Journal of Comparative Pathology最新文献

{"title":"Intestinal histoplasmosis with granulomatous colonic and mesenteric lymphadenitis due to Histoplasma mississippiense infection in an American Mammoth Jackstock donkey (Equus asinus).","authors":"Justin M Stilwell, Julianne M White, Clare C Brown, Amelia I Andersson, Bryan Waldridge, Natalie K Stilwell","doi":"10.1016/j.jcpa.2024.12.004","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.12.004","url":null,"abstract":"<p><p>Histoplasmosis is a rarely reported clinical disease of equids in North America and is historically attributed to Histoplasma capsulatum var. capsulatum. This report details a case of intestinal histoplasmosis with lymphadenitis in an American Mammoth Jackstock donkey from Mississippi. Clinically, the donkey had chronic wasting, poor appetite, diarrhoea and an intra-abdominal mass detected by ultrasound. Grossly, the distal small and proximal large intestines contained multifocal, raised, tan, nodular, button ulcers along the mucosal surface. The associated colonic and mesenteric lymph nodes were severely enlarged, mottled tan to red and firm, and formed a large multinodular mass within the mesentery. Microscopically, lesions consisted of nodular infiltrates of epithelioid macrophages and multinucleated giant cells laden with numerous yeasts, along with mucosal ulceration and necrosis. Fungal polymerase chain reaction from lesioned intestines and lymph nodes targeting the internal transcribed spacer region yielded a 585 bp sequence that matched identically to two human isolates of Histoplasma mississippiense, one of several cryptic species previously classified together as H. capsulatum var. capsulatum endemic to North America. This case represents the first molecular identification of a Histoplasma species infecting a North American equid and the second report of histoplasmosis in a donkey from North America.</p>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"217 ","pages":"11-15"},"PeriodicalIF":0.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143023365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocardiosis in domestic ferrets (Mustela putorius furo).","authors":"Carles Juan-Sallés, Luary C Martínez-Chavarría, Andrés Montesinos, Jacobo Giner, Xavier Valls, Javier Bermúdez, Rigoberto Hernández-Castro, María Ardiaca, Vicente González, José Villora, Alberto Marco","doi":"10.1016/j.jcpa.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.12.001","url":null,"abstract":"<p><p>Nocardia spp are ubiquitous, gram-positive, variably acid-fast, branching and beaded filamentous, facultative intracellular bacteria that are resistant to phagocytosis and can cause localized or systemic disease in a variety of mammals, including humans, as well as in birds, fish and reptiles. Seventeen pet domestic ferrets (Mustela putorius furo) were diagnosed with nocardiosis by several methods including cytological evaluation, histopathology, Ziehl-Neelsen staining and polymerase chain reaction (PCR). All except two ferrets were 2 years old or older at the time of clinical presentation. Clinical findings included anorexia, weight loss, lymphadenomegaly, splenomegaly, masses/nodules in internal organs, hindlimb weakness or paresis, vomiting, dyspnoea, central nervous system signs, diarrhoea, abdominal pain and coughing. Anaemia, leucocytosis, neutrophilia, hypoalbuminaemia and hyperglobulinaemia were frequent. All ferrets had granulomatous or pyogranulomatous inflammation involving most commonly the lymph nodes, spleen, lungs, liver and adipose tissue. Intralesional acid-fast, branching filamentous bacilli were detected in 15 of 17 ferrets. PCR for the 16S rRNA gene of Nocardia spp was positive in 13 of 15 ferrets, including the two that were negative by acid-fast staining; of these two ferrets, one had intralesional coronavirus antigen. BLASTn analysis of eight sequences revealed six different Nocardia spp, including N. globerula, N. seriolae and N. donostiensis, that have rarely been reported to cause disease in humans and terrestrial animals. Antibiotic treatment (most commonly trimethoprim-sulfamethoxazole alone or in combination with clarithromycin and marbofloxacin) was followed by a marked improvement in several patients, although relapses were frequent. Six ferrets had concurrent neoplasia as a potential predisposing factor. Nocardiosis should be included in the differential diagnosis of granulomatous/pyogranulomatous inflammation in ferrets, particularly in those over 2 years of age.</p>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"217 ","pages":"1-10"},"PeriodicalIF":0.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated protothecosis caused by Prototheca bovis in two dogs.","authors":"Vinicius Dahm, Crisan Smaniotto, Alessandra da Cruz, Amália Ferronato, Camila Campagnolo, Fernanda de Oliveira Lazzaretti, Mayane Faccin, Olicies da Cunha, Thais Fray Dos Santos, Manoela Marchezan Piva, Aline de Marco Viott","doi":"10.1016/j.jcpa.2024.11.005","DOIUrl":"10.1016/j.jcpa.2024.11.005","url":null,"abstract":"<p><p>Protothecosis is an infectious disease caused by unicellular algae of the genus Prototheca, which are mainly known for causing mastitis in farm animals. However, there are reports of protothecosis in humans and other animals, such as dogs and cats, which develop cutaneous lesions or systemic lesions. Dogs with the systemic form generally develop bloody diarrhoea and blindness and neurological signs may also occur. The condition generally leads to the animal being euthanized due to the unfavourable prognosis. The objective of this work was to report two cases of disseminated protothecosis, one in a Pekingese dog (case 1) and the other in a German Shepherd Dog (case 2). Both animals had a history of chronic diarrhoea with haematochezia, which was unresponsive to various treatments in case 2. Both dogs were euthanized due to their clinical condition and were sent to the Veterinary Pathology Laboratory of the Federal University of Paraná for post-mortem examination. Macroscopically, the lesions in both cases were similar and were characterized by multifocal millimetre-sized white nodulations in the heart, skeletal muscles and intestinal serosa, as well as signs of fibrinonecrotic enterocolitis and lymphoplasmacytic interstitial nephritis. In both cases there was also retinal displacement with lymphoplasmacytic uveitis and chorioretinitis. The cytological and histopathological evaluation of the tissues revealed the presence of structures compatible with Prototheca spp. Polymerase chain reaction identified Prototheca bovis in both cases. This is a rarely reported disease and must be considered as a differential diagnosis in cases of chronic diarrhoea with haematochezia that progress to blindness in dogs.</p>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"216 ","pages":"33-39"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal systemic bacterial infections in two harbour porpoises (Phocoena phocoena) secondary to bite wounds from grey seals (Halichoerus grypus).","authors":"Nicholas J Davison, Mark P Dagleish, Geoffrey Foster, Anne Ridley, Mariel Ten Doeschate, Andrew Brownlow","doi":"10.1016/j.jcpa.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.12.002","url":null,"abstract":"<p><p>Mycoplasma phocicerebrale, the causative agent of seal ('speck') finger, a zoonotic disease, is a common commensal in the oral cavity of various seal species. Historically associated with seal hunters, it remains a significant risk for those handling or rehabilitating marine mammals. While primarily known for causing severe cellulitis in humans, M. phocicerebrale can also lead to severe infections in seals, including osteomyelitis and sepsis. Recent studies have revealed the predatory behaviour of grey seals (Halichoerus grypus) on harbour porpoises (Phocoena phocoena). Examination of scarring patterns on stranded animals suggest that some initial predation attempts are unsuccessful, and porpoises escape only to succumb to infection originating from bite wounds. Here we describe two cases in which the isolation of M. phocicerebrale and other bacterial species from chronically infected bite wounds, the lungs and other internal organs of harbour porpoises suggest failed predation attempts by grey seals. Therefore, the impact of delayed, indirect mortality from sympatric predation attempts may be a significant additional and underestimated cause of mortality in harbour porpoises. One of the cases examined in this study involved a harbour porpoise with gross and histological evidence of a failed predation attempt and a fatal systemic M. phocicerebrale infection. These findings highlight the severe consequences of such infections and underscore the importance of understanding the ecological implications of grey seal predation on harbour porpoise populations.</p>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"216 ","pages":"50-56"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmissible venereal tumour with encephalic metastasis in dogs.","authors":"Erick P F Souto, Daniel R Rissi, Artefio M Oliveira, Dlean S Garcia, Rinaldo A Mota, Almir P de Souza, Glauco J N Galiza, Antônio F M Dantas","doi":"10.1016/j.jcpa.2024.11.004","DOIUrl":"10.1016/j.jcpa.2024.11.004","url":null,"abstract":"<p><p>From January 2000 to December 2023 the Laboratory of Animal Pathology of the Federal University of Campina Grande received 6,218 canine autopsy and biopsy submissions, with six (0.09%) autopsy cases diagnosed as transmissible venereal tumour (TVT) with encephalic metastases. The mean age of affected dogs (four females and two males) was 7 years. Dogs were all from urban areas and were either semidomiciled (four cases) or stray (two cases). Clinical findings consisted of multilobular, ulcerated masses affecting the genital area (five cases) or skin (one case). Neurological signs were reported in three cases and included lethargy, seizures and ataxia. Grossly, encephalic metastases were subdural and extraparenchymal and affected the telencephalic hemispheres (four cases) or the base of the brain (two cases). In all cases, histology revealed a round cell neoplasm arranged in sheets supported by a scant fibrovascular stroma. In the brain, tumours often compressed and occasionally infiltrated the surrounding neuroparenchyma. Neoplastic cells had immunolabelling for vimentin, CD45RA, Iba1 and lysozyme, and no immunolabelling for MHC class II, CD117, CD3, CD79 and MUM1. Encephalic metastases of TVT should be included in the differential diagnosis of nervous system diseases of dogs in endemic areas where TVT is diagnosed in genital or extragenital tissues.</p>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"216 ","pages":"25-32"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyglucosan storage disease in a black-capped parrot (Pionitesmelanocephalus).","authors":"Kelsey R Fiddes, Jess Magnotti, Anibal G Armien, Elise E B LaDouceur","doi":"10.1016/j.jcpa.2024.11.003","DOIUrl":"10.1016/j.jcpa.2024.11.003","url":null,"abstract":"<p><p>Following an episode of sudden lethargy, an 18-month-old female black-capped parrot (Pionites melanocephalus) died while being examined. On gross examination, there was fluid within the coelom, hepatomegaly with yellow colouration and the heart appeared enlarged with pallor throughout the myocardium. On histological examination, cardiomyocytes were swollen with loss of cross striations and contained 6-12-μm diameter intrasarcoplasmic pale grey inclusions of storage material. Cardiomyocytes were occasionally karyomegalic with mitotic figures, lost or replaced by fibrosis and inflammation. Within the liver, there was periportal and centrilobular fibrosis and mild lipid-type vacuolar change with extramedullary haematopoiesis. In the lung, the bronchi and parabronchi had luminal haemorrhage and oedema with hypertrophy of epithelium lining the parabronchi. On transmission electron microscopy, the storage material was non-membrane bound, fibrillar and intrasarcoplasmic and had an occasional homogeneous, electron-dense, central core. The morphological features of this material, combined with the histological findings, are consistent with a diagnosis of polyglucosan storage disease and subsequent heart failure.</p>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"216 ","pages":"20-24"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac pathology associated with hypertension and chronic kidney disease in aged cats.","authors":"Zara Flora, Pak K Tang, Ken Smith, Jonathan Elliott","doi":"10.1016/j.jcpa.2024.11.006","DOIUrl":"10.1016/j.jcpa.2024.11.006","url":null,"abstract":"<p><p>Hypertension is a common condition in older cats, often secondary to chronic kidney disease (CKD). Although the heart is one of the organs damaged by hypertension, the pathology of the feline hypertensive (HT) heart has been poorly studied. The aim of this retrospective study was to describe the gross and microscopic pathology of hearts obtained from cats at post-mortem examination and to compare cats diagnosed with hypertension with cats of similar age and kidney function for which antihypertensive treatment was not deemed clinically necessary. Hearts from 32 cats were examined‒18 from HT and 14 from normotensive (NT) cats. The prevalence of CKD was 72.2% vs. 78.6% in the HT and NT groups, respectively. The time-averaged blood pressure over the longitudinal follow-up from diagnosis was significantly higher in the HT group compared with the NT group (153.4 ± 20.8 vs. 133.9 ± 19.3 mmHg; P = 0.0106), respectively. HT cats, when compared with NT cats, had a thicker left ventricular free wall (7.67 [5.45-9.29] vs. 5.07 [4.72-7.16] mm; P = 0.001) and interventricular septum (6.92 [6.26-7.56] vs. 4.96 [4.15-6.46] mm; P = 0.008) and higher ventricular weight as a percentage of body weight (0.34 [0.29-0.36] vs. 0.28 [0.21-0.31]%; P = 0.02), respectively. Myocardial fibrosis was present in 72% of cases with no significant difference in the prevalence (P = 0.45) or score (P = 0.81) between the HT (1 [0.75-2]; 77.8% scoring one or above) and NT cats (1 [0-2]; 64.3% scoring one or above). Similarly, the population prevalence of myocyte hypertrophy, myofibre disarray and microvascular change was 71.9%, 50% and 43.7%, respectively, and did not differ significantly between groups. These results suggest that age-related cardiac pathology, exacerbated by azotaemic CKD, in cats is very common. The role that hypertension plays in mediating these pathological changes is uncertain.</p>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"216 ","pages":"40-49"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular pathophysiology of Leptospira interrogans infection in canine testicular tissue: role of the TLR4/NF-kB/JNK pathway.","authors":"İsmail Bolat, Merve Bolat, Metin Kiliçlioğlu, Serkan Yıldırım, Yavuz S Sağlam, Selim Çomaklı, Berrah Gözegir","doi":"10.1016/j.jcpa.2024.11.001","DOIUrl":"10.1016/j.jcpa.2024.11.001","url":null,"abstract":"<p><p>Leptospirosis is a prevalent zoonotic disease in dogs. Although it is known that leptospires are primarily harboured in kidney tissues of dogs, it has been reported that they also infect testicular tissue. Leptospira interrogans causes various lesions in canine testicular tissues; however, the pathogenesis has not been clearly explained. In this study, 20 canine testicular tissue samples infected with L. interrogans were investigated for evidence of oxidative DNA damage, inflammation, apoptosis and autophagy. Ten samples of canine testicular tissue that were negative for L. interrogans were used as a positive control group. All tissues were examined by histopathological, immunohistochemistry (IHC) and immunofluorescence (IF) methods. Histopathological examination revealed that testicular tissues infected with L. interrogans had inflammation and oedema, and degeneration and necrosis of spermatocytes. In cases of severe disease, enzyme-linked immunosorbent assay, reverse transcriptase polymer chain reaction and IHC and IF indicated significant increases in levels of TLR4, NF-kB, IL-1β, TNF-α, 8-OHdG, JNK1/3, caspase-8, caspase-3, LC3A and LC3B but lower levels in milder cases. These results indicate that L. interrogans stimulated the immune system through the TLR4/NF-kB/JNK pathway in dog testicular tissues, leading to inflammation and apoptosis. The infection also caused oxidative DNA damage and autophagy.</p>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"216 ","pages":"10-19"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometry, cellular characterization and temporal evolution of granulomas induced by aluminium oxyhydroxide in sheep.","authors":"Ana Rodríguez-Largo, Álex Gómez, Estela Pérez, Ricardo de Miguel, Irati Moncayola, Lucia Biagini, Giacomo Rossi, Ignacio de Blas, Antonio Fernández, Marta Pérez, Idoia Glaria, Ramsés Reina, Lluís Luján","doi":"10.1016/j.jcpa.2024.11.002","DOIUrl":"10.1016/j.jcpa.2024.11.002","url":null,"abstract":"<p><p>Persistent subcutaneous granulomas form at the injection site following administration of aluminium oxyhydroxide (AlOOH), a widely used vaccine adjuvant. Small ruminant lentiviruses (SRLVs) can infect macrophages within granulomas induced by commercial AlOOH-based vaccines in sheep. The entry of SRLVs into target cells involves the mannose receptor (MR), while catalytic polypeptide-like 3 protein containing Z1 domain (A3Z1) is considered a restriction factor for lentiviral replication. The objective of this study was to investigate the temporal evolution of AlOOH-induced post-vaccination granulomas in sheep experimentally infected with SRLVs. Twenty-four male lambs underwent two identical vaccination protocols and were challenged with SRLVs. Granulomas were detected in vaccinated groups only and progressively decreased in size. At post-mortem examination, 91.3% of the granulomas were recovered. Fistulas were present in granulomas following the second vaccination protocol. Central necrosis was present in 58.0% of granulomas and was associated with the vaccine used. Orthokeratotic keratin was seen within granulomas in 47.1% of the lambs. Considering all granulomas studied, significantly higher expression of MR was found compared with A3Z1. Differences in MR expression were related to the type of vaccine and the time since vaccination. A3Z1 expression was upregulated in granulomas from the infected groups. Macrophage polarization may influence SRLV infection of granulomas. While SRLV infection does not influence the architecture of post-vaccination granulomas, it may modulate their immune microenvironment. Further studies are needed to elucidate the complex interactions between AlOOH-induced granulomas and SRLV infection in sheep.</p>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"216 ","pages":"1-9"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomopathological characterization of hepatic lesions of feline infectious peritonitis in cats","authors":"Fernanda G. Cony,&nbsp;Vanessa C. Pereira,&nbsp;Mônica Slaviero,&nbsp;Rafael P. Lima,&nbsp;Lucas T. de Castro,&nbsp;José T.R. de Moraes,&nbsp;João M.G. Aliardi,&nbsp;David Driemeier,&nbsp;Luciana Sonne,&nbsp;Welden Panziera,&nbsp;Saulo P. Pavarini","doi":"10.1016/j.jcpa.2024.10.003","DOIUrl":"10.1016/j.jcpa.2024.10.003","url":null,"abstract":"<div><div>Feline infectious peritonitis (FIP) is one of the most important infectious diseases and a significant cause of death in cats. While the pathology of FIP has been well documented, there is little information on the hepatic lesions. The aim of this study was to characterize the macroscopic, microscopic and immunohistochemical patterns of the liver lesions in cats with FIP. A retrospective study was conducted on 131 cats with FIP, of which 59 had histological inflammatory lesions in the liver and were immunopositive for feline coronavirus. Four major gross patterns were defined: perihepatitis (21/59); nodular with perihepatitis (18/59); nodular multifocal (13/59); and diffuse (7/59). Four histological patterns were observed: (1) random pyogranulomas; (2) random multifocal to coalescent caseous necrosis surrounded by pyogranulomatous inflammatory infiltrate, fibrin and cellular debris; (3) perihepatitis; and (4) random multifocal to coalescent caseous necrosis surrounded by neutrophils, macrophages, lymphocytes and plasma cells. Most cats had more than one histological pattern. FIP virus antigen was detected in macrophages in the pyogranulomas and around the necrotic areas. The diagnosis of FIP remains challenging, especially in cats without effusion. The liver can be considered a suitable site for biopsy when feasible.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 59-65"},"PeriodicalIF":0.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}