Graciela G. Orantes , Robert A. Foster , Todd R. Cecil , Elise E.B. LaDouceur
{"title":"Cystic rete testis in a central bearded dragon (Pogona vitticeps)","authors":"Graciela G. Orantes , Robert A. Foster , Todd R. Cecil , Elise E.B. LaDouceur","doi":"10.1016/j.jcpa.2025.07.004","DOIUrl":"10.1016/j.jcpa.2025.07.004","url":null,"abstract":"<div><div>The rete testis forms from the mesonephric tubules in a series of interconnected channels in which spermatozoa travel in a high volume of fluid between the seminiferous tubules and efferent ductules. Cystic rete testis can be identified by uni- or multilocular cysts with a wall lined by low cuboidal epithelial cells and a dense fibrous stroma. An 11-year-old male central bearded dragon (<em>Pogona vitticeps</em>) was evaluated for a coelomic mass. The animal had no other clinical signs apart from coelomic mass effect. Exploratory surgery revealed a mass in the region of the right testis that was excised and submitted for histology. The central bearded dragon had no post-operative clinical abnormalities. Grossly, the 6-cm diameter, smooth, yellow mass was composed of numerous, 0.5–3.0-cm diameter cysts filled with yellow fluid. Histologically, the cysts were lined by simple cuboidal to flattened epithelial cells that rarely formed small tufts or papillary projections. Cyst lumina occasionally connected with seminiferous tubules, approximately 10 % of which were dilated and all of which had normal spermatogenesis. Epithelial cells had a small amount of eosinophilic, slightly vacuolated cytoplasm, rare apical cilia and basilar, round nuclei with coarse chromatin and small, distinct nucleoli. This is the first description of a cystic rete testis in a reptile or any non-mammalian species. Cystic rete testis can be primary or secondary to obstruction of the efferent ductules or epididymis. The lack of inflammation and absence of diffuse dilation of the seminiferous tubules suggest that spermatozoa were able to escape, consistent with primary cystic rete testis.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"221 ","pages":"Pages 22-25"},"PeriodicalIF":0.8,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew F. Starost , Christopher King , Kelli L. Vaughan , Julie A. Mattison
{"title":"Myoepithelial-rich pleomorphic adenoma of the soft palate in a rhesus monkey (Macaca mulatta)","authors":"Matthew F. Starost , Christopher King , Kelli L. Vaughan , Julie A. Mattison","doi":"10.1016/j.jcpa.2025.07.001","DOIUrl":"10.1016/j.jcpa.2025.07.001","url":null,"abstract":"<div><div>A 39-year-old female rhesus macaque (<em>Macaca mulatta</em>) presented for stertor that had progressed over a 2-year period. A mass involving the soft palate was seen partially obstructing the oropharynx. Histopathological examination revealed a well-circumscribed, partially encapsulated mass composed primarily of myoepithelial cells with scattered duct-like structures, squamous metaplasia and hyaline stroma. The mass was diagnosed as a myoepithelial-rich pleomorphic adenoma. To the best of our knowledge, this is the first reported case in non-human primates.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"221 ","pages":"Pages 14-18"},"PeriodicalIF":0.8,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Soltero-Rivera , Janny V. Evenhuis , Boaz Arzi , Frank J.M. Verstraete
{"title":"Dental and temporomandibular joint pathology of the North American wolverine (Gulo gulo luscus)","authors":"Maria Soltero-Rivera , Janny V. Evenhuis , Boaz Arzi , Frank J.M. Verstraete","doi":"10.1016/j.jcpa.2025.07.003","DOIUrl":"10.1016/j.jcpa.2025.07.003","url":null,"abstract":"<div><div>This study evaluated dental and temporomandibular joint (TMJ) pathology in North American wolverines (<em>Gulo gulo luscus</em>) from coastal southern Alaska, using 182 specimens (43.4 % females, 54.4 % male, 2.2 % unknown) collected across the 20th century. Among the individuals, 2.2 % were classified as young adults, 83.0 % as adults and 14.8 % had an undetermined age. High rates of dental diseases were identified, reflecting patterns seen in other wild carnivores, with acquired conditions occurring more frequently than congenital ones. Periodontitis was the most common pathology (98.9 %), with most cases showing mild severity (stage 2 = 98.9 %). Tooth fractures were identified in over two-thirds of the specimens, with deeper structural damage (complicated crown fractures = 26.2 %, complicated crown-root fractures = 23.1 %, root fractures = 31.3 %) observed more often than enamel fractures, likely due to typical biting behaviour. No significant differences in fracture prevalence were found between sexes (<em>P</em> = 0.3741). Enamel hypoplasia was rare (5.5 %), suggesting minimal systemic stress during dental development. Variations in root numbers were frequently noted (27.5 %), potentially reflecting an adaptive trait for dietary handling. Periapical lesions (9.9 %) were linked to pulp exposure (17.6 %, OR = 49.09, 95 % CI = 28.01–85.22, <em>P</em> <-0.0001), especially in the canine teeth, but were also seen in association with moderate to severe bone loss due to periodontitis (stages 3 and 4 = 65.9 %, OR = 7.75, 95 % CI = 2.20–24.80, <em>P</em> <0.0001). Attrition and abrasion were common (96.1 %), particularly affecting incisor and canine teeth, with a slightly higher incidence in females (U = 2,922, n = 79, n = 99, <em>P</em> = 0.0036), hinting at potential behavioural or dietary differences. TMJ pathology was uncommon (1.6 %) and mild, potentially suggesting that wolverine feeding habits may exert less stress on the joint compared to species with high bite-force diets. Overall, the observed dental and TMJ lesions align with patterns in other wild carnivores, suggesting similar environmental and behavioural influences. Future studies on dietary, genetic and longitudinal health factors could provide deeper insight into the dental adaptations and resilience of North American wolverines in their natural habitats.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"221 ","pages":"Pages 6-13"},"PeriodicalIF":0.8,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kátia R. Groch , Fernanda L.N. Attademo , Josué Díaz-Delgado , Gláucia P. Sousa , Augusto C. da B. Freire , Fabiano S. Costa , Carlos Sacristán , Jean C. Ramos da Silva , José L. Catão-Dias , Fábia de Oliveira Luna
{"title":"Thoracolumbar kyphoscoliosis in a captive geriatric Antillean manatee (Trichechus manatus manatus)","authors":"Kátia R. Groch , Fernanda L.N. Attademo , Josué Díaz-Delgado , Gláucia P. Sousa , Augusto C. da B. Freire , Fabiano S. Costa , Carlos Sacristán , Jean C. Ramos da Silva , José L. Catão-Dias , Fábia de Oliveira Luna","doi":"10.1016/j.jcpa.2025.07.002","DOIUrl":"10.1016/j.jcpa.2025.07.002","url":null,"abstract":"<div><div>Vertebral column deviations, namely scoliosis, kyphosis, lordosis and combinations thereof, are poorly characterized in marine mammals. Here we present the clinical history and the post-mortem pathological and computed tomography (CT) scan analysis results on a 52-year-old captive female Antillean manatee (<em>Trichechus manatus manatus</em>) from Brazil. This animal had been kept at multiple small enclosures for most of its life. The main gross pathological and CT scan findings were severe thoracolumbar kyphoscoliosis that resulted in spinal canal stenosis and spinal cord compression. The adjacent thoracolumbar epaxial and hypaxial muscles were pale and atrophic. Acute and chronic myopathic changes, atrophy, as well as lipomatosis were confirmed microscopically. In this manatee, severe thoracolumbar kyphoscoliosis was probably triggered by captivity-related restricted mobility and postural and swimming alterations, including intermittent circling over decades. We surmise that postural, degenerative, spinal muscular/neuromuscular and muscle disuse atrophy occurred concurrently over time. These lesions probably resulted in sustained pain and could explain the behavioural alterations reported. This case sheds light on captivity-related vertebral column disease in sirenians and provides scientific evidence to inform housing recommendations for this taxon.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"221 ","pages":"Pages 1-5"},"PeriodicalIF":0.8,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Concomitant intestinal lymphoma and squamous cell Carcinoma in a cat: A case report","authors":"E.R. Riera , G. Ramirez , J. Molín","doi":"10.1016/j.jcpa.2025.03.084","DOIUrl":"10.1016/j.jcpa.2025.03.084","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Pages 22-23"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Fox , M. Dobromylskyj , A. Ide , O. Davies , K. Boyd , I. Schofield , A. Oksman , E. Vaara
{"title":"Automated assessment of KI-67 proliferation index of canine cutaneous mast tumours using deep learning","authors":"R. Fox , M. Dobromylskyj , A. Ide , O. Davies , K. Boyd , I. Schofield , A. Oksman , E. Vaara","doi":"10.1016/j.jcpa.2025.03.071","DOIUrl":"10.1016/j.jcpa.2025.03.071","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Page 19"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Högler , A. Müllebner , A. Stommel , I. Anna Maria Magnet , M. Müller , A. Szinovatz , P. Kodajova , T. Schütz , M. Holzer , W. Weihs , J. Catharina Duvigneau , A. Kozlov
{"title":"SUSTAINED REDUCTION OF 2-OXOGLUTARATE DEHYDROGENASE Complex activity in rat brain after ventricular fibrillation cardiac arrest may contribute to extended excitotoxicity","authors":"S. Högler , A. Müllebner , A. Stommel , I. Anna Maria Magnet , M. Müller , A. Szinovatz , P. Kodajova , T. Schütz , M. Holzer , W. Weihs , J. Catharina Duvigneau , A. Kozlov","doi":"10.1016/j.jcpa.2025.03.036","DOIUrl":"10.1016/j.jcpa.2025.03.036","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Page 9"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}