Journal of Clinical and Translational Science最新文献

{"title":"Description and toolkit for a research participant referral service.","authors":"Nicholas Eberlein, Michael D Musty, Jamie Roberts, Sierra Lindo, W Schuyler Jones, Ranee Chatterjee","doi":"10.1017/cts.2025.33","DOIUrl":"10.1017/cts.2025.33","url":null,"abstract":"<p><p>The success of clinical research studies depends on effective recruitment and retention of study participants, yet only a small fraction of patients engage in research studies, even in academic health systems. Increasing awareness of research opportunities and facilitating connections with clinical research study teams would help to improve the success of research programs. In this Special Communications, we describe the creation and evolution of and tools used for the My Research Partners Concierge Service (MRPcs) of an academic health system. The MRPcs provides a centralized point of contact or hub for patients and community members, as well as clinical research organizations and academic partners, who have research-related questions or interests. The MRPcs helps to connect the users of the service with relevant research study teams, personnel, or resources to facilitate their engagement in a clinical research program. Our experience with the MRPcs informs our recommendation that peer institutions organize similar research service hubs for their clinical research programs to help increase awareness of and participation in clinical research by the public and to help increase the success of research programs at fulfilling their ultimate goal of improving the health of their population.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e52"},"PeriodicalIF":2.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975765/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greater gulf coast regional translational workforce development: Assessment and action plan.","authors":"Courtney D Hunt, Richard Sucgang, Ming Guo, Glenn Sanford, Dorothy E Lewis, Melinda Sheffield-Moore, Rebecca M Hall","doi":"10.1017/cts.2025.31","DOIUrl":"10.1017/cts.2025.31","url":null,"abstract":"<p><p>Converting knowledge from basic research into innovations that improve clinical care requires a specialized workforce that converts a laboratory invention into a product that can be developed and tested for clinical use. As the mandate to demonstrate more real-world impact from the national investment in research continues to grow, the demand for staff that specialize in product development and clinical trials continues to outpace supply. In this study, two academic medical institutions in the greater Houston-Galveston region termed this population the \"bridge and clinical research professional\" (B + CRP) workforce and assessed its turnover before and after the onset of the COVID-19 pandemic . Both institutions realized growth (1.2 vs 2.3-fold increase) in B + CRP-specific jobs from 2017 to 2022. Turnover increased 1.5-2-fold after the onset of the pandemic but unlike turnover in the larger clinical and translational research academic workforce, the instability did not resolve by 2022. These results are a baseline measurement of the instability of our regional B + CRP workforce and have informed the development of a regional alliance of universities, academic medical centers, and economic development organizations in the greater Houston-Galveston region to increase this highly specialized and skilled candidate pool.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e62"},"PeriodicalIF":2.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975780/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data science and artificial intelligence in biology, health, and healthcare.","authors":"Peter L Elkin, Christopher Lindsell, Julio Facelli, Manisha Desai, Chunhua Weng, Heidi Spratt, Shari Messinger, Lemuel Russell Waitman, JaMor Hairston, Ruth O'Hara, Jareen Meinzen-Derr","doi":"10.1017/cts.2025.28","DOIUrl":"10.1017/cts.2025.28","url":null,"abstract":"","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e56"},"PeriodicalIF":2.1,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adoption of E2PLUS tools and resources to promote the development of institutional capacity for patient-centered and community-engaged research at a cancer center.","authors":"Katherine J Briant, Prajakta Adsul, Elizabeth A Carosso, Marty Chakoian, Diane Mapes, Terri Coutee, Bridgette Hempstead, Laurie Hassell, Wendy Law, Jason A Mendoza","doi":"10.1017/cts.2025.27","DOIUrl":"10.1017/cts.2025.27","url":null,"abstract":"<p><strong>Introduction: </strong>The Fred Hutch/University of Washington/Seattle Children's Cancer Consortium's (Consortium) Office of Community Outreach & Engagement (OCOE) joined Stanford Medicine and Morehouse School of Medicine in implementing Engage for Equity Plus (E2PLUS), a multi-institutional community of practice to learn and share patient-centered and community-engaged research (P/CEnR) practices. University of New Mexico (UNM) facilitated this collaboration.</p><p><strong>Methods: </strong>The Consortium formed a Champion Team of 12 people who participated in two virtual workshops facilitated by UNM. Consortium executive leadership (<i>n</i> = 4) participated in interviews, and investigators (<i>n</i> = 4) and community members/patient advocates (<i>n</i> = 8) participated in focus groups to provide institutional context regarding P/CEnR. This is a paper on the process and findings.</p><p><strong>Results: </strong>Through E2PLUS engagement, the Champion Team identified four strategies to address institutional health inequities: 1) increase participation of underrepresented groups at all levels of institutional leadership and advisory boards; 2) create an Office of Patient Engagement to train and support patients who participate in institutional initiatives and advise research teams; 3) expand community engagement training, resources, and institutional commitment to focus on community-identified social and health needs; and 4) establish an umbrella entity for health equity efforts across the Consortium.</p><p><strong>Conclusion: </strong>While the Consortium had longstanding community advisory boards and faculty and staff with P/CEnR expertise, it did not have centralized and institutionally supported P/CEnR resources, policies, and infrastructure. By participating in E2PLUS, the Champion Team received technical assistance to leverage qualitative data to influence strategies to guide the development of Consortium health equity infrastructure and capacity for P/CEnR in Washington.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e72"},"PeriodicalIF":2.1,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975779/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2024 Physician-Scientist Trainee Diversity Summit conference proceedings.","authors":"Jessica Weng, Cynthia Y Tang, Kyle T Enriquez, Rohini N Guin, Briana Christophers, Yentli E Soto Albrecht, Daniel B Amusin, Deborah D Rupert, Paige Cooper Byas","doi":"10.1017/cts.2025.24","DOIUrl":"10.1017/cts.2025.24","url":null,"abstract":"<p><p>The Physician-Scientist Trainee Diversity Summit, hosted by the American Physician Scientists Association and the Burroughs Wellcome Fund, was conceived in 2019 with the mission of developing strategic plans to diversify the physician-scientist community using human-centered design thinking. In June 2024, the second iteration of this conference was held in Raleigh, North Carolina, and brought together a network of scientific and medical organizations to discuss issues of justice, equity, diversity, and inclusion facing physician-scientist trainees. This article summarizes the progress made from the first meeting, the proceedings of the 2024 Summit, and a thematic analysis of the recent meeting, offering tangible solutions to the physician-scientist community for supporting diversity and accessibility.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e49"},"PeriodicalIF":2.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward equity in cultivating a \"<i>garden of mentors</i>:\" An exploration of networking experiences in an implementation research training program.","authors":"Loni J Parrish, Amanda Gilbert, Kate Hoppe, Gloria D Coronado, Karen M Emmons, Amy A Eyler, Debra Haire-Joshu, Rebekah R Jacob, Alison B Hamilton, Shelly J Kannuthurai, Ross C Brownson","doi":"10.1017/cts.2025.17","DOIUrl":"10.1017/cts.2025.17","url":null,"abstract":"<p><strong>Introduction: </strong>The Institute for Implementation Science Scholars (IS-2) is a dissemination and implementation (D&I) science training and mentoring program. A key component of IS-2 is collaborating and networking. To build knowledge on effective networking and mentoring, this study sought to 1) conduct a social network analysis to determine whether underrepresented scholars have equivalent levels of connection and 2) gain insights into the differences in networking among racial/ethnic subgroups of scholars.</p><p><strong>Methods: </strong>Social network survey data were used to select participants based on number of collaborative connections (highest, lowest) and racial/ ethnic category (underrepresented, not underrepresented). Interviews were recorded, transcribed, and coded using an iterative process.</p><p><strong>Results: </strong>The sample consisted of eight highly networked scholars, eight less networked scholars, seven from underrepresented racial and ethnic groups, and nine from not underrepresented groups. Qualitative data showed a lack of connection, reluctance to network, and systematic issues including institutional biases as possible drivers of group differences. In addition, scholars provided suggestions on how to overcome barriers to networking and provided insights into how IS-2 has impacted their D&I research and knowledge.</p><p><strong>Conclusions: </strong>Underrepresented scholars have fewer network contacts than not underrepresented scholars in the IS-2 training program. It is imperative for leadership to be intentional with mentorship pairing, especially for underrepresented scholars. Future research might include interviews with program leaders to understand how network pairings are built to improve the mentorship experience.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e50"},"PeriodicalIF":2.1,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building a community-centered clinical research center in an underserved New York City neighborhood to enhance access to research, equity, and quality of care.","authors":"Amin Yakubov, James Holahan, Aaron Lord, Melanie Jay, Rachel Gross, Celia Engelson, Zariya Alvarez, Miguel Rodriguez, Leomaris Caba Caceres, Michael Reyes, Emily Drum, Xiaoting Xing, Rosario Medina, Shilpa Londhe, Brita Roy, Imad Alsayed, Gabrielle Gold-von Simson, Miriam A Bredella","doi":"10.1017/cts.2025.23","DOIUrl":"10.1017/cts.2025.23","url":null,"abstract":"<p><p>Access to an academic clinical research center (CRC) in health professional shortage areas (HPSA) can help address healthcare disparities and increase research accessibility and enrollment. Here we describe the development of a community-centered CRC in the underserved area of Sunset Park, Brooklyn, New York, centered within a larger academic health network and the evaluation of its outcomes within the first two years. In addition to resources and space, establishment of the CRC required a culturally competent and multilingual team of healthcare professionals and researchers and buy-in from the community. Between 1/2022 and 12/2023, the CRC opened 21 new trials (10 interventional and 11 noninterventional) with greater than 500 participant visits that reflect the racial and ethnic diversity of the community. These participants represent 110 distinct zip codes; 76% of these zip codes are underserved and designated HPSA. 60% self-identified as non-White and 20% identified as Hispanic, with 12 other distinct ethnicities represented. 28% of participants speak 11 languages other than English. Community-based CRCs can be created with sustainable growth to align with the mission of the National Institutes of Health and U.S. Food and Drug Administration to meet the ever-growing clinical, social, and research needs of the communities they serve.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e51"},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A three-tiered mentorship approach for supporting high school students interested in science, technology, engineering, and mathematics (STEM) careers.","authors":"Brittney D Browning, Janiece S Glover, Lindsay R Meredith, Anna E Kirkland, Kathryn S Gex, Rachel L Tomko, Felicity Duong, Lindsay M Squeglia","doi":"10.1017/cts.2025.19","DOIUrl":"https://doi.org/10.1017/cts.2025.19","url":null,"abstract":"<p><p>Racially and ethnically minoritized individuals, first-generation college students, and women are significantly underrepresented in science, technology, engineering, and mathematics (STEM) careers. This lack of equal representation limits creativity and progress in these fields and perpetuates systemic barriers that discourage students from pursuing STEM pathways. This special communication introduces the three-tiered mentorship model employed in the Teen Science Ambassador Program (TSAP), which incorporates senior mentors, near-peer mentors, and high school ambassadors (i.e., mentees) to promote education, hands-on research, and career development in STEM for underrepresented students. We discuss the benefits and challenges of the three-tiered model and offer recommendations for optimizing its effectiveness to enhance mentorship experiences for all participants. Findings from the TSAP program suggest that the three-tiered approach benefited all participants: high school ambassadors gained STEM skills and confidence, near-peer mentors developed leadership and communication abilities, and senior mentors improved mentorship skills. However, the effectiveness of near-peer mentorship is highly dependent on clearly defined roles and structured involvement. Thus, feedback collected from each mentorship tier was used to inform subsequent iterations of the program. The layered mentorship structure fostered a sense of community and belonging, which is crucial for retaining individuals from underrepresented groups in STEM.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e54"},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementing TeamMAPPS: Formative qualitative findings from the dissemination and implementation study of a new evidence-based team science intervention.","authors":"Stephen Molldrem, Heidi Luft, Jeffrey S Farroni, Elizabeth J Lyons, Kevin Wooten","doi":"10.1017/cts.2025.22","DOIUrl":"10.1017/cts.2025.22","url":null,"abstract":"<p><strong>Introduction: </strong>Team Methods to Advance Processes and Performance in Science (TeamMAPPS) is an evidence-based Team Science competency model and intervention. TeamMAPPS was developed by experts in the Science of Team Science with translational teams in mind. TeamMAPPS focuses on three core teamwork competencies: (1) psychological safety, (2) awareness and exchange, and (3) self-correction and adaptation. In 2023, the TeamMAPPS framework was operationalized into five online training modules that can be used to train whole teams or individuals, with or without facilitation, in any order. This article reports formative findings from the pre-implementation stage of the TeamMAPPS Dissemination and Implementation (D&I) study.</p><p><strong>Methods: </strong>We conducted 27 interviews and participant-observation fieldwork with 23 individuals involved in the conceptualization, design, or implementation of TeamMAPPS (four were interviewed twice). All implementers were affiliated with a Clinical and Translational Science Award (CTSA) hub. Data were collected during pre-implementation, when modules were being tested and early-stage implementers were being trained. We used D&I theories and frameworks to structure the study, analyze interview data, and recommend implementation strategies.</p><p><strong>Findings: </strong>\"Adoption,\" \"reach,\" and \"effectiveness\" emerged as key implementation outcomes. TeamMAPPS was perceived to be evidence-based, highly adaptable, and a Team Science intervention offering unique benefits. We draw on participants' responses and expert recommendations to suggest implementation strategies.</p><p><strong>Conclusions: </strong>CTSAs and other organizations can use varied strategies to implement TeamMAPPS. The flexibility of the intervention and its rootedness in an evidence-base synthesized by Team Science leaders make TeamMAPPS appealing for CTSAs seeking to enhance their team training offerings.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e68"},"PeriodicalIF":2.1,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Goal alignment and unintended consequences of accountable care: How the structure of Oregon's Medicaid coordinated care model shapes health plan-clinic partnerships.","authors":"Erin S Kenzie, Jean Campbell, Mellodie Seater, Maya A Singh, Alissa Robbins, Melinda M Davis","doi":"10.1017/cts.2025.26","DOIUrl":"10.1017/cts.2025.26","url":null,"abstract":"<p><strong>Introduction: </strong>Accountable care models for Medicaid reimbursement aim to improve care quality and reduce costs by linking payments to performance. Oregon's coordinated care organizations (CCOs) assume financial responsibility for their members and are incentivized to help clinics improve performance on specific quality metrics. This study explores how Oregon's CCO model influences partnerships between payers and primary care clinics, focusing on strategies used to enhance screening and treatment for unhealthy alcohol use (UAU).</p><p><strong>Methods: </strong>In this qualitative study, we conducted semi-structured interviews with informants from 12 of 13 Oregon CCOs active in 2019 and 2020. The interviews focused on payer-provider partnerships, specifically around UAU screening and treatment, which is a long-standing CCO metric. We used thematic analysis to identify key themes and causal-loop diagramming to uncover feedback dynamics and communicate key findings. Meadows' leverage point framework was applied to categorize findings based on their potential to drive change.</p><p><strong>Results: </strong>CCO strategies to support clinics included building relationships, reporting on metric progress, providing EHR technical assistance, offering training, and implementing alternative payment methods. CCOs prioritized clinics with more members and those highly motivated. Our analysis showed that while the CCO model aligned goals between payers and clinics, it may perpetuate rural disparities by prioritizing larger, better-resourced clinics.</p><p><strong>Conclusions: </strong>Oregon's CCO model fosters partnerships centered on quality metrics but may unintentionally reinforce rural disparities by incentivizing support for larger clinics. Applying the Meadows framework highlighted leverage points within these partnerships.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e46"},"PeriodicalIF":2.1,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}