Journal of Comparative Pathology最新文献

{"title":"Review of the comparative pathological and immunohistochemical features of human and canine cutaneous melanocytic neoplasms","authors":"Isabeli J. Contel ,&nbsp;Carlos E. Fonseca-Alves ,&nbsp;Heitor F. Ferrari ,&nbsp;Renee Laufer-Amorim ,&nbsp;José C.C. Xavier-Júnior","doi":"10.1016/j.jcpa.2024.04.001","DOIUrl":"10.1016/j.jcpa.2024.04.001","url":null,"abstract":"<div><p>Melanocytic neoplasms originate from melanocytes and melanoma, the malignant form, is a common canine neoplasm and the most aggressive human skin cancer. Despite many similarities between these neoplasms in both species, only a limited number of studies have approached these entities in a comparative manner. Therefore, this review compares benign and malignant melanocytic neoplasms in dogs and humans, exclusively those arising in the haired skin, with regard to their clinicopathological, immunohistochemical and molecular aspects. Shared features include spontaneous occurrence, macroscopic features and microscopic findings when comparing human skin melanoma in the advanced/invasive stage and canine cutaneous melanoma, immunohistochemical markers and several histopathological prognostic factors. Differences include the apparent absence of active mutations in the <em>BRAF</em> gene in canine cutaneous melanoma and less aggressive clinical behaviour in dogs than in humans. Further studies are required to elucidate the aetiology and genetic development pathways of canine cutaneous melanocytic neoplasms. Evaluation of the applicability of histopathological prognostic parameters commonly used in humans for dogs are also needed. The similarities between the species and the recent findings regarding genetic mutations in canine cutaneous melanomas suggest the potential utility of dogs as a natural model for human melanomas that are not related to ultraviolet radiation.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"211 ","pages":"Pages 26-35"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140957729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White spots amidst the gold: ultrastructural and histological aspects of the chronic inflammatory response of goldfish with ichthyophthiriasis","authors":"Bruno de Lima Araújo ,&nbsp;Carla Renata Serantoni Moyses ,&nbsp;Diva Denelle Spadacci-Morena ,&nbsp;José Guilherme Xavier ,&nbsp;Maria Anete Lallo","doi":"10.1016/j.jcpa.2024.04.003","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.04.003","url":null,"abstract":"<div><p><em>Ichthyophthirius multifiliis</em>, the causative agent of white spot disease, is a ciliated protozoan parasite that infects freshwater fish and induces high mortality. Outbreaks occur both in natural and production sites. The aim of the present study was to describe the lesions caused by chronic infection by <em>I. multifiliis</em> in goldfish (<em>Carassius auratus</em>) from an ornamental fish farm, highlighting important ultrastructural aspects of this protozoan. Damaged skin and gills, collected from fish with white or ulcerative skin lesions, were routinely processed for histological analysis and transmission electron microscopy. The parasitic forms present in the skin were associated with an inflammatory infiltrate consisting of macrophages, lymphocytes and other polymorphonuclear cells. The lesions associated with the presence of the parasite were organized in the form of granulomas, with macrophages in the layers closest to the parasites. A trophont-thickened membrane and induction of granulomatous inflammation were identified in this study as mechanisms for evasion of the immune response. We concluded that the presence of <em>I. multifiliis</em> trophonts resulted in the formation of granulomatous inflammation, whether associated or not with pathogen lysis, suggesting that the parasite can use an inflammatory response to evade the immune response.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"211 ","pages":"Pages 21-25"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140950011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissecting aortitis in a goat associated with Pasteurella multocida and Staphylococcus spp infection","authors":"Cecilia Gola ,&nbsp;Sai Fingerhood ,&nbsp;Nicola M. Parry ,&nbsp;Josué Diaz-Delgado","doi":"10.1016/j.jcpa.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.04.002","url":null,"abstract":"<div><p>Reports of primary cardiovascular disease in goats are rare and most commonly include ventricular septal defect, valvular endocarditis, traumatic pericarditis, ionophore poisoning and nutritional cardiomyopathies. We now report the pathological findings in a 67 kg, 6-year-old, adult female Boer goat that presented with neurological signs (ie, head pressing, unsteadiness and paddling) and hyperthermia 2 days prior to death. Lack of therapeutic response to meloxicam and penicillin‒streptomycin and poor prognosis led to euthanasia of the animal. At necropsy, the main findings included severe aortic dissection with luminal thrombosis and stenosis, and pulmonary congestion and oedema. Histological examination of the aorta revealed severe chronic granulomatous and fibrosing dissecting aortitis with mineralization. Bacterial culture of the affected aortic segment resulted in isolation of a profuse growth of <em>Pasteurella multocida</em> and a moderate growth of <em>Staphylococcus</em> spp. Histopathological findings in the central nervous system were consistent with neurolisteriosis.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"211 ","pages":"Pages 17-20"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002469/pdfft?md5=ea26cba14b2978df7fc2de43dae1aa0e&pid=1-s2.0-S0021997524002469-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140950147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Air leak syndrome in animals: definition and pathogenesis","authors":"Carlos López-Figueroa ,&nbsp;Mariano Domingo ,&nbsp;Padraig J. Duignan ,&nbsp;Maria Cuvertoret-Sanz ,&nbsp;Bernat Martí-García ,&nbsp;Ester Pintado ,&nbsp;Maggie Martinez ,&nbsp;Jorge Martínez","doi":"10.1016/j.jcpa.2024.04.005","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.04.005","url":null,"abstract":"<div><p>Air leak syndrome (ALS) is described in human medicine as a constellation of clinical disorders including pneumomediastinum, pneumopericardium, pulmonary interstitial emphysema, pneumothorax, pneumoperitoneum, pneumoretroperitoneum and subcutaneous emphysema. The pathogenesis of ALS depends on the anatomy of the mediastinum and its associations with thoracic, abdominal and cervical connective tissues, as well as a physical phenomenon referred to as the Macklin effect. Various animal species develop diverse combinations of these lesions, although ALS has not been recognized in animals. However, this term aids pathologists in addressing this disease compilation. The aim of this retrospective study is to illustrate examples of ALS in animals by arbitrarily selecting 13 cases in dogs, cats, pinnipeds, sea otters and harbour porpoises. ALS can be classified into three groups based on aetiology: iatrogenic, secondary or spontaneous. Iatrogenic ALS was diagnosed in two cats with tracheal laceration following endotracheal intubation. Secondary ALS was identified in two dogs, one with acute respiratory distress syndrome and the other due to grass awn migration. Secondary ALS in pinnipeds was diagnosed following severe pulmonary parasitism, uraemic pneumonia and oesophageal perforation. The other marine mammals developed ALS following trauma. Spontaneous ALS was also diagnosed in one cat and one dog without any apparent predisposing causes.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"211 ","pages":"Pages 42-51"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002494/pdfft?md5=aaf4dafa5238df3747d0b9c1033717d5&pid=1-s2.0-S0021997524002494-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141078730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What ails the pet rat? A retrospective study of more than 300 biopsy samples of externally palpable masses submitted from pet rats for histopathology (2013–2021)","authors":"Melanie J. Dobromylskyj ,&nbsp;Rebecca Hederer ,&nbsp;Ken C. Smith","doi":"10.1016/j.jcpa.2024.04.004","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.04.004","url":null,"abstract":"<div><p>Biopsy data on externally palpable masses in pet rats (<em>Rattus norvegicus</em>) were retrieved from the archives of a large commercial pathology laboratory between November 2013 and July 2021. A total of 330 samples were submitted from 292 individual animals. Of the 330 samples submitted, 182 (55.2%) were of mammary gland origin and the majority were benign neoplasms, with fibroadenoma most frequent. Of the remaining 148 samples, 101 were neoplastic in nature, with 76 tumours classified as mesenchymal, 23 as epithelial and two classified only as malignant neoplasia not otherwise specified. Malignant neoplasms accounted for 88 of these non-mammary masses, with the most diagnosed tumours including soft tissue sarcoma (including fibrosarcoma) and sarcomas not otherwise specified.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"211 ","pages":"Pages 36-41"},"PeriodicalIF":0.8,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphomas in seabirds: case reports in a black skimmer (Rynchops niger) and a brown booby (Sula leucogaster)","authors":"Isabella C.R. Boaventura ,&nbsp;Vanessa L. Ribeiro ,&nbsp;Alex J.S. de Souza ,&nbsp;Ruy D. Chacón ,&nbsp;Antônio J.P. Ferreira ,&nbsp;Victor H.B. Marutani ,&nbsp;Juliana P. Guimarães ,&nbsp;Lilian R.M. Sá","doi":"10.1016/j.jcpa.2024.03.206","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.03.206","url":null,"abstract":"<div><p>A black skimmer (<em>Rynchops niger</em>) and a brown booby (<em>Sula leucogaster</em>) were rescued and gross, histopathological, immunohistochemical and polymerase chain reaction evaluations were conducted to investigate the cause of death. There were neoplastic infiltrations of CD3+ PAX5- lymphocytes in the black skimmer and CD3- PAX5+ lymphocytes in the brown booby. Molecular assays for viral agents were negative in both cases. This is the first report of disseminated lymphoma as the cause of stranding and death in these species in Brazil.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"211 ","pages":"Pages 12-16"},"PeriodicalIF":0.8,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140621114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal complications associated with caesarean section in the bitch: post-mortem investigation of 17 cases","authors":"Yannick Van de Weyer,&nbsp;Anna Orlowska,&nbsp;Flavia Zendri,&nbsp;Hayley E. Crosby-Durrani","doi":"10.1016/j.jcpa.2024.03.205","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.03.205","url":null,"abstract":"<div><p>This case series describes the post-mortem findings in 17 bitches (<em>Canis lupus familiaris</em>) with a recent (&lt;7 days) history of caesarean section, most (94%) of which had undergone conservative caesarean section with preservation of the uterus. Brachycephalic breeds accounted for 71% of all cases, with the French Bulldog (35%, n = 6), English Bulldog (18%, n = 3) and Boston Terrier (12%, n = 2) overrepresented. Eleven animals (65%) died between 4 and 48 h after surgery, whereas six (35%) died during the procedure. The most common cause of death was septicaemia (41%, n = 7) associated with <em>Streptococcus canis</em> (29%, n = 5) and/or <em>Escherichia coli</em> (24%, n = 4). Other causes of death included brachycephalic obstructive airway syndrome (BOAS)-associated respiratory failure (24%, n = 4), haemorrhagic shock (18%, n = 3), inconclusive (12%, n = 2) and gastric dilatation and volvulus (6%, n = 1). Histopathological changes were seen in the uterus of 10 cases and included marked inflammation (60%, n = 6), marked haemorrhage (20%, n = 2) or both (20%, n = 2). Metritis was often characterized by fibrinonecrotic, neutrophilic to mixed inflammation, consistent with acute infection. However, prominent lymphohistiocytic infiltrates in two cases suggested that infection had been present prior to surgery. Peritonitis, myositis and panniculitis commonly (35%, n = 6) surrounded the incision sites. The presence of inflammation and bacterial colonies within multiple surgical sites suggested iatrogenic implantation of bacteria, potentially from the uterine lumen. Bacterial culture and isolation, as well as tape measurements for evaluation of conformational BOAS risk factors where applicable, are recommended as part of the routine post-mortem work-up for bitches that die shortly after caesarean section.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"211 ","pages":"Pages 1-7"},"PeriodicalIF":0.8,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002342/pdfft?md5=1759acf4dc308e3e8055bac7d6f80bbc&pid=1-s2.0-S0021997524002342-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140557432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrugated intimal surface of the ovine aorta: when physiology resembles pathology","authors":"Natalia Calvo-Sánchez ,&nbsp;Ana Rodríguez-Largo ,&nbsp;Leonor Puzol ,&nbsp;Ricardo de Miguel ,&nbsp;Estela Pérez ,&nbsp;Álex Gómez ,&nbsp;Juan F. Micheloud ,&nbsp;Lluís Luján","doi":"10.1016/j.jcpa.2024.03.207","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.03.207","url":null,"abstract":"<div><p>The aortic lumen in healthy animals is characterized by a smooth, whitish surface, but sheep have macroscopic corrugation of the intimal surface in the thoracic aorta (TA). Our aim was to determine if this finding was pathological or physiological. Thirteen sheep aortas were included in this work together with aortas from cattle (n = 3), a goat (n = 1), horses (n = 4), dogs (n = 2), rabbits (n = 2) and a pig (n = 1). A corrugated intimal surface in the TA was seen in all the sheep and the goat but was less evident in the cattle. Histologically, in sheep the TA intimal surface was seen to have multifocal bulging areas that protruded into the lumen. The outer half of the tunica media had numerous, randomly distributed muscle islands that disrupted the arrangement of the elastic lamella, displacing them towards the lumen. We conclude that the intimal corrugation of the TA in sheep is physiological and must not be misinterpreted as pathological.</p></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"211 ","pages":"Pages 8-11"},"PeriodicalIF":0.8,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0021997524002366/pdfft?md5=e4600316a4431216fe13a57585ffd5dc&pid=1-s2.0-S0021997524002366-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140607301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Angiogenesis: Unveiling Vessel Co-option and Vasculogenic Mimicry in Highly Malignant Canine Cancer","authors":"G. Valdivia,&nbsp;C. Colomina,&nbsp;L. Barreno,&nbsp;Á. Alonso-Diez,&nbsp;L. Peña","doi":"10.1016/j.jcpa.2024.03.047","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.03.047","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"210 ","pages":"Page 63"},"PeriodicalIF":0.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140604354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive pathological analysis of Northern White-Breasted hedgehog (Erinaceus roumanicus): Insights into health and disease","authors":"E. Gagniuc ,&nbsp;O.C. Vasiliu ,&nbsp;A.I. Anton ,&nbsp;G.L. Nicolae ,&nbsp;G. Dinescu ,&nbsp;M. Ionita","doi":"10.1016/j.jcpa.2024.03.102","DOIUrl":"https://doi.org/10.1016/j.jcpa.2024.03.102","url":null,"abstract":"","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"210 ","pages":"Page 80"},"PeriodicalIF":0.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140604404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}