Journal of Comparative Pathology最新文献

{"title":"Immunophenotype investigation in feline intestinal non-B-cell lymphoma","authors":"Birgitt Wolfesberger ,&nbsp;Gabriele Gradner ,&nbsp;Barbara C. Rütgen ,&nbsp;Katharina M. Hittmair ,&nbsp;Ingrid Walter ,&nbsp;Taryn A. Donovan ,&nbsp;Miriam Kleiter ,&nbsp;Alexander Krischak ,&nbsp;Iwan A. Burgener ,&nbsp;Andrea Fuchs-Baumgartinger","doi":"10.1016/j.jcpa.2024.05.004","DOIUrl":"10.1016/j.jcpa.2024.05.004","url":null,"abstract":"<div><p>Lymphoma is the most common tumour of domestic cats, developing most frequently in the small intestine. Feline small intestinal lymphoma predominantly demonstrates a T-cell immunophenotype identified by standard immunopositivity for T cells with CD3 or immunopositivity for B cells with CD20. In contrast, a wide spectrum of immunohistochemical antibodies are applied in humans to diagnose the various specific lymphoma subtypes according to the WHO classification. Our aim was to augment our knowledge of immunophenotypes in feline non-B-cell lymphomas forming macroscopic masses in the intestinal tract. We evaluated the combined immunohistochemistry and flow cytometry findings from 15 cases. Neoplastic lymphoid cells were immunopositive for CD3 in 93% (14/15), granzyme B in 87% (13/15), CD5 in 20% (3/15), CD8 in 13% (2/15), CD4 in 7% (1/15) and CD56 in 7% (1/15) of cases. Cytotoxic granules indicating a cytotoxic origin of the neoplastic cells were identified by histopathology only in 13% (2/15) and by cytology in 47% (7/15) of the cases. Without immunohistochemical labelling of the cytotoxic protein granzyme B, the cytotoxic status would have been missed in 46% (6/13) of the cytological and in 85% (11/13) of the histopathological slides. These findings suggest that more complex immunophenotyping may advance our understanding and help prognosticate small intestinal T-cell lymphoma in cats.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"212 ","pages":"Pages 20-26"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002627/pdfft?md5=49e641153ea8436c190c1241892b7b2d&pid=1-s2.0-S0021997524002627-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium deposition in an atypically disintegrated hoof wall in a Thoroughbred racehorse with alkali disease: Proof by energy-dispersive X-ray fluorescence analysis","authors":"Atustoshi Kuwano ,&nbsp;Takanori Ueno ,&nbsp;Yusuke Katsurashima ,&nbsp;Oki Tateno ,&nbsp;Shigeaki Saitoh","doi":"10.1016/j.jcpa.2024.06.002","DOIUrl":"10.1016/j.jcpa.2024.06.002","url":null,"abstract":"<div><p>From summer 2018 to summer 2019, several Thoroughbred racehorses held at the Miho Training Centre of the Japan Racing Association inadvertently ingested excessive amounts of sodium selenite, resulting in typical chronic selenium (Se) poisoning – the so-called alkali disease. The typical abnormality was a hoof wall disorder with a circumferentially deep ring and/or transverse hoof wall cracks parallel to the coronet on all feet and appearing after excessive ingestion. One affected Thoroughbred male was unique in that all the hooves had a rough surface with a very fragile hoof wall, but no wall rings or transverse cracking. This horse was euthanized because of dysstasia due to the permanent foot pain associated with hoof wall deformities in the front feet. To detect Se deposition in the hooves, we used energy-dispersive X-ray fluorescence (EDXRF) analysis to measure the Se signal intensity of each lesion. Characteristic Se-kα signals were emitted from the areas of histologically damaged hoof wall at 33.76 ± 11.78 (mean ± SD) counts per second (cps)/mm². In contrast, the signal from the uninjured proximal hoof wall was 1.43 ± 0.14 cps/mm² and that from the uninjured distal hoof wall was 1.51 ± 0.23 cps/mm². The much greater Se deposition in the injured hoof walls suggests that their disintegration was caused by alkali disease. These results indicate that atypical hoof wall abnormalities due to alkali disease can be diagnosed by EDXRF analysis.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"212 ","pages":"Pages 51-55"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002664/pdfft?md5=5db0eb0256fed579142f5bb2743f75b3&pid=1-s2.0-S0021997524002664-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Canine ovarian epithelial tumours: histopathological and immunohistochemical evaluation with proposed histopathological classification system","authors":"Tamara Dolenšek ,&nbsp;Tanja Knific ,&nbsp;Gustavo A. Ramírez ,&nbsp;Kerstin Erles ,&nbsp;Hannah E. Mallon ,&nbsp;Simon L. Priestnall ,&nbsp;Alejandro Suárez-Bonnet","doi":"10.1016/j.jcpa.2024.05.006","DOIUrl":"10.1016/j.jcpa.2024.05.006","url":null,"abstract":"<div><p>Canine ovarian epithelial tumours (OETs) are currently divided into ovarian adenomas and carcinomas, which are further inconsistently subclassified as papillary or cystic, whereas in human medicine, OETs are subdivided into several subtypes. This study aimed to establish clear morphological features enabling more consistent distinction between benign OETs and ovarian carcinomas (OvCas) as well as defining different histopathological patterns of canine OvCas. Analysis revealed a mitotic count threshold of &gt;2 as a potential criterion for differentiating OvCas from benign OETs. Alongside ovarian adenomas, ovarian borderline tumours were introduced as a distinct category among benign OETs. OvCas exhibited five different histopathological patterns, namely papillary, solid with tubular differentiation, micropapillary, cystic and sarcomatous. Since some OvCas can morphologically overlap with other ovarian tumours, the expression of cytokeratin 7, a cytokeratin expressed in ovarian epithelium, was assessed and proved helpful, although it was not expressed in all cases. Furthermore, we investigated the expression of 14-3-3σ and cyclooxygenase 2 (COX-2). Based on the frequent expression of 14-3-3σ, this marker appears to have a role in canine OETs since it is not expressed in normal canine ovaries. The infrequent expression of COX-2 suggests that it is a poor candidate as a potential therapeutic target in canine OvCas.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"212 ","pages":"Pages 42-50"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002640/pdfft?md5=0d53671ece2d4be731c44d48f1fb1ef1&pid=1-s2.0-S0021997524002640-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of sialic acid receptors for influenza A virus in snakes","authors":"Yasmin C. e Silva ,&nbsp;Pedro A. Rezende ,&nbsp;Carlos E.B. Lopes ,&nbsp;Marcelo C. Lopes ,&nbsp;Eric S. Oliveira ,&nbsp;Marcelo P.N. de Carvalho ,&nbsp;Erica A. Costa ,&nbsp;Roselene Ecco","doi":"10.1016/j.jcpa.2024.06.001","DOIUrl":"10.1016/j.jcpa.2024.06.001","url":null,"abstract":"<div><p>The tissue tropism and the wide host range of influenza A viruses are determined by the presence of sialic acid (SA) α2,3-Gal and SA α2,6-Gal receptors. Recent studies have shown that animals possessing both receptors allow for the rearrangement and emergence of new viral strains of public health importance. This study aimed to evaluate the expression and distribution of human and avian influenza A receptors in nine Neotropical snake species using lectin immunohistochemistry. We selected 17 snakes that were examined <em>post mortem</em> at the Veterinary Pathology Sector of the Universidade Federal de Minas Gerais between 2019 and 2023. Sections of nasal turbinate, trachea, lung, oral mucosa, stomach and intestine were subjected to immunohistochemical analysis using the lectins <em>Maackia amurensis</em> and <em>Sambucus nigra</em>. This research detected, for the first time, co-expression of SA α2,3-Gal and SA α2,6-Gal receptors in the respiratory and digestive tracts of snakes, indicating the possible susceptibility of these species to influenza A virus of avian and human origin. Consequently, snakes can be considered important species for monitoring influenza A in wild, urban and peri-urban environments. More studies should be conducted to investigate the role of snakes in influenza A epidemiology.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"212 ","pages":"Pages 27-31"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erysipelothrix rhusiopathiae infection in a captive white-lipped peccary (Tayassu pecari) in Finland","authors":"Hanna-Maaria Javela ,&nbsp;Taru Lienemann ,&nbsp;Heli Nordgren ,&nbsp;Sanna Malkamäki ,&nbsp;Sanna Sainmaa ,&nbsp;Jonna Kyyrö ,&nbsp;Niina Airas","doi":"10.1016/j.jcpa.2024.05.003","DOIUrl":"10.1016/j.jcpa.2024.05.003","url":null,"abstract":"<div><p><em>Erysipelothrix rhusiopathiae</em> is a zoonotic pathogen that causes infections in several animal species, including erysipelas in swine, lambs and turkeys. In October 2022, a captive, 1-year-old white-lipped peccary (<em>Tayassu pecari</em>), kept in a herd of five peccaries in a zoo in Finland, suddenly developed signs of inappetence and reluctance to move. Despite treatment, the peccary was found dead. At necropsy, the main gross finding was severe acute segmental necrotizing enteritis. Several other organs had lesions compatible with acute septicaemia, including petechiae and ecchymoses. Histopathology of the intestine revealed severe acute multifocal necrotizing enteritis with neutrophilic vasculitis, vascular fibrinoid microthrombi and myriad clusters of densely packed, rod-shaped, gram-positive bacteria on the tips of the intestinal villi. Bacterial culture was identified as <em>E. rhusiopathiae</em> by MALDI-TOF mass spectrometry. To our knowledge, this is the first report of a naturally occurring <em>E. rhusiopathiae</em> infection in a captive white-lipped peccary. Our findings suggest that regular vaccination of captive white-lipped peccaries should be taken into consideration in preventing infections due to <em>E. rhusiopathiae</em>.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"212 ","pages":"Pages 16-19"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002536/pdfft?md5=e1f8c83962f0c4d828d4ed2571d72f0c&pid=1-s2.0-S0021997524002536-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141446292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal Hymenolepis nana-associated visceral larva migrans in captive juvenile white-tailed antsangies (Brachytarsomys albicauda)","authors":"Karen R. Archer ,&nbsp;Andrea Waeschenbach ,&nbsp;Claire Griffin ,&nbsp;Imogen L. Payne ,&nbsp;Johnpaul Houston ,&nbsp;D. Timothy J. Littlewood ,&nbsp;Andrew F. Rich","doi":"10.1016/j.jcpa.2024.05.005","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.05.005","url":null,"abstract":"<div><p>White-tailed antsangies (<em>Brachytarsomys albicauda)</em> are Madagascan rodents uncommonly kept in captivity. <em>Hymenolepis nana</em> is a cestode with an unusual life cycle, incorporating direct, indirect and autoinfective stages. This case series represents the first reported outbreak of <em>H. nana</em> cestodiasis in white-tailed antsangies, summarizing macroscopic and histological findings in four cases. On post-mortem examination (PME), numerous cysticerci were detected consistently throughout the intestinal serosa, liver, mesenteric lymphatic vasculature and mesenteric lymph nodes. Pancreatic cysticerci were observed in one case. Adult tapeworms, larvae and eggs were found only in the small intestine, and faecal egg shedding was a feature. Histopathological examination identified adult, larval and encysted cestodes within the respective gross lesions, with pulmonary, pancreatic and splenic involvement detected in a single case. The cestodes sampled on PME were identified by polymerase chain reaction and DNA sequencing, with <em>H. nana</em> confirmed in all cases. Visceral larva migrans was consistent throughout all specimens, in contrast with the natural infections of standard rodent hosts, and may be considered a likely pathological feature of <em>H. nana</em> infection in white-tailed antsangies.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"212 ","pages":"Pages 32-41"},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological characterization and grading of chronic enterocolitis in Sulawesi crested macaques (Macaca nigra)","authors":"Yannick Van de Weyer ,&nbsp;Mark R. Howard ,&nbsp;Mark F. Stidworthy ,&nbsp;Alberto R. Barbon ,&nbsp;Julian Chantrey ,&nbsp;Stamatios A. Tahas ,&nbsp;Ethan Wrigglesworth ,&nbsp;Lewis J. Rowden ,&nbsp;Amanda Guthrie ,&nbsp;Simon Spiro","doi":"10.1016/j.jcpa.2024.05.002","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.05.002","url":null,"abstract":"<div><p>Sulawesi crested macaques (<em>Macaca nigra</em>) (SCMs) are critically endangered and frequently suffer from chronic intestinal disease in captivity. Often, despite routine diagnostic investigations and confirmation of intestinal inflammation, an aetiology cannot be identified, leading to a non-specific categorization as chronic enterocolitis rather than an aetiological diagnosis. This study evaluates the histological features of gastrointestinal tissues from 23 SCMs, comparing animals with a clinical history suggestive of chronic enterocolitis (n = 14) with those without gastrointestinal clinical signs (n = 9). Tissues were graded according to the Nancy index (NI), a scoring system used in human medicine to evaluate disease activity in ulcerative colitis, a common form of human inflammatory bowel disease (IBD). Additionally, inflammatory cells in the colonic lamina propria were visually identified by type, counted and subsequently compared between diseased and control animals. Moderate to severe lymphoplasmacytic inflammation and structural changes were most common in the colons of affected SCMs, whereas histopathological changes were absent or mild in all examined small intestine (n = 17) and stomach (n = 11) tissues. The colonic NI had a significant positive correlation with clinical disease severity and 57% (n = 8) of animals with clinical signs had a NI grade of ≥2, consistent with moderate to severe, active IBD. Half of SCMs with recurrent rectal prolapse (n = 6) had a NI grade of 0, suggesting that intestinal inflammation is not always part of this condition's pathogenesis. The numbers of colonic lymphocytes, plasma cells, neutrophils, macrophages and total leucocytes were significantly higher in diseased animals. This study validated the use of the NI in SCMs, enabling a more standardized histopathological evaluation of the colon in this species.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"212 ","pages":"Pages 6-15"},"PeriodicalIF":0.8,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002524/pdfft?md5=b9570134443e69da9774884d0cf1c5e3&pid=1-s2.0-S0021997524002524-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD117 expression in canine ovarian tumours","authors":"Hannah E. Mallon ,&nbsp;Gustavo A. Ramírez ,&nbsp;Tamara Dolenšek ,&nbsp;Kerstin Erles ,&nbsp;Bernat Martí-Garcia ,&nbsp;Simon L. Priestnall ,&nbsp;Alejandro Suárez-Bonnet","doi":"10.1016/j.jcpa.2024.05.001","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.05.001","url":null,"abstract":"<div><p>Canine ovarian cancer poses a significant diagnostic and therapeutic challenge. The heterogeneous nature of ovarian tumours makes accurate histological identification difficult, whilst treatment is limited to surgical excision. The tyrosine kinase receptor CD117 is neo-expressed in many tumours and represents a potential diagnostic and prognostic biomarker and therapeutic target. This study aimed to establish if CD117 is neoexpressed in canine ovarian tumours. Immunohistochemistry was employed to assess expression of CD117 in 29 canine ovarian tumour samples. CD117 labelling was assessed with a semiquantitative immunoreactivity score, and the location of labelling was recorded as membranous, focal cytoplasmic or diffuse cytoplasmic. Histological morphology was assessed and used to assign subgroups based on growth pattern. Cytokeratin 7 labelling was used to indicate the tumour type as epithelial or sex-cord stromal in origin. Mitotic index, percentage of necrosis and vascular invasion were also assessed and evaluated for association with CD117 expression. Overall, 81% of ovarian tumours neoexpressed CD117 and normal ovarian tissue did not express CD117. Positive immunolabelling was seen in a subset of cells in both ovarian carcinomas (n = 20) and ovarian granulosa cell tumours (n = 3). There was no association between CD117 expression and patient age, histological subtype, mitotic index, percentage of necrosis or vascular invasion. This is the largest study to identify the expression of CD117 in canine ovarian tumours, but further research is needed to elucidate its prognostic and therapeutic value.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"212 ","pages":"Pages 1-5"},"PeriodicalIF":0.8,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002512/pdfft?md5=5df5e7953ad543c559fb5e4ed47c8a63&pid=1-s2.0-S0021997524002512-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141322609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two cases of congenital lipomatosis in calves","authors":"Nermin Caliskan,&nbsp;Annelies Vandekerckhove,&nbsp;Evelien Forrez,&nbsp;Emily Rolly,&nbsp;Marieke Strubbe,&nbsp;Stefan Roels","doi":"10.1016/j.jcpa.2024.04.006","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.04.006","url":null,"abstract":"<div><p>Fetal tumours in domestic animals are considered rare. Congenital lipomatous changes have been sporadically reported in fetal, neonatal and young bovids. Their prognosis is often guarded compared with benign lipocytic tumours and depends on their location and degree of infiltration. They can infiltrate the subcutis, deeper musculature and even the skeleton. Four cases of congenital infiltrative lipomatosis have been described in bovine fetuses and young calves. In this report we describe an additional two cases in a neonatal Belgian Blue White calf and a fetal dairy calf. A potential role in bovine abortion needs further investigation. Furthermore, a suggestion is made to adapt the nomenclature from infiltrative lipoma to lipomatosis in order to emphasize the poor prognosis due to the local infiltrative behaviour of these lesions.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"211 ","pages":"Pages 52-56"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141090407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review of the comparative pathological and immunohistochemical features of human and canine cutaneous melanocytic neoplasms","authors":"Isabeli J. Contel ,&nbsp;Carlos E. Fonseca-Alves ,&nbsp;Heitor F. Ferrari ,&nbsp;Renee Laufer-Amorim ,&nbsp;José C.C. Xavier-Júnior","doi":"10.1016/j.jcpa.2024.04.001","DOIUrl":"10.1016/j.jcpa.2024.04.001","url":null,"abstract":"<div><p>Melanocytic neoplasms originate from melanocytes and melanoma, the malignant form, is a common canine neoplasm and the most aggressive human skin cancer. Despite many similarities between these neoplasms in both species, only a limited number of studies have approached these entities in a comparative manner. Therefore, this review compares benign and malignant melanocytic neoplasms in dogs and humans, exclusively those arising in the haired skin, with regard to their clinicopathological, immunohistochemical and molecular aspects. Shared features include spontaneous occurrence, macroscopic features and microscopic findings when comparing human skin melanoma in the advanced/invasive stage and canine cutaneous melanoma, immunohistochemical markers and several histopathological prognostic factors. Differences include the apparent absence of active mutations in the <em>BRAF</em> gene in canine cutaneous melanoma and less aggressive clinical behaviour in dogs than in humans. Further studies are required to elucidate the aetiology and genetic development pathways of canine cutaneous melanocytic neoplasms. Evaluation of the applicability of histopathological prognostic parameters commonly used in humans for dogs are also needed. The similarities between the species and the recent findings regarding genetic mutations in canine cutaneous melanomas suggest the potential utility of dogs as a natural model for human melanomas that are not related to ultraviolet radiation.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"211 ","pages":"Pages 26-35"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}