Journal of Clinical and Translational Science最新文献

{"title":"Community-driven partnerships with Community-Engaged Research teams bring resources and reliable information to Baltimore residents.","authors":"Emily Kumpf, Veena Thamilselvan, Ethan Wang, Patricia Barger, Janice Gentry, Chevelle Bash, Donald Young, Samuel Byiringiro, Joann Bodurtha, Antoinette Brown, Minli Guo, Audrey Carter, Latrice Price, Percy Smith, Cyd Lacanienta, Cheryl Himmelfarb, Albert W Wu","doi":"10.1017/cts.2024.606","DOIUrl":"10.1017/cts.2024.606","url":null,"abstract":"<p><p>This case study presents an analysis of community-driven partnerships, focusing on the nonprofit Baltimore CONNECT (BC) network and its collaborative efforts with a Community-Engaged Research (CEnR) team of the Johns Hopkins Institute for Clinical and Translational Research (ICTR). BC has built a network of over 30 community-based organizations to provide health and social services in Baltimore City. The study emphasizes the role of CEnR in supporting community-led decision-making, specifically in the planning and implementation of community health resource fairs. These fairs address social determinants of health by offering a variety of services, including health education, screenings, vaccinations, and resource distribution. The paper details the methods, resource mobilization, and collaborative framing processes in the execution of these fairs in a community-academic collaboration with the ICTR. Results from a 2.5-year period show the positive impact of the fairs on individuals, families, and the community at large in East Baltimore. The findings underscore the importance of community-led collaborations in addressing health disparities and improving overall community well-being. It concludes by reflecting on the sustained engagement, trust-building, and shared learning that emerges from such partnerships, suggesting a model for future community-academic health initiatives.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e205"},"PeriodicalIF":2.1,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: 264 Building Empowerment through FITness (BeFIT) - CORRIGENDUM.","authors":"Kimberly McCall, Keith McGregor, Jewell Dickson, Raymond Jones, Samantha Giordano-Mooga, Shellie Layne","doi":"10.1017/cts.2024.633","DOIUrl":"https://doi.org/10.1017/cts.2024.633","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1017/cts.2024.240.].</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e169"},"PeriodicalIF":2.1,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: 178 Pace and Pitch: Predictive Factors for Seed Funding and Development - CORRIGENDUM.","authors":"Alyson Eggleston, Camelia Kantor","doi":"10.1017/cts.2024.634","DOIUrl":"https://doi.org/10.1017/cts.2024.634","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1017/cts.2024.169.].</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e171"},"PeriodicalIF":2.1,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: 93 Investigating the minimal requirements for startup procurement by healthcare institutions in Ontario, Canada - CORRIGENDUM.","authors":"Zoya Aziz Bhatti, Derek Choi, Joseph Ferenbok, Edyta Marcon, Marissa Bird, Juli Smyth, Bibaswan Ghoshal","doi":"10.1017/cts.2024.635","DOIUrl":"https://doi.org/10.1017/cts.2024.635","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1017/cts.2024.91.].</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e168"},"PeriodicalIF":2.1,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and results of a novel emergency medicine residency research immersion program.","authors":"Kaitlin Ray, Catherine Burger, Alexander T Clark, Emily K Pauw, Wesley H Self, Jesse O Wrenn, William B Stubblefield, Jin H Han, Michael J Ward","doi":"10.1017/cts.2024.626","DOIUrl":"10.1017/cts.2024.626","url":null,"abstract":"<p><p>Creating a sustainable residency research program is necessary to develop a sustainable research pipeline, as highlighted by the recent Society for Academic Emergency Medicine 2024 Consensus Conference. We sought to describe the implementation of a novel, immersive research program for first-year emergency medicine residents. We describe the curriculum development, rationale, implementation process, and lessons learned from the implementation of a year-long research curriculum for first-year residents. We further evaluated resident perception of confidence in research methodology, interest in research, and the importance of their research experience through a 32-item survey. In two cohorts, 25 first-year residents completed the program. All residents met their scholarly project requirements by the end of their first year. Two conference abstracts and one peer-reviewed publication were accepted for publication, and one is currently under review. Survey responses indicated that there was an increase in residents' perceived confidence in research methodology, but this was limited by the small sample size. In summary, this novel resident research curriculum demonstrated a standardized, reproducible, and sustainable approach to provide residents with an immersive research program.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e170"},"PeriodicalIF":2.1,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating adoption and reach in a pragmatic randomized trial of community paramedicine for intermediate acuity patient care.","authors":"Jennifer L Ridgeway, Wendy J S Sundt, Tami S Krpata, Amy Glasgow, Olivia A Smith, Michelle A Lampman, Jamie L Smith-Stellflug, Terri L Menser, Michael B Juntunen, Chad P Liedl, Joseph G Hentz, Jessica J McCoy, Rozalina G McCoy","doi":"10.1017/cts.2024.646","DOIUrl":"10.1017/cts.2024.646","url":null,"abstract":"<p><strong>Introduction: </strong>Pragmatic trials aim to speed translation to practice by integrating study procedures in routine care settings. This study evaluated implementation outcomes related to clinician and patient recruitment and participation in a trial of community paramedicine (CP) and presents successes and challenges of maintaining pragmatic study features.</p><p><strong>Methods: </strong>Adults in the pre-hospital setting, emergency department (ED), or hospital being considered for referral to the ED/hospital or continued hospitalization for intermediate-level care were randomized 1:1 to CP care or usual care. Referral and enrollment data were tracked administratively, and patient characteristics were abstracted from the electronic health record (EHR). Enrolled patients completed baseline surveys, and a subset of intervention patients were interviewed. All CPs and a sample of clinicians and administrators were invited to complete a survey and interview.</p><p><strong>Results: </strong>Between January 2022 and February 2023, 240 enrolled patients (42% rural) completed surveys, and 22 completed an interview; 63 staff completed surveys and 20 completed an interview. Ninety-three clinicians in 27 departments made at least one referral. Factors related to referrals included program awareness and understanding the CP practice scope. Most patients were enrolled in the hospital, but characteristics were similar to the primary care population and included older and medically complex patients. Challenges to achieving representativeness included limited EHR infrastructure, constraints related to patient consenting, and clinician concerns about patient randomization disrupting preferred care.</p><p><strong>Conclusion: </strong>Future pragmatic trials in busy clinical settings may benefit from regulatory policies and EHR capabilities that allow for real-world study conduct and representative participation. Trial registration: NCT05232799.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e199"},"PeriodicalIF":2.1,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embedding clinical trial elements into clinical practice: Experiences from trial designers and implementers.","authors":"Carrie Dombeck, Teresa Swezey, Lindsay Kehoe, Kraig Kinchen, Matthew Roe, Mark Stewart, Amy Corneli","doi":"10.1017/cts.2024.647","DOIUrl":"10.1017/cts.2024.647","url":null,"abstract":"<p><strong>Introduction: </strong>Researchers and policymakers recognize that leveraging data routinely collected in clinical practice can support improved research and patient care. Embedding elements of clinical trials, such as patient identification and trial data acquisition, into clinical practice can enable research access and increase efficiencies by reducing duplication of trial and care activities. Yet, cultural, administrative, and data barriers exist. The Clinical Trials Transformation Initiative (CTTI) developed evidenced-based, multi-partner recommendations to facilitate embedding interventional, randomized trials into clinical practice.</p><p><strong>Methods: </strong>We conducted in-depth interviews (IDIs) with trial designers and implementers to describe their motivations for embedding interventional, randomized trials into clinical practice. Additionally, we aimed to identify barriers and potential solutions to implementing such trials. Interviews were audio-recorded and analyzed using applied thematic analysis.</p><p><strong>Results: </strong>We conducted 16 IDIs with 18 trial designers and implementers. Motivations for embedding trials into clinical practice included the desire to implement a learning health system and evaluate trials in real-world settings. Barriers to trial implementation focused on limited staff time and availability, the lack of buy-in, and difficulties using electronic health record data. Solutions included minimizing healthcare settings and patient burden, having a sufficient data and research infrastructure in place, and creating a culture change.</p><p><strong>Conclusion: </strong>The results informed CTTI recommendations to facilitate the design and operation of embedded trials. These recommendations emphasize areas where sponsors and investigators can rethink the design and conduct of clinical trials to ultimately realize an aligned system of research and care.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"202"},"PeriodicalIF":2.1,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626573/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using the Translational Science Benefits Model to assess the impact of the Penn Implementation Science Center in Cancer Control.","authors":"Robert Schnoll, Justin E Bekelman, Daniel Blumenthal, David A Asch, Alison M Buttenheim, Krisda H Chaiyachati, Susan M Domchek, Oluwadamilola M Fayanju, Peter Gabriel, Brian P Jenssen, Frank T Leone, Anne Marie McCarthy, Katherine L Nathanson, Ravi B Parikh, Katharine A Rendle, Rachel C Shelton, Lawrence N Shulman, Samuel U Takvorian, Susan Ware, E Paul Wileyto, Rinad S Beidas","doi":"10.1017/cts.2024.554","DOIUrl":"https://doi.org/10.1017/cts.2024.554","url":null,"abstract":"<p><p>Traditional approaches for evaluating the impact of scientific research - mainly scholarship (i.e., publications, presentations) and grant funding - fail to capture the full extent of contributions that come from larger scientific initiatives. The Translational Science Benefits Model (TSBM) was developed to support more comprehensive evaluations of scientific endeavors, especially research designed to translate scientific discoveries into innovations in clinical or public health practice and policy-level changes. Here, we present the domains of the TSBM, including how it was expanded by researchers within the Implementation Science Centers in Cancer Control (ISC3) program supported by the National Cancer Institute. Next, we describe five studies supported by the Penn ISC3, each focused on testing implementation strategies informed by behavioral economics to reduce key practice gaps in the context of cancer care and identify how each study yields broader impacts consistent with TSBM domains. These indicators include <i>Capacity Building, Methods Development</i> (within the Implementation Field) and <i>Rapid Cycle Approaches</i>, implementing <i>Software Technologies</i>, and improving <i>Health Care Delivery</i> and <i>Health Care Accessibility</i>. The examples highlighted here can help guide other similar scientific initiatives to conceive and measure broader scientific impact to fully articulate the translation and effects of their work at the population level.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e166"},"PeriodicalIF":2.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Spanish translation, adaptation, and validation of a Community-Engaged Research survey and a pragmatic short version: Encuesta Comunitaria and FUERTES.","authors":"Patricia Rodriguez Espinosa, Juan M Peña, Carlos Devia, Blake Boursaw, Magdalena Avila, Diana Rudametkin, Sergio Aguilar-Gaxiola, Margarita Alegria, Lourdes E Soto de Laurido, Edna Acosta Pérez, Nina Wallerstein","doi":"10.1017/cts.2024.613","DOIUrl":"10.1017/cts.2024.613","url":null,"abstract":"<p><strong>Introduction: </strong>Community-Engaged Research (CEnR) and Community-Based Participatory Research (CBPR) require validated measures and metrics for evaluating research partnerships and outcomes. There is a need to adapt and translate existing measures for practical use with diverse and non-English-speaking communities. This paper describes the Spanish translation and adaptation of Engage for Equity's Community Engagement Survey (E² CES), a nationally validated and empirically-supported CEnR evaluation tool, into the full-length \"<i>Encuesta Comunitaria</i>,\" and a pragmatic shorter version \"<i>Fortaleciendo y Uniendo EsfueRzos Transdisciplinarios para Equidad de Salud</i>\" (FUERTES).</p><p><strong>Methods: </strong>Community and academic partners from the mainland US, Puerto Rico, and Nicaragua participated in translating and adapting E² CES, preserving content validity, psychometric properties, and importance to stakeholders of items, scales, and CBPR constructs (contexts, partnership processes, intervention and research actions, and outcomes). Internal consistency was assessed using Cronbach's alpha and convergent validity was assessed via a correlation matrix among scales.</p><p><strong>Results: </strong><i>Encuesta Comunitaria</i> respondents (<i>N</i> = 57) self-identified as primarily Latinos/as/x (97%), female (74%), and academics (61%). Cronbach's alpha values ranged from 0.72 to 0.88 for items in the context domain to 0.90-0.92 for items in the intervention/research domain. Correlations were found as expected among subscales, with the strongest relationships found for subscales within the same CBPR domain. Results informed the creation of FUERTES.</p><p><strong>Conclusions: </strong><i>Encuenta Comunitaria</i> and FUERTES offer CEnR/CBPR practitioners two validated instruments for assessing their research partnering practices, and outcomes. Moreover, FUERTES meets the need for shorter pragmatic tools. These measures can further strengthen CEnR/CBPR involving Latino/a/x communities within the US, Latin America, and globally.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e165"},"PeriodicalIF":2.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical researchers' insights on key data for eligibility screening in clinical studies.","authors":"Betina Idnay, Emily R Gordon, Aubrey S Johnson, Jordan G Nestor, Karen Marder, Chunhua Weng","doi":"10.1017/cts.2024.617","DOIUrl":"https://doi.org/10.1017/cts.2024.617","url":null,"abstract":"<p><strong>Introduction: </strong>Clinical research is critical for healthcare advancement, but participant recruitment remains challenging. Clinical research professionals (CRPs; e.g., clinical research coordinator, research assistant) perform eligibility prescreening, ensuring adherence to study criteria while upholding scientific and ethical standards. This study investigates the key information CRP prioritizes during eligibility prescreening, providing insights to optimize data standardization, and recruitment approaches.</p><p><strong>Methods: </strong>We conducted a freelisting survey targeting 150 CRPs from diverse domains (i.e., neurological disorders, rare diseases, and other diseases) where they listed essential information they look for from medical records, participant/caregiver inquiries, and discussions with principal investigators to determine a potential participant's research eligibility. We calculated the salience scores of listed items using Anthropac, followed by a two-level analytic procedure to classify and thematically categorize the data.</p><p><strong>Results: </strong>The majority of participants were female (81%), identified as White (44%) and as non-Hispanic (64.5%). The first-level analysis universally emphasized age, medication list, and medical history across all domains. The second-level analysis illuminated domain-specific approaches in information retrieval: for instance, history of present illness was notably significant in neurological disorders during participant and principal investigator inquiries, while research participation was distinctly salient in potential participant inquiries within the rare disease domain.</p><p><strong>Conclusion: </strong>This study unveils the intricacies of eligibility prescreening, with both universal and domain-specific methods observed. Variations in data use across domains suggest the need for tailored prescreening in clinical research. Incorporating these insights into CRP training and refining prescreening tools, combined with an ethical, participant-focused approach, can advance eligibility prescreening practices.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e167"},"PeriodicalIF":2.1,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}