Journal of Clinical Imaging Science最新文献

{"title":"Correlation analysis of multiparametric magnetic resonance imaging features and molecular subtypes of breast cancer.","authors":"Junping Li, Guanghui Huo, Xiaoye Lei, Guang Li, Mengxing Yu, Ziyang Nie, Zhenhua Guo, Yue Zhang","doi":"10.25259/JCIS_162_2024","DOIUrl":"10.25259/JCIS_162_2024","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the relationship between multiparametric magnetic resonance imaging (MRI) features - including T2-weighted imaging (T2WI), apparent diffusion coefficient (ADC), and dynamic contrast enhancement (DCE) - and molecular subtypes of breast cancer, to enhance non-invasive diagnostic stratification.</p><p><strong>Material and methods: </strong>This retrospective study enrolled 134 consecutive patients with pathologically confirmed breast cancer. A comparative analysis was performed to evaluate intergroup variations in clinicopathological characteristics, morphological features, and multiparametric MRI parameters (including T2WI signal intensity, ADC value, early-phase enhancement rate, and time-intensity curve pattern) across the four molecular subtypes.</p><p><strong>Results: </strong>The cohort comprised 134 breast cancer patients stratified into molecular subtypes as follows: Luminal A (<i>n</i> = 22, 16.4%), Luminal B (<i>n</i> = 82, 61.2%), human epidermal growth factor receptor-2 (HER-2) (+) (<i>n</i> = 13, 9.7%), and triple-negative breast cancer (TNBC) (<i>n</i> = 17, 12.7%). Among the subtypes, there were statistically significant differences in terms of age, Ki-67 index, mass shape, margin, internal enhancement characteristic, T2WI signal, ADC value, early enhancement rate, and time intensity curve (TIC) pattern (<i>P</i> = 0.025; <i>P</i> < 0.001; <i>P</i> = 0.039; <i>P</i> < 0.001; <i>P</i> = 0.043; <i>P</i> = 0.014; <i>P</i> < 0.001; <i>P</i> = 0.009; and <i>P</i> = 0.020, respectively). Luminal subtypes predominantly exhibited irregular shapes, unclear/spiculated margins, heterogeneous enhancement, and uneven hypointense or isointense signal on T2WI. TNBC displayed regular shapes with smooth margins, ring enhancement, and uneven high signal on T2WI. The mean ADC value was significantly higher in HER-2 (+). Luminal A exhibited the highest early enhancement rate, while HER-2 (+) demonstrated the lowest. Analysis of TIC pattern revealed that type III curves were predominant across all subtypes, with a higher proportion observed in Luminal A and TNBC compared to Luminal B and HER-2 (+). Notably, no significant differences were observed between molecular subtypes in terms of menopausal status, axillary node metastasis, lesion type, number, size, and distribution, internal characteristics of non-mass enhancement lesions (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>Multiparametric MRI features, particularly ADC values, DCE kinetics, and T2WI signals, demonstrate significant associations with breast cancer molecular subtypes. These imaging biomarkers offer potential for non-invasive subtype prediction, supporting more tailored diagnostic and treatment strategies.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"15 ","pages":"37"},"PeriodicalIF":1.3,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12530772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145329497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the quality of prostate images from different diffusion-weighted imaging sequences: Single-shot echo-planar, reduced field-of-view, readout-segmented multi-shot.","authors":"Li Xu, Along Qiao, Fei Li, Xiaoyan Zhang, Rui Wu, Wenya Liu, Bo Jiang, Minghua Sun","doi":"10.25259/JCIS_64_2025","DOIUrl":"10.25259/JCIS_64_2025","url":null,"abstract":"<p><strong>Objectives: </strong>The objectives of the study are to compare the prostate image quality (IQ) obtained with single-shot echo-planar diffusion-weighted imaging (ss-DWI), reduced field-of-view diffusion-weighted imaging (rf-DWI), and readout-segmented multi-shot diffusion-weighted imaging (rs-DWI), along with their diagnostic efficacy for clinically significant prostate cancer (csPCa), to optimize prostate magnetic resonance diffusion-weighted imaging sequences.</p><p><strong>Material and methods: </strong>We have analyzed prostate images from 72 patients who underwent ss-DWI, rs-DWI, and rf-DWI magnetic resonance imaging (MRI) scans from March 2023 to September 2024. Two radiologists qualitatively evaluated the IQ of three diffusion-weighted imaging (DWI) sequences and corresponding apparent diffusion coefficient (ADC) images as well as Prostate Imaging Reporting and Data System Version 2.1 (PI-RADS v2.1) category of prostate nodules and measured the anterior-posterior diameter and right-left (RL) diameters of the prostate on both types of images and ADC values of prostate nodules. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were calculated. Qualitative and quantitative differences across DWI techniques were statistically compared.</p><p><strong>Results: </strong>The rf-DWI images demonstrated optimal clarity, minimal distortion/artifacts, and the highest CNR and lowest SNR. The RL diameter of the prostate measured on T2-weighted images was larger than those on ss-DWI images, and the RL diameter measured on ss-DWI images was smaller than those measured on rf-DWI images (<i>P</i> < 0.05). The rf-DWI-based PI-RADS v2.1 categorization and ADC values showed higher diagnostic accuracy for csPCa versus ss-DWI/rs-DWI, with optimal ADC cutoffs of 0.958 × 10³ mm²/s (transition zone) and 0.769 × 10³ mm²/s (peripheral zone).</p><p><strong>Conclusion: </strong>Compared to ss-DWI and rs-DWI, the rf-DWI sequence demonstrates optimal IQ and quantitative parameters with the optimum diagnostic performance for csPCa, making it the best choice for prostate scans.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"15 ","pages":"36"},"PeriodicalIF":1.3,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12530774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145329481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography and ¹⁸F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging in lung cancer metastasis after surgery.","authors":"Yongzhu Pu, Kesheng Zhou, Yunchao Huang, Long Chen","doi":"10.25259/JCIS_6_2025","DOIUrl":"10.25259/JCIS_6_2025","url":null,"abstract":"<p><p>A 68-year-old female patient, diagnosed with stage Ib left upper lobe lung cancer, underwent surgery in June 2021. The patient underwent both ¹⁸F-fluorodeoxyglucose positron emission tomography (PET)/computed tomography (CT) and PET/magnetic resonance imaging (MRI) examinations on December 19. In our study, we found that PET/MRI identified more pleural and bone metastases and provided accurate total metabolic tumor volume, which might have significant value for the treatment options and prognosis assessment of certain patients, while PET/CT clearly underestimated this aspect. In conclusion, we believed that although there was no significant difference between PET/CT and PET/MRI in the clinical staging of patients with advanced lung cancer, PET/MRI provided richer and more accurate lesion information. The predictive models constructed from these parameter data held important value for changes in treatment methods, survival time, and prognosis for some patients also in the advanced stage of lung cancer.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"15 ","pages":"35"},"PeriodicalIF":1.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12530768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145329425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sample size matters: A step-by-step guide for radiologists.","authors":"Ramon Gheno, Rogério Boff Borges, Rodrigo Citton Padilha Dos Reis","doi":"10.25259/JCIS_36_2025","DOIUrl":"10.25259/JCIS_36_2025","url":null,"abstract":"<p><p>Sample size is an essential step in any research study because it directly affects precision and statistical power. This article describes the main factors that determine the number of observations needed (power of a hypothesis test, significance criterion, minimum expected difference, variability, and asymmetry of the hypothesis test) and techniques for minimizing these factors. Our paper clearly presents examples of sample size calculations in radiology related to descriptive (mean and proportion) and comparative (two means, two proportions, intraclass correlations, and analysis of variance) studies. These examples are solved both manually and computationally using free R-based software.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"15 ","pages":"34"},"PeriodicalIF":1.3,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copyright and creative commons licenses in scholarly publishing: A practical guide for researchers.","authors":"Himel Mondal","doi":"10.25259/JCIS_22_2025","DOIUrl":"10.25259/JCIS_22_2025","url":null,"abstract":"<p><p>Copyright is a crucial aspect of scholarly publishing, governing the ownership, distribution, and permissible use of academic content. Traditional copyright laws grant exclusive rights to authors or publishers. In the era of open-access publication, Creative Commons (CC) licenses offer the flexibility to share scholarly work more openly while maintaining proper attribution. Understanding these licensing options is essential for researchers. This article explores the fundamental concepts of copyright, licensing, and CC in the context of scholarly publishing. It briefly explains how to search for copyright and licensing information on an article, properly attribute credit, and obtain permission for content reuse from the copyright holder. Failure to comply with copyright regulations can result in consequences such as legal disputes, financial penalties, and reputational damage. Hence, an understanding and responsible application of copyright and licensing principles are therefore essential for ethical and legally compliant scholarly communication.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"15 ","pages":"32"},"PeriodicalIF":1.3,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the glymphatic system using the DTI-ALPS index in type 2 diabetes mellitus-induced cognitive impairment.","authors":"Nan Wang, Rendi Yin, Yao Fang, Xiaole Wei, Li Shen, Wei Feng, Haorui Lv, Xiaoyan Zhou, Chao Zhang, Changjiang Ying, Xuan Liu","doi":"10.25259/JCIS_142_2024","DOIUrl":"10.25259/JCIS_142_2024","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of the study is to assess the utility of the perivascular space diffusion tensor imaging - along the perivascular space (DTI-ALPS) index in evaluating the activity of the brain glymphatic system in patients with type 2 diabetes mellitus (T2DM) and cognitive impairment.</p><p><strong>Material and methods: </strong>This study included 40 T2DM patients with cognitive impairment and 40 healthy controls (HCs). All participants underwent DTI, and the DTI-ALPS index was calculated based on relevant DTI parameters. Statistical analyses were performed using the Statistical Package for the Social Sciences version 26.0, with significance set at <i>P</i> < 0.05.</p><p><strong>Results: </strong>The DTI-ALPS index in T2DM patients with cognitive impairment were significantly lower than that of the HCs. A significant negative correlation was observed between the DTI-ALPS index and glycated hemoglobin levels, while positive correlations were found with vitamin D, Montreal Cognitive Assessment scores, and high-density lipoprotein cholesterol levels.</p><p><strong>Conclusion: </strong>This study confirms glymphatic dysfunction in T2DM patients with cognitive impairment, as indicated by the reduced DTI-ALPS index. Furthermore, it demonstrates the feasibility of utilizing the DTI-ALPS method to assess glymphatic system activity in this patient population.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"15 ","pages":"31"},"PeriodicalIF":1.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477971/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ulnar variance - Reliability of three different methods of measurement.","authors":"Asger Jepsen, Benjamin S Rasmussen, Ole Graumann, Meinhard Reinert Hansen, Hans B Tromborg, Janni Jensen","doi":"10.25259/JCIS_49_2024","DOIUrl":"10.25259/JCIS_49_2024","url":null,"abstract":"<p><strong>Objectives: </strong>Ulnar variance (UV), i.e., the length of the ulna relative to the radius is a radiographic measurement commonly used to estimate fracture compression of distal radius fractures. Different methods for measuring UV have been described in the literature. The aim of this study was to assess the inter- and intra-rater reliability of three different methods of measuring UV among raters with different professional backgrounds and levels of experience.</p><p><strong>Material and methods: </strong>Nine raters, one musculoskeletal radiologist, three radiology residents, one PhD student, one medical student, and three reporting radiographers, participated in the study. They measured UV on 21 radiographs using three different measurement methods: The method of central reference point (CRP), the lateral method (LM), and the method of perpendiculars (MoP). Inter-rater reliability was assessed using the intra-class correlation coefficient (ICC), while intra-rater agreement was estimated using Bland-Altman (BA) analysis with limits of agreement (LoA).</p><p><strong>Results: </strong>Inter-rater reliability estimated by ICCs was 0.91, 0.96, and 0.97 for the methods of CRP, LM, and MoP, respectively. Intra-rater agreement, assessed by BA LoA for rater1/rater2, was ±2.94/±1.45, ±1.92/±2.36, and ±2.14/±1.33 for the methods of CRP, LM, and MoP, respectively.</p><p><strong>Conclusion: </strong>All three methods of measurement displayed excellent reliability with ICCs ranging from 0.91 to 0.97. The findings suggest that UV measurements can be reliably obtained across raters with different professional backgrounds and levels of experience using all three methods of measuring.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"15 ","pages":"30"},"PeriodicalIF":1.3,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microwave ablation for hepatocellular carcinoma in cirrhotic patients with diuretic-resistant ascites.","authors":"Sawyer Blair, Jack Newcomer, Driss Raissi","doi":"10.25259/JCIS_11_2025","DOIUrl":"10.25259/JCIS_11_2025","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to evaluate the feasibility, safety, and efficacy of computed tomography (CT)-guided percutaneous microwave ablation (MWA) of liver hepatocellular carcinoma (HCC) lesions in patients with pre-existing diuretic-resistant ascites. There is logical hesitation among clinicians to pursue MWA in these decompensated patients for fear of worsening an already bleak prognosis, but there is limited evidence to justify this behavior.</p><p><strong>Material and methods: </strong>A retrospective review of HCC treated with percutaneous MWA at a single center was performed. 18 patients who underwent CT-guided MWA with pre-existing diuretic-resistant ascites were identified. A control group of 29 patients who underwent CT-guided MWA without pre-existing diuretic-resistant ascites was identified, which was further narrowed to 18 patients after matching by Model for End-Stage Liver Disease-Sodium score and age. The effectiveness of treatment was compared between the two groups and evaluated by disease-free survival, residual disease, and overall survival over 36 months. Kaplan-Meier curves plotting the survival function were constructed to compare these variables in both groups.</p><p><strong>Results: </strong>MWA was successfully performed in all patients. The probability of survival at 1 year for the ascites and matched control groups were 0.778 and 1.00, respectively (<i>P</i> = 0.038). The probability of survival at 3 years for the ascites and matched control groups were 0.556 and 0.630, respectively (<i>P</i> = 0.237). There were no significant differences between residual disease and disease-free survival between the two groups at 1 or 3 years.</p><p><strong>Conclusion: </strong>CT-guided percutaneous MWA for HCC in select patients with pre-existing diuretic-resistant ascites is a feasible, safe, and effective treatment option.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"15 ","pages":"33"},"PeriodicalIF":1.3,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12477949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145199689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mind the right ventricle: Tackling right heart dysfunction in left ventricular diverticulum with omphalocele.","authors":"Pavana Gokhale, Tanya Mital, Pradeep R Reddy, Poonam Malhotra Kapoor","doi":"10.25259/JCIS_161_2024","DOIUrl":"10.25259/JCIS_161_2024","url":null,"abstract":"<p><p>Left ventricular diverticulum (LVD) is a rare congenital anomaly characterized by an abnormal outpouching of the left ventricular wall. It is often identified during childhood, as it is commonly associated with midline thoracoabdominal defects and other congenital heart abnormalities. Here, we present a 10-month-old boy with a LVD and omphalocele posted for surgical management who had difficulty weaning in the post-operative period. We discuss the unique challenges that necessitate meticulous planning and execution to optimize right ventricular function and prevent pulmonary arterial hypertension in such patients.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"15 ","pages":"29"},"PeriodicalIF":1.3,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Roadmap to success: Blueprint for enterprise-wide deployment of a point-of-care ultrasound platform, inclusive of governance, policy, education, credentialing, and quality assurance (Part 2).","authors":"David Waldman, John Doughton, Chelsea Pino","doi":"10.25259/JCIS_76_2025","DOIUrl":"10.25259/JCIS_76_2025","url":null,"abstract":"<p><p>Point-of-care ultrasound (POCUS) has emerged as a cost-effective diagnostic tool that significantly enhances physical examinations. Serving as an extension of traditional examination methods, POCUS is particularly appealing to the next generation of clinicians. It holds the potential to become the modern-day stethoscope in various medical assessments and procedures. At the University of Rochester, we are in the midst of a major initiative, deploying 2,000 POCUS probes while simultaneously reinforcing compliance standards for image storage and documentation across established POCUS platforms. Three years into our 4-year deployment plan, we will discuss the evolution of our governance structure, improved utilization, continued educational initiatives, and credentialing strategies. Over the past decade, POCUS adoption has grown organically, and our goal is to implement a comprehensive strategy that ensures adherence to established protocols for image storage and documentation. At present, we have successfully deployed 1,199 probes, up from 789 in year 2, with integration across more than 70 departments and divisions within our information technology (IT) platform. Notably, this implementation has led to a 26% growth in hospital charges, highlighting the tangible impact of POCUS integration. However, achieving compliance and education among established providers continues to be a challenge. The integration of fellowship-trained POCUS physicians into various departments has been invaluable, and developing physician champions has significantly improved both utilization and compliance. Recent initiatives include transitioning from traditional bladder scanners to ultrasound (US) probes mounted on iPad stands and developing a nursing POCUS-guided US program. Nursing education has played a pivotal role in supporting this transition. Over the first 6 months, 86 US probes used by nursing staff have facilitated approximately 70,000 bladder examinations.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"15 ","pages":"28"},"PeriodicalIF":1.3,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12361668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}