Journal of Comparative Pathology最新文献

A case of epithelioid glioblastoma with lung metastases in a young Cane Corso dog 一例上皮样胶质母细胞瘤伴肺转移的年轻肯恩柯索犬病例。

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-10-22 DOI: 10.1016/j.jcpa.2024.09.005

引用次数: 0

Intravascular central nervous system T-cell lymphoma in a common dolphin (Delphinus delphis) with cerebral infarction 普通海豚（Delphinus delphis）血管内中枢神经系统 T 细胞淋巴瘤并发脑梗塞。

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-10-19 DOI: 10.1016/j.jcpa.2024.09.004

引用次数: 0

Intra-abdominal heterotopic mesenteric ossification associated with intestinal volvulus in a sow (Sus scrofa domesticus) 一头母猪（Sus scrofa domesticus）腹腔内异位肠系膜骨化并伴有肠套叠。

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-10-19 DOI: 10.1016/j.jcpa.2024.09.003

引用次数: 0

Annual congress of the European Society of Veterinary Pathology and the European College of Veterinary Pathologists 欧洲兽医病理学学会和欧洲兽医病理学家学院年度大会

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-10-11 DOI: 10.1016/j.jcpa.2024.09.002

引用次数: 0

Special AT-rich sequence-binding protein 2 immunohistochemistry in the diagnosis of osteosarcoma in dogs 特殊富AT序列结合蛋白2免疫组化在犬骨肉瘤诊断中的应用。

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-10-04 DOI: 10.1016/j.jcpa.2024.09.001

{"title":"Special AT-rich sequence-binding protein 2 immunohistochemistry in the diagnosis of osteosarcoma in dogs","authors":"","doi":"10.1016/j.jcpa.2024.09.001","DOIUrl":"10.1016/j.jcpa.2024.09.001","url":null,"abstract":"<div><div>Malignant osteoblasts can have markedly pleomorphic phenotypes and variable amounts of tumour-associated matrix, complicating the ability of pathologists to accurately differentiate osteosarcoma (OSA) from other types of neoplasms using only histopathology. Current immunohistochemical markers for animals have limited sensitivity and specificity in identifying OSA or produce inconsistent results. Immunohistochemistry (IHC) for special AT-rich sequence-binding protein 2 (SATB2) has been used in human medicine to aid in identification of normal and neoplastic osteoblasts, and the objective of this study was to determine whether this marker could also be useful for the diagnosis of canine OSA. Initially, SATB2 IHC was performed on eight samples from cases of well-differentiated canine OSA and on other tumour types for which OSA is a differential diagnosis, as well as on normal tissues, to assess sensitivity and cross-reactivity. Following confirmation that SATB2 is immunoreactive for normal and neoplastic canine osteoblasts and negative in other non-osseous mesenchymal cell types and organs, SATB2 IHC was tested on 123 cases of poorly differentiated malignant neoplasms as part of a panel with other immunohistochemical markers, as appropriate, based on histomorphology and differential diagnoses. The conclusion is that SATB2 IHC is a sensitive and specific marker for identifying canine OSA when used in a panel with other immunohistochemical markers and in conjunction with supportive clinical history.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142377884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Striking and widespread microglial activation in the brains of Southdown lambs with type II glucocerebrosidosis (neuronopathic Gaucher disease) 患有 II 型葡糖酸中毒（神经病变性戈谢病）的南道羔羊大脑中惊人而广泛的小胶质细胞活化

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-09-14 DOI: 10.1016/j.jcpa.2024.08.003

{"title":"Striking and widespread microglial activation in the brains of Southdown lambs with type II glucocerebrosidosis (neuronopathic Gaucher disease)","authors":"","doi":"10.1016/j.jcpa.2024.08.003","DOIUrl":"10.1016/j.jcpa.2024.08.003","url":null,"abstract":"<div><p>Glucocerebrosidosis (termed Gaucher disease in humans) is a lysosomal storage disease, caused by a deficiency of the enzyme glucocerebrosidase, which results in accumulation of the glycolipid substrate glucocerebroside in the macrophage–monocyte system. Three principal forms are recognized in humans, two being neuronopathic and resulting in neurodegeneration. Only two spontaneously arising cases have been described in domestic animals, one in a dog and the other in a flock of Southdown sheep. Since microglial activation is increasingly being recognized as having an important role in the pathogenesis of Gaucher disease and archival brains were available from lambs with type II glucocerebrosidosis, we wanted to determine whether microglia were activated in these brains. Ionized calcium binding adaptor molecule 1 (Iba1), a specific and the most widely expressed immunohistochemical marker of microglial activation, was used. Striking and widely distributed activation of microglia was demonstrated, suggesting that microglia actively participate in the development of neuropathological changes in ovine Gaucher disease. This aspect of Gaucher disease requires further study in any future cases detected in domestic animal species, including the mechanism by which this markedly increased Iba1 expression is related to disease progression.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002962/pdfft?md5=b72c41ee933986ee106a06860b83a4ee&pid=1-s2.0-S0021997524002962-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid lesions in a population of domestic cats submitted to necropsy without clinical suspicion of thyroid disease 在没有临床怀疑甲状腺疾病的情况下接受尸体解剖的家猫群体中发现甲状腺病变

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-09-13 DOI: 10.1016/j.jcpa.2024.08.002

{"title":"Thyroid lesions in a population of domestic cats submitted to necropsy without clinical suspicion of thyroid disease","authors":"","doi":"10.1016/j.jcpa.2024.08.002","DOIUrl":"10.1016/j.jcpa.2024.08.002","url":null,"abstract":"<div><p>Although hyperthyroidism is the most common endocrine disorder in elderly cats, systematic studies investigating the prevalence of thyroid lesions in feline animals are scarce. Our objective was to evaluate morphological changes in the thyroid glands of 61 cats submitted to necropsy without clinical suspicion of hyperthyroidism. Thirteen (13/61 [21.3%]) cats had thyroid enlargement and 54/61 (88.5%) had some histological thyroid changes. Proliferative lesions were histologically seen in 33/61 (54%) cats while non-proliferative lesions were observed in 48/61 (78.7%) cats. Thyroid hyperplasia (18/33 [54.5%]) and cystic adenoma (6/33 [18.2%]) were the most prevalent proliferative changes and lesions with little or no clinical significance (37/61 [60.6%]), degenerative (31/61 [50.8%]) and inflammatory changes (12/61 [19.7%]) were the most common non-proliferative changes. Among cats with proliferative lesions, 16/33 (48.4%) had a proliferation grade ≥A4, a grade previously associated with clinical hyperthyroidism. Although the cats from this study did not have any clinical diagnosis of thyroid disease, it is possible that one or more had some degree of clinically unnoticed thyroid dysfunction. The high prevalence of follicular lesions in this study highlights the importance of a more careful clinical and pathological investigation regarding thyroid diseases in mature and elderly cats.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The digital revolution in veterinary pathology 兽医病理学的数字革命。

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-09-05 DOI: 10.1016/j.jcpa.2024.08.001

{"title":"The digital revolution in veterinary pathology","authors":"","doi":"10.1016/j.jcpa.2024.08.001","DOIUrl":"10.1016/j.jcpa.2024.08.001","url":null,"abstract":"<div><p>For the past two centuries, the use of traditional light microscopy to examine tissues to make diagnoses has remained relatively unchanged. While the fundamental concept of tissue slide analysis has stayed the same, our interaction with the microscope is undergoing significant changes. Digital pathology (DP) has gained momentum in veterinary science and is on the verge of becoming a vital tool in diagnostics, research and education. Many diagnostic laboratories have incorporated DP as a critical part of their workflows. Innovations in DP and whole slide image technology have made telediagnosis (the process of transmitting digital clinical data using telecommunication networks for distant diagnosis) more accessible, leading to improved patient care through streamlining of workflows and greater accessibility of second opinions. The integration of machine learning and artificial intelligence and human-in-the-loop protocols for DP workflows will further the development of computer-aided diagnosis and prognostic tools. Despite its present weaknesses, DP will progressively aid veterinary clinicians and pathologists in delivering more accurate and reliable diagnoses. Consistent incorporation of DP frontline advancements into routine veterinary diagnostic pipelines will assist in improving current tools and help prepare pathologists for the progression of digitalization in the field.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002883/pdfft?md5=20c9d4f136102a289296cce0d9b4e46b&pid=1-s2.0-S0021997524002883-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunocytochemistry of bone marrow aspirates: a tool in the diagnosis of feline leukemia virus infection in cats 骨髓抽吸物的免疫细胞化学：诊断猫感染猫白血病病毒的工具

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-08-26 DOI: 10.1016/j.jcpa.2024.07.007

{"title":"Immunocytochemistry of bone marrow aspirates: a tool in the diagnosis of feline leukemia virus infection in cats","authors":"","doi":"10.1016/j.jcpa.2024.07.007","DOIUrl":"10.1016/j.jcpa.2024.07.007","url":null,"abstract":"<div><p>Feline leukemia virus (FeLV) is a highly debilitating cat pathogen due to its ability to cause many pathological changes. Therefore, identifying the virus directly in bone marrow can be a highly relevant diagnostic tool even in the absence of viraemia. The aim of this study was to compare the diagnostic efficiency of immunocytochemistry (ICC) of bone marrow aspirates with enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR). Blood samples were collected from 188 cats and separated into aliquots of whole blood for nested PCR using the U3 LTR region and the gag gene of FeLV-A as reference and serum for detection of the p27 antigen by ELISA. Bone marrow samples from these cats were placed on silanized slides for anti-FeLV ICC using gp70 as primary antibody. A total of 28.2% of the cats tested for FeLV were positive in at least one of the tests, with 26.6% positive by PCR, 18.1% by ICC and 11.2% by ELISA. Cohen's kappa agreement test revealed moderate agreement between ELISA and PCR results and substantial agreement between ICC and ELISA and between ICC and PCR. The results indicated that ICC of bone marrow is an efficient novel diagnostic test for FeLV infection.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric adenocarcinoma with carcinomatosis and degenerative joint disease of the xiphisternum in a Bactrian camel (Camelus bactrianus) 双峰驼（Camelus bactrianus）胃腺癌伴癌转移和髋关节退行性病变。

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-08-20 DOI: 10.1016/j.jcpa.2024.07.006

{"title":"Gastric adenocarcinoma with carcinomatosis and degenerative joint disease of the xiphisternum in a Bactrian camel (Camelus bactrianus)","authors":"","doi":"10.1016/j.jcpa.2024.07.006","DOIUrl":"10.1016/j.jcpa.2024.07.006","url":null,"abstract":"<div><p>Gastric adenocarcinomas have been sporadically reported in camelids. This report describes a primary gastric adenocarcinoma and subsequent peritoneal carcinomatosis in a 20-year-old female Bactrian camel (<em>Camelus bactrianus</em>). Numerous metastases were present throughout the omentum, liver, abdominal lymph nodes, intestinal serosa, kidneys and lungs. The primary tumour macroscopically resembled an ulcerated crater and originated from the distal four-fifths of the C3 compartment, an anatomical region with naturally prominent gastric rugae and true glands. Moderate numbers of <em>Helicobacter</em> spp colonies were present within gastric pits and necrotic areas of C3. Ménetrier's disease has previously been implicated as a predisposing condition for the development of gastric adenocarcinoma in another camel, but no evidence of this premalignant disorder was found in this case. This camel also suffered from a chronic skin wound of the hump and severe degenerative joint disease of the xiphisternum, the latter of which was presumably associated with excessive pressure on the sternum.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S002199752400286X/pdfft?md5=ca1ec01f7e88a70b2dbd3b88a0acd82f&pid=1-s2.0-S002199752400286X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0