Journal of Clinical and Translational Science最新文献

{"title":"Trends in turnover and turbulence at a large academic medical center before and during COVID-19: Analyzing structured clinical research professional roles.","authors":"Marissa Stroo, Camila Reyes, Christine Deeter, Stephanie A Freel, Heather Gaudaur, Richard Sloane, Denise C Snyder","doi":"10.1017/cts.2025.10063","DOIUrl":"10.1017/cts.2025.10063","url":null,"abstract":"<p><strong>Introduction: </strong>High workforce turbulence has plagued clinical research, becoming intensified during the COVID-19 pandemic, especially for patient-facing workers. In a time of great uncertainty and risk among healthcare workers, researchers included, the pandemic also brought increased demand for research studies in volume, speed, and complexity, triggering elevated staff turnover. This has posed significant hurdles for employers, especially research sites, where retaining skilled patient-facing clinical research professionals (CRPs) is pivotal for sustaining medical innovation. Lack of job standardization and advancement pathways has been noted to play an important role both in turnover and contributes to the inability to accurately measure workforce trends. To address these factors, Duke University adopted a competency-based job classification system for CRPs in 2016.</p><p><strong>Methods: </strong>Since that adoption of competency-based jobs, employee-level staffing data for all CRPs have been tracked monthly, creating a master data file from September 2016 through June 2024. This study updates previous analyses, evaluating turnover and turbulence rates, and demographic changes in the CRP workforce over this period.</p><p><strong>Results: </strong>Over the last six years, the Duke CRP workforce remained relatively stable. Voluntary turnover rates fluctuated, peaking at 19.1% in FY 2021 during the COVID-19 pandemic, and have steadily declined each year since then.</p><p><strong>Conclusions: </strong>Despite national workforce challenges exacerbated by the pandemic, our data indicate that proactive measures to standardize clinical research jobs and assess the resultant well-defined site-based employee data may have mitigated extremes in workforce turnover at Duke University. Turbulence rates, while stabilizing, signal areas for further study.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e134"},"PeriodicalIF":2.1,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260974/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the effect of a non-attendance fee on writing workshop attendance, grant submission, and success rates among K award applicants.","authors":"Phillip A Ianni, Brenda L Eakin, Elias M Samuels, Christine Byks-Jazayeri, Ellen Champagne, Matheos Yosef, Shokoufeh Khalatbari, Vicki L Ellingrod","doi":"10.1017/cts.2025.10079","DOIUrl":"10.1017/cts.2025.10079","url":null,"abstract":"<p><p>In 2009, the University of Michigan's Michigan Institute for Clinical and Health Research developed a three-session K Writing workshop. Beginning in 2016, we implemented a non-attendance fee to encourage attendance across the three sessions. We examined whether this fee improved attendance, increased submission of an NIH K or R grant proposal, and improved success rates. Between 2012 and 2021, 373 participants attended the workshop. After the non-attendance fee was implemented, significantly more participants attended all three sessions of the workshop, and there was a statistical trend suggesting an increase in the success rate, while submission rates remained constant.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e145"},"PeriodicalIF":2.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translating knowledge into action: Community-centered recommendations from the RADx-UP COVID-19 Equity Evidence Academy virtual conference series.","authors":"Alicia Bilheimer, Blen Mengesha Biru, Enomen Idiagbonya, Cassidy Fox, Renee Leverty, Camille Brown-Lowery, Lori Carter-Edwards","doi":"10.1017/cts.2025.10075","DOIUrl":"10.1017/cts.2025.10075","url":null,"abstract":"<p><p>The Rapid Acceleration of Diagnostics-Underserved Populations' COVID-19 Equity Evidence Academy (RADx-UP EA) was a series of virtual conferences hosted between 2021 and 2023 that assembled community members, researchers, and governmental leaders from across the US to discuss and devise ways to promote equity in COVID-19 testing and vaccination. Using community-engaged methodologies in its design and implementation, this series provided a framework and forum for community and academic partners to engage in collaborative idea generation and consensus building during a public health emergency. The ideas and strategies gained during the EAs were disseminated to inform future research and action related to COVID-19. This conference paper highlights the specific engagement approaches used and the themes and recommendations generated. This model and its findings have broad utility beyond RADx-UP and can be used by researchers and practitioners to inform and advance community-engaged research and practice in diverse public health settings.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e142"},"PeriodicalIF":2.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305377/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: 271 Research follow-up: Outcomes/preliminary results - BeFit Toolbox Collaboration: Building empowerment through Fitness program - CORRIGENDUM.","authors":"Kimberly McCall, Jewell Dickson-Clayton, Jordin Lane, Keith McGregor, Shellie Layne, Raymond Jones","doi":"10.1017/cts.2025.10074","DOIUrl":"https://doi.org/10.1017/cts.2025.10074","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1017/cts.2024.914.].</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e126"},"PeriodicalIF":2.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209957/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing translational science roadblocks to disability research.","authors":"Karen Bonuck, Ariel Fishman","doi":"10.1017/cts.2025.10073","DOIUrl":"10.1017/cts.2025.10073","url":null,"abstract":"<p><p>Disability is a common and universal human experience. Yet, people with disabilities (PWDs) are in poorer health and have less access to quality healthcare than their non-disabled peers. In fact, the National Institutes of Health's (NIH) designated PWDs as a health disparities population in 2023. This paper illustrates the application of translational science (TS) principles to overcoming roadblocks to reducing PWDs' health disparities. Part I provides an overview of health disparities among PWDs and the recent designation - situating both within a TS framework. Part II summarizes literature on specific factors that contribute to PWDs' exclusion from research, how these factors are reflected in background reports that impelled the designation of PWDs as a disparity population, and how the suggested steps to implement the designation reflect TS principles and its research agenda. Part III describes \"Reducing Researcher Roadblocks to Including People with Disabilities in Research (D2/R3),\" a TS solution to overcoming PWDs exclusion from research. D2/R3 is our institution's Clinical and Translational Science Award research project - a mixed-methods study that targets research teams' knowledge, attitudes, biases, and perceptions that contribution to under representation of persons with developmental disabilities in research.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e174"},"PeriodicalIF":2.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444705/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building an evaluation infrastructure to capture process and progress within a Clinical and Translational Science Awards hub.","authors":"Maggie Padek, Dinesh Pal Mudaranthakam, Sam Pepper, Mary Penne Mays, Shellie D Ellis","doi":"10.1017/cts.2025.10047","DOIUrl":"10.1017/cts.2025.10047","url":null,"abstract":"<p><p>To improve its management capacity, Frontiers Clinical and Translational Science Institute overhauled its evaluation infrastructure to be comprehensive, efficient, and transparent in demonstrating outputs and outcomes. We built a platform that standardized measures across program areas, integrated continuous improvement processes, and reduced the data entry burden for investigators. Using the Utilization-Focused Evaluation Framework, we created logic models to identify appropriate metrics. We built the evaluation data platform within REDCap to capture requests, events, attendance, and outcomes and to push work processes to Navigators. We initiated a membership model to serve as the backbone of the platform which allowed tailored communication, demographic data capture, and reduced data entry burden. The platform consists of nine REDCap projects across multiple programmatic areas. Using REDCap Dynamic SQL query fields and External Modules, the membership module was integrated into all forms to check and collect membership before service access. Data is synched to a dashboard for tracking outputs and outcomes in real-time. Since the launch of the evaluation platform in Fall 2022, Frontiers has increased its workflow efficiency and streamlined continuous improvement communication. The platform can serve as a model for other hubs to build efficient processes to create comprehensive and transparent evaluation plans.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e136"},"PeriodicalIF":2.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating community engagement efforts in a clinical and translational research initiative.","authors":"Kelly Finck Waters, Brenda Joly, Carolyn E Gray, Jan K Carney, Kathleen M Fairfield","doi":"10.1017/cts.2025.10069","DOIUrl":"10.1017/cts.2025.10069","url":null,"abstract":"<p><p>A priority of the Northern New England Clinical and Translational Research (NNE-CTR) Network is conducting, promoting, and advancing community-engaged research through its Community Engagement and Outreach (CEO) Core. We sought to measure the CEO Core's success in strengthening community-level research partnerships using a validated survey platform based on network science to map and track collaborations over time. The survey was completed by 59/76 organizations (77.6% response rate). Key findings included a high level of trust and a modest level of perceived value relative to published benchmarks. Additional specific findings will inform opportunities to improve the network as the NNE-CTR matures.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e135"},"PeriodicalIF":2.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Designing for dissemination through community advisory board engagement in an implementation mapping process: A case study.","authors":"Gabriella M McLoughlin, Yerusalem Yohannes, Molly Kerstetter, Omar Martinez, Alex Dopp, Jennifer O Fisher, Maura Kepper, Rachel G Tabak, Ross C Brownson","doi":"10.1017/cts.2025.10065","DOIUrl":"10.1017/cts.2025.10065","url":null,"abstract":"<p><strong>Introduction: </strong>The purpose of this study was to document the development of a Community Advisory Board (CAB) to enhance equitable dissemination of research findings within an implementation mapping study to enhance equitable impact of Universal School Meals (USM) through the Designing for Dissemination and Sustainability (D4DS) process.</p><p><strong>Methods: </strong>The D4DS process comprises 7 key elements to facilitate meaningful dissemination. To accomplish Step 1: Identify Partners, the research team conducted snowball recruitment methods within the local Philadelphia community and with existing connections. To Empathize and Outline the Problem (Step 2) and Understand the Context (Step 3), an interest meeting was held followed by monthly meetings. Our team Confirmed and Co-designed the Product (Step 4) and Developed the Dissemination Plan (Step 5) through collaborative brainstorming sessions. Finally, we started the Iterative Evaluation (Step 6) and Plan for Sustainability (Step 7) by administering a baseline and follow-up survey measuring CAB members' perceived utility, effectiveness, and sustainability of the board.</p><p><strong>Results: </strong>The final CAB included 8 members. The co-created dissemination products and plan comprised a 2-page infographic, social media toolkits, and a webinar slide deck, which were disseminated locally by the research team via presentations, websites, and email communication, in spring 2024. Initial findings from baseline and follow-up surveys indicated that CAB members benefited from skill development, compensation, writing credit, and autonomy in dissemination designing.</p><p><strong>Conclusions: </strong>Sharing power and decision-making enhanced the capacity for local-level dissemination, which is much needed to advance the science of community partnerships.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e138"},"PeriodicalIF":2.1,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12260986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing a community health center-driven process for engaging with translational scientists: What will it take?","authors":"Tracy A Battaglia, Kareem I King, Allyson Richmond, Erika Christenson, Rebecca Lobb, Astraea Augsberger, Celia Bora, Stephen M Tringale, Linda Sprague Martinez, Charles T Williams","doi":"10.1017/cts.2025.10058","DOIUrl":"10.1017/cts.2025.10058","url":null,"abstract":"<p><p>Actively engaging community health centers (CHCs) in research is necessary to ensure evidence-based practices are relevant to all communities and get us closer to closing the health equity gap. We report here on the Boston HealthNet Research Collaborative, a partnership between health centers, Boston HealthNet and the Boston University Clinical, and Translational Science Institute with the explicit goal of supporting research partnerships early in the planning phase of the study lifecycle. We used the principles of community engagement guided by a collective impact framework to codesign, pilot, and evaluate a process for facilitating research partnerships. Accomplishments in the first 2 years include a web-based Toolkit with a step-by-step guide and an active learning collaborative with health center representatives to support research capacity building. The process resulted in 81 new research project partnerships across 50 individual research projects. Most research partnership requests were made later in the research lifecycle, after the planning phase. Partnership acceptance was largely driven by the Collaborative's pre-defined <i>Guiding Principles</i> and <i>Rules of Engagement.</i> These lessons drive an iterative process to improve the longitudinal relationship between our translational research program and our CHC partners.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e177"},"PeriodicalIF":2.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12444707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145113424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating an internal pitch competition for entrepreneurial training in medical innovation: The alligator tank at Mayo Clinic Florida.","authors":"Shavonnye Rath, Marissa N Russo, Maarten Rotman","doi":"10.1017/cts.2025.10055","DOIUrl":"10.1017/cts.2025.10055","url":null,"abstract":"<p><p>There is a general separation between medical and business education, despite the substantial intersection of these fields in hospital and industry settings. This separation hinders medical innovators, who rarely have opportunities to see how entrepreneurial concepts apply to the translation of medical innovation. To address this, the Office of Entrepreneurship at Mayo Clinic Florida provides experiential entrepreneurial training through an internal pitch competition: the alligator tank (AT). This study evaluates the impact and efficacy of the first seven years of the AT. Key metrics include a modified technology readiness level (TRL), determined by the presence of a disclosure, prototype, and preliminary data. A high TRL is not indicative of success in the pitch competition, leveling the playing field for early-stage inventions. The AT is characterized by broad representation across academic and professional ranks, departments, and genders, as well as strong participant retention. Innovators with prior disclosures are more likely to win the AT, presumably due to their experience. The AT serves as an institution-wide initiative that cultivates an inclusive, supportive innovation culture, fosters interdisciplinary medical innovation, and helps advance innovation maturity. Adopting the AT framework may help similar medical systems build an innovation ecosystem within their institutions.</p>","PeriodicalId":15529,"journal":{"name":"Journal of Clinical and Translational Science","volume":"9 1","pages":"e144"},"PeriodicalIF":2.0,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12305374/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}