Journal of Clinical and Translational Science最新文献

{"title":"Keeping the network alive: The importance of professional social networks for long-term research career development.","authors":"Marisa N Spann, May Hua, Daichi Shimbo, Melissa Begg, Robyn Gartrell, Fatemeh Momen-Heravi, Melissa Accordino, Eileen Connolly, Andrew Einstein, Katherine Dimitropoulou, Bernard Chang, Badri Vardarajan","doi":"10.1017/cts.2025.10105","DOIUrl":"10.1017/cts.2025.10105","url":null,"abstract":"","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e170"},"PeriodicalIF":2.0,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usage and perceived effectiveness of recruitment techniques among clinical trials recruiters.","authors":"Jewels Watts, Lauren Kaiser-Jackson, Bob Wong, Azra Helac, Molly Volkmar, Jessica W Berg, Aaron J Goldenberg, Eric Kodish, Ben Schwan, Cathy Wolfsfeld, Erin Rothwell, Maxwell Mehlman, Kimberly A Kaphingst","doi":"10.1017/cts.2025.10117","DOIUrl":"10.1017/cts.2025.10117","url":null,"abstract":"<p><strong>Introduction: </strong>Effective recruitment techniques are essential for researchers to recruit and retain potential participants in studies, particularly as recruitment numbers into clinical trials have decreased. While recruitment techniques have been investigated, there is a gap in understanding the perspectives of clinical trials recruiters. This paper examines recruiters' usage and perceived effectiveness of various recruitment techniques, as well as their perspectives on related ethical issues.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey of 381 clinical trials recruiters. Closed-ended items examined whether recruiters had used 31 pre-defined recruitment techniques and their perceptions of the effectiveness of each technique. For techniques perceived to be highly effective or ineffective, open-ended items examined recruiter reasoning. The multiple methods analysis integrated the closed-ended and open-ended data.</p><p><strong>Results: </strong>Recruitment techniques such as <i>reassured potential participants about confidentiality</i> (96.3%) and <i>reassured about data sharing</i> (95.8%) had high usage, while techniques like <i>having the PI approach and enroll</i> had a high average perceived effectiveness (<i>M</i> = 4.23, SD = 0.91). Recruiters often rated techniques as more highly effective when they had prior experience using them. They also identified concerns about professionalism, ethics, and transparency in standard practice recruitment techniques.</p><p><strong>Conclusions: </strong>Our findings indicate that there is significant variation in the usage of clinical trial recruitment techniques and how different recruiters view the effectiveness of each technique. The unique perspectives of those who recruit into clinical trials can help inform future decisions regarding which recruitment techniques to utilize, along with how and when to use particular recruitment techniques in an ethical manner.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e190"},"PeriodicalIF":2.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A conversation with Andrew H. Talal, MD, MPH, professor of medicine, university at buffalo jacobs school of medicine and biomedical sciences.","authors":"","doi":"10.1017/cts.2025.10095","DOIUrl":"https://doi.org/10.1017/cts.2025.10095","url":null,"abstract":"","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e167"},"PeriodicalIF":2.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The power of social talk: A longitudinal network analysis of conversations in fostering interdisciplinary collaboration.","authors":"Yingshi Huang, Jinwen Luo, Vivek Shetty, Minjeong Jeon","doi":"10.1017/cts.2025.10124","DOIUrl":"10.1017/cts.2025.10124","url":null,"abstract":"<p><strong>Introduction: </strong>Interdisciplinary collaboration is essential for addressing scientific challenges, particularly in integrated fields like mobile health (mHealth), which combines computer communication and medicine to deliver healthcare services. The formation of collaborative relationships in such field is an emerging topic, with conversations among interdisciplinary scholars serving as a critical indicator of relationship development. This study aims to examine the specific effects of different conversation types (research or social oriented) on interdisciplinary collaboration and explore the impact of communication mode.</p><p><strong>Methods: </strong>We tracked conversations among interdisciplinary scholars participating in a 15-day hybrid mHealth training program, which uniquely captures both scholars' conversation networks and the conversation quality. Three types of conversation networks were recorded (topics about current research, future research, or small talk). Using longitudinal network models, we compared the effect of different types of conversation quality on network formation and evaluated the interaction between conversation quality and communication mode (in-person or online).</p><p><strong>Results: </strong>We found that the quality of social conversations on non-research-related topics had robust effects in promoting the formation of interdisciplinary communications. In-person communication is more conducive for current and future research conversations, while online communication is valued for small talk.</p><p><strong>Conclusion: </strong>This study highlights the power of perception of personal conversation in interdisciplinary collaboration formation. The diverse effects of communication mode on different conversation networks are revealed. Our findings offer valuable insights for the event designs of interdisciplinary training program.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e194"},"PeriodicalIF":2.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches and tools to measure individual-level research experience, activities, and outcomes: A narrative review.","authors":"Brenda M Joly, Carolyn Gray, Julia Rand, Katy Bizier, Karen Pearson","doi":"10.1017/cts.2025.10076","DOIUrl":"10.1017/cts.2025.10076","url":null,"abstract":"<p><p>Strengthening the research workforce is essential for meeting the evolving needs and challenges in the health and biomedical fields. To do so effectively, it requires an understanding of how the experiences of a researcher shift over time and how one's research career evolves, particularly as supports are put in place to foster research. This narrative review provides a summary of published individual-level assessment measures and survey tools from 2000-2024. All measures were abstracted, classified, and coded during analyses to describe the areas of focus, and they were organized into one of six research categories. The review identified a range of measures and methods across all categories. However, the measures were often narrow, focused on outputs, and not ideal for assessing the full range of experiences a researcher may have throughout their career. The most common metrics were related to research productivity and bibliometric measures. Our review of survey tools revealed a gap in comprehensive approaches available to assess an individual's research experience, efforts, supports, and impact. As efforts expand to evaluate and study the research workforce, tools that focus on a broad range of individual-level measures, tied to specific underlying constructs and drawn from the literature, may prove useful.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e161"},"PeriodicalIF":2.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The development, validity, and reliability of the Researcher Investment Tool.","authors":"Brenda M Joly, Carolyn Gray, Kassandra Cousineau, Karen Pearson, Valerie S Harder","doi":"10.1017/cts.2024.673","DOIUrl":"10.1017/cts.2024.673","url":null,"abstract":"<p><strong>Background: </strong>Over the last two decades, there have been significant investments designed to advance clinical and translational research (CTR) with an emphasis on supporting early career investigators and building a cadre of skilled researchers. Despite the investments, there are no comprehensive measurement tools to track individual-level progress along the research continuum as supports are put in place.</p><p><strong>Objective: </strong>The Researcher Investment Tool (RIT) is a novel tool that was created to provide a consistent approach for measuring individual-level changes in the research career trajectory of investigators receiving support from CTR programs.</p><p><strong>Methods: </strong>The RIT is a 90-item questionnaire, with eight domains and four sub-domains, designed to measure a researcher's experiences and perceptions. Several rounds of testing were conducted to assess the tool's face and content validity as well as the internal consistency and test-retest reliability.</p><p><strong>Results: </strong>Psychometric testing revealed strong content validity and good internal consistency with Cronbach's alpha coefficients ranging from 0.85 to 0.97 across all domains. Test-retest reliability results also revealed stability in the domain measures over time with Pearson's correlation coefficients ranging from 0.70 to 0.98 for all but one domain (.53).</p><p><strong>Conclusions: </strong>This novel RIT may be useful to evaluators when measuring the impact of investments designed to support early career clinical and translational researchers.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e160"},"PeriodicalIF":2.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating the bench to bedside maze: Lessons from CTSA hubs on streamlining research support in academic medical centers.","authors":"Leah Pope, Bernard Chang, Michelle McClave, Sheila Marie O'Byrne, Kawthar Muhammad, Zainab Abedin, Mary Purcell, Anjana Nair, Kayla Zalcgendler, Muredach P Reilly","doi":"10.1017/cts.2025.10118","DOIUrl":"10.1017/cts.2025.10118","url":null,"abstract":"<p><strong>Background: </strong>Academic Medical Centers (AMCs) with Clinical and Translational Science Awards (CTSAs) offer a range of resources to support clinical and translational research and science. However, research professionals often face challenges in navigating these resources effectively.</p><p><strong>Objective: </strong>Our study sought to examine research navigation services across CTSA hubs to identify successful strategies, common challenges, and best practices for supporting research teams.</p><p><strong>Methods: </strong>We conducted interviews with representatives from ten CTSA hubs and performed a landscape analysis to explore the types of research navigation services available, the methods of advertising and orienting faculty and staff, and the challenges faced in launching and maintaining these services.</p><p><strong>Results: </strong>Our analysis identified three primary types of research navigation services offered at CTSA hubs: online resource libraries, personalized research navigation with dedicated staff, and interdisciplinary research \"studios\" for protocol development. Despite these offerings, challenges such as low awareness, difficulties coordinating across siloed university systems, and limited metrics for evaluating navigation services persist.</p><p><strong>Conclusion: </strong>Effective research navigation requires a combination of web-based applications and in-person support, backed by institutional commitment to foster engagement and streamline access. Key strategies for successful navigation services include proactive advertising, integration with orientation programs, and cross-departmental collaboration. Our findings offer actionable recommendations for enhancing research navigation at AMCs, ultimately aiming to increase research productivity and collaboration.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e188"},"PeriodicalIF":2.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444686/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Grassroots: Leveraging mission-aligned developmental programs to enhance the academic health center.","authors":"Jennifer A Croker, Keith A Jones, Anupam Agarwal, David T Redden, Robert P Kimberly","doi":"10.1017/cts.2025.10100","DOIUrl":"10.1017/cts.2025.10100","url":null,"abstract":"<p><p>Academic health centers (AHC) characterized by an integrated mission serving education, research and clinical care reflect these values in the institution's vision, decision-making and culture. Embracing this strategy, the University of Alabama at Birmingham (UAB) created a novel, competitive funding initiative through its faculty practice with the Health Services Foundation General Endowment Fund (HSF-GEF). This partnership with the faculty practice leveraged faculty and staff creativity to inform and lead capacity-building and innovation in patient-oriented and laboratory research, clinical care development and education aligned with the best interests of the enterprise. Since 1996, the HSF-GEF has invested over $66M in 442 peer-reviewed proposals led by transdisciplinary teams representing strategic advances with strong potential to generate future extramural support, to improve healthcare delivery, to enhance research capacity and to promote active learning. Beyond financial return on investment, program evaluation revealed benefit on culture, collaboration, camaraderie and infrastructure. By engaging the broad workforce to articulate, select and implement projects, UAB has fostered a purpose-driven culture of collaboration within the AHC that thrives on broad representation, enthusiasm, and ingenuity as well as peer engagement across multiple schools in the academic community.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e187"},"PeriodicalIF":2.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-evaluative practices of Clinical and Translational Research evaluators.","authors":"Sue Giancola, John F Stevenson, Ingrid Philibert","doi":"10.1017/cts.2025.10121","DOIUrl":"10.1017/cts.2025.10121","url":null,"abstract":"<p><strong>Introduction: </strong>The National Institutes of Health (NIH) Institutional Development Award (IDeA) program was created to build capacity and enhance research in states with historically low levels of NIH funding. IDeA Clinical and Translational Research (CTR) networks are focused on building statewide and regional capacity to conduct biomedical research. The tracking and evaluation component of each CTR is tasked with collecting data to facilitate continuous improvement and measure impact.</p><p><strong>Methods: </strong>This paper presents findings from a survey conducted with IDeA-CTR evaluators examining the following questions: 1) To what extent do evaluators use meta-evaluative practices and how does meta-evaluation inform their evaluation? and 2) What challenges evaluators face in their evaluation planning and implementation?</p><p><strong>Results: </strong>Findings show that 50% of CTRs conducted some form of meta-evaluation. Further, quantitative and qualitative responses tell a compelling story of the challenges in translational research evaluation. The most prominent were the development of feasible and useful data management systems, the selection and endorsement of program-wide impact metrics, and the promulgation of realistic expectations regarding feasibility and utility for recipients of the evaluation, including expectations for project impacts that lead to systemic change.</p><p><strong>Conclusions: </strong>Findings suggest the importance of internally adopting a participatory, collaborative approach to evaluation and externally sharing insights with and adopting strategies from fellow evaluators within a learning community. This study promotes the value of conducting meta-evaluation in CTR settings, demonstrates means for and results from doing so, and shares best practices for addressing challenges encountered by many CTR evaluators.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e193"},"PeriodicalIF":2.0,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444698/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of group-to-individual generalizability in people with lower urinary tract symptoms emphasizes the need for deep phenotyping and personalized treatments.","authors":"Victor P Andreev, Caroline Smerdon, Brian Bieber, Abigail R Smith, Kathryn Flynn, J Quentin Clemens, David Cella, Claire C Yang, Ziya Kirkali, Kevin Weinfurt","doi":"10.1017/cts.2025.10113","DOIUrl":"10.1017/cts.2025.10113","url":null,"abstract":"<p><strong>Introduction: </strong>Understanding how different symptoms co-occur and are correlated may provide insights into the pathophysiology of disease. The lack of group-to-individual generalizability of co-occurrence of symptoms was recently demonstrated by comparing intra-individual and inter-individual correlations in several psychological studies. Here, we investigate this phenomenon for lower urinary tract symptoms (LUTS).</p><p><strong>Methods: </strong>We analyzed data collected in the Symptoms of Lower Urinary Tract Dysfunction Research Network Recall Study. Participants responded to questions about their urinary symptoms for 25 consecutive days. These questions queried urologic symptoms including storage (urinary urgency, frequency, nocturia, and urinary incontinence), voiding (slow/weak stream), and post-micturition (incomplete emptying and post-micturition dribble) symptoms. We calculated Pearson correlation coefficients and cosine similarity measures and compared distributions of intra-individual and inter-individual (cohort) metrics.</p><p><strong>Results: </strong>Among 234 participants, distributions of intra-individual measures were 10-fold wider than those of inter-individual correlations. There are pairs of questions with distributions of correlations and cosine similarities containing individuals with extreme positive (>0.8) and extreme negative values (<-0.8). There are groups of participants with strong positive and negative correlations of urinary frequency and nocturia, urinary incontinence and weak flow, as well as strong negative and positive correlations of urinary frequency and dribbling. Information on these extreme groups is averaged out and lost in the inter-individual correlations.</p><p><strong>Conclusions: </strong>Lack of group-to-individual generalizability previously shown for psychological symptoms is confirmed for LUTS. Wealth of information on the co-occurrence and co-evolution of LUTS in the intra-individual correlations and cosine similarities corroborates heterogeneity of LUTS and can be useful for deep phenotyping and for identifying personalized treatments of LUTS.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e192"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}