ethnic minority residents despite the city's efforts to hire and train community members as contact tracers by engaging a wide range of CBOs. Preparedness plans for future pandemic events will benefit from strategies to improve community response to surveillance programs.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e88"},"PeriodicalIF":2.7,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crowdsourced educational resource to distinguish Translational Science (TS) from Translational Research (TR).","authors":"Nathaniel Hafer, Karen Cielo, Paul Duguid, Mendy Dunn, Maryam Gholami, Kristi Holmes, Joe Hunt, Cathleen Kane, Patricia Moussatche, Christy Navarro, Brittney Jackson Patterson, Alfred Vitale, Jennifer Croker","doi":"10.1017/cts.2026.10747","DOIUrl":"10.1017/cts.2026.10747","url":null,"abstract":"","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e87"},"PeriodicalIF":2.7,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and implementation of the Forge AHEAD Center: A collaborative research center addressing cardiometabolic disease through academic-community partnership in the Deep South.","authors":"Gareth R Dutton, Monica L Baskin, Orlando M Gutiérrez, Caroline E Compretta, Michael J Mugavero, April A Agne, Lauren Hebert-Henderson, Trudi V Horton, Rikki M Tanner, April P Carson, Peter T Katzmarzyk, Timothy Turner, Tapan S Mehta, Kara D Denstel, Aseel El Zein, Michael E Hall, Sharonda Hardy, Eboni Price-Haywood, Andrea L Cherrington","doi":"10.1017/cts.2026.10746","DOIUrl":"10.1017/cts.2026.10746","url":null,"abstract":"<p><p>The Deep South has the highest rates of obesity, diabetes, and hypertension in the nation, with marked disparities by race, socioeconomic status, and rurality. The mission of the Forge AHEAD Center is to improve health outcomes and reduce the burden of cardiometabolic diseases across the Deep South, with a particular focus on the prevention and treatment of these chronic diseases. Forge AHEAD is unified thematically by its application of a precision public health approach across the care continuum, defined as delivering the right intervention to the right population at the right time. This approach acknowledges the importance of context and individual beliefs and preferences, as well as the need for multi-level and multi-domain interventions to achieve health improvements. The Center brings together an interdisciplinary team of investigators from 4 institutions in 3 contiguous states in the region, as well as non-academic partners to extend cardiometabolic research into real-world community and clinical settings. Given the high prevalence of cardiometabolic diseases in the Deep South and the strong research base of the partnering institutions, the Forge AHEAD Center is ideally situated to inform research, clinical care, and policy to improve health outcomes in a region of substantial need.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e90"},"PeriodicalIF":2.7,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13237192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148199125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in clinical trial participant recruitment and retention: A scoping review and meta-analysis.","authors":"Ziran Yin, Yun-Chung Liu, Jonathan Chong Kai Liew, Rui Yang, Stephanie Hendren, Elisa Ma, Zhaomei Geng, Jiahan Wang, Henry Foote, Christopher Lindsell, Chuan Hong","doi":"10.1017/cts.2026.10743","DOIUrl":"10.1017/cts.2026.10743","url":null,"abstract":"<p><p>Recruitment and retention challenges continue to hinder the success of clinical trials. Artificial intelligence (AI) has emerged as a promising means to optimize various clinical trial processes; however, its impact specifically on recruitment and retention has not been comprehensively evaluated. This scoping review utilized the Joanna Briggs Institute framework and adhered to PRISMA-ScR guidelines, systematically searching literature published between January 2018 and June 2024 across multiple databases. Of the 21,573 records screened, 121 studies were included. A meta-analysis was conducted to quantitatively assess the performance of AI-driven tools. AI applications for patient screening demonstrated strong performance, achieving a pooled sensitivity of 0.91 (95% CI: 0.84-0.95) and an area under the curve (AUC) of 0.79 (95% CI: 0.72-0.85). AI tools employed for eligibility identification and classification also exhibited strong outcomes, with pooled sensitivities of 0.80 (95% CI: 0.76-0.84) and 0.92 (95% CI: 0.84-0.96), respectively, and precisions of 0.84 (95% CI: 0.80-0.88) and 0.91 (95% CI: 0.85-0.95). AI tools aimed at identifying patient cohorts showed moderate effectiveness (pooled sensitivity: 0.70 [95% CI: 0.52-0.84]; AUC: 0.74 [95% CI: 0.61-0.84]). Overall, AI presents significant potential for enhancing clinical trial recruitment and retention, with effectiveness varying across specific applications. These findings underscore AI's valuable role in improving trial efficiency and data quality.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e98"},"PeriodicalIF":2.7,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13312366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148352097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-production of a National Botswana Tobacco Control Resource Center through Community Engagement Studio.","authors":"Lillian Okui, Marie-Claude C Lavoie, Florence Bada, Selebaleng Mokonopi, Kaizer Ikgopoleng, Mpho Zwinila, Ndwapi Ndwapi, Manhattan Charurat, Niharika Khanna, Bontle Mbongwe","doi":"10.1017/cts.2026.10742","DOIUrl":"10.1017/cts.2026.10742","url":null,"abstract":"<p><p>Tobacco use causes over 8 million deaths annually, with low- and middle-income countries (LMICs) bearing most of the burden. In Botswana, tobacco use prevalence rose from 17.6% in 2017 to 22.2% in 2024. Despite this, tobacco control infrastructure remains limited. Tobacco Control Resource Centers (TCRCs) have been established to consolidate provider training, research, and dissemination of tobacco control resources. The World Health Organization (WHO) Centre for Tobacco Control in Africa (CTCA), a regional TCRC, has a cross-country mandate that could be further strengthened through complementary, country-specific support. We applied the Community Engagement Studio (CES) methodology to co-design of a Botswana-based TCRC-assessing acceptability, priorities, potential challenges, and implementation strategies. In July 2025, 12 stakeholders from the Botswana Smoking Abstinence Reinforcement Trial (BSMART), a NIH-funded study aimed at integrating smoking cessation interventions in HIV clinics, participated in a 2-hour CES. Stakeholders endorsed the need for a national TCRC, prioritizing provider training, dissemination, and cessation services. Sustainable financing emerged as a key challenge, prompting proposals for diversified funding models. We successfully conducted a CES to guide the co-design of a Botswana-based TCRC, illustrating the acceptability of a national TCRC and how CES can be leveraged to strengthen tobacco control infrastructure in Botswana.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e86"},"PeriodicalIF":2.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13227121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qualitative evaluation of a coaching and leadership program for early-stage researchers in KL2 and T32 training programs.","authors":"Lauren Jodi Van Scoy, Erika VanDyke, Marie L Boltz, Dale Fallon, Jessica Petrie, David Rábago","doi":"10.1017/cts.2026.10740","DOIUrl":"10.1017/cts.2026.10740","url":null,"abstract":"<p><strong>Background: </strong>Early-stage clinical and translational researchers require not only technical expertise but also leadership and communication skills for long-term success. Many training programs lack structured approaches to building these essential \"soft skills.\"</p><p><strong>Objective: </strong>To evaluate the impact and perceived value of a structured coaching and leadership program for trainees in KL2 and T32 programs.</p><p><strong>Methods: </strong>This qualitative evaluation assessed a Coaching and Leadership Program (CLP) that include individualized coaching and group workshops incorporating leadership development and the DISC behavioral communication model (Dominance, Influence, Steadiness, and Conscientiousness). Semi-structured interviews were conducted with twelve KL2 and postdoctoral T32 trainees between July and August 2025. Transcripts were analyzed using descriptive content analysis and inductive coding by two analysts in MAXQDA.</p><p><strong>Results: </strong>Five key themes emerged: 1) Both T and K trainees consistently described the CLP as a broadly positive and beneficial experience; 2) Coaching helped trainees build concrete organizational strategies, particularly around time management and logistical processes; 3) The CLP helped build trainees' confidence and professional identity, especially around communication with mentors, bosses, or their team; 4) The CLP was perceived as complementary and well integrated within KL2 and T32 training, particularly by addressing \"soft skills\" missing elsewhere; and 5) Participants recommended stronger orientation, more opportunities for practical skill-building during sessions, and offering greater variety and choice in coaches.</p><p><strong>Conclusions: </strong>The CLP complements scientific training for early-career translational researchers. Trainees gained practical tools for team management, conflict resolution, and strategic planning, while benefiting from a confidential space for professional growth. Findings suggest coaching is a valuable enhancement to training programs for developing translational research leaders.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e83"},"PeriodicalIF":2.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the perioperative experiences of youth undergoing cardiac surgery: A qualitative needs assessment for tailoring a mobile self-management app.","authors":"Tieghan Killackey, Jill O'Hare, Sandra Merklinger, Lauren Harris, Mansi Patel, Nicole Drumm, Selini Jayawickrema, Fiona Campbell, Katherine Taylor, Jennifer Russell, Rachel D Vanderlaan, Fareha Nishat, Laura Veloso, Maya Samarasekera, Jennifer N Stinson","doi":"10.1017/cts.2026.10741","DOIUrl":"10.1017/cts.2026.10741","url":null,"abstract":"<p><strong>Introduction: </strong>One in five children who undergo cardiac surgery report experiencing moderate to severe pain lasting more than 3 months after surgery which has a significant impact on quality of life. iCanCope with PostOperative Pain (\"iCanCope POP\") is a smartphone app that provides adolescents with evidence-based strategies to manage postoperative pain. The goal of this study was to explore the unique needs and pain-management experiences of youth undergoing cardiac surgery to inform the development of a tailored iteration of iCanCope POP.</p><p><strong>Methods: </strong>A descriptive qualitative design using semi-structured interviews and focus groups was conducted with adolescents ages 12-18 who had received cardiac surgery, caregivers of youth undergoing cardiac surgery, and interdisciplinary healthcare providers (HCPs). Qualitative data were inductively and deductively coded using a content analysis approach to outline participants' pain management experiences and perspectives on the iCanCope POP app.</p><p><strong>Results: </strong>14 interviews and 1 focus group were completed with 6 children, 6 parents, and 12 HCPs (<i>n</i> = 24 participants). Content analysis resulted in 3 key categories: 1. Riding the rollercoaster of the surgical journey (e.g., ups and downs of pre- and post-operative phases); 2. Postoperative pain experience (e.g., tubes, technologies, and devices; pain management strategies); and 3. App feedback (e.g., usefulness, appropriateness, suggested modifications).</p><p><strong>Discussion/conclusion: </strong>Participants reported significant challenges during the perioperative pediatric cardiac surgery journey and identified potential opportunities for a tailored mobile self-management app to improve their surgical experience. Future research should use these perspectives to inform a new iteration of the iCanCope POP app for youth undergoing cardiac surgery.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e85"},"PeriodicalIF":2.7,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13202492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring what matters: Modern evaluation practices in clinical and translational science.","authors":"Boris Volkov, Valerie Harder, Brenda Joly","doi":"10.1017/cts.2026.10739","DOIUrl":"10.1017/cts.2026.10739","url":null,"abstract":"","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e81"},"PeriodicalIF":2.7,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13168826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147941687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Institutional transformations for authentic community engaged and participatory research.","authors":"Nina Wallerstein, Milton Mickey Eder, Lori Carter-Edwards, Paige Castro-Reyes, Tanja Gangarova, Linda Sprague Martinez, Lloyd Michener","doi":"10.1017/cts.2026.10715","DOIUrl":"10.1017/cts.2026.10715","url":null,"abstract":"<p><p>This special issue of the <i>Journal of Clinical Translational Science</i> on Institutional Transformation provides strategies to strengthen community and patient engagement in research in which collaborative knowledge creation is valued and centered in the history, knowledge, and evidence within communities. Recognizing the important role of academic health centers, schools of public health and research institutes in engaged research, the guest editors sought articles that challenged institutions to transform policies, practices, norms and structures towards power-sharing in research and towards commitment to sustainable research partnerships for health equity. While these articles were mostly written before the current context of large-scale terminations of grants and programs, this special issue recognized the well-founded historical distrust of communities in academic centers and the ongoing challenges of regaining trust in science. We first provide an historical context of institutional barriers and facilitators of engaged and participatory research and then review articles, including from the Engage for Equity PLUS national initiative. We end with recommendations for the field, as we recognize we still need to be self-critical about the structures that maintain academic dominance in research rather than valuing multiple ways of knowing and the importance of communities for authentic co-creation and leadership of research.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e60"},"PeriodicalIF":2.7,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harmonizing interactions between clinical trial sponsors and study research sites: An appraisal of the key challenges and recommendations for addressing them.","authors":"Kesley Holmes, Kasey Boynton, Monique Adams, Jenny Garcia, Priscilla Pemu","doi":"10.1017/cts.2026.10734","DOIUrl":"10.1017/cts.2026.10734","url":null,"abstract":"<p><p>Successful completion of industry-sponsored clinical trials requires effective collaboration between sponsors and clinical research sites recruiting patients. As pharmaceutical companies specialize in more therapy areas, complexity and volume of clinical trials increases, with study sites facing growing operational and logistical challenges. These may be administrative, financial, technological, or workforce-related and can prevent sites from meeting trial obligations, inhibiting long-term site sustainability. Here we outline a suggested framework (with metrics) designed to address three key pillars: site infrastructure, workforce, and the establishment of a 'trial funnel' to maintain sufficient trial volume. We review key site-level challenges and barriers to success in clinical trial conduct and argue that issues could be mitigated by sponsors investing programmatically in their site partnerships, including investing in research-naïve sites. Long-term programmatic planning and investment has the potential to deliver greater efficiency and sustainability in trial delivery; site investment upfront would increase working capital for the site, maximizing commitment and security on both sides. This, however, requires safeguarding through the implementation of targets and metrics of success. Many of the challenges faced in modern clinical research can be mitigated by new and longer-term thinking, concerning the working relationship and methods adopted between sponsors and research sites.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e79"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13184653/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}