Journal of Comparative Pathology最新文献_第2页

Striking and widespread microglial activation in the brains of Southdown lambs with type II glucocerebrosidosis (neuronopathic Gaucher disease) 患有 II 型葡糖酸中毒（神经病变性戈谢病）的南道羔羊大脑中惊人而广泛的小胶质细胞活化

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-09-14 DOI: 10.1016/j.jcpa.2024.08.003

John Finnie , Kim Hemsley , Jim Manavis , Helen Beard , John Brealey , Thomas Robertson , Peter Blumbergs

{"title":"Striking and widespread microglial activation in the brains of Southdown lambs with type II glucocerebrosidosis (neuronopathic Gaucher disease)","authors":"John Finnie , Kim Hemsley , Jim Manavis , Helen Beard , John Brealey , Thomas Robertson , Peter Blumbergs","doi":"10.1016/j.jcpa.2024.08.003","DOIUrl":"10.1016/j.jcpa.2024.08.003","url":null,"abstract":"<div><p>Glucocerebrosidosis (termed Gaucher disease in humans) is a lysosomal storage disease, caused by a deficiency of the enzyme glucocerebrosidase, which results in accumulation of the glycolipid substrate glucocerebroside in the macrophage–monocyte system. Three principal forms are recognized in humans, two being neuronopathic and resulting in neurodegeneration. Only two spontaneously arising cases have been described in domestic animals, one in a dog and the other in a flock of Southdown sheep. Since microglial activation is increasingly being recognized as having an important role in the pathogenesis of Gaucher disease and archival brains were available from lambs with type II glucocerebrosidosis, we wanted to determine whether microglia were activated in these brains. Ionized calcium binding adaptor molecule 1 (Iba1), a specific and the most widely expressed immunohistochemical marker of microglial activation, was used. Striking and widely distributed activation of microglia was demonstrated, suggesting that microglia actively participate in the development of neuropathological changes in ovine Gaucher disease. This aspect of Gaucher disease requires further study in any future cases detected in domestic animal species, including the mechanism by which this markedly increased Iba1 expression is related to disease progression.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 10-13"},"PeriodicalIF":0.8,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002962/pdfft?md5=b72c41ee933986ee106a06860b83a4ee&pid=1-s2.0-S0021997524002962-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thyroid lesions in a population of domestic cats submitted to necropsy without clinical suspicion of thyroid disease 在没有临床怀疑甲状腺疾病的情况下接受尸体解剖的家猫群体中发现甲状腺病变

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-09-13 DOI: 10.1016/j.jcpa.2024.08.002

Alana P. Herbichi, Douglas M. Lorenzetti, Matheus Y. dos Santos, Gabriela Hartmann, Rafael A. Fighera, Mariana M. Flores

{"title":"Thyroid lesions in a population of domestic cats submitted to necropsy without clinical suspicion of thyroid disease","authors":"Alana P. Herbichi, Douglas M. Lorenzetti, Matheus Y. dos Santos, Gabriela Hartmann, Rafael A. Fighera, Mariana M. Flores","doi":"10.1016/j.jcpa.2024.08.002","DOIUrl":"10.1016/j.jcpa.2024.08.002","url":null,"abstract":"<div><p>Although hyperthyroidism is the most common endocrine disorder in elderly cats, systematic studies investigating the prevalence of thyroid lesions in feline animals are scarce. Our objective was to evaluate morphological changes in the thyroid glands of 61 cats submitted to necropsy without clinical suspicion of hyperthyroidism. Thirteen (13/61 [21.3%]) cats had thyroid enlargement and 54/61 (88.5%) had some histological thyroid changes. Proliferative lesions were histologically seen in 33/61 (54%) cats while non-proliferative lesions were observed in 48/61 (78.7%) cats. Thyroid hyperplasia (18/33 [54.5%]) and cystic adenoma (6/33 [18.2%]) were the most prevalent proliferative changes and lesions with little or no clinical significance (37/61 [60.6%]), degenerative (31/61 [50.8%]) and inflammatory changes (12/61 [19.7%]) were the most common non-proliferative changes. Among cats with proliferative lesions, 16/33 (48.4%) had a proliferation grade ≥A4, a grade previously associated with clinical hyperthyroidism. Although the cats from this study did not have any clinical diagnosis of thyroid disease, it is possible that one or more had some degree of clinically unnoticed thyroid dysfunction. The high prevalence of follicular lesions in this study highlights the importance of a more careful clinical and pathological investigation regarding thyroid diseases in mature and elderly cats.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"215 ","pages":"Pages 1-9"},"PeriodicalIF":0.8,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142229027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The digital revolution in veterinary pathology 兽医病理学的数字革命。

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-09-05 DOI: 10.1016/j.jcpa.2024.08.001

Kenneth Ancheta , Sophie Le Calvez , Jonathan Williams

{"title":"The digital revolution in veterinary pathology","authors":"Kenneth Ancheta , Sophie Le Calvez , Jonathan Williams","doi":"10.1016/j.jcpa.2024.08.001","DOIUrl":"10.1016/j.jcpa.2024.08.001","url":null,"abstract":"<div><p>For the past two centuries, the use of traditional light microscopy to examine tissues to make diagnoses has remained relatively unchanged. While the fundamental concept of tissue slide analysis has stayed the same, our interaction with the microscope is undergoing significant changes. Digital pathology (DP) has gained momentum in veterinary science and is on the verge of becoming a vital tool in diagnostics, research and education. Many diagnostic laboratories have incorporated DP as a critical part of their workflows. Innovations in DP and whole slide image technology have made telediagnosis (the process of transmitting digital clinical data using telecommunication networks for distant diagnosis) more accessible, leading to improved patient care through streamlining of workflows and greater accessibility of second opinions. The integration of machine learning and artificial intelligence and human-in-the-loop protocols for DP workflows will further the development of computer-aided diagnosis and prognostic tools. Despite its present weaknesses, DP will progressively aid veterinary clinicians and pathologists in delivering more accurate and reliable diagnoses. Consistent incorporation of DP frontline advancements into routine veterinary diagnostic pipelines will assist in improving current tools and help prepare pathologists for the progression of digitalization in the field.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"214 ","pages":"Pages 19-31"},"PeriodicalIF":0.8,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002883/pdfft?md5=20c9d4f136102a289296cce0d9b4e46b&pid=1-s2.0-S0021997524002883-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunocytochemistry of bone marrow aspirates: a tool in the diagnosis of feline leukemia virus infection in cats 骨髓抽吸物的免疫细胞化学：诊断猫感染猫白血病病毒的工具

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-08-26 DOI: 10.1016/j.jcpa.2024.07.007

Thierry G. de Cristo , Giovana Biezus , Aline R. Maciel , Geanice Ledo , Mayara Vavassori , Ubirajara M. da Costa , Luiz C. Miletti , Renata A. Casagrande

{"title":"Immunocytochemistry of bone marrow aspirates: a tool in the diagnosis of feline leukemia virus infection in cats","authors":"Thierry G. de Cristo , Giovana Biezus , Aline R. Maciel , Geanice Ledo , Mayara Vavassori , Ubirajara M. da Costa , Luiz C. Miletti , Renata A. Casagrande","doi":"10.1016/j.jcpa.2024.07.007","DOIUrl":"10.1016/j.jcpa.2024.07.007","url":null,"abstract":"<div><p>Feline leukemia virus (FeLV) is a highly debilitating cat pathogen due to its ability to cause many pathological changes. Therefore, identifying the virus directly in bone marrow can be a highly relevant diagnostic tool even in the absence of viraemia. The aim of this study was to compare the diagnostic efficiency of immunocytochemistry (ICC) of bone marrow aspirates with enzyme-linked immunosorbent assay (ELISA) and polymerase chain reaction (PCR). Blood samples were collected from 188 cats and separated into aliquots of whole blood for nested PCR using the U3 LTR region and the gag gene of FeLV-A as reference and serum for detection of the p27 antigen by ELISA. Bone marrow samples from these cats were placed on silanized slides for anti-FeLV ICC using gp70 as primary antibody. A total of 28.2% of the cats tested for FeLV were positive in at least one of the tests, with 26.6% positive by PCR, 18.1% by ICC and 11.2% by ELISA. Cohen's kappa agreement test revealed moderate agreement between ELISA and PCR results and substantial agreement between ICC and ELISA and between ICC and PCR. The results indicated that ICC of bone marrow is an efficient novel diagnostic test for FeLV infection.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"214 ","pages":"Pages 12-18"},"PeriodicalIF":0.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142076638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gastric adenocarcinoma with carcinomatosis and degenerative joint disease of the xiphisternum in a Bactrian camel (Camelus bactrianus) 双峰驼（Camelus bactrianus）胃腺癌伴癌转移和髋关节退行性病变。

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-08-20 DOI: 10.1016/j.jcpa.2024.07.006

Yannick Van de Weyer , Charlotte Bentley , Anna Orlowska , Alberto R. Barbon , Julian Chantrey

{"title":"Gastric adenocarcinoma with carcinomatosis and degenerative joint disease of the xiphisternum in a Bactrian camel (Camelus bactrianus)","authors":"Yannick Van de Weyer , Charlotte Bentley , Anna Orlowska , Alberto R. Barbon , Julian Chantrey","doi":"10.1016/j.jcpa.2024.07.006","DOIUrl":"10.1016/j.jcpa.2024.07.006","url":null,"abstract":"<div><p>Gastric adenocarcinomas have been sporadically reported in camelids. This report describes a primary gastric adenocarcinoma and subsequent peritoneal carcinomatosis in a 20-year-old female Bactrian camel (<em>Camelus bactrianus</em>). Numerous metastases were present throughout the omentum, liver, abdominal lymph nodes, intestinal serosa, kidneys and lungs. The primary tumour macroscopically resembled an ulcerated crater and originated from the distal four-fifths of the C3 compartment, an anatomical region with naturally prominent gastric rugae and true glands. Moderate numbers of <em>Helicobacter</em> spp colonies were present within gastric pits and necrotic areas of C3. Ménetrier's disease has previously been implicated as a predisposing condition for the development of gastric adenocarcinoma in another camel, but no evidence of this premalignant disorder was found in this case. This camel also suffered from a chronic skin wound of the hump and severe degenerative joint disease of the xiphisternum, the latter of which was presumably associated with excessive pressure on the sternum.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"214 ","pages":"Pages 7-11"},"PeriodicalIF":0.8,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S002199752400286X/pdfft?md5=ca1ec01f7e88a70b2dbd3b88a0acd82f&pid=1-s2.0-S002199752400286X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated paracoccidioidomycosis in a captive western black-handed tamarin (Saguinus niger) 一只人工饲养的西部黑手犭(Saguinus niger)体内的散播性副球孢子菌病

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-08-17 DOI: 10.1016/j.jcpa.2024.07.005

Isabelle D. de Oliveira , Eduardo Ferreira-Machado , Jamile M. Garcia , Sarah R.J.S. Simões , Ketlyn B. Figueiredo , Rodrigo A. Ressio , André L.M. da Costa , Flora N. Matos , Cássia R.R. Gonzaga , Shamira S. Leandro , Marina A. de Medeiros , Rodrigo H.F. Teixeira , Mariana C. Martins , Juliana P.F. Takahashi , Leonardo J.T. de Araújo , Natália C.C. de Azevedo Fernandes , Juliana M. Guerra

{"title":"Disseminated paracoccidioidomycosis in a captive western black-handed tamarin (Saguinus niger)","authors":"Isabelle D. de Oliveira , Eduardo Ferreira-Machado , Jamile M. Garcia , Sarah R.J.S. Simões , Ketlyn B. Figueiredo , Rodrigo A. Ressio , André L.M. da Costa , Flora N. Matos , Cássia R.R. Gonzaga , Shamira S. Leandro , Marina A. de Medeiros , Rodrigo H.F. Teixeira , Mariana C. Martins , Juliana P.F. Takahashi , Leonardo J.T. de Araújo , Natália C.C. de Azevedo Fernandes , Juliana M. Guerra","doi":"10.1016/j.jcpa.2024.07.005","DOIUrl":"10.1016/j.jcpa.2024.07.005","url":null,"abstract":"<div><p>Paracoccidioidomycosis (PCM) is an endemic fungal disease that occurs in Latin America and primarily affects humans. The disease has been rarely documented in non-human primates. This report details a disseminated and fatal case of PCM caused by <em>Paracoccidioides brasiliensis</em> in a western black-handed tamarin (<em>Saguinus niger</em>) under human care. Histopathological examination revealed extensive pyogranulomatous inflammation in the lungs, spleen, liver, lymph nodes, kidneys, epididymis, right testicle, heart, adrenal gland and intestines, associated with characteristic yeast forms consistent with <em>Paracoccidioides</em> spp and confirmed by immunohistochemistry. Molecular analysis indicated a high nucleotide similarity with <em>P. brasiliensis</em> sequences for both the <em>18S</em> rRNA and <em>gp43</em> genes. This naturally occurring infection highlights the susceptibility of these animals to PCM and their role in ecoepidemiology warrants further investigation.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"214 ","pages":"Pages 1-6"},"PeriodicalIF":0.8,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Disseminated granulomatous encephalitis caused by Schizophyllum commune in a dog with severe neurological signs 一只有严重神经症状的狗患上了由五味子引起的播散性肉芽肿性脑炎

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-08-01 DOI: 10.1016/j.jcpa.2024.07.004

Tomokazu Nagashima , Shohei Tsumoto , Daisuke Yazawa , Miki Omura , Kazuhiko Ochiai , Karin Yoshida , Kayoko Sugibayashi , Yukino Machida , Ryoichi Suzuki , Koh Igarashi , Koichi Makimura , Yasushi Hara , Masaki Michishita

{"title":"Disseminated granulomatous encephalitis caused by Schizophyllum commune in a dog with severe neurological signs","authors":"Tomokazu Nagashima , Shohei Tsumoto , Daisuke Yazawa , Miki Omura , Kazuhiko Ochiai , Karin Yoshida , Kayoko Sugibayashi , Yukino Machida , Ryoichi Suzuki , Koh Igarashi , Koichi Makimura , Yasushi Hara , Masaki Michishita","doi":"10.1016/j.jcpa.2024.07.004","DOIUrl":"10.1016/j.jcpa.2024.07.004","url":null,"abstract":"<div><p>A 10-year-old spayed mixed breed dog presented with severe neurological signs. Computed tomography revealed a cranial mediastinal mass, osteolysis of the right second rib and second thoracic vertebra, tracheobronchial and mesenteric lymph node enlargement, pneumonia and pleural effusion. Magnetic resonance imaging detected lesions in the white matter of the right frontal lobe and left cerebral hemisphere with contrast-enhanced T1-weighted images showing demarcated enhancement. On cut section, the surface of the right cerebral frontal lobe and left cerebral hemisphere corticomedullary junctions were indistinct and the white matter was discoloured. Microscopically, multicentric granulomatous inflammation was seen in the brain, cranial mediastinal mass, masses on the right second rib, tracheobronchial and mesenteric lymph nodes, heart, kidneys, lungs and oesophagus. Necrosis and hyaline fungal structures were frequently observed in the centre of the granulomas. These fungi had septae, Y-shaped branching and were 2–3 μm in width. Sequence analysis of DNA from formalin-fixed paraffin-embedded samples identified the fungi as <em>Schizophyllum commune</em>. Based on these findings, this case was diagnosed as disseminated <em>S. commune</em> infection. This is the first report of granulomatous encephalitis caused by <em>S. commune</em> in a dog.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"213 ","pages":"Pages 73-77"},"PeriodicalIF":0.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141985774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bibliometric study of the application of the chicken embryo chorioallantoic membrane model in cancer research: the top 100 most cited articles 鸡胚绒毛膜模型在癌症研究中的应用文献计量学研究：被引用次数最多的 100 篇文章。

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-08-01 DOI: 10.1016/j.jcpa.2024.07.001

Chang Song , Dan-Dan Xiong , Rong-Quan He , Xiang-Zhi Yong , Zhi-Guang Huang , Yi-Wu Dang , Gang Chen , Yu-Yan Pang , Chun-Yan Zhao , Ning Qu , Dan-Ming Wei

{"title":"Bibliometric study of the application of the chicken embryo chorioallantoic membrane model in cancer research: the top 100 most cited articles","authors":"Chang Song , Dan-Dan Xiong , Rong-Quan He , Xiang-Zhi Yong , Zhi-Guang Huang , Yi-Wu Dang , Gang Chen , Yu-Yan Pang , Chun-Yan Zhao , Ning Qu , Dan-Ming Wei","doi":"10.1016/j.jcpa.2024.07.001","DOIUrl":"10.1016/j.jcpa.2024.07.001","url":null,"abstract":"<div><p>The chicken embryo chorioallantoic membrane (CAM) model has played a crucial role in various aspects of cancer research. The purpose of this study is to help researchers clarify the research direction and prospects of the CAM model. A bibliometric analysis was conducted on the top 100 most cited articles on use of the CAM model in tumour research, retrieved from the Web of Science Core Collection database. Tools such as Bibliometrix, VOSviewer, CiteSpace and Excel were utilized for the visualization network analysis. The 100 articles analysed were mainly from the USA, China and European countries such as Germany and France. Tumour research involving CAM model experiments demonstrated reliability and scientific rigor (average citation count = 156.2). The analysis of keywords, topics and subject areas revealed that the applications of this model ranged from the biological characteristics of tumours to molecular mechanisms and signaling pathways, to recent developments in nanotechnology and clinical applications. Additionally, nude mouse experiments have been more frequently performed in recent years. We conclude that the CAM model is efficient, simple and cost-effective, and has irreplaceable value in various aspects of cancer research. In the future, the CAM model can further contribute to nanotechnology research.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"213 ","pages":"Pages 59-72"},"PeriodicalIF":0.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

First report of a neurofibrosarcoma in the penis of a bull 首次报告公牛阴茎神经纤维肉瘤。

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-08-01 DOI: 10.1016/j.jcpa.2024.07.003

Juan A. Chiaraviglio , María del Rocío Marini , Eduardo M. Belotti , Natalia R. Salvetti , Hugo H. Ortega , Ruben A. Mazzini , Fabian O. Barberis , Josefina Y. Bandeo , Ana M. Canal

引用次数: 0

Mammary and reproductive tract tumours and tumour-like lesions of 286 small pet mammals: a retrospective study 286只小型宠物哺乳动物的乳腺和生殖道肿瘤及肿瘤样病变：一项回顾性研究。

IF 0.8 4区农林科学

Journal of Comparative Pathology Pub Date : 2024-08-01 DOI: 10.1016/j.jcpa.2024.07.002

Katarzyna Paździor-Czapula, Mateusz Mikiewicz, Joanna Fiedorowicz, Iwona Otrocka-Domagała

{"title":"Mammary and reproductive tract tumours and tumour-like lesions of 286 small pet mammals: a retrospective study","authors":"Katarzyna Paździor-Czapula, Mateusz Mikiewicz, Joanna Fiedorowicz, Iwona Otrocka-Domagała","doi":"10.1016/j.jcpa.2024.07.002","DOIUrl":"10.1016/j.jcpa.2024.07.002","url":null,"abstract":"<div><p>Small mammals are very popular companion animals, and the incidence of particular tumour types in these animals is the subject of extensive research. We carried out a retrospective and comparative analysis of the incidence of reproductive tract and mammary tumours and tumour-like lesions collected from 103 pet rabbits, 75 pet rats, 71 guinea pigs, 12 mice, 11 hamsters, eight African pygmy hedgehogs, four ferrets and two chinchillas. The results indicate that uterine tumours and tumour-like lesions are common in pet rabbits, guinea pigs and African pygmy hedgehogs. In pet rabbits, the most common uterine tumour was endometrial adenocarcinoma, while in guinea pigs benign lesions predominated (ie, leiomyoma, endometrial adenoma, cystic endometrial hyperplasia and deciduoma). Uterine tumours in African pygmy hedgehogs included adenosarcomas and endometrial polyps. Ovarian lesions were found only in guinea pigs (ovarian rete adenomas, rete cysts) and African pygmy hedgehogs (mostly granulosa cell tumours), while testicular tumours were diagnosed in pet rabbits, one pet rat and one guinea pig. Mammary tumours were common in pet rabbits, pet rats, guinea pigs, mice, hamsters and African pygmy hedgehogs. In pet rats, the most common mammary tumour was fibroadenoma, while in other animals carcinomas predominated. In guinea pigs and, to a lesser extent, in pet rats, a significant percentage of mammary tumours occurred in males. Guinea pigs seem to be predisposed to mammary tumours of ductal origin. This study describes for the first time uterine angioleiomyoma in the pet rabbit and mammary spindle cell carcinoma in the Djungarian hamster and chinchilla.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"213 ","pages":"Pages 46-58"},"PeriodicalIF":0.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002731/pdfft?md5=a7d8c9ff8e259cd851d446905e0ae88b&pid=1-s2.0-S0021997524002731-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0