Journal of Clinical and Translational Science最新文献_第10页

Team training in the real world: A cluster-randomized hybrid effectiveness-implementation trial of TeamTRACS in rural Children's Advocacy Centers. 现实世界中的团队培训：TeamTRACS在农村儿童倡导中心的集群-随机混合效果实施试验。

IF 2

Journal of Clinical and Translational Science Pub Date : 2025-11-26 eCollection Date: 2025-01-01 DOI: 10.1017/cts.2025.10203

Elizabeth A McGuier, Jaely D Wright, Greg Flett, Scott D Rothenberger, Eduardo Salas, David J Kolko

{"title":"Team training in the real world: A cluster-randomized hybrid effectiveness-implementation trial of TeamTRACS in rural Children's Advocacy Centers.","authors":"Elizabeth A McGuier, Jaely D Wright, Greg Flett, Scott D Rothenberger, Eduardo Salas, David J Kolko","doi":"10.1017/cts.2025.10203","DOIUrl":"10.1017/cts.2025.10203","url":null,"abstract":"Introduction: Children's Advocacy Centers (CACs) use multidisciplinary teams to respond to child abuse allegations. These fluid teams can benefit from team training to enhance team functioning and performance and strengthen the workforce, but they need guidance and resources to support the implementation of team training.Methods: We conducted a cluster-randomized hybrid effectiveness-implementation trial to test the effectiveness of team training and evaluate a self-guided implementation process. Six rural CACs (N = 172 team members) were randomized to TeamTRACS (Team Training in Roles, Awareness, Communication, & Support; n = 4) or a waitlist comparison (n = 2). Simultaneous mixed methods evaluated the effectiveness of TeamTRACS (QUAN + qual) and the implementation process (quan + QUAL).Results: Reactions to TeamTRACS were positive (mean ratings > 4.5 on 1-5 scale), and TeamTRACS significantly increased teamwork knowledge (estimated marginal means = 80% vs. 75% [intent-to-treat]; 85% vs. 76% [training attendance]). There were no effects on skill use or work-related outcomes. Changes in team-level outcomes were small and inconsistent; one TeamTRACS team made substantial improvements. Reactions to self-guided implementation were positive (mean ratings > 4 on 1-5 scale). However, only one team completed the implementation process. Challenges included difficulty forming and maintaining a change team, turnover and understaffing, and competing priorities and a short timeframe.Conclusions: Overall, TeamTRACS and its self-guided implementation process were positively received. Incomplete implementation may have limited TeamTRACS' effectiveness. Longer timeframes and external support may improve the implementation of team training in low-resource settings.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e275"},"PeriodicalIF":2.0,"publicationDate":"2025-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supporting rural primary care through Project ECHO: A brief case report. 通过ECHO项目支持农村初级保健：一个简短的案例报告。

IF 2

Journal of Clinical and Translational Science Pub Date : 2025-11-17 eCollection Date: 2025-01-01 DOI: 10.1017/cts.2025.10196

Jennifer L Kraschnewski, Laura L Felix, Sarah Cichy, Matthew Silvis, Chad Shaffer, Erik B Lehman, Ruth Hogentogler, Cynthia H Chuang

引用次数: 0

Developing a genetic return of results service core. 开发遗传结果返回服务核心。

IF 2

Journal of Clinical and Translational Science Pub Date : 2025-11-17 eCollection Date: 2025-01-01 DOI: 10.1017/cts.2025.10197

Jennifer A McKenzie, Erin McRoy, Kevin M Bowling, Jorge Luis Granadillo De Luque, Jessica Mozersky, Erin Linnenbringer, Dustin Baldridge, Jonathan W Heusel, Julie A Neidich, Amanda F Cashen, Laura J Bierut, Sarah M Hartz, Christina A Gurnett

{"title":"Developing a genetic return of results service core.","authors":"Jennifer A McKenzie, Erin McRoy, Kevin M Bowling, Jorge Luis Granadillo De Luque, Jessica Mozersky, Erin Linnenbringer, Dustin Baldridge, Jonathan W Heusel, Julie A Neidich, Amanda F Cashen, Laura J Bierut, Sarah M Hartz, Christina A Gurnett","doi":"10.1017/cts.2025.10197","DOIUrl":"10.1017/cts.2025.10197","url":null,"abstract":"Research participants should be informed of genetic test results that could impact their health, particularly when they have expressed interest in receiving such information. Furthermore, the return of genetic test results is essential to improve trust, transparency, and health equity. However, investigators often encounter barriers in returning genetic test results to research participants. We examined genomic research at a large, research-intensive medical school and found less than 6% of protocols included plans to return results to participants. This study describes our development of protocols for returning primary and secondary genetic test results and implementation of a Genomic Return of Results (gROR) service. This arose through a collaboration with experts in community engagement, genetics, and pathology to consider consent adequacy, analytical/clinical validity, and clinical utility when returning results. The gROR service reduces investigator burden and provides participants with genetic information and guidance to address any potential health risks. Genetic results are returned by a genetic counselor at no cost to participants or their family. Investigator costs are subsidized to incentivize the delivery of actionable genetic test results to research participants. Our approach prioritizes transparency, accessibility, and informed decision-making, thereby promoting equitable sharing of genetic knowledge and personalized healthcare interventions.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e265"},"PeriodicalIF":2.0,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patient attitudes toward HPV self-sampling and community health worker-delivered cervical cancer screening services in an underserved area. 在服务不足的地区，患者对HPV自我抽样和社区卫生工作者提供的宫颈癌筛查服务的态度。

IF 2

Journal of Clinical and Translational Science Pub Date : 2025-11-17 eCollection Date: 2025-01-01 DOI: 10.1017/cts.2025.10172

Mrithula Suresh Babu, Monica L Kasting, Natalia M Rodriguez

{"title":"Patient attitudes toward HPV self-sampling and community health worker-delivered cervical cancer screening services in an underserved area.","authors":"Mrithula Suresh Babu, Monica L Kasting, Natalia M Rodriguez","doi":"10.1017/cts.2025.10172","DOIUrl":"10.1017/cts.2025.10172","url":null,"abstract":"Introduction: In Indiana, Black women had 12% higher cervical cancer incidence, and 21% higher mortality compared to White women during the years 2008-2017. Human Papillomavirus (HPV) self-sampling delivered by community health workers (CHW) has demonstrated potential to increase cervical cancer screening rates among at-risk populations. This study aims to understand patient attitudes toward HPV self-sampling and CHW-delivered screening.Methods: We conducted a cross-sectional online survey among patients from three Planned Parenthood clinics in Lake County, IN, which has one of the highest cervical cancer mortality rates in Indiana. Patients' willingness to self-sample and to receive health education and services related to cervical cancer screening from CHWs was analyzed using logistic regression.Results: In the final sample (N = 140), the largest proportions of respondents were below age 30 (54.3%), aware of cervical cancer (78.6%), up to date on cervical cancer screening (84.3%), had no prior self-sampling experience (53.6%) and were aware of CHWs (52.1%). Multivariable logistic regression analyses showed Black patients had higher odds of being willing to: self-sample at home (aOR = 3.749, 95% CI = 1.619-8.681), receive health education from CHWs (aOR = 4.952, 95% CI = 2.124-11.548), and receive health services from CHWs (aOR = 3.305, 95% CI = 1.479-7.388) compared to White patients.Conclusion: Our results showed Black patients had higher willingness for HPV self-sampling and CHW delivery of cervical cancer screening services. Study findings can be used to inform future CHW-led interventions for outreach, education, and delivery of self-sampling interventions to increase cervical cancer screening rates among Black women in underserved areas.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e270"},"PeriodicalIF":2.0,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12722056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145827840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing survey delivery methods in healthcare: A randomized study. 比较医疗保健中的调查递送方法：一项随机研究。

IF 2

Journal of Clinical and Translational Science Pub Date : 2025-11-17 eCollection Date: 2025-01-01 DOI: 10.1017/cts.2025.10195

Gayane Tumyan, Kathleen Esselink, Ann Marie Navar, Ildiko Lingvay

{"title":"Comparing survey delivery methods in healthcare: A randomized study.","authors":"Gayane Tumyan, Kathleen Esselink, Ann Marie Navar, Ildiko Lingvay","doi":"10.1017/cts.2025.10195","DOIUrl":"10.1017/cts.2025.10195","url":null,"abstract":"Objective: To compare healthcare survey response rates using two widely utilized recruitment methods: email and the electronic health record (EHR) patient portal.Materials and methods: Adults with a prior history of any bariatric surgery were randomly assigned (1:1) to receive a survey invitation via email or through the EHR patient portal. A second reminder was sent using the same method. A third invitation used a crossover approach, switching to the alternate method. We compared survey completion rates, changes in research preference status, and time to survey completion. Predictors of response were assessed using multivariable logistic regression.Results: The email group had a 9.9% response rate after the first invitation and 6.5% after the second. The EHR portal group had 8.4% and 4.5% response rates, respectively. Following crossover, the third invitation yielded a 4.4% response for those switched to the EHR portal and 7.5% for those switched to email. The EHR portal group was 27% less likely to complete the survey compared to the email group. Respondents were more likely to be female, non-Hispanic, White, have a recent healthcare encounter, and have recently logged into the portal. Median time to completion was under 24 hours in both groups, with over two-thirds of responses received on the day of or the day after the invitation. A change in research preference status was observed in 2.5% of email and 4.0% of portal participants.Discussion and conclusion: Email-based recruitment yielded higher response rates than EHR portal-based recruitment, with most responses occurring shortly after invitation.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e263"},"PeriodicalIF":2.0,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking the potential of Contract Research Organizations in Africa's clinical trials ecosystem. 释放合同研究组织在非洲临床试验生态系统中的潜力。

IF 2

Journal of Clinical and Translational Science Pub Date : 2025-11-12 eCollection Date: 2025-01-01 DOI: 10.1017/cts.2025.10194

Shiferaw Tesfaye Tilahun, Tsegahun Manyazewal, Immanuel Azaad Moonesar, Hee Soo Kim

{"title":"Unlocking the potential of Contract Research Organizations in Africa's clinical trials ecosystem.","authors":"Shiferaw Tesfaye Tilahun, Tsegahun Manyazewal, Immanuel Azaad Moonesar, Hee Soo Kim","doi":"10.1017/cts.2025.10194","DOIUrl":"10.1017/cts.2025.10194","url":null,"abstract":"Despite representing 18% of the world's population and 20% of the disease burden, only an estimated 2% of global clinical trials include at least one study site in Africa. This underscores the critical need for continued research on how to overcome clinical trial challenges on the continent. In countries with established reputations for clinical trials, Contract Research Organizations (CROs) play a vital role, accounting for half of the research workforce and effectively managing clinical trials for pharmaceutical, biotechnology, and medical device companies. In contrast, the potential of CROs in Africa's clinical trials ecosystem remains largely unexplored. This narrative review discusses the challenges, opportunities, best practices, emerging trends, and prospects of clinical trials in Africa. Major challenges in clinical trial implementation in Africa stem from gaps in financial and human resources, infrastructure, and regulatory systems, while opportunities are linked to Africa's large population, genetic diversity, disease burden, lower operating costs, positive economic outlook, and growing interest from global health and research players. Emerging trends, such as the decentralization of clinical trials and conducting trials during public health emergencies, offer promising avenues for maintaining research continuity. Ultimately, the paper proposes a context-specific framework, aimed at maximizing the effectiveness of CROs in the continent's clinical trials ecosystem.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e272"},"PeriodicalIF":2.0,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protocol for applying an enhanced quality-by-design program across the translational science spectrum. 在转化科学领域应用增强的设计质量方案的协议。

IF 2

Journal of Clinical and Translational Science Pub Date : 2025-11-12 eCollection Date: 2025-01-01 DOI: 10.1017/cts.2025.10200

Allison Zumberge Orechwa, Leslie Aguilar, Megan Castiel, Cathelin Huang, Jeanne Dzekov, Nicole M G Maccalla, Wendy Mack, Zoe Mele, Kaelyn Moses, Cecilia Patino-Sutton, Saira Shah, Amytis Towfighi, Thomas Buchanan

{"title":"Protocol for applying an enhanced quality-by-design program across the translational science spectrum.","authors":"Allison Zumberge Orechwa, Leslie Aguilar, Megan Castiel, Cathelin Huang, Jeanne Dzekov, Nicole M G Maccalla, Wendy Mack, Zoe Mele, Kaelyn Moses, Cecilia Patino-Sutton, Saira Shah, Amytis Towfighi, Thomas Buchanan","doi":"10.1017/cts.2025.10200","DOIUrl":"10.1017/cts.2025.10200","url":null,"abstract":"The quality by design (QbD) framework holds promise for improving success rates for completion of clinical studies, which often fail to complete on time. Initially used in manufacturing, the framework is now frequently applied to clinical trials to anticipate risks and avoid challenges that impact study completion or the credibility of results. The Southern California Clinical and Translational Science Institute created and implemented a program based on QbD to increase the success of research studies, including clinical trials and other study designs, being conducted by scholars in our Mentored Career Development Program and awardees in our Pilot Grant Programs. The program's three components are QbD Design Studios, project management, and team science support. The overall goal is to increase study quality and efficiency, thereby improving study completion success rates and, ultimately, driving innovations in healthcare and public health. The current article describes QbD program elements in detail, along with preliminary results from initial implementation, approaches for evaluating the program's implementation and impact on study success, and plans to disseminate the program widely.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e269"},"PeriodicalIF":2.0,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence-based strategies for delivering grant writing skills to clinical and translational science faculty in the Mountain West. 为西部山区临床和转化科学教师提供拨款写作技巧的循证策略。

IF 2

Journal of Clinical and Translational Science Pub Date : 2025-11-12 eCollection Date: 2025-01-01 DOI: 10.1017/cts.2025.10198

Ruben K Dagda, Larissa Myaskovsky, Akshay Sood, Kathrene Conway, Joseph Guerrero Lopez, Mark Burge, Lorraine S Evangelista, Francisco S Sy

{"title":"Evidence-based strategies for delivering grant writing skills to clinical and translational science faculty in the Mountain West.","authors":"Ruben K Dagda, Larissa Myaskovsky, Akshay Sood, Kathrene Conway, Joseph Guerrero Lopez, Mark Burge, Lorraine S Evangelista, Francisco S Sy","doi":"10.1017/cts.2025.10198","DOIUrl":"10.1017/cts.2025.10198","url":null,"abstract":"Acquiring the skills to obtain extramural funding is a major challenge for early- and mid-career investigators. The Professional Development Core (PDC) of the NIH-funded Mountain West Clinical and Translational Research Infrastructure Network (MW CTR-IN) aims to support early-stage and mid-career investigators pursuing independent careers in clinical and translational science research. Since 2018, the PDC's Grant Writing Workshops (GWWs) have provided CTR investigators with didactic content and interactive feedback on their NIH grant applications, helping them reach this key career milestone. Four one-day GWWs were offered in person, and two half-day GWWs were offered virtually across two days during the COVID-19 pandemic. Evaluation data for each cohort revealed that participants' knowledge and confidence in the relevant sections of NIH R-series grants consistently improved following GWW attendance and resulted in notable enhancements in participants' feelings of positivity toward grant writing, regardless of delivery mode (virtual vs. in-person). Follow-up data showed that 12 GWW participants acquired external funding with a 21% success rate and $12,584,938 in total funding. This manuscript provides a roadmap for planning and implementing a successful virtual or in-person GWW that positively impacts the careers of early-stage and mid-career investigators.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e268"},"PeriodicalIF":2.0,"publicationDate":"2025-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A paired survey study on community perceptions of clinical trials: Shaping outcomes across medical fields. 一项关于社区对临床试验看法的配对调查研究：塑造跨医学领域的结果。

IF 2

Journal of Clinical and Translational Science Pub Date : 2025-11-12 eCollection Date: 2025-01-01 DOI: 10.1017/cts.2025.10199

Mallory Von Lotten, Meredith Burns, Passiah L White, Tiffany Mayo

引用次数: 0

Centralized clinical research operations reporting for a multi-network, multi-study research program: The NHLBI COVID-19 CONNECTS experience. 多网络、多研究研究项目的集中临床研究操作报告：NHLBI COVID-19 CONNECTS体验。

IF 2

Journal of Clinical and Translational Science Pub Date : 2025-11-11 eCollection Date: 2025-01-01 DOI: 10.1017/cts.2025.10189

Kayla Nowak, Sean Hanlon, Jeanette Auman, Heather Meier, Katherine Asman, Tracy Nolen

{"title":"Centralized clinical research operations reporting for a multi-network, multi-study research program: The NHLBI COVID-19 CONNECTS experience.","authors":"Kayla Nowak, Sean Hanlon, Jeanette Auman, Heather Meier, Katherine Asman, Tracy Nolen","doi":"10.1017/cts.2025.10189","DOIUrl":"10.1017/cts.2025.10189","url":null,"abstract":"The Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies (CONNECTS) was a novel network of networks created in response to the COVID-19 pandemic. This program brought together a large matrix of clinical research networks to swiftly design and/or implement concurrent clinical studies. Successful coordination of this large-scale collaboration required innovative solutions for timely and transparent centralized operations reporting. As the Administrative Coordinating Center (ACC) for CONNECTS, RTI International developed and maintained a web-based infrastructure that served as the central communication and reporting hub. This single-platform approach provided a robust collection of key topics to support daily operational oversight (e.g., enrollment and retention, site coverage, study milestones, financial tracking). Underlying data acquisition, harmonization, and portal reporting methods aimed to address nuances of the network of networks (e.g., disparate data sources, diverse user needs) while providing the necessary speed and agility to combat the COVID-19 pandemic. The resulting system was well received, readily adapted to changes, and successfully supported three years of early COVID-19 research. Although the CONNECTS central reporting methods arose from necessity during an urgent and dynamic public health emergency, they are a model for efficient and effective centralized operational reporting for any large-scale public health research effort.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e264"},"PeriodicalIF":2.0,"publicationDate":"2025-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12779487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145952218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0