Disseminated paracoccidioidomycosis in a captive western black-handed tamarin (Saguinus niger)

IF 0.8 4区农林科学 Q4 PATHOLOGY

Journal of Comparative Pathology Pub Date : 2024-08-17 DOI:10.1016/j.jcpa.2024.07.005

Isabelle D. de Oliveira , Eduardo Ferreira-Machado , Jamile M. Garcia , Sarah R.J.S. Simões , Ketlyn B. Figueiredo , Rodrigo A. Ressio , André L.M. da Costa , Flora N. Matos , Cássia R.R. Gonzaga , Shamira S. Leandro , Marina A. de Medeiros , Rodrigo H.F. Teixeira , Mariana C. Martins , Juliana P.F. Takahashi , Leonardo J.T. de Araújo , Natália C.C. de Azevedo Fernandes , Juliana M. Guerra

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引用次数: 0

Abstract

Paracoccidioidomycosis (PCM) is an endemic fungal disease that occurs in Latin America and primarily affects humans. The disease has been rarely documented in non-human primates. This report details a disseminated and fatal case of PCM caused by Paracoccidioides brasiliensis in a western black-handed tamarin (Saguinus niger) under human care. Histopathological examination revealed extensive pyogranulomatous inflammation in the lungs, spleen, liver, lymph nodes, kidneys, epididymis, right testicle, heart, adrenal gland and intestines, associated with characteristic yeast forms consistent with Paracoccidioides spp and confirmed by immunohistochemistry. Molecular analysis indicated a high nucleotide similarity with P. brasiliensis sequences for both the 18S rRNA and gp43 genes. This naturally occurring infection highlights the susceptibility of these animals to PCM and their role in ecoepidemiology warrants further investigation.

查看原文本刊更多论文

一只人工饲养的西部黑手犭(Saguinus niger)体内的散播性副球孢子菌病

副球孢子菌病（PCM）是一种发生在拉丁美洲的地方性真菌病，主要影响人类。在非人类灵长类动物中很少有这种疾病的记录。本报告详细描述了一例由巴西副球孢子菌（Paracoccidioides brasiliensis）引起的 PCM 传播性致命病例，该病例发生在一只由人类照料的西部黑手犭胥（Saguinus niger）身上。组织病理学检查显示，肺、脾、肝、淋巴结、肾、附睾、右侧睾丸、心脏、肾上腺和肠道出现广泛的脓毒血症炎症，伴有与副球孢子菌属一致的特征性酵母形式，并经免疫组化证实。分子分析表明，18S rRNA 和 gp43 基因的核苷酸与巴西疟原虫序列高度相似。这种自然发生的感染凸显了这些动物对 PCM 的易感性，它们在生态流行病学中的作用值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Comparative Pathology 生物-病理学

CiteScore

1.60

自引率

0.00%

发文量

208

审稿时长

50 days

期刊介绍： The Journal of Comparative Pathology is an International, English language, peer-reviewed journal which publishes full length articles, short papers and review articles of high scientific quality on all aspects of the pathology of the diseases of domesticated and other vertebrate animals. Articles on human diseases are also included if they present features of special interest when viewed against the general background of vertebrate pathology.