Journal of Clinical and Translational Science最新文献

{"title":"Domain-specific participant recruitment exceeds the application of \"Targeted\" advertisement from common online advertising platforms.","authors":"Joseph Powell, Kyle Webster, Siobhan Efionayi, Timothy Engelman, W H Wilson Tang, P Xiao Li","doi":"10.1017/cts.2025.61","DOIUrl":"10.1017/cts.2025.61","url":null,"abstract":"<p><strong>Introduction: </strong>Insufficient sample sizes threatened the fidelity of the primary research trials. Even if the research group recruits a sufficient sample size, the sample may lack diversity, reducing the generalizability of the results of the study. Evaluating the effectiveness of online advertising platforms (e.g., Facebook & Google Ads) versus traditional recruitment methods (e.g., flyers, clinical participation) is essential.</p><p><strong>Methods: </strong>Patients were recruited through email, electronic direct message, paper advertisements, and word-of-mouth advertisement (traditional) or through Google Ads and Facebook Ads (advertising) for a longitudinal study on monitoring COVID-19 using wearable devices. Participants were asked to wear a smart watch-like wearable device for ∼ 24 hours per day and complete daily surveys.</p><p><strong>Results: </strong>The initiation conversion rate (ICR, impressions to pre-screen ratio) was better for traditional recruitment (24.14) than for Google Ads, 28.47 ([0.80, 0.88]; p << 0.001). The consent conversion rate (CCR, impressions to consent ratio) was also higher for traditional recruitment (66.54) than for Google Ads, 2961.20 ([0.015, 0.030]; p << 0.001). Participants recruited through recommendations or by paper flier were more likely to participate initially (Χ² = 23.65; p < 0.005). Clinical recruitment led to more self-reporting white participants, while other methods yielded great diversity (Χ² = 231.47; p << 0.001).</p><p><strong>Conclusions: </strong>While Google Ads target users based on keywords, they do not necessarily improve participation. However, our findings are based on a single study with specific recruitment strategies and participant demographics. Further research is needed to assess the generalizability of these findings across different study designs and populations.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e106"},"PeriodicalIF":2.1,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives of older adults with memory decline participating in a prolonged nightly fasting (PNF) pilot study: A qualitative exploration.","authors":"Dara L James, Erica Ahlich, Molly Maxfield, Afton Kechter, Sarah E James, Alexis M Koskan, Dorothy D Sears","doi":"10.1017/cts.2025.63","DOIUrl":"10.1017/cts.2025.63","url":null,"abstract":"<p><strong>Introduction: </strong>Cognitive decline and sleep concerns are significant health issues among older adults. Nonpharmacological treatments to address these concerns are needed, particularly for older adults who are more likely to be prescribed multiple medications and experience adverse effects of additional drugs. The aim of the current qualitative study was to understand and document the experiences of older adults with subjective memory decline participating in prolonged nightly fasting (PNF) intervention.</p><p><strong>Methods: </strong>This single-group pilot study was conducted as a fully remote, 8-week, pre/postintervention. Postintervention, 16 participants (≥65 years) participated in semistructured qualitative exit interviews about their experiences with the PNF intervention. Interviews lasted approximately 20-30 minutes, were conducted by trained study staff, and then analyzed by the team to understand relevant themes.</p><p><strong>Results: </strong>Two major themes that emerged from the data were engagement with and perceived effects of the PNF intervention. Within these two themes, nine subthemes emerged: accountability; use of days off; feasibility; intervention tools; behavioral strategies; timing/routine; awareness; self-efficacy; and perceived health-related outcomes. Overall, interviews suggested strong engagement with the PNF intervention as well as a number of positive perceived effects of the intervention.</p><p><strong>Conclusions: </strong>These findings contribute to a broad field of intermittent fasting by exploring and understanding the direct experiences of older adults participating in PNF. Some participants identified challenges of participation, yet this qualitative approach can guide future PNF implementation with older adults. Notably, responses support the quantitative data suggesting that PNF is a feasible and acceptable intervention for older adults.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e112"},"PeriodicalIF":2.1,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective integration capability: A valid and reliable measurement instrument for assessing knowledge integration readiness in interdisciplinary collaborations.","authors":"Maritza Salazar Campo, Theresa K Lant","doi":"10.1017/cts.2025.54","DOIUrl":"10.1017/cts.2025.54","url":null,"abstract":"<p><strong>Background: </strong>Work in science, medicine, and engineering increasingly relies on collaborations among diverse experts to solve complex problems. Despite the importance of interprofessional training and practice to enhance collaboration and knowledge integration, there is a lack of a conceptually meaningful, valid, and reliable measure of individual capacity for interdisciplinary knowledge integration. This study contributes a conceptual framework and empirical tool to facilitate both research and practice of interdisciplinary collaborations.</p><p><strong>Methods: </strong>We conduct a three-phase, five-study investigation to develop and validate a measure of individual perspective integration capability (PIC), which assesses individual willingness and ability to integrate knowledge with others during collaborative work. Phase 1 includes item generation and reduction in three studies using different samples of respondents. Phase 2 demonstrates convergent and discriminant validity with conceptually related and unrelated constructs, using a separate sample of respondents. Phase 3 tests criterion-related validity and mediation by examining the multilevel relationships between PIC and key antecedents and outcomes, using data from a unique sample of research scientists in interdisciplinary medical research teams.</p><p><strong>Results: </strong>Across the three phases of our study, the results demonstrate support for the PIC instrument's factor structure, reliability, and validity. We also demonstrated that the PIC construct has important implications for individuals engaged in interdisciplinary collaborations.</p><p><strong>Conclusions: </strong>Having a conceptually meaningful, valid, reliable, and easily administered survey instrument will facilitate further study of interdisciplinary collaboration, and the development and evaluation of integration efforts of teams engaged in convergent and translational initiatives.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e93"},"PeriodicalIF":2.1,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of deploying community health workers to assist with health-related social needs and hypertension in community care clinics.","authors":"Brian Robusto, Iris Cheng, Rohan Mahabaleshwarkar, Jessica McCutcheon, Nancy Denizard-Thompson, Sara R Kinny, Selina Quinones, Henry Bundy, Yhenneko J Taylor, Deepak Palakshappa","doi":"10.1017/cts.2025.53","DOIUrl":"10.1017/cts.2025.53","url":null,"abstract":"<p><p>We conducted a pilot study of implementing community health workers (CHWs) to assist patients with hypertension and social needs. As part of clinical care, patients identified as having an unmet need were referred to a CHW. We evaluated changes in blood pressure and needs among 35 patients and conducted interviews to understand participants' experiences. Participants had a mean age of 54.1 years and 29 were Black. Twenty-six completed follow-up. Blood pressure and social needs improved from baseline to 6 months. Participants reported being accepting of CHWs, but also challenges with establishing a relationship with a CHW and being unclear about their role.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e81"},"PeriodicalIF":2.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating research study participant compensation practices at a California academic and research institution.","authors":"Mariam Carson, Paula Fleisher, Rana Barar, Li Zhang, Elizabeth Tioupine, Hilary Seligman","doi":"10.1017/cts.2025.57","DOIUrl":"10.1017/cts.2025.57","url":null,"abstract":"<p><strong>Introduction: </strong>While providing compensation for participation in research studies is common, there is an ongoing debate surrounding compensation models and how they can be equitably applied. This work attempts to better understand the landscape of research compensation by evaluating factors associated with compensation of research study participants across instiutional review board (IRB)-approved studies at a single academic institution in California.</p><p><strong>Methods: </strong>We extracted all IRB applications for social, behavioral, educational, and public policy research studies between January 1, 2019, and December 31, 2021, at the University of California, San Francisco. Compensation amounts, time estimates for participation, and location of study activities (hybrid, remote, in-person) were extracted from free text entries in the IRB application and reorganized into discrete variables. Multivariable logistic regression was used to assess factors associated with receiving payment after adjusting for time.</p><p><strong>Results: </strong>We analyzed 403 unique IRB applications. Studies held at public hospitals and clinics were more likely to provide compensation to study participants, whereas studies held at the university hospitals and clinics were less likely to provide compensation. Unfunded studies also were less likely to provide compensation to research study participants. While participants that were classified as \"economically/educationally disadvantaged\" and \"unable to read, speak, or understand English\" within the institution's IRB application were more likely to receive compensation, those that had \"diminished capacity to consent\" were less likely to receive compensation.</p><p><strong>Conclusions: </strong>While there are multiple frameworks for compensation, there is still significant variability in compensation strategies. Institutions should center equity in considering standardized approaches to compensation for research participation.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e103"},"PeriodicalIF":2.1,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of research review boards in the context of community-academic settings: A scoping review.","authors":"Katarzyna Wilczek, Ashley Nordsletten, Patricia Piechowski, Luther Evans, Sharon Saddler, Ella Greene-Moton, Susan Woolford, Polly Y Gipson Allen, Jodyn E Platt","doi":"10.1017/cts.2025.50","DOIUrl":"10.1017/cts.2025.50","url":null,"abstract":"<p><p>Community advisory boards (CABs) have traditionally been formed in the context of discrete projects and served to support community protections within the confines of the associated investigation(s). However, as funding bodies increasingly prioritize health equity, CABs have shifted - evolving into long-running organizations with broader scope and value. An emerging cornerstone of these project-independent boards (PICABs) has been the formation of \"Research Review Boards\" (RRBs). While unified in their goal of promoting community protection and representation in health research, it is unknown to what degree RRBs differ on key features including membership, leadership, service reach, and - crucially - impact. A scoping review was conducted according to PRISMA-ScR guidelines to analyze current practices for RRBs. Of screened articles (<i>n</i>= 1878), 25 were included, corresponding to 24 unique RRBs. Findings indicated overlaps in the stated missions, funding structures, and processes of most RRBs. Differences in membership composition, location, service-reach, leadership structures, evaluation procedures, and perceived impact were evident. Where data is available, RRBs receive positive endorsement from both internal members and external users. Standardization of evaluation procedures is needed to fully quantify impact. Additional challenges to sustainability, communication, and conflicts (e.g., of interest, commitment, and power differentials) merit further consideration.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e82"},"PeriodicalIF":2.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decentralized subject recruitment for a prospective community surveillance system: The influence of social determinants of health on inclusion of minorities in research.","authors":"Paul Takahashi, Chung-Il Wi, Robert Pignolo, Wendelyn Bosch, Katherine King, Euijung Ryu, Traci Natoli, Kathy Ihrke, Matthew Spiten, Lisa Speiser, Brandon Hidaka, Young Juhn","doi":"10.1017/cts.2025.18","DOIUrl":"10.1017/cts.2025.18","url":null,"abstract":"<p><strong>Background/objective: </strong>Decentralized research has many advantages; however, little is known about the representativeness of a source population in decentralized studies. We recruited participants aged 18-64 years from four states from June to December 2022 for a prospective cohort study to assess viral epidemiology. Our aim was to determine the association between age, gender, race/ethnicity, rurality, and socioeconomic status (SES) on study participation in a decentralized prospective cohort study.</p><p><strong>Methods: </strong>We consented 9,286 participants from 231,099 (4.0%) adults with the mean age of 45.6 years (±12.0). We used an electronic decentralized approach for recruitment. Consented participants were more likely to be non-Hispanic White, female, older, urban residents, have more health conditions, and possessed higher socioeconomic status (SES) compared to those non-consented.</p><p><strong>Results: </strong>We observed an interaction between SES and race-ethnicity on the odds of consent (<i>P</i> = 0.006). Specifically, SES did not affect non-Hispanic white participation rates(OR 1.24 95% CI 1.16 - 1.32] for the highest SES quartile compared to those with the lowest SES quartile) as much as it did participants combined across the other races (OR 1.73; 95% CI 1.45 - 2.98]).</p><p><strong>Conclusion: </strong>The relationship between SES and consent rates might be disproportionately greater in historically disadvantaged groups, compared to non-Hispanic White. It suggests that instead of focusing on enrollment of specific minority groups in research, there is value in future research exploring and addressing the diversity of barriers to trials within minority groups. Our study highlights that decentralized studies need to address social determinants of health, especially in under-resourced populations.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e104"},"PeriodicalIF":2.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12100557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-doctoral fellow and faculty perceptions and experiences of inclusion at academic medical centers.","authors":"Chantele Mitchell-Miland, Doris M Rubio, Tiffany L Gary-Webb, Galen Switzer, Gretchen E White, Natalia E Morone, Audrey J Murrell, Megan Hamm","doi":"10.1017/cts.2025.21","DOIUrl":"10.1017/cts.2025.21","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this research was to understand perceptions and experiences of inclusion among underrepresented early-career biomedical researchers (postdoctoral fellows and early-career faculty) enrolled in the Building Up study. Because inclusion is vital to job satisfaction and engagement, our goal was to shed light on aspects of and barriers to inclusion within the academic workforce.</p><p><strong>Methods: </strong>We used qualitative interviews to assess workplace experiences of 25 underrepresented postdoctoral fellows and early-career faculty including: their daily work experiences; sense of the workplace culture within the institutions; experiences with microaggressions, racism, and discrimination; and whether the diversity, equity, and inclusion (DEI) policies and practices at their institution enhanced their experiences. Using qualitative methods, we identified themes that highlighted high-level characteristics of inclusion.</p><p><strong>Results: </strong>Four distinct themes were identified: (1) participants appreciated the flexibility, versatility, and sense of fulfillment of their positions which enhanced feelings of inclusion; (2) greater psychological safety led to a greater sense of belonging to a research community; (3) participants had varied experiences of inclusion in the presence of microaggressions, racism, and discrimination; and (4) access to opportunities and resources increased feelings of value within the workplace.</p><p><strong>Discussion: </strong>Our findings provide new insight into how inclusion is experienced within the institution among underrepresented early-career biomedical researchers. This research points to specific approaches that could be used to enhance experiences of inclusion and to address barriers. More research is needed to understand how to accomplish a balance between the two, so that perceptions of inclusion outweigh negative experiences.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e91"},"PeriodicalIF":2.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089847/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How do study participants want to be informed about study results: Findings from a malaria trial in Cambodia, Ethiopia, Pakistan, and Indonesia.","authors":"Samuel Alemu Bamboro, Fareeha Abdul Jabbar, Mary Bagita-Vangana, Nurfadhilah Hasibuan, Tamiru Shibiru Degaga, Najia Ghanchi, Mohammad Asim Beg, Rupam Tripura, Ayodhia Pasaribu Pitaloka, Tedla Teferi Tego, Widya Safitri, Yulita, Sarah Cassidy-Seyoum, Muthoni Mwaura, Hellen Mnjala, Grant Lee, Lek Dysoley, Lorenz von Seidlein, Ric N Price, Holger W Unger, Bipin Adhikari, Kamala Thriemer","doi":"10.1017/cts.2025.56","DOIUrl":"10.1017/cts.2025.56","url":null,"abstract":"<p><strong>Background: </strong>Researchers acknowledge the need to share study results with the patients and their communities, but this is not done consistently due to a plethora of barriers, including a paucity of data to guide best practice approaches in different populations.</p><p><strong>Methods: </strong>This study was nested within a large multi-center randomized controlled trial of antimalaria treatment. Data on dissemination preferences were collected at the third-month follow-up visit using a short questionnaire. Data were analyzed using descriptive statistics and subsequently fed into an iterative process with key stakeholders, to develop suitable strategies for result dissemination.</p><p><strong>Results: </strong>A total of 960 patients were enrolled in the trial, of whom 84.0% participated in the nested survey. A total of 601 (74.6%) participants indicated interest in receiving trial results. There was significant heterogeneity by study country, with 33.3% (58/174) of patients indicating being interested in Cambodia, 100% (334/334) in Ethiopia, 97.7% (209/214) in Pakistan, but none (0/85) in Indonesia. The preferred method of dissemination varied by site, with community meetings, favored in Ethiopia (79.0%, 264/334) and individualized communication such as a letter (27.6%, 16/58) or phone calls (37.9%, 22/58) in Cambodia. Dissemination strategies were designed with key stakeholders and based on patient preferences but required adaptation to accommodate local logistical challenges.</p><p><strong>Conclusion: </strong>The varying preferences observed across different sites underscore that a one-size-fits-all approach is inadequate. Strategies can be tailored to patient preference but require adaptation to accommodate logistical challenges.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e83"},"PeriodicalIF":2.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical considerations for engaging staff in resource-constrained healthcare settings in implementation research: A qualitative focus group and consensus building study.","authors":"Kelly A Aschbrenner, Callie Walsh-Bailey, Meagan C Brown, Tanveer Khan, Travis P Baggett, Salene M W Jones, Douglas E Levy, Lydia E Pace, Jonathan P Winickoff","doi":"10.1017/cts.2025.29","DOIUrl":"10.1017/cts.2025.29","url":null,"abstract":"<p><strong>Background: </strong>The primary purpose of this study was to assess perceived burdens and benefits of participating in implementation research among staff employed in resource-constrained healthcare settings. Another objective was to use findings to generate considerations for engaging staff in research across different phases of implementation research.</p><p><strong>Methods: </strong>This qualitative focus group and consensus building study involved researchers affiliated with the National Cancer Institute Implementation Science Centers in Cancer Control program and nine Community Health Centers (CHCs) in Massachusetts. Six focus groups (n = 3 with CHC staff; <i>n</i> = 3 with researchers) assessed barriers and facilitators to staff participation in implementation research. During consensus discussions, we used findings to develop considerations for engaging staff as participants and partners throughout phases of implementation research.</p><p><strong>Results: </strong>Sixteen researchers and 14 staff participated in separate focus groups; nine researchers and seven staff participated in separate consensus discussions. Themes emerged across participant groups in three domains: (1) influences on research participation; (2) research burdens and benefits; and (3) ways to facilitate staff participation in research. Practical considerations included: (a) aligning research with organizational and staff values and priorities; (b) applying user-centered design to research methods; (c) building organizational and individual research capacity; and (d) offering equitable incentives for staff participation.</p><p><strong>Conclusions: </strong>Engaging staff as participants and partners across different phases of implementation research requires knowledge about what contributes to research burden and benefits and addressing context-specific burdens and benefits.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e65"},"PeriodicalIF":2.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}