Journal of Comparative Pathology最新文献

{"title":"Congenital myofibroblastic fibrosarcoma of the temporal bone in a newborn Arabian foal","authors":"Jessica P. Johnson ,&nbsp;Felipe A. Cardenas ,&nbsp;Midori G. Asakawa ,&nbsp;Masa-aki Oikawa","doi":"10.1016/j.jcpa.2025.01.003","DOIUrl":"10.1016/j.jcpa.2025.01.003","url":null,"abstract":"<div><div>Myofibroblastic fibrosarcoma (MFS) is a malignant soft tissue tumour that is rare in domestic animals. Here we report a case of congenital MFS in an Arabian foal at birth. A large solitary subcutaneous mass arising in the left temporal region was found in the foal. On cut section, an unencapsulated hemispheric, white-yellowish, elastic fibrous mass was attached to the temporal bone. Histologically, the mass was composed of a neoplastic proliferation of spindle-shaped fibroblasts arranged in fasciculate or interwoven streams and bundles, with low nuclear atypia and mitotic rate, local invasion of the surrounding soft tissues and temporal bone, non-metastasis and abundant collagenous stroma. Immunohistochemically, vimentin, calponin, desmin and alpha-smooth muscle actin were strongly and diffusely labelled, S100 was mildly labelled and h-caldesmon was weakly labelled in the cytoplasm of the neoplastic cells; however, the neoplastic cells were immunonegative for pancytokeratin AE1/AE3 and p63. Based on the histological and immunohistochemical findings, a diagnosis of MFS was made. To our knowledge, this is the first report of congenital MFS in animals.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"217 ","pages":"Pages 49-53"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laryngeal osseous metaplasia in companion animals","authors":"Daniel F. Barrantes Murillo ,&nbsp;Tatiane T. Negrão Watanabe","doi":"10.1016/j.jcpa.2025.01.009","DOIUrl":"10.1016/j.jcpa.2025.01.009","url":null,"abstract":"<div><div>Laryngeal ossification is a form of heterotopic ossification widely recognized in humans and seldom reported in companion animals, with selected case reports available in domestic and wild animals. Through a retrospective multi-institutional study, we collected laryngeal specimens from canine and feline patients submitted for autopsy. The relevant clinical information, including age, breed, sex, weight and final diagnosis, was recorded in each case. Histological examination assessed the percentage ossification in four standardized anatomical plane sections of the laryngeal cartilages and tracheal rings. Cricoid and thyroid ossification was reported in 70.9% (88/124) and 57.2% (71/124) of the canine cases, respectively, and in 11.1% (3/27) and 3.7% (1/27) of the feline cases. The prevalence percentages differed significantly between the species. Interestingly, the cricoid ossification differed significantly in relation to bodyweight (<em>P</em> &lt;0.001), sex (<em>P</em> &lt;0.011) and age (<em>P</em> &lt;0.005) with the higher ossification recorded in larger and older males. Thyroid ossification in dogs differed significantly only with the bodyweight variable (<em>P</em> &lt;0.001) with higher scoring in large breeds. Through a logistic regression model, bodyweight was identified as a risk factor for osseous metaplasia in the cricoid and thyroid cartilage in dogs. The ossification score did not differ significantly with concurrent aspiration pneumonia and megaoesophagus, and primary laryngeal disease was seldom observed in dogs with marked ossification. Therefore, we suggest that laryngeal ossification is a common incidental finding in dogs in relation to the age, sex and breed of the animal. Laryngeal osseous metaplasia is a rare finding in cats.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"217 ","pages":"Pages 66-72"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Escherichia coli-associated granulomatous diseases in three cats","authors":"Milena C. Paz ,&nbsp;Igor R. Santos ,&nbsp;Lucas T. de Castro ,&nbsp;Gabriela Hartmann ,&nbsp;Luan C. Henker ,&nbsp;Jacqueline Raiter ,&nbsp;Regina T. Kemper ,&nbsp;Júlia G. Wronski ,&nbsp;Eryca C. Lamego ,&nbsp;Luiza da Rosa Robusto ,&nbsp;Luciana Sonne ,&nbsp;David Driemeier ,&nbsp;Saulo P. Pavarini","doi":"10.1016/j.jcpa.2025.01.005","DOIUrl":"10.1016/j.jcpa.2025.01.005","url":null,"abstract":"<div><div>Granulomatous diseases associated with <em>Escherichia coli</em> infection are uncommon in domestic animals. In cats, malakoplakia and granulomatous ulcerative colitis are the only described forms. We investigated the clinical and pathological findings of <em>E. coli</em>-associated granulomatous diseases in three cats. In all cases the affected organs were infiltrated by many macrophages containing periodic acid–Schiff-positive intracytoplasmic granules. The macrophages immunolabelled for ionized calcium-binding adapter molecule 1 and <em>E. coli</em>. The first case involved the urinary bladder and was diagnosed as malakoplakia. The second case had small intestinal granulomatous enteritis and lymphadenitis of the mesenteric, celiac, colonic, mandibular and mediastinal lymph nodes. The third case had granulomatous enteritis, splenitis and lymphadenitis of the mesenteric, iliac, aortic, renal, hypogastric and sacral lymph nodes. Peyer's patches were predominantly affected in the small intestines of both the second and third cases. Although malakoplakia has been documented previously, the findings in the second and third cases suggest novel forms of granulomatous disease associated with <em>E. coli</em> in cats, with notable primary involvement of lymphoid tissue.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"217 ","pages":"Pages 54-61"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gross, cytological and histological features of a cholangiocarcinoma, with immunolabelling of cytokeratin 19, in a bronze-winged parrot (Pionus chalcopterus)","authors":"Christian Atkins ,&nbsp;Cassia H.Z. Hare ,&nbsp;Iain Cope ,&nbsp;Katherine Hughes","doi":"10.1016/j.jcpa.2025.01.006","DOIUrl":"10.1016/j.jcpa.2025.01.006","url":null,"abstract":"<div><div>An adult bronze-winged parrot (<em>Pionus chalcopterus</em>) was presented for post-mortem examination following death without antecedent clinical signs. Macroscopically, the liver was expanded by a 14 × 12 × 10 mm, off-white to grey, infiltrative mass with 3–8 mm diameter nodular masses on the serosa of the duodenum. Cytology of impression smears of the hepatic mass revealed a monomorphic population of epithelial cells, arranged in cohesive clusters, occasionally with an acinar-like arrangement. Histologically, the neoplasm was unencapsulated, infiltrative, well-demarcated and moderately densely cellular. Neoplastic cells were arranged in well-defined, variably sized acini and tubules that were supported by a fine collagenous stroma. Acini and tubules frequently contained intraluminal eosinophilic proteinaceous material. Neoplastic cells were small to moderately sized and were generally columnar or cuboidal with well-delineated cell boundaries and a small amount of eosinophilic to basophilic cytoplasm. The nuclei were round, frequently basally located and had densely stippled chromatin and usually a single, prominent, magenta nucleolus. There were two mitoses in 10 high-power fields (2.37 mm²). Vascular invasion was observed and metastatic nodules of similar neoplastic cells were present on the duodenal serosa. Immunohistochemical labelling for cytokeratin 19 revealed weak to moderate, punctate cytoplasmic expression in &lt;10% of neoplastic cells. Macroscopically, cytologically and histologically the neoplasm was consistent with a cholangiocarcinoma.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"217 ","pages":"Pages 62-65"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143436899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent bacterial pneumonia in Irish Wolfhounds – histopathology and characterization of bronchial cartilage changes","authors":"Vappu M. Hukkinen ,&nbsp;Kristel Kegler ,&nbsp;Sanna J. Viitanen ,&nbsp;Pernilla Syrjä","doi":"10.1016/j.jcpa.2025.01.002","DOIUrl":"10.1016/j.jcpa.2025.01.002","url":null,"abstract":"<div><div>An increased incidence of bacterial pneumonia (BP) has been reported in Irish Wolfhounds (IWHs) and the disease typically recurs repeatedly. The aetiology is unclear but the development of bronchiectasis in the absence of clinical findings indicative of interstitial lung disease is common in affected IWHs. This observation led us to hypothesize that the primary cause could be at bronchial level. We evaluated bronchial cartilage structure and composition in IWHs (n = 10) with previous episodes of pneumonia compared with IWH control dogs (n = 5) and other large-breed control dogs (n = 5) without a history of respiratory disease. Histological evaluation of lung sections was performed with haematoxylin and eosin, Masson’s trichrome and Prussian blue staining as well as with immunohistochemistry (IHC) for CD3 and CD79a antigens and pancytokeratin. Bronchial cartilage proteoglycan content was evaluated in sections stained with safranin ‘O’ (SO) and chondrocyte apoptosis by IHC for cleaved caspase-3. Image analysis was used to measure the bronchial cartilage to lumen area ratio as well as the SO staining intensity and caspase-3-positive cell count in digital whole slide images. The most consistent histological finding in the lungs of IWHs with recurrent BP was chronic lymphoplasmacytic inflammation in the peribronchial and perivascular pulmonary interstitium, along with remodelling of the bronchial walls. The bronchial cartilage to lumen area ratio was significantly lower in all IWHs than in control dogs of other breeds (<em>P</em> = 0.011), suggesting less cartilage support in the bronchi of the IWH breed. The SO staining intensity of the bronchial cartilage was significantly higher (<em>P</em> = 0.008) in affected IWHs than in control dogs of other breeds. Analysis of caspase-3 immunolabelling of large bronchial cartilage revealed significantly fewer apoptotic chondrocytes in affected IWHs than in all control dogs (<em>P</em> = 0.045). Based on these findings, altered cartilage metabolism, as a breed-related feature or secondary to chronic inflammation, may play a role in the pathogenesis of bronchiectasis development and recurrent lung infections in IWHs.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"217 ","pages":"Pages 25-33"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spindle cell rhabdomyosarcoma in a cockatiel (Nymphicus hollandicus)","authors":"Tainah P. Dal Pont ,&nbsp;Igor R. Santos ,&nbsp;Vanessa C. Pereira ,&nbsp;Flávia E. Ferrari ,&nbsp;Victória R.Q. Schmidt ,&nbsp;Marcele B. Bandinelli ,&nbsp;Marcelo Meller Alievi ,&nbsp;Saulo P. Pavarini","doi":"10.1016/j.jcpa.2025.01.004","DOIUrl":"10.1016/j.jcpa.2025.01.004","url":null,"abstract":"<div><div>A 2-year-old cockatiel (<em>Nymphicus hollandicus</em>) was presented with a large nodule on the ventral aspect of the right wing. Due to an accidental cutaneous trauma, the patient developed haemorrhage and subsequently died. The main necropsy finding was a pedunculated nodule that extended from the right pronator superficialis and biceps brachii muscles. Cytology of the nodule revealed neoplastic spindle cells with cytoplasmic cross-striations and multinucleate strap cells. Histologically, the nodule was composed of neoplastic spindle cells arranged in fascicles with a herringbone pattern. Neoplastic cells had multifocal cytoplasmic immunolabelling for vimentin and desmin, multifocal nuclear and cytoplasmic immunolabelling for myoblast determination protein 1 and rare cytoplasmic immunolabelling for α-smooth muscle actin. Neoplastic cells were negative for pancytokeratin. The final diagnosis was spindle cell rhabdomyosarcoma, a subtype rare in animals.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"217 ","pages":"Pages 34-38"},"PeriodicalIF":0.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143139908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disseminated protothecosis caused by Prototheca bovis in two dogs","authors":"Vinicius Dahm ,&nbsp;Crisan Smaniotto ,&nbsp;Alessandra da Cruz ,&nbsp;Amália Ferronato ,&nbsp;Camila Campagnolo ,&nbsp;Fernanda de Oliveira Lazzaretti ,&nbsp;Mayane Faccin ,&nbsp;Olicies da Cunha ,&nbsp;Thais Fray dos Santos ,&nbsp;Manoela Marchezan Piva ,&nbsp;Aline de Marco Viott","doi":"10.1016/j.jcpa.2024.11.005","DOIUrl":"10.1016/j.jcpa.2024.11.005","url":null,"abstract":"<div><div>Protothecosis is an infectious disease caused by unicellular algae of the genus <em>Prototheca</em>, which are mainly known for causing mastitis in farm animals. However, there are reports of protothecosis in humans and other animals, such as dogs and cats, which develop cutaneous lesions or systemic lesions. Dogs with the systemic form generally develop bloody diarrhoea and blindness and neurological signs may also occur. The condition generally leads to the animal being euthanized due to the unfavourable prognosis. The objective of this work was to report two cases of disseminated protothecosis, one in a Pekingese dog (case 1) and the other in a German Shepherd Dog (case 2). Both animals had a history of chronic diarrhoea with haematochezia, which was unresponsive to various treatments in case 2. Both dogs were euthanized due to their clinical condition and were sent to the Veterinary Pathology Laboratory of the Federal University of Paraná for post-mortem examination. Macroscopically, the lesions in both cases were similar and were characterized by multifocal millimetre-sized white nodulations in the heart, skeletal muscles and intestinal serosa, as well as signs of fibrinonecrotic enterocolitis and lymphoplasmacytic interstitial nephritis. In both cases there was also retinal displacement with lymphoplasmacytic uveitis and chorioretinitis. The cytological and histopathological evaluation of the tissues revealed the presence of structures compatible with <em>Prototheca</em> spp. Polymerase chain reaction identified <em>Prototheca bovis</em> in both cases. This is a rarely reported disease and must be considered as a differential diagnosis in cases of chronic diarrhoea with haematochezia that progress to blindness in dogs.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"216 ","pages":"Pages 33-39"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmissible venereal tumour with encephalic metastasis in dogs","authors":"Erick P.F. Souto ,&nbsp;Daniel R. Rissi ,&nbsp;Artefio M. Oliveira ,&nbsp;Dlean S. Garcia ,&nbsp;Rinaldo A. Mota ,&nbsp;Almir P. de Souza ,&nbsp;Glauco J.N. Galiza ,&nbsp;Antônio F.M. Dantas","doi":"10.1016/j.jcpa.2024.11.004","DOIUrl":"10.1016/j.jcpa.2024.11.004","url":null,"abstract":"<div><div>From January 2000 to December 2023 the Laboratory of Animal Pathology of the Federal University of Campina Grande received 6,218 canine autopsy and biopsy submissions, with six (0.09%) autopsy cases diagnosed as transmissible venereal tumour (TVT) with encephalic metastases. The mean age of affected dogs (four females and two males) was 7 years. Dogs were all from urban areas and were either semidomiciled (four cases) or stray (two cases). Clinical findings consisted of multilobular, ulcerated masses affecting the genital area (five cases) or skin (one case). Neurological signs were reported in three cases and included lethargy, seizures and ataxia. Grossly, encephalic metastases were subdural and extraparenchymal and affected the telencephalic hemispheres (four cases) or the base of the brain (two cases). In all cases, histology revealed a round cell neoplasm arranged in sheets supported by a scant fibrovascular stroma. In the brain, tumours often compressed and occasionally infiltrated the surrounding neuroparenchyma. Neoplastic cells had immunolabelling for vimentin, CD45RA, Iba1 and lysozyme, and no immunolabelling for MHC class II, CD117, CD3, CD79 and MUM1. Encephalic metastases of TVT should be included in the differential diagnosis of nervous system diseases of dogs in endemic areas where TVT is diagnosed in genital or extragenital tissues.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"216 ","pages":"Pages 25-32"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142828907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal systemic bacterial infections in two harbour porpoises (Phocoena phocoena) secondary to bite wounds from grey seals (Halichoerus grypus)","authors":"Nicholas J. Davison ,&nbsp;Mark P. Dagleish ,&nbsp;Geoffrey Foster ,&nbsp;Anne Ridley ,&nbsp;Mariel ten Doeschate ,&nbsp;Andrew Brownlow","doi":"10.1016/j.jcpa.2024.12.002","DOIUrl":"10.1016/j.jcpa.2024.12.002","url":null,"abstract":"<div><div><em>Mycoplasma phocicerebrale</em>, the causative agent of seal (‘speck’) finger, a zoonotic disease, is a common commensal in the oral cavity of various seal species. Historically associated with seal hunters, it remains a significant risk for those handling or rehabilitating marine mammals. While primarily known for causing severe cellulitis in humans, <em>M. phocicerebrale</em> can also lead to severe infections in seals, including osteomyelitis and sepsis. Recent studies have revealed the predatory behaviour of grey seals (<em>Halichoerus grypus</em>) on harbour porpoises (<em>Phocoena phocoena</em>). Examination of scarring patterns on stranded animals suggest that some initial predation attempts are unsuccessful, and porpoises escape only to succumb to infection originating from bite wounds. Here we describe two cases in which the isolation of <em>M. phocicerebrale</em> and other bacterial species from chronically infected bite wounds, the lungs and other internal organs of harbour porpoises suggest failed predation attempts by grey seals. Therefore, the impact of delayed, indirect mortality from sympatric predation attempts may be a significant additional and underestimated cause of mortality in harbour porpoises. One of the cases examined in this study involved a harbour porpoise with gross and histological evidence of a failed predation attempt and a fatal systemic <em>M. phocicerebrale</em> infection. These findings highlight the severe consequences of such infections and underscore the importance of understanding the ecological implications of grey seal predation on harbour porpoise populations.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"216 ","pages":"Pages 50-56"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polyglucosan storage disease in a black-capped parrot (Pionites melanocephalus)","authors":"Kelsey R. Fiddes ,&nbsp;Jess Magnotti ,&nbsp;Anibal G. Armien ,&nbsp;Elise E.B. LaDouceur","doi":"10.1016/j.jcpa.2024.11.003","DOIUrl":"10.1016/j.jcpa.2024.11.003","url":null,"abstract":"<div><div>Following an episode of sudden lethargy, an 18-month-old female black-capped parrot (<em>Pionites melanocephalus</em>) died while being examined. On gross examination, there was fluid within the coelom, hepatomegaly with yellow colouration and the heart appeared enlarged with pallor throughout the myocardium. On histological examination, cardiomyocytes were swollen with loss of cross striations and contained 6–12-μm diameter intrasarcoplasmic pale grey inclusions of storage material. Cardiomyocytes were occasionally karyomegalic with mitotic figures, lost or replaced by fibrosis and inflammation. Within the liver, there was periportal and centrilobular fibrosis and mild lipid-type vacuolar change with extramedullary haematopoiesis. In the lung, the bronchi and parabronchi had luminal haemorrhage and oedema with hypertrophy of epithelium lining the parabronchi. On transmission electron microscopy, the storage material was non-membrane bound, fibrillar and intrasarcoplasmic and had an occasional homogeneous, electron-dense, central core. The morphological features of this material, combined with the histological findings, are consistent with a diagnosis of polyglucosan storage disease and subsequent heart failure.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"216 ","pages":"Pages 20-24"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}