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Journal of Comparative Pathology最新文献

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Evaluation of tumour biomarkers associated with invasion, metastasis and immune escape in cats with exocrine pancreatic carcinoma 评估与外分泌胰腺癌侵袭、转移和免疫逃逸相关的肿瘤生物标志物
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2025-07-01 DOI: 10.1016/j.jcpa.2025.05.009
Alexandra Guillén , Kara Kropp , Francesco Rogato , Andrew D. Yale , Gabriella Hetesy , Jérémy Béguin , Kerstin Erles , Simon L. Priestnall , Edouard Reyes-Gomez , Alexandros Hardas
{"title":"Evaluation of tumour biomarkers associated with invasion, metastasis and immune escape in cats with exocrine pancreatic carcinoma","authors":"Alexandra Guillén ,&nbsp;Kara Kropp ,&nbsp;Francesco Rogato ,&nbsp;Andrew D. Yale ,&nbsp;Gabriella Hetesy ,&nbsp;Jérémy Béguin ,&nbsp;Kerstin Erles ,&nbsp;Simon L. Priestnall ,&nbsp;Edouard Reyes-Gomez ,&nbsp;Alexandros Hardas","doi":"10.1016/j.jcpa.2025.05.009","DOIUrl":"10.1016/j.jcpa.2025.05.009","url":null,"abstract":"<div><div>In humans and cats, pancreatic carcinoma (PC) arising from the exocrine pancreas is considered an aggressive cancer associated with a poor prognosis due to its high metastatic rate. The aim of this retrospective multi-institutional study was to investigate tissue expression of biomarkers of tumour invasiveness, metastasis and immune escape in cats with PC. A secondary aim was to correlate the overall immunohistochemical scores (OISs) with histological characteristics, presence of metastasis and survival. Immunohistochemistry for COX-2, E-cadherin, CD44, c-KIT and PD-L1 was performed on 40 PC tissue samples. CD44 was expressed in all PCs with 27 (67 %) having a moderate to high OIS. PD-L1, E-cadherin, COX-2 and c-KIT expression was seen in 20 (50 %), 21 (52 %), 18 (45 %) and 14 (35 %) cases, respectively, with predominantly low OISs. Metastasis was present in 43 % of cats with a median survival time (MST) of 7 days (95 % CI 0–20; range, 1–1,094) and a 1-year survival rate of 13.8 %. When excluding cats that died or were euthanized at diagnosis, the MST was 19 days (95 % CI 0–99; range, 2–1,094). No statistical associations were found between COX-2, E-cadherin, PD-L1, CD44 or c-KIT OIS and histological subtype, necrosis, vascular invasion, mitotic count, presence of metastasis or survival. Positive E-cadherin expression was significantly associated with the presence of perineural invasion (<em>P</em> = 0.009; OR 1.50 [95 % CI 1.11–2.03]).</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Pages 47-55"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative anatomy and histology of gustatory papillae in laboratory animal species 实验动物味觉乳头的比较解剖学和组织学
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2025-07-01 DOI: 10.1016/j.jcpa.2025.03.007
R. Miguel , K. Weber , F. José Mayoral , P. Ortega , R. Kreutzer , Y. Okazaki , O. Richard , A. Ben Abdeljelil , K. Kegler , R. Vallejo
{"title":"Comparative anatomy and histology of gustatory papillae in laboratory animal species","authors":"R. Miguel ,&nbsp;K. Weber ,&nbsp;F. José Mayoral ,&nbsp;P. Ortega ,&nbsp;R. Kreutzer ,&nbsp;Y. Okazaki ,&nbsp;O. Richard ,&nbsp;A. Ben Abdeljelil ,&nbsp;K. Kegler ,&nbsp;R. Vallejo","doi":"10.1016/j.jcpa.2025.03.007","DOIUrl":"10.1016/j.jcpa.2025.03.007","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Page 2"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From concept to reality: the journey of establishing the Australian companion animal registry of cancers (ACARCinom) 从概念到现实：建立澳大利亚癌症伴侣动物登记处（ACARCinom）的历程
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2025-07-01 DOI: 10.1016/j.jcpa.2025.03.008
C. Palmieri , P. Bennett , M. Bruce , M. Krockenberger , P. McLaren , T. Meiring , K. Mengersen , A. Peaston , A. Roach , G. Rossi , A. Stent , R. Soares-Magalhaes
{"title":"From concept to reality: the journey of establishing the Australian companion animal registry of cancers (ACARCinom)","authors":"C. Palmieri ,&nbsp;P. Bennett ,&nbsp;M. Bruce ,&nbsp;M. Krockenberger ,&nbsp;P. McLaren ,&nbsp;T. Meiring ,&nbsp;K. Mengersen ,&nbsp;A. Peaston ,&nbsp;A. Roach ,&nbsp;G. Rossi ,&nbsp;A. Stent ,&nbsp;R. Soares-Magalhaes","doi":"10.1016/j.jcpa.2025.03.008","DOIUrl":"10.1016/j.jcpa.2025.03.008","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Page 2"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of lung and thymus lesions as target organs in piglets infected with a new virulent PRRSV-1 strain 新型强毒PRRSV-1株感染仔猪肺和胸腺病变作为靶器官的特征
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2025-07-01 DOI: 10.1016/j.jcpa.2025.03.062
K. Fristiková , J.M. Sánchez-Carvajal , C. Álvarez-Delgado , F. Larenas-Muñoz , M. Rodríguez-Ruíz , G. Capaldi , I. Ruedas-Torres , F. José Pallarés , E. Mateu , L. Carrasco , I. Magdalena Rodríguez-Gómez , J. Gómez-Laguna
{"title":"Characterization of lung and thymus lesions as target organs in piglets infected with a new virulent PRRSV-1 strain","authors":"K. Fristiková ,&nbsp;J.M. Sánchez-Carvajal ,&nbsp;C. Álvarez-Delgado ,&nbsp;F. Larenas-Muñoz ,&nbsp;M. Rodríguez-Ruíz ,&nbsp;G. Capaldi ,&nbsp;I. Ruedas-Torres ,&nbsp;F. José Pallarés ,&nbsp;E. Mateu ,&nbsp;L. Carrasco ,&nbsp;I. Magdalena Rodríguez-Gómez ,&nbsp;J. Gómez-Laguna","doi":"10.1016/j.jcpa.2025.03.062","DOIUrl":"10.1016/j.jcpa.2025.03.062","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Pages 16-17"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinicopathological and immunohistochemical characteristics of mesotheliomas of the tunica vaginalis testis in dogs (2000–2023) 犬睾丸阴道膜间皮瘤临床病理及免疫组织化学特征分析（2000-2023）
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2025-07-01 DOI: 10.1016/j.jcpa.2025.03.082
J. Molín , A. Suárez-Bonnet , J. Altimira , C.G. Jesús , G.A. Ramírez
{"title":"Clinicopathological and immunohistochemical characteristics of mesotheliomas of the tunica vaginalis testis in dogs (2000–2023)","authors":"J. Molín ,&nbsp;A. Suárez-Bonnet ,&nbsp;J. Altimira ,&nbsp;C.G. Jesús ,&nbsp;G.A. Ramírez","doi":"10.1016/j.jcpa.2025.03.082","DOIUrl":"10.1016/j.jcpa.2025.03.082","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Page 22"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detection of highly pathogenic avian influenza H5N1 in marine mammals from South America 在南美洲海洋哺乳动物中检测高致病性H5N1禽流感
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2025-07-01 DOI: 10.1016/j.jcpa.2025.03.016
E. Sierra , M. Ulloa , C. Fiorito , A. Colom-Rivero , V. Neira , A. Fernández
{"title":"Detection of highly pathogenic avian influenza H5N1 in marine mammals from South America","authors":"E. Sierra ,&nbsp;M. Ulloa ,&nbsp;C. Fiorito ,&nbsp;A. Colom-Rivero ,&nbsp;V. Neira ,&nbsp;A. Fernández","doi":"10.1016/j.jcpa.2025.03.016","DOIUrl":"10.1016/j.jcpa.2025.03.016","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Page 4"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ovine ichthyosis congenita: Description and clinicopathologic evolution 绵羊先天性鱼鳞病：描述和临床病理演变
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2025-07-01 DOI: 10.1016/j.jcpa.2025.03.045
Á. Gómez , A. Rodríguez-Largo , H. Ruiz , E. Pérez , S. Villanueva-Saz , C. Hernández , M. José Blasco , T. Navarro , L. Monteagudo , D. Lacasta , L. Luján
{"title":"Ovine ichthyosis congenita: Description and clinicopathologic evolution","authors":"Á. Gómez ,&nbsp;A. Rodríguez-Largo ,&nbsp;H. Ruiz ,&nbsp;E. Pérez ,&nbsp;S. Villanueva-Saz ,&nbsp;C. Hernández ,&nbsp;M. José Blasco ,&nbsp;T. Navarro ,&nbsp;L. Monteagudo ,&nbsp;D. Lacasta ,&nbsp;L. Luján","doi":"10.1016/j.jcpa.2025.03.045","DOIUrl":"10.1016/j.jcpa.2025.03.045","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Page 12"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital histopathology analysis of lymphoid organs from goats experimentally infected with highly and mildly virulent PPRV strains 高毒力和轻毒力PPRV实验感染山羊淋巴器官的数字组织病理学分析
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2025-07-01 DOI: 10.1016/j.jcpa.2025.03.032
L. Grau-Roma , T. Groenen , R. Eloiflin , V. Lasserre , S. Phyton , S. Seibold , E. Párraga-Ros , S. De Brot , P. Totte , O. García-Nicolás , S. Talker , A. Bataille , A. Summerfield
{"title":"Digital histopathology analysis of lymphoid organs from goats experimentally infected with highly and mildly virulent PPRV strains","authors":"L. Grau-Roma ,&nbsp;T. Groenen ,&nbsp;R. Eloiflin ,&nbsp;V. Lasserre ,&nbsp;S. Phyton ,&nbsp;S. Seibold ,&nbsp;E. Párraga-Ros ,&nbsp;S. De Brot ,&nbsp;P. Totte ,&nbsp;O. García-Nicolás ,&nbsp;S. Talker ,&nbsp;A. Bataille ,&nbsp;A. Summerfield","doi":"10.1016/j.jcpa.2025.03.032","DOIUrl":"10.1016/j.jcpa.2025.03.032","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Page 8"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementing AI in digital histopathology: Towards quantitative analysis and machine learning integration in diagnostics and research 在数字组织病理学中实现人工智能：在诊断和研究中实现定量分析和机器学习的集成
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2025-07-01 DOI: 10.1016/j.jcpa.2025.03.051
C. De Meeûs d’Argenteuil , D. Desmecht , M. Garigliany
{"title":"Implementing AI in digital histopathology: Towards quantitative analysis and machine learning integration in diagnostics and research","authors":"C. De Meeûs d’Argenteuil ,&nbsp;D. Desmecht ,&nbsp;M. Garigliany","doi":"10.1016/j.jcpa.2025.03.051","DOIUrl":"10.1016/j.jcpa.2025.03.051","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Pages 13-14"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral inflammatory myofibroblastic tumour in a dog 犬口腔炎性肌成纤维细胞瘤
IF 0.8 4区 农林科学
Journal of Comparative Pathology Pub Date : 2025-07-01 DOI: 10.1016/j.jcpa.2025.03.080
S. Muller , M. Croci , I. Porcellato , P. Slootweg , M. Busch
{"title":"Oral inflammatory myofibroblastic tumour in a dog","authors":"S. Muller ,&nbsp;M. Croci ,&nbsp;I. Porcellato ,&nbsp;P. Slootweg ,&nbsp;M. Busch","doi":"10.1016/j.jcpa.2025.03.080","DOIUrl":"10.1016/j.jcpa.2025.03.080","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"220 ","pages":"Pages 21-22"},"PeriodicalIF":0.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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