Journal of Clinical and Translational Science最新文献_第2页

Impact of the CTSA on nutrition research infrastructure: Perspectives from research dietitian nutritionists.

IF 2.1

Journal of Clinical and Translational Science Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.563

Rachelle Bross, Catherine A Chenard, Andrea Moosreiner, Amy Schweitzer

引用次数: 0

A conversation with Demilade Adedinsewo, M.B., Ch.B., Assistant Professor of Medicine, Mayo Clinic.

IF 2.1

Journal of Clinical and Translational Science Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.639

引用次数: 0

Erratum: Re-validation of the mentoring competency assessment to evaluate skills of research mentors: The MCA-21 - CORRIGENDUM.

IF 2.1

Journal of Clinical and Translational Science Pub Date : 2024-11-05 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.637

So Hee Hyun, Jenna G Rogers, Stephanie C House, Christine A Sorkness, Christine Pfund

引用次数: 0

Ethical considerations for respectful research participant payment processes.

IF 2.1

Journal of Clinical and Translational Science Pub Date : 2024-11-04 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.650

Devan M Duenas, Elliott Mark Weiss, Benjamin S Wilfond, Stephanie A Kraft

{"title":"Ethical considerations for respectful research participant payment processes.","authors":"Devan M Duenas, Elliott Mark Weiss, Benjamin S Wilfond, Stephanie A Kraft","doi":"10.1017/cts.2024.650","DOIUrl":"10.1017/cts.2024.650","url":null,"abstract":"Background: Researchers and research organizations acknowledge the importance of paying research participants but often overlook the process of providing participant payments as a locus for improving equity and inclusion in clinical research. In this conceptual paper, we argue that participants' lived experiences and social context should be recognized and respected when developing these processes.Methods: We consider how participant payment processes that require specific payment types, delay the timing of payment, or require sharing sensitive information may impose barriers to equitable research. Building on findings from empirical research of participants' perspectives on respect in research and a relational ethics framework of person-oriented research ethics, we explore how researchers and research organizations can better demonstrate respect through the research participation payment process.Results: We propose five considerations for demonstrating respect when providing payment: (1) practice cultural humility, (2) be mindful of socioeconomic factors, (3) be flexible, (4) be transparent, and (5) maintain open communication. These considerations are intended to address the lack of existing ethical guidance around the process for participant payments and promote more inclusive clinical research. We provide a set of sample questions for research teams to consider how they could modify their payment processes to better demonstrate respect.Conclusions: By better demonstrating respect for participants when providing payment, researchers can work toward ensuring that their research procedures are more inclusive, respond to the needs of diverse communities, and result in more equitable relationships with participants.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e204"},"PeriodicalIF":2.1,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REDCap as an accreditation tool for academic programs in clinical research: A case study.

IF 2.1

Journal of Clinical and Translational Science Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.615

Barbara Tafuto, Doreen W Lechner

{"title":"REDCap as an accreditation tool for academic programs in clinical research: A case study.","authors":"Barbara Tafuto, Doreen W Lechner","doi":"10.1017/cts.2024.615","DOIUrl":"10.1017/cts.2024.615","url":null,"abstract":"The Master of Science in Clinical Research Management program at Rutgers Biomedical Health Sciences underwent significant restructuring aligned with the Clinical and Translational Science Award funding parameters. This evolution necessitated formal evaluation through accreditation by the Commission on Accreditation of Allied Health Education Programs. The years-long accreditation process posed challenges, particularly regarding the collection of course learning outcomes data aligned with accreditation competency standards. The objective of this special communication is to report the rationale behind pursuing accreditation for clinical research degrees, the data collection challenges during the accreditation process, and a potential solution. In order to address existing university metric data gaps, Research Electronic Data Capture (REDCap) software was used to develop a data collection tool that streamlined the accreditation process and reduced the administrative burden. REDCap was effective in allowing faculty to self-report 3 years of course outcomes data for accreditation. There was an elevated level of user satisfaction compared to alternative data collection methods. A SWOT analysis identified the strengths and weaknesses of using REDCap, emphasizing strengths in functionality that include customizability, data validation, and compliance with regulatory standards. Overall, the advantages of leveraging REDCap for accreditation data collection, including customization, data security, and user-friendliness outweigh the key disadvantage of REDCap, which is its limited reporting capabilities.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e185"},"PeriodicalIF":2.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Community Engagement Studios to advance multi-site research with older adults.

IF 2.1

Journal of Clinical and Translational Science Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.630

Meredith C Masel, Kerri L Cavanaugh, Sharon P Croisant, Krista Bohn, James S Goodwin, Martha L Bruce, Paul J Barr

{"title":"Community Engagement Studios to advance multi-site research with older adults.","authors":"Meredith C Masel, Kerri L Cavanaugh, Sharon P Croisant, Krista Bohn, James S Goodwin, Martha L Bruce, Paul J Barr","doi":"10.1017/cts.2024.630","DOIUrl":"10.1017/cts.2024.630","url":null,"abstract":"Introduction: Operationalizing multi-site Community Engagement (CE) Studios to inform a research program is valuable for researchers. We describe the process and outcomes of hosting three CE Studios with Community Experts aged 65 years or older with chronic conditions and care partners of older adults. Experts gave feedback about processes for testing the feasibility, efficacy, effectiveness, and implementation of audio recording clinic visits and sharing recordings with patients who have multimorbidity and their care partners.Methods: The CE Cores of the Clinical and Translational Science Awards Programs at three academic health science centers created a joint CE Studio guide. Studios were conducted iteratively by site. Following receipt of the final reports, responses were compared to find themes, similarities, and differences on four topics in addition to overall commentary: Recruitment and Retention, Study Protocol, Study Reminders and Frequency, and Recording Technology.Results: Eighteen older adults and care partners in three states provided valuable feedback to inform multi-site trials. Feedback influenced multiple aspects of trials in process or subsequently funded. Experts provided critique on the wording of study invitations, information sheets, and reminders to engage in study procedures. Experts were concerned for participants being disappointed by randomization to a control arm and advised how investigators should prepare to address that.Conclusions: Multi-site CE Studios should be consecutive, so each team can learn from the previous teams. Using the CES Toolkit ensures that final reports were easily comparable and utilized to develop a research program that now includes three federally funded clinical trials.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e186"},"PeriodicalIF":2.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the impact of the QUARTET USA trial using the translational science benefits model.

IF 2.1

Journal of Clinical and Translational Science Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.641

Guhan Iyer, Danielle Lazar, Abigail S Baldridge, Jairo Mejia, Clara K Chow, Namratha R Kandula, Olutobi A Sanuade, Linda Rosul, Jody D Ciolino, Mark D Huffman

引用次数: 0

Accelerating evidence generation: Addressing critical challenges and charting a path forward.

IF 2.1

Journal of Clinical and Translational Science Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.621

Jeeyon G Rim, Jennifer G Jackman, Christoph P Hornik, Joni L Rutter, Haider Warraich, Janet Wittes, Lee Fleisher, Brian S Anderson, Ester Krofah, Elizabeth Kinter, Trevan Locke, Lindsay Kehoe, Ali Abbasi, Hilary Marston, Ann Meeker-O'Connell, Wendy Weber, Tracy Wang, Adrian F Hernandez, Martin Landray, Scott M Palmer

{"title":"Accelerating evidence generation: Addressing critical challenges and charting a path forward.","authors":"Jeeyon G Rim, Jennifer G Jackman, Christoph P Hornik, Joni L Rutter, Haider Warraich, Janet Wittes, Lee Fleisher, Brian S Anderson, Ester Krofah, Elizabeth Kinter, Trevan Locke, Lindsay Kehoe, Ali Abbasi, Hilary Marston, Ann Meeker-O'Connell, Wendy Weber, Tracy Wang, Adrian F Hernandez, Martin Landray, Scott M Palmer","doi":"10.1017/cts.2024.621","DOIUrl":"10.1017/cts.2024.621","url":null,"abstract":"Efficient evidence generation to assess the clinical and economic impact of medical therapies is critical amid rising healthcare costs and aging populations. However, drug development and clinical trials remain far too expensive and inefficient for all stakeholders. On October 25-26, 2023, the Duke Clinical Research Institute brought together leaders from academia, industry, government agencies, patient advocacy, and nonprofit organizations to explore how different entities and influencers in drug development and healthcare can realign incentive structures to efficiently accelerate evidence generation that addresses the highest public health needs. Prominent themes surfaced, including competing research priorities and incentives, inadequate representation of patient population in clinical trials, opportunities to better leverage existing technology and infrastructure in trial design, and a need for heightened transparency and accountability in research practices. The group determined that together these elements contribute to an inefficient and costly clinical research enterprise, amplifying disparities in population health and sustaining gaps in evidence that impede advancements in equitable healthcare delivery and outcomes. The goal of addressing the identified challenges is to ultimately make clinical trials faster, more inclusive, and more efficient across diverse communities and settings.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e184"},"PeriodicalIF":2.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626582/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of neonatal sepsis on serum selenium levels: Evidence of decreased selenium in sepsis-affected neonates.

IF 2.1

Journal of Clinical and Translational Science Pub Date : 2024-10-31 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.611

Seyed Hossein Saadat, Rakhshaneh Goodarzi, Zeynab Elahi, Aref Ameri

{"title":"Impact of neonatal sepsis on serum selenium levels: Evidence of decreased selenium in sepsis-affected neonates.","authors":"Seyed Hossein Saadat, Rakhshaneh Goodarzi, Zeynab Elahi, Aref Ameri","doi":"10.1017/cts.2024.611","DOIUrl":"10.1017/cts.2024.611","url":null,"abstract":"Introduction: Essential trace elements and micronutrients are critical in eliciting an effective immune response to combat sepsis, with selenium being particularly noteworthy. The objective of this investigation is to analyze and the levels of serum selenium in neonates within sepsis and control groups.Methodology: In 2023, a case-control study was carried out involving 66 hospitalized infants - 33 diagnosed with sepsis forming the case group and 33 free from sepsis constituting the control group - along with their mothers, at Children's and Shariati Hospitals in Bandar Abbas. The serum selenium concentrations (expressed in micrograms per deciliter) were quantified utilizing atomic absorption spectrometry. Subsequently, the data were processed and analyzed using IBM SPSS statistical software, version 22.Results: The average serum selenium level in neonates with sepsis (42.06 ± 20.40 µg/dL) was notably lower compared to the control group (55.61 ± 20.33 µg/dL), a difference that was statistically significant (p-value = 0.009). The levels of serum selenium were comparable between neonates and mothers across both study groups.Conclusion: The findings of this research indicate that selenium levels in the sepsis group were reduced compared to the control group, despite similar selenium levels in the mothers and neonates in both groups, suggesting that sepsis could be associated with a decrease in selenium levels.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e183"},"PeriodicalIF":2.1,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Race, ethnicity, and considerations for data collection and analysis in research studies.

IF 2.1

Journal of Clinical and Translational Science Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI: 10.1017/cts.2024.632

Sima Sharghi, Shokoufeh Khalatbari, Amy Laird, Jodi Lapidus, Felicity T Enders, Jareen Meinzen-Derr, Amanda L Tapia, Jody D Ciolino

{"title":"Race, ethnicity, and considerations for data collection and analysis in research studies.","authors":"Sima Sharghi, Shokoufeh Khalatbari, Amy Laird, Jodi Lapidus, Felicity T Enders, Jareen Meinzen-Derr, Amanda L Tapia, Jody D Ciolino","doi":"10.1017/cts.2024.632","DOIUrl":"10.1017/cts.2024.632","url":null,"abstract":"Research studies involving human subjects require collection of and reporting on demographic data related to race and ethnicity. However, existing practices lack standardized guidelines, leading to misrepresentation and biased inferences and conclusions for underrepresented populations in research studies. For instance, sometimes there is a misconception that self-reported racial or ethnic identity may be treated as a biological variable with underlying genetic implications, overlooking its role as a social construct reflecting lived experiences of specific populations. In this manuscript, we use the We All Count data equity framework, which organizes data projects across seven stages: Funding, Motivation, Project Design, Data Collection, Analysis, Reporting, and Communication. Focusing on data collection and analysis, we use examples - both real and hypothetical - to review common practice and provide critiques and alternative recommendations. Through these examples and recommendations, we hope to provide the reader with some ideas and a starting point as they consider embedding a lens of justice, equity, diversity, and inclusivity from research conception to dissemination of findings.","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"8 1","pages":"e182"},"PeriodicalIF":2.1,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0