Journal of Clinical and Translational Science最新文献

{"title":"Building capacity, driving impact: A landscape analysis of community engagement and outreach cores' activities.","authors":"Emily Frankel, Stephanie Broyles, Stephenie Kennedy-Rea, Casey Solsrud, Elizabeth Woods, Deborah Goebert, Zsolt Nagykaldi, Holly Huye, Lee M Pachter","doi":"10.1017/cts.2026.10781","DOIUrl":"10.1017/cts.2026.10781","url":null,"abstract":"<p><p>Community Engagement and Outreach (CEO) Cores are a key component of the IDeA Clinical and Translational Research (IDeA-CTR) Program, serving to develop and implement capacity-building initiatives that empower communities to engage and collaborate with investigators in community-engaged research. To strengthen collaboration and shared learning across sites, a CEO Special Interest Group was established. In 2022, the group conducted a landscape analysis to systematically characterize and categorize CEO Core activities across the IDeA-CTR network, with a focus on capacity-building efforts related to knowledge transfer, co-learning, and infrastructure development. The analysis revealed several common approaches to community engagement and capacity building across sites, as well as distinctive strategies tailored to the specific needs and communities served. Multiple innovative practices were identified and disseminated across the network, highlighting opportunities to enhance collective impact and inform future community-engaged efforts.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e124"},"PeriodicalIF":2.7,"publicationDate":"2026-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NCATS TL1/T32 William Schnaper Visiting Scientist program: Trainee-driven mini-symposium.","authors":"Alexander Thomas Brunfeldt, Brittany M Hufft-Martinez, Jason S Hatfield, My Linh H Nguyen-Novotny, Kathryn Sandberg, Dexter Lee, Desiree M Sigala","doi":"10.1017/cts.2026.10802","DOIUrl":"10.1017/cts.2026.10802","url":null,"abstract":"<p><p>The William Schnaper Visiting Scientist (WSVS) Mini-Symposium was established within the National Center for Advancing Translational Sciences (NCATS) Clinical and Translational Science Award (CTSA) consortium to provide predoctoral and postdoctoral trainees with opportunities to present research, develop communication skills, and foster cross-institutional collaboration through a fully virtual, trainee-centered format. We describe the structure, implementation, and outcomes of seven WSVS Mini-Symposia conducted from 2021 to 2025. Program metrics included participation across CTSA hubs, trainee roles, research domains represented, and survey-based evaluations from presenters and attendees assessing perceived value, professional development, and program logistics. Seven symposia featured 62 trainee presenters from 28 CTSA hubs across 21 U.S. states. Most presenters were predoctoral trainees (79%), and research spanned basic (34%), clinical (52%), and implementation/public health (13%) domains. Survey responses indicated strong perceived benefit: 100% of presenters reported value for professional development and roughly 50% reported receiving useful feedback and establishing new professional contacts; 78% of attendees reported the symposium was a valuable learning experience. The WSVS Mini-Symposium demonstrates that a scalable, trainee-led virtual forum can effectively promote scientific communication, networking, and workforce development across geographically distributed training programs. This model provides a sustainable framework for enhancing translational science training nationwide.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e140"},"PeriodicalIF":2.7,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring change in domains of health-related quality of life and well-being in Black or African American adolescent football athletes from rural communities across a single football season.","authors":"Jessica Wallace, Justin E Karr, Danae Delfin Talley, Eric Ingram, Claire Brewer, Trevor Anesi, Mary Margaret Williamson, Zachary Y Kerr, Tamaria Hibbler, Douglas Terry, Aaron Yengo-Kahn","doi":"10.1017/cts.2026.10794","DOIUrl":"10.1017/cts.2026.10794","url":null,"abstract":"<p><strong>Background: </strong>Physical activity and team sport participation in adolescence are associated with positive health outcomes, stronger social skills, and improved mental health. However, negative health consequences are frequently associated with contact/collision sports like football. The objective of this study was to examine any change in health-related quality of life (HRQoL) and pediatric well-being among adolescent males after participating in a single season of football.</p><p><strong>Method: </strong>A cross-sectional study design was utilized in a high school football setting. Participants included Black/African American adolescent male football players (<i>n</i> = 83) from five schools within rural Alabama. Pediatric HRQoL and well-being measures were administered at preseason and postseason, including Life Satisfaction, Emotional Support, Psychological Stress, Physical Stress, Depressive Symptoms, Sleep Disturbance, and Peer Relationships. Based on normative data, participants' scores were classified as within normal limits (WNL) (<i>T</i>-score = 40-60) or clinically reduced (<i>T</i>-score < 40) or elevated (<i>T</i>-score > 60) depending on orientation of each questionnaire. Each outcome from pre-to-postseason evaluation was compared using a within-persons <i>t</i>-test.</p><p><strong>Results: </strong>Most participants (69.9-84.3%) had HRQoL/well-being scores WNL and scores remained unchanged at postseason evaluations. However, on average, physical (<i>p</i> = 0.035, <i>d</i> = 0.24) and psychological stress (<i>p</i> = 0.014, <i>d</i> = 0.28) showed small, but significant increases from pre-to-postseason.</p><p><strong>Conclusions: </strong>Modest increases in physical and psychological stress were found from preseason to postseason. Both football and non-football-related stressors could have contributed to this change. Other HRQoL/well-being scores generally showed no change. Though the health risks associated with contact/collision sports deserve attention, current findings suggest a season of football may not be associated with adverse changes in HRQoL/well-being.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e137"},"PeriodicalIF":2.7,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445466/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An innovative and comprehensive approach to community health and research engagement using the Social Ecological Model.","authors":"Farra Kahalnik, Saundra Pennington, Libby Gracia, Emilie Ruiz, Christelle King, Robin T Higashi, Heather Kitzman, Meera J Patel","doi":"10.1017/cts.2026.10795","DOIUrl":"10.1017/cts.2026.10795","url":null,"abstract":"<p><p>Equitable participation in clinical research is essential to generating broadly generalizable findings and advancing public health. Yet persistent sociodemographic disparities, driven by mistrust, limited access, and inadequate community engagement, continue to exclude underrepresented racial and ethnic groups from research. To address these barriers, the University of Texas Southwestern Medical Center developed a comprehensive, multi-component community engagement model designed to build trust and enhance research readiness among UREG. The model integrates eight synergistic programs aligned across the five-level Social Ecological Model, including HealthStreet screening events, a Health Needs Assessment, the Community Research Registry, the North Texas Community Health Coalition, Community Engagement Grand Rounds, the Spanish Language Resource, the Community Advisory Panel, and a Community Health Grant Program. These initiatives collectively provide culturally informed outreach and structured pathways for bidirectional input from community members. Since 2023, the model has achieved substantial impact, including 5069 community-based health screenings, over 100 consultations to investigators, and more than $44 million in funded grants. Findings demonstrate that sustained, multi-level engagement can strengthen trust, expand research access, and support more equitable translational science.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e138"},"PeriodicalIF":2.7,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What does it take to support community-engaged research in an academic medical center? A mixed-methods study of community and academic perspectives.","authors":"Prajakta Adsul, Alena Kuhlemeier, Mark Wieland, Irene Sia, Sagar Dugani, Vesna D Garovic, Nina Wallerstein","doi":"10.1017/cts.2026.10771","DOIUrl":"10.1017/cts.2026.10771","url":null,"abstract":"<p><strong>Introduction: </strong>There is growing focus on community-engaged research (CEnR) in the clinical and translational sciences, supportive policies, environments, and processes within academic medical centers. The purpose of this evaluation was to gather academic and community member perspectives on key actionable strategies for supporting CEnR in an academic medical center.</p><p><strong>Materials and methods: </strong>We used a sequential mixed method design by first conducting qualitative in-depth interviews with academic leaders, investigators, and staff (total, <i>n</i> = 54) and focus group discussions with community members (<i>n</i> = 33). Themes from these qualitative data informed the adaptation of an institutional survey that gathered perspectives from a broader group of academic and community members affiliated with the institution (<i>n</i> = 85). Both qualitative and quantitative data were integrated to inform actionable strategies.</p><p><strong>Results: </strong>Survey findings revealed that the institution was perceived as committed to health equity and CEnR, but institutional respondents expressed more concerns than community members about instrumental support of the work. Interviews and focus groups highlighted the opportunity to better align research efforts with community needs through more robust CEnR infrastructure and through interface with the clinical practice to promote patient access. Academic and community members emphasized the need for authentic, sustained engagement beyond federal mandates, including financial investment, capacity-building, and fostering trust. Leaders acknowledged structural challenges, siloed efforts, and the necessity for stronger coordination to increase integration of community engagement into the institutional mission.</p><p><strong>Conclusion: </strong>Findings suggest that aligning academic leaders, researchers, staff perspectives, and community members is essential to support and promote CEnR at an institutional level.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e123"},"PeriodicalIF":2.7,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights from the development of an online toolkit to promote community-engaged substance use research in the Southwest Borderlands Region.","authors":"Andrew Gorvetzian, Maria Sanchez, Christina Phillips, Joseph Allbright, Alexandra Yonkovich, Cynthia Killough, Randy Benally, Janet Page-Reeves, Mary Alice Scott, Kimberly Page, Ivan de la Rosa","doi":"10.1017/cts.2026.10804","DOIUrl":"10.1017/cts.2026.10804","url":null,"abstract":"<p><strong>Background: </strong>Underrepresented communities in the Southwestern United States Borderlands region face disproportionate substance use disorder (SUD) burdens yet remain largely excluded from clinical trials. No existing resource integrates health beliefs, research literacy, and vulnerability frameworks to support diverse community engagement in SUD clinical trials.</p><p><strong>Methods: </strong>We developed the Exploring Health Beliefs for Community Engagement and Diversity in Clinical Trials (EXPLORE) Toolkit through a multi-phase process (2021-2024) including systematic review of existing toolkits, domain development, platform design, individual interviews (<i>n</i> = 10), and two rounds of theater testing with community health workers serving Hispanic communities in Southern New Mexico (<i>n</i> = 60) and American Indian communities in Northern New Mexico (<i>n</i> = 25). Pre/post surveys assessed feasibility, acceptability, community interest, and research literacy. Ripple Effects Mapping evaluated the development process.</p><p><strong>Results: </strong>Domain-specific toolkit importance ratings averaged 4.48-4.61 on a 5-point scale; 79% of participants rated the toolkit \"very important\" for promoting culturally competent research, and 64% were \"very likely\" to recommend it. Post-theater testing scores improved for perceived feasibility of conducting clinical research in participants' communities (pre: 7.19 vs. post: 7.94, 10-point scale) and research terminology understanding (pre: 7.97 vs. post: 8.74). Qualitative themes included cultural appropriateness, the role of community gatekeepers, and confidentiality concerns in rural and border communities.</p><p><strong>Conclusions: </strong>The EXPLORE Toolkit demonstrates promise for bridging researcher-community gaps in SUD clinical trials. Findings highlight the value of interdisciplinary, community-centered development and the need for ongoing cultural adaptation. The toolkit is freely available at https://www.exploretoolkit.org/.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e139"},"PeriodicalIF":2.7,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13445463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148684669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case study in teaching and learning the design, conduction, and analysis of Bayesian adaptive trials through an application.","authors":"Naima Alam, Alexandra Brown, Xiaosong Shi, Sreejata Dutta, Kate Young, Jianzheng Wu, Kaustubh Nimkar, Geethanjalee Mudunkotuwa, Elena Shergina, Joshuna Bernal, Md Tamzid Islam, Lauren Yoksh, Junqiang Dai, Nasrin Sultana, Milind A Phadnis, Jo Wick, Byron Gajewski","doi":"10.1017/cts.2026.10796","DOIUrl":"10.1017/cts.2026.10796","url":null,"abstract":"<p><strong>Introduction: </strong>Gaining clinical trial design and management experience can be challenging for students in class. Opportunities for students to participate in designing and implementing a \"from scratch\" design are essential to succeeding after graduating. Limited materials are available that provide meaningful opportunities for learners to practice and implement adaptive trial design. As a solution, we developed an open-source case study framework that instructors can use directly in a course to give students hands-on experience with Bayesian adaptive trial design and implementation.</p><p><strong>Materials and methods: </strong>We developed an open case study (DRIVE trial) project, which offers an instructor-ready framework organized into seven components. Each component is designed to map onto a distinct stage of a clinical trial and include materials that instructors can adapt to match their course level and chosen scientific questions. These components are tied together by a worked example in which, after comparing multiple study designs, a Bayesian adaptive design with response adaptive randomization was chosen and implemented throughout the framework.</p><p><strong>Results and discussion: </strong>The framework provides instructors with a complete, ready-to-use template for bringing adaptive trial experience into the classroom without building a case study from scratch. The study's significance lies in its broader implications for biostatistics student training and experience. The trial underscored the effectiveness of comparing study designs and the necessity for collaboration when implementing a clinical trial. This offers valuable practical training and resources for future biostatisticians, serving as a template across various fields. Supplementary materials for this article can be found online (https://github.com/BayesPhase/DRIVE).</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e134"},"PeriodicalIF":2.7,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13430487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148669714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Community-informed development of an in-person forum to promote breast cancer screening and research preparedness in rural and low-socioeconomic status women.","authors":"Pravesh Sharma, Kaylynn Imsande, Anni Vitriago, Maria Seibel, Joshua Pritchett, Bongi Rudder, Linh Tran, Stephanie Larson, Carolyn Flock, Crystal Murphy, Christi A Patten, Gladys Asiedu, Folakemi Odedina, Brian A Lynch, Tufia Haddad","doi":"10.1017/cts.2026.10788","DOIUrl":"10.1017/cts.2026.10788","url":null,"abstract":"<p><p>Rural and low-socioeconomic status women face social determinants of health barriers leading to disproportionately low rates of breast cancer screening and markedly reduced participation in clinical trials. To address this gap, we developed the WeCARE (Women's Engagement for Cancer Awareness, Resources, and Education) intervention using a community-engaged approach. This paper describes how Community Advisory Board feedback informed the development of Mayo Clinic Health System's WeCARE intervention components. Their input was systematically analyzed using the Consolidated Framework for Implementation Research (CFIR 2.0) to identify determinants of acceptability, appropriateness, and feasibility and to guide actionable refinements to intervention content and delivery.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e131"},"PeriodicalIF":2.7,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact evaluation of the Hypertension Treatment in Nigeria program using the Translational Science Benefits Model.","authors":"Guhan Iyer, Nanna Ripiye, Ikechukwu Anthony Orji, Gabriel Lamkur Shedul, Grace J Shedul, Eugenia N Ugwuneji, Tunde M Ojo, Emmanuel Okpetu, Samuel Osagie, Namratha Kandula, Malau M Toma, Bunmi R Oshundele, Sunday Victor Eze, Erica L Jamro, Chisom Obiezu-Umeh, Abigail S Baldridge, Lisa R Hirschhorn, Dike Bevis Ojji, Mark D Huffman","doi":"10.1017/cts.2026.10790","DOIUrl":"10.1017/cts.2026.10790","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is a leading cause of cardiovascular disease with significant burden experienced in low-and middle-income countries. The Hypertension Treatment in Nigeria (HTN) Program implemented a large-scale hypertension treatment program in the Federal Capital Territory (FCT) of Nigeria. Identification of benefits is important to acknowledge and demonstrate the value of research beyond evaluation of pre-identified scientific outcomes. This manuscript aims to identify the benefits and impact of the HTN Program using the Translational Science Benefits Model (TSBM).</p><p><strong>Methods: </strong>The HTN Program was a type II interrupted time series trial conducted from January 2020 to December 2023 to evaluate effectiveness and implementation of a multilevel hypertension control program in 60 primary healthcare centers in Nigeria. TSBM benefits were identified and verified by cataloging events, results, and procedures and aligning using the Translating for Impact Toolkit. The domains include policy, community, clinical, economic, and a new fifth domain, capacity building.</p><p><strong>Results: </strong>The HTN Program enrolled 21,922 patients. Hypertension treatment increased from 86.8% (95%CI: 86.5%, 87.2%) at baseline to 96.2% (95%CI: 96.0%, 96.4%) at the end of the study period. Hypertension control also increased from 22.3% (95%CI: 21.7%, 22.9%) at baseline to 56.4% (95%CI: 55.9%, 56.8%). Thirty-three TSBM benefits were identified across five domains. Most benefits were identified in the policy (9), capacity building (9), and community (7) domains.</p><p><strong>Conclusion: </strong>The HTN Program not only improved hypertension treatment and control in primary care in the FCT of Nigeria but also demonstrated broader impacts beyond its initial effectiveness and implementation objectives supporting program sustainment and scale-up.Trial Registration: NCT04158154.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e130"},"PeriodicalIF":2.7,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148630640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing translational workforce development programs using the research knowledge and transfer utilization framework.","authors":"Alexandria A Carey, Elizabeth C Dunn, April N Braxton, Jennifer Moses, Ramzi G Salloum","doi":"10.1017/cts.2026.10789","DOIUrl":"10.1017/cts.2026.10789","url":null,"abstract":"<p><p>Translational Workforce Development (TWD) is critical for Clinical and Translational Science Award (CTSA) hubs preparing Clinical Research Professionals (CRPs) to conduct high-quality research. Yet programs struggle to reflect the practical demands of CRP roles, and generalized training often leads to disengagement and limited transfer of learning into practice. Using dissemination science principles, we applied findings from a single-site CRP needs assessment and the Research Knowledge Transfer Utilization (RKTU) framework to inform a redesigned approach to TWD. Survey data (<i>n</i> = 65) were analyzed to identify training needs, contextual factors, preferred formats, motivators, and knowledge broker and champion roles in supporting engagement and sustained knowledge use. CRPs described inconsistent onboarding, limited structured support, and challenges aligning existing training with real-world workflows. Respondents expressed interest in practice-based, role-aligned learning delivered through blended formats such as on-demand modules, hybrid workshops, and hands-on simulation. Motivators included career pathways, community connection, and protected time, while workload and system complexity were key barriers. Despite these challenges, CRPs demonstrated readiness to learn when supported by clear expectations and accessible resources. The resulting model provides administrators with a scalable, context-informed approach for co-creating TWD programs embedded within organizational systems and aligned with the realities of clinical research practice.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"10 1","pages":"e136"},"PeriodicalIF":2.7,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}