Journal of Clinical and Translational Science最新文献

{"title":"A multiphase recruitment approach to enroll Latinas diagnosed with cervical cancer into a qualitative study at an academic medical center in the Pacific Northwest.","authors":"Cirila Estela Vasquez Guzman, Yareli Cornejo Torres, Meredith Zauflik","doi":"10.1017/cts.2025.85","DOIUrl":"10.1017/cts.2025.85","url":null,"abstract":"<p><p>Recruitment of diverse populations into research studies continues to be a challenge. There remains a gap in knowledge and practice on how to best engage with and recruit diverse populations, specifically among Latinos who account for 11% of research participants nationally. Our study focused on Latinas with pre-cervical and cervical cancer in the Pacific Northwest. Our research team took a multilevel approach to diversify recruitment and enrollment processes, focused on methods within healthcare, community-based, and paid media advertisements. This article shares strategies and lessons learned that helped increase participant diversity, meet enrollment goals, and expand relationships with community-based organizations.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e127"},"PeriodicalIF":2.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the success of community engagement in the Implementation Science Center for Cancer Control Equity.","authors":"Lydia E Pace, Madeline Davies, Stephanie Martinez, Leslie Salas Karnes, Leslie Pelton-Cairns, Susan Dargon-Hart, Melissa Holguin, James G Daly, Rebekka M Lee, Gina R Kruse, Karen M Emmons","doi":"10.1017/cts.2025.86","DOIUrl":"10.1017/cts.2025.86","url":null,"abstract":"<p><p>Community-engaged research is essential to advance the implementation of evidence-based practices, but engagement quality is rarely assessed. We evaluated community health centers' (CHCs) experiences partnering with the Implementation Science Center for Cancer Control Equity (ISCCCE) using an online survey of 59 CHC staff. Of 38 respondents (64.4% response rate), most perceived their engagement positively, with over 92% feeling respected by ISCCCE collaborators and perceiving projects as beneficial. Limited staff time and resources were the main challenges identified. This study suggests the utility of gathering feedback to evaluate community research engagement and inform adaptations of research processes to optimize partnership quality.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e122"},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring the aggregated impact of research: Establishing criteria for coding Translational Science Benefits Model data.","authors":"Nicole Miovsky, Amanda Woodworth, Stephanie Andersen, Rosalina Das, Julie Heidbreder, Rechelle Paranal, Clara M Pelfrey, Jessica Sperling, Beth Tigges, Boris B Volkov, Margaret Schneider","doi":"10.1017/cts.2025.76","DOIUrl":"10.1017/cts.2025.76","url":null,"abstract":"<p><strong>Introduction: </strong>A promising approach to assessing research impact draws on the Translational Science Benefits Model (TSBM), an evaluation model that tracks the applied benefits of research in four domains: Clinical and Medical; Community and Public Health; Economic; and Policy and Legislative. However, standardized methods to verify TSBM benefit data, to aid in aggregating impact data within quantitative summaries, do not currently exist.</p><p><strong>Methods: </strong>A panel of 11 topic experts participated in a modified Delphi process for establishing content and face validity of a set of criteria for verifying qualitative TSBM data. Two survey rounds were completed by panelists, with a moderated discussion in between rounds to discuss criteria not reaching consensus. Criteria with panel consensus at or above 70% in the survey rounds were confirmed as validated.</p><p><strong>Results: </strong>Criteria fell into 9 categories: Content Relevant, Project Related, Who, Reach, What, How, Novel, Documented Evidence, and When. The Delphi process yielded 197 total criteria across the 30 benefits characterized by the TSBM (range = 5-8 criteria per benefit).</p><p><strong>Discussion: </strong>The results of this Delphi process lay the foundation for developing a TSBM coding tool for evaluating and quantifying TSBM data. Standardizing this process will enable data aggregation, group analysis, and the comparison of research impact across contexts.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e129"},"PeriodicalIF":2.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: 160 Empowering future healthcare leaders and clinical researchers across a decade: UCLA's Clinical and Translational Science Institute - Research Associates Program - CORRIGENDUM.","authors":"Omar Selim, Tiffany Chen, Laurie Shaker-Irwin, Noah Federman, Jim Morrison, Denise Gellene, Angshuman Saha, Brisa Garcia","doi":"10.1017/cts.2025.75","DOIUrl":"https://doi.org/10.1017/cts.2025.75","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1017/cts.2024.818.].</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e84"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12083198/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building boundary-crossers in clinical-translational research: An exploratory study of a novel communication intervention.","authors":"Carrie Cameron, Irene Rull-Garcia, Laura G Meyer, Jose-Armando Fernandez-Guerrero, Erin K Dahlstrom, Christine Bell, Christine Pribbenow","doi":"10.1017/cts.2025.78","DOIUrl":"10.1017/cts.2025.78","url":null,"abstract":"<p><strong>Introduction: </strong>Integrating scientific research across multiple disciplines to advance breakthroughs is at the heart of clinical-translational science (CTS); among competencies that have been identified as essential for progress, skillful communication is critical. Few tools are available to address the social dynamics of the multidimensional diversity characteristics of CTS. We created the \"Building a Diverse Biomedical Workforce Through Communication Across Difference (CAD)\" workshop intervention. Based on principles of intercultural communication, CAD taught novel situationally-based communication skills to dyads of near-peer mentors and their undergraduate mentees. This study reports on the effectiveness of the operative mechanisms employed in CAD workshops for helping participants navigate highly diverse research environments.</p><p><strong>Methods: </strong>Participant data were collected from multiple sources, including workshop artifacts as well as focus groups conducted post-workshop. Data were organized, individually coded, and then iteratively and collectively into pre-defined and emergent themes.</p><p><strong>Results: </strong>Responses indicated that the content and activities resonated strongly with participants and illuminated their understanding of challenges (both their own and others') related to belonging, confidence, and connectedness to the research environment; several participants shared that they planned to use or had successfully used the skills. Focus group comments revealed that participants recognized the potential of the skills to include significant opportunities for non-instrumental interaction, contributing to a psychologically healthier workplace.</p><p><strong>Conclusion: </strong>A brief intervention to develop communication skills across a variety of differences characteristic of clinical-translational settings improves communication between mentors and mentees and with peers and increases sense of belonging in the workplace, with potential benefits to wellbeing.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e107"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Boosting scientific community values: The impact of social inclusion interventions on biomedical instructors.","authors":"Paul R Hernandez, Wenyi Du, Cristian Cervantes Aldana, Nichole A Broderick, Jo Handelsman, Hyewon Lee, Linlin Luo, Natalia Maldonado, Holly A Miller, Sarah Miller, Megan Patterson, Rachelle Pedersen, Perla Sandoval, Janice Vong, Mica Estrada","doi":"10.1017/cts.2025.81","DOIUrl":"10.1017/cts.2025.81","url":null,"abstract":"<p><p>Interventions to foster inclusive learning environments may benefit college STEMM instructors (NASEM, 2019). We investigated the impact of a social inclusion intervention (SII) on scientific self-efficacy, identity, community values, and persistence intentions in a large and diverse sample of biomedical college instructors (<i>n</i> = 116) in the USA. The results indicated that the SII group developed stronger scientific community values than the control group, and the effect was the strongest for instructors who had initially expressed lower values. From a mentoring perspective, the intervention helps boost feelings of community values, which is linked to increased persistence in STEMM careers.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e105"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respectful closure of a CEnR DNA integrity study: A bridge to sustained interactions with research participants.","authors":"Martha I Arrieta, L Lynette Parker, Erica Sutherland, Robert W Sobol","doi":"10.1017/cts.2025.82","DOIUrl":"10.1017/cts.2025.82","url":null,"abstract":"<p><strong>Introduction: </strong>Community engagement in research (CEnR) is fundamental to recruitment and retention in research studies. CEnR study closure, with a view to promote subsequent interactions with participants, can foster long-term relationships between research teams and participants. We detail the principles, procedures and outcomes of respectful closure in a study focused on scaling-up tools to measure DNA integrity in population samples.</p><p><strong>Methods: </strong>The study incorporated CEnR principles and practices, engaging a Community Advisory Board (CAB) to guide most study procedures. The CAB-designed closure protocol included 1) attempts at one-on-one contact via telephone, followed by a letter, if no contact was established; 2) provision of a study closure packet; 3) periodic mailing of study updates; and 4) a request for sustained interaction with the Community Engagement Team (CE Team), including participants' approval to receive invitations for future projects. Items 3 and 4 were framed as choices to further interaction and its extent.</p><p><strong>Results: </strong>Among 191 participants enrolled, 119 were contacted at closure (62% retention rate). Most frequently (97.5%), contacted participants agreed to receive information about new research projects, while 90.8% agreed to receive ongoing information about the DNA integrity study. Subsequently, the CE Team implemented two study update mailings and two CEnR studies, enrolling 18 participants in a consultative role and four in a collaborative role.</p><p><strong>Conclusions: </strong>Respectful study closure offers avenues for sustained interaction between CEnR teams and study participants, beyond the discrete boundaries of specific research projects. It can support the long-term connections that enable the positive outcomes of CEnR.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e110"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-generated health data: Impact on promoting patient-centered point of care tobacco treatment in patients with cancer.","authors":"Jessica Liu, Timothy B Baker, Jingling Chen, Nina Smock, Nicholas B Griffith, Ramaswamy Govindan, Paula Goldberg, Jodi Thole, Kristin Daly, James Reddy, Alex T Ramsey, Laura J Bierut, Aimee James, Robert A Schnoll, Ross C Brownson, Li-Shiun Chen","doi":"10.1017/cts.2025.77","DOIUrl":"10.1017/cts.2025.77","url":null,"abstract":"<p><strong>Introduction: </strong>Guideline-based tobacco treatment is infrequently offered. Electronic health record-enabled patient-generated health data (PGHD) has the potential to increase patient treatment engagement and satisfaction.</p><p><strong>Methods: </strong>We evaluated outcomes of a strategy to enable PGHD in a medical oncology clinic from July 1, 2021 to December 31, 2022. Among 12,777 patients, 82.1% received a tobacco screener about use and interest in treatment as part of eCheck-in via the patient portal.</p><p><strong>Results: </strong>We attained a broad reach (82.1%) and moderate response rate (30.9%) for this low-burden PGHD strategy. Patients reporting current smoking (<i>n</i> = 240) expressed interest in smoking cessation medication (47.9%) and counseling (35.8%). As a result of patient requests via PGHD, most tobacco treatment requests by patients were addressed by their providers (40.6-80.3%). Among patients with active smoking, those who received/answered the screener (<i>n</i> = 309 ) were more likely to receive tobacco treatment compared with usual care patients who did not have the patient portal (<i>n</i> = 323) (OR = 2.72, 95% CI = 1.93-3.82, <i>P</i> < 0.0001) using propensity scores to adjust for the effect of age, sex, race, insurance, and comorbidity. Patients who received yet ignored the screener (<i>n</i> = 1024) compared with usual care were also more likely to receive tobacco treatment, but to a lesser extent (OR = 2.20, 95% CI = 1.68-2.86, <i>P</i> < 0.0001). We mapped observed and potential benefits to the Translational Science Benefits Model (TSBM).</p><p><strong>Discussion: </strong>PGHD via patient portal appears to be a feasible, acceptable, scalable, and cost-effective approach to promote patient-centered care and tobacco treatment in cancer patients. Importantly, the PGHD approach serves as a real world example of cancer prevention leveraging the TSBM.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e114"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating community perspectives to improve survey completion rates in public health research by refining controversial survey elements.","authors":"Arleth A Escoto, Angel Lomeli, Maria Linda Burola, Breanna Reyes, Ana Perez-Portillo, Scarlet Flores, Kayleigh Kornher, Norma Porras, Ariel Cohen, Linda Salgin, Borsika A Rabin, Louise C Laurent, Marva Seifert, Nicole A Stadnick","doi":"10.1017/cts.2025.80","DOIUrl":"10.1017/cts.2025.80","url":null,"abstract":"<p><strong>Background: </strong>Many factors can impact survey completion rates, including survey length, sensitivity of the topics addressed, and clarity of wording. This study used cognitive interviews (CIs), a methodological tool that can aid in developing and refining elements for multi-faceted assessments, and previous survey response patterns to refine, streamline, and increase response rates of RADx-UP Common Data Elements (CDEs) for survey/questionnaire use.</p><p><strong>Methods: </strong>Ten previously enrolled CO-CREATE study participants were interviewed between May-June 2023. Interviewees identified CDEs that were \"confusing, uncomfortable, and/or not applicable,\" along with their reasoning. Interview data were analyzed using a rapid qualitative analytic approach, resulting in a summary matrix categorized by language. For further contextualization, CDE response rates were calculated for the 9147 surveys administered during the CO-CREATE study (May 2021-March 2023) and compared against their survey position.</p><p><strong>Results: </strong>Of the 94 CDEs evaluated in the CIs, 20 (21.3%) were flagged by one or more interviewees. Nine (9.6%) English while fourteen (14.9%) Spanish CDEs were flagged by interviewees, with some overlap. Also, CDE response rates differed according to position in the survey, with lower response rates for questions positioned later in the survey. Following review by the research team and the RADx-UP program, 10 English and 15 Spanish were revised, and seven were removed in both languages in the final survey.</p><p><strong>Conclusion: </strong>Our findings underscore the importance of integrating community member perspectives to enhance the relevance and clarity of assessment instruments, optimizing the impact of public health research among underrepresented populations.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e123"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209967/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying and addressing institutional barriers to community partner compensation for engaged research: A Clinical and Translational Science Award case study.","authors":"Alicia Bilheimer, Nixola Datta, Mary E Grewe, Simone Frank, Mysha Wynn, Christopher Tunstall, Jubilo Tommy White, Guadalupe C Hernandez, Lori Carter-Edwards","doi":"10.1017/cts.2025.79","DOIUrl":"10.1017/cts.2025.79","url":null,"abstract":"<p><p>Little guidance exists for developing institutional policies and procedures that support financial management of community-engaged research, including those related to compensating community partners equitably and efficiently for their expertise and time. To address this gap at our institution, the North Carolina Translational and Clinical Sciences Institute at the University of North Carolina at Chapel Hill (UNC) pursued an iterative, multi-pronged approach to identify and address institutional barriers and facilitators related to community partner compensation for research engagement. This case study describes the approach used to involve research administrative leadership, research teams, and community partners at UNC in the identification of institutional barriers to efficient partner compensation. It also elucidates our efforts to develop policies, processes, and resources to address these barriers. The approaches and solutions described can be adapted by other academic research institutions to enhance compensation processes and to facilitate incorporation of community perspectives into the design and implementation of institutional processes that directly impact their engagement in research.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e111"},"PeriodicalIF":2.1,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171912/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144317054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}