Journal of Comparative Pathology最新文献

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Anatomopathological characterization of hepatic lesions of feline infectious peritonitis in cats 猫传染性腹膜炎肝脏病变的解剖病理学特征。
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2024-11-01 DOI: 10.1016/j.jcpa.2024.10.003
Fernanda G. Cony, Vanessa C. Pereira, Mônica Slaviero, Rafael P. Lima, Lucas T. de Castro, José T.R. de Moraes, João M.G. Aliardi, David Driemeier, Luciana Sonne, Welden Panziera, Saulo P. Pavarini
{"title":"Anatomopathological characterization of hepatic lesions of feline infectious peritonitis in cats","authors":"Fernanda G. Cony,&nbsp;Vanessa C. Pereira,&nbsp;Mônica Slaviero,&nbsp;Rafael P. Lima,&nbsp;Lucas T. de Castro,&nbsp;José T.R. de Moraes,&nbsp;João M.G. Aliardi,&nbsp;David Driemeier,&nbsp;Luciana Sonne,&nbsp;Welden Panziera,&nbsp;Saulo P. Pavarini","doi":"10.1016/j.jcpa.2024.10.003","DOIUrl":"10.1016/j.jcpa.2024.10.003","url":null,"abstract":"<div><div>Feline infectious peritonitis (FIP) is one of the most important infectious diseases and a significant cause of death in cats. While the pathology of FIP has been well documented, there is little information on the hepatic lesions. The aim of this study was to characterize the macroscopic, microscopic and immunohistochemical patterns of the liver lesions in cats with FIP. A retrospective study was conducted on 131 cats with FIP, of which 59 had histological inflammatory lesions in the liver and were immunopositive for feline coronavirus. Four major gross patterns were defined: perihepatitis (21/59); nodular with perihepatitis (18/59); nodular multifocal (13/59); and diffuse (7/59). Four histological patterns were observed: (1) random pyogranulomas; (2) random multifocal to coalescent caseous necrosis surrounded by pyogranulomatous inflammatory infiltrate, fibrin and cellular debris; (3) perihepatitis; and (4) random multifocal to coalescent caseous necrosis surrounded by neutrophils, macrophages, lymphocytes and plasma cells. Most cats had more than one histological pattern. FIP virus antigen was detected in macrophages in the pyogranulomas and around the necrotic areas. The diagnosis of FIP remains challenging, especially in cats without effusion. The liver can be considered a suitable site for biopsy when feasible.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 59-65"},"PeriodicalIF":0.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous ependymoma in a free-ranging juvenile black-horned capuchin (Sapajus nigritus) 一只自由放养的黑角卷尾猴(Sapajus nigritus)幼年自发性脑外膜瘤。
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2024-11-01 DOI: 10.1016/j.jcpa.2024.10.004
Carolina Fontana , Amália Ferronato , Vinicius Dahm , Marina M. Berón , Stacy Wu , Ronaldo J. Piccoli , Anderson L. de Carvalho , Aline de Marco Viott
{"title":"Spontaneous ependymoma in a free-ranging juvenile black-horned capuchin (Sapajus nigritus)","authors":"Carolina Fontana ,&nbsp;Amália Ferronato ,&nbsp;Vinicius Dahm ,&nbsp;Marina M. Berón ,&nbsp;Stacy Wu ,&nbsp;Ronaldo J. Piccoli ,&nbsp;Anderson L. de Carvalho ,&nbsp;Aline de Marco Viott","doi":"10.1016/j.jcpa.2024.10.004","DOIUrl":"10.1016/j.jcpa.2024.10.004","url":null,"abstract":"<div><div>A young free-ranging black-horned capuchin (<em>Sapajus nigritus</em>) with a history of ataxia, anisocoria, diminished threat and pupil reflexes and increased cranial circumference was referred for evaluation to the Medicine and Wildlife Conservation Section, Federal University of Paraná, Paraná, Brazil. Due to the clinical presentation and radiographic findings of hydrocephalus, euthanasia was performed. Necropsy revealed a dark red mass (1.5 × 1.8 cm) in the region of the third ventricle and marked dilation of the lateral ventricles. Histopathological findings were characterized by proliferation of ciliated round cells with eosinophilic cytoplasm, as well as the formation of ependymal rosettes and pseudorosettes. In some areas the cells contained brown cytoplasmic pigment, which stained with Fontana-Masson. The neoplastic cells were immunoreactive for glial fibrillary acidic protein and negative for pancytokeratin. Considering the anatomopathological and immunohistochemical findings, the diagnosis was ependymoma grade II with melanocytic features, which is the first report of this neoplasm in any member of the genus <em>Sapajus</em>.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 66-70"},"PeriodicalIF":0.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uveal iridophoroma in a betta fish (Betta splendens) 贝塔鱼(Betta splendens)的葡萄膜虹膜瘤。
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2024-11-01 DOI: 10.1016/j.jcpa.2024.09.006
Lisa Crevoiserat , Nina Katzenstein , Elise E.B. LaDouceur
{"title":"Uveal iridophoroma in a betta fish (Betta splendens)","authors":"Lisa Crevoiserat ,&nbsp;Nina Katzenstein ,&nbsp;Elise E.B. LaDouceur","doi":"10.1016/j.jcpa.2024.09.006","DOIUrl":"10.1016/j.jcpa.2024.09.006","url":null,"abstract":"<div><div>Chromatophoromas are neoplasms arising from pigment cells in vertebrates. Iridophoromas are a type of chromatophoroma that are reported in several teleost species. There are multiple case reports of this diagnosis in betta fish (<em>Betta splendens</em>), but all previously reported cases originated from the skin. This is the first report of an intra-ocular iridophoroma. An adult betta fish had buphthalmia of the right eye and enucleation was performed. The fish survived surgery but was found dead 2 days later. The eye and entire body were examined histologically, and the right eye was also examined ultrastructurally. Histologically, the uveal tract of the right eye was unilaterally and markedly expanded by a neoplasm that expanded and obliterated the iris and choroid and regionally invaded the cornea and sclera. The neoplasm was composed of spindle cells that contained pale green, birefringent, crystalline granules (iridophores). Transmission electron microscopy revealed that neoplastic cells contained a single elongated nucleus and one or more thin cytoplasmic bundles of reflecting plates that were oriented parallel to the basal lamina, further confirming the diagnosis of iridophoroma. This is the first reported case of an iridophoroma arising from the uveal tract. Most cases of iridophoromas and other chromatophoromas in fish are reported as benign. However, there are no established histological criteria of malignancy in these neoplasms. Despite the bland cellular morphology, most reported cases of iridophoromas and other chromatophoromas in bettas (including this case) had substantial tissue invasion and/or destruction. This suggests that iridophoromas and chromatophoromas in bettas may have local invasion, consistent with malignancy, despite bland cytological features.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 71-75"},"PeriodicalIF":0.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hyperkeratotic gastritis in two-toed sloths (Choloepus didactylus) from wildlife rescue 来自野生动物救助站的双趾树懒(Choloepus didactylus)的过度角化性胃炎。
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2024-11-01 DOI: 10.1016/j.jcpa.2024.10.002
Washington A. Pereira , David F. Conga , Antônio M. Costa , Adriana C. Jaques , Alexsandro P. Damasceno , Samara C. Loura , Pedro H. Portela , Andressa B. Menezes , Ana S. Ribeiro
{"title":"Hyperkeratotic gastritis in two-toed sloths (Choloepus didactylus) from wildlife rescue","authors":"Washington A. Pereira ,&nbsp;David F. Conga ,&nbsp;Antônio M. Costa ,&nbsp;Adriana C. Jaques ,&nbsp;Alexsandro P. Damasceno ,&nbsp;Samara C. Loura ,&nbsp;Pedro H. Portela ,&nbsp;Andressa B. Menezes ,&nbsp;Ana S. Ribeiro","doi":"10.1016/j.jcpa.2024.10.002","DOIUrl":"10.1016/j.jcpa.2024.10.002","url":null,"abstract":"<div><div>Xenarthran mammals of the suborder Folivora are arboreal species that feed mainly on leaves and <em>Cecropia</em> spp, an abundant plant in the Brazilian Amazon region, is favoured. The stomach of sloths represents 20–30% of their body weight and is adapted to gastric fermentation of plant material. These anatomical and physiological adaptations can be altered by many factors when confined to captivity, which favours fatal gastric conditions. The objective of this study was to describe the gastric anatomopathological lesions in three two-toed sloths (<em>Choloepus didactylus</em>) from a wildlife rescue centre. Necropsy revealed wide variation in the thickness of the gastric mucosa, with large areas having a papilliform appearance. Histologically, hyperkeratinization of the stratified squamous epithelium of the aglandular gastric region and infiltration of lymphocytic and plasmacytic cells were seen. The histopathological diagnosis was chronic hyperkeratotic gastritis, which has not previously been reported in sloths. Repeated exposure to dietary antigens, drugs, chemicals, toxins or infectious agents can initiate allergic or immune-mediated responses that can ultimately lead to chronic gastritis in these animals.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 55-58"},"PeriodicalIF":0.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous soft tissue tumours in aged mouse lemurs (Microcebus spp) 老龄鼠狐猴(Microcebus spp)的自发性软组织肿瘤。
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2024-11-01 DOI: 10.1016/j.jcpa.2024.10.001
Martina Bleyer , Ute Radespiel , Annette Klein , Annika Kollikowski , Philipp Ströbel , Kerstin Mätz-Rensing , Eva Gruber-Dujardin
{"title":"Spontaneous soft tissue tumours in aged mouse lemurs (Microcebus spp)","authors":"Martina Bleyer ,&nbsp;Ute Radespiel ,&nbsp;Annette Klein ,&nbsp;Annika Kollikowski ,&nbsp;Philipp Ströbel ,&nbsp;Kerstin Mätz-Rensing ,&nbsp;Eva Gruber-Dujardin","doi":"10.1016/j.jcpa.2024.10.001","DOIUrl":"10.1016/j.jcpa.2024.10.001","url":null,"abstract":"<div><div>Mouse lemurs (<em>Microcebus</em> spp) are small Madagascan strepsirrhine primates increasingly used as an animal model in ageing research. During a period of 10 years, neoplastic disease occurred in 47 grey (<em>Microcebus murinus</em>) and Goodman's (<em>Microcebus lehilahtsara</em>) mouse lemurs from a captive colony in Germany. Approximately half of these tumours appeared histologically as soft tissue tumours (STTs) with a significantly higher proportion of STTs in Goodman's mouse lemurs (87.5%) compared with grey mouse lemurs (38.5%) (<em>P</em> ≤0.025). Most STTs grew subcutaneously in old or senile animals and were commonly located on the trunk, less often on the head and rarely at visceral sites. The majority of STTs were of fibrous or myofibroblastic origin, followed by undifferentiated pleomorphic sarcomas and extraskeletal chondro-osseous neoplasia. Histological grading of malignant STTs revealed all but one as grade II or III, with more than 60% being grade III. Female mouse lemurs of both species were affected significantly more often by grade II and III tumours than males (<em>P</em> = 0.0412). This study gives a comprehensive overview of the spectrum of mesenchymal neoplastic disease in mouse lemurs and highlights some histomorphological characteristics of spontaneous STTs in this small non-human primate species.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 47-54"},"PeriodicalIF":0.8,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142621430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of epithelioid glioblastoma with lung metastases in a young Cane Corso dog 一例上皮样胶质母细胞瘤伴肺转移的年轻肯恩柯索犬病例。
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2024-10-22 DOI: 10.1016/j.jcpa.2024.09.005
Yannick Van de Weyer, Emanuele Ricci, Gail Leeming
{"title":"A case of epithelioid glioblastoma with lung metastases in a young Cane Corso dog","authors":"Yannick Van de Weyer,&nbsp;Emanuele Ricci,&nbsp;Gail Leeming","doi":"10.1016/j.jcpa.2024.09.005","DOIUrl":"10.1016/j.jcpa.2024.09.005","url":null,"abstract":"<div><div>Astrocytomas are relatively common primary brain tumours of humans and companion animals. In dogs, they represent approximately 17–28% of primary central nervous system tumours. However, extracranial metastasis is extremely rare. This case report describes a grade IV astrocytoma (glioblastoma) in the cerebrum of a young Cane Corso dog with pulmonary metastases. The diagnosis was obtained via histopathological morphology and immunophenotyping, which showed strong positivity for glial fibrillary acidic protein, vimentin and connexin-43. The glioblastoma in this Cane Corso had epithelioid morphology with histological features of malignancy including high mitotic count, microvascular proliferation, serpentine necrosis and subventricular zone involvement. Epithelioid glioblastoma is a rare subtype that has only relatively recently been formally acknowledged in human medicine and it can also pose a diagnostic challenge in veterinary medicine.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 42-46"},"PeriodicalIF":0.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intravascular central nervous system T-cell lymphoma in a common dolphin (Delphinus delphis) with cerebral infarction 普通海豚(Delphinus delphis)血管内中枢神经系统 T 细胞淋巴瘤并发脑梗塞。
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2024-10-19 DOI: 10.1016/j.jcpa.2024.09.004
Mark E. Wessels , Mariel T.I. ten Doeschate , Richard Fox , Elise Squirrell , Andrew Brownlow
{"title":"Intravascular central nervous system T-cell lymphoma in a common dolphin (Delphinus delphis) with cerebral infarction","authors":"Mark E. Wessels ,&nbsp;Mariel T.I. ten Doeschate ,&nbsp;Richard Fox ,&nbsp;Elise Squirrell ,&nbsp;Andrew Brownlow","doi":"10.1016/j.jcpa.2024.09.004","DOIUrl":"10.1016/j.jcpa.2024.09.004","url":null,"abstract":"<div><div>Lymphoid and haematopoietic neoplasms are rare in cetaceans. This report describes intravascular lymphoma in an adult common dolphin that presented with neurological signs prior to stranding. Intravascular lymphoma is a rare neoplasm previously recorded in humans, dogs, a cat and a horse. The condition is characterized by intravascular neoplastic lymphocytic proliferation, the sequelae of which are dependent on the organ affected. Key pathological findings in this case included multifocal cerebrocortical malacia secondary to vascular occlusion associated with intravascular neoplastic lymphocytic proliferation. Immunohistochemistry supported a T-cell phenotype similar to that observed in dogs. The neurological presentation was consistent with that seen in other species in which the central nervous system is involved. The aetiology and pathogenesis have not been established in other species and although no further investigations were made in this common dolphin, this report adds to the short list of species affected by this rare neoplasm.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 37-41"},"PeriodicalIF":0.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intra-abdominal heterotopic mesenteric ossification associated with intestinal volvulus in a sow (Sus scrofa domesticus) 一头母猪(Sus scrofa domesticus)腹腔内异位肠系膜骨化并伴有肠套叠。
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2024-10-19 DOI: 10.1016/j.jcpa.2024.09.003
Davide Corbetta , Sara Degl’Innocenti , Carlo Bianco , Tom Iveson , Ana Ortiz , Carlo Anselmi , Antonia Morey-Matamalas
{"title":"Intra-abdominal heterotopic mesenteric ossification associated with intestinal volvulus in a sow (Sus scrofa domesticus)","authors":"Davide Corbetta ,&nbsp;Sara Degl’Innocenti ,&nbsp;Carlo Bianco ,&nbsp;Tom Iveson ,&nbsp;Ana Ortiz ,&nbsp;Carlo Anselmi ,&nbsp;Antonia Morey-Matamalas","doi":"10.1016/j.jcpa.2024.09.003","DOIUrl":"10.1016/j.jcpa.2024.09.003","url":null,"abstract":"<div><div>An adult, female, mixed breed sow from a commercial breeding unit, with a clinical history of lethargy, poor body condition, hypersalivation, dyspnoea and reddened ears, was submitted for necropsy. Post-mortem examination identified the presence of an intestinal volvulus, which developed around an osseous intra-abdominal mesenteric lesion. Gross pathology and histopathology combined with post-mortem computed tomography (CT) of the mass confirmed the lesion as intra-abdominal heterotopic mesenteric ossification (IHMO), according to criteria applied to human disease. This report highlights a rare case of porcine IHMO, a poorly understood metaplastic condition, comparable to the human disease. We highlight the importance of a combination of CT and histopathology to reach a final diagnosis of the disease. Histopathology and further investigation of similar cases may contribute to a better understanding of the pathogenesis in animals, which is currently poorly understood.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 32-36"},"PeriodicalIF":0.8,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Annual congress of the European Society of Veterinary Pathology and the European College of Veterinary Pathologists 欧洲兽医病理学学会和欧洲兽医病理学家学院年度大会
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2024-10-11 DOI: 10.1016/j.jcpa.2024.09.002
{"title":"Annual congress of the European Society of Veterinary Pathology and the European College of Veterinary Pathologists","authors":"","doi":"10.1016/j.jcpa.2024.09.002","DOIUrl":"10.1016/j.jcpa.2024.09.002","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 30-31"},"PeriodicalIF":0.8,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142426467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Special AT-rich sequence-binding protein 2 immunohistochemistry in the diagnosis of osteosarcoma in dogs 特殊富AT序列结合蛋白2免疫组化在犬骨肉瘤诊断中的应用。
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2024-10-04 DOI: 10.1016/j.jcpa.2024.09.001
Alba Maria M. Shank , Eric Snook , Kimberly Cavender , Joseph McCoy , Nicolas Sorensen , Bradley Siegrist , Brian Tabb
{"title":"Special AT-rich sequence-binding protein 2 immunohistochemistry in the diagnosis of osteosarcoma in dogs","authors":"Alba Maria M. Shank ,&nbsp;Eric Snook ,&nbsp;Kimberly Cavender ,&nbsp;Joseph McCoy ,&nbsp;Nicolas Sorensen ,&nbsp;Bradley Siegrist ,&nbsp;Brian Tabb","doi":"10.1016/j.jcpa.2024.09.001","DOIUrl":"10.1016/j.jcpa.2024.09.001","url":null,"abstract":"<div><div>Malignant osteoblasts can have markedly pleomorphic phenotypes and variable amounts of tumour-associated matrix, complicating the ability of pathologists to accurately differentiate osteosarcoma (OSA) from other types of neoplasms using only histopathology. Current immunohistochemical markers for animals have limited sensitivity and specificity in identifying OSA or produce inconsistent results. Immunohistochemistry (IHC) for special AT-rich sequence-binding protein 2 (SATB2) has been used in human medicine to aid in identification of normal and neoplastic osteoblasts, and the objective of this study was to determine whether this marker could also be useful for the diagnosis of canine OSA. Initially, SATB2 IHC was performed on eight samples from cases of well-differentiated canine OSA and on other tumour types for which OSA is a differential diagnosis, as well as on normal tissues, to assess sensitivity and cross-reactivity. Following confirmation that SATB2 is immunoreactive for normal and neoplastic canine osteoblasts and negative in other non-osseous mesenchymal cell types and organs, SATB2 IHC was tested on 123 cases of poorly differentiated malignant neoplasms as part of a panel with other immunohistochemical markers, as appropriate, based on histomorphology and differential diagnoses. The conclusion is that SATB2 IHC is a sensitive and specific marker for identifying canine OSA when used in a panel with other immunohistochemical markers and in conjunction with supportive clinical history.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 14-29"},"PeriodicalIF":0.8,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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