Journal of Clinical Imaging Science最新文献

{"title":"Using virtual reality simulation for training practical skills in musculoskeletal wrist X-ray - A pilot study.","authors":"Janni Jensen,&nbsp;Ole Graumann,&nbsp;Rune Overgaard Jensen,&nbsp;Signe K K Gade,&nbsp;Maria Grabau Thielsen,&nbsp;Winnie Most,&nbsp;Pia Iben Pietersen","doi":"10.25259/JCIS_45_2023","DOIUrl":"https://doi.org/10.25259/JCIS_45_2023","url":null,"abstract":"<p><strong>Objectives: </strong>Using virtual reality (VR), students of radiography can practice acquisition and positioning of musculoskeletal radiographs and get immediate feedback on their performance within the simulator. The purpose of this study was to assess usability of a newly developed VR simulator and to explore self-perceived clinical readiness (SPCR) of radiography students before and after training acquisition of wrist radiographs in the VR simulator.</p><p><strong>Material and methods: </strong>A prospective methodology was applied where the students (<i>n</i> = 10) estimated their own SPCR in regard to acquisition of wrist radiographs pre- and post-VR training. A questionnaire on usability, realism, and educational value of the simulator was answered post-VR training. Usability and SPCR scores were calculated. The student's paired <i>t</i>-test was applied to explore the impact of VR training on SPCR.</p><p><strong>Results: </strong>The students (90%) reported that the simulator was realistic and they thought that it could contribute to learning. The pre- and post-SPCR scores were 75 (95% confidence interval [CI]: 54-96) and 77 (95% CI: 59-95), respectively. There was no significant difference (<i>P</i> = 0.4574) between the pre- and post-SPCR scores.</p><p><strong>Conclusion: </strong>Results indicated that the concept of training acquisition and positioning of wrist radiographs in a VR simulator is feasible with positive feedback from the students. The SPCR scores improved slightly, although not statistically significant, after completion of the training session.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"13 ","pages":"20"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/1c/JCIS-13-20.PMC10408651.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9972772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of failed inferior vena cava filter retrieval for complex cases: A case series.","authors":"Po Lam Kwok,&nbsp;Wai Hung Lester Shiu,&nbsp;Yip Kan Kendrick Tang,&nbsp;Kam Wing Leung","doi":"10.25259/JCIS_30_2023","DOIUrl":"https://doi.org/10.25259/JCIS_30_2023","url":null,"abstract":"<p><p>The aim of this report is to describe our experience in managing cases of difficult inferior vena cava (IVC) filter retrieval with emphasis on different advanced retrieval techniques. We report three cases of difficult IVC filter retrieval at our institution. We included three patients age ranging from 42 to 72 years. Two of the cases were presenting with the lower limb deep vein thrombosis and one of the cases had pulmonary embolism and they all had Retrievable Celect Platinum IVC filter (Cook Medical, Bloomington, Ind.) inserted preoperatively. One case was managed conservatively after failing IVC filter retrieval using standard retrieval set, meaning the filter was left in place, one was successfully removed with advanced endovascular retrieval techniques, and one failing advanced endovascular retrieval and finally had it removed with open surgery. We reviewed the risk factors contributing to difficult IVC filter retrieval and discussed the different options for managing these cases including conservative management, endovascular treatment, and open surgery for retrievable type of IVC filter which can be placed permanently. Knowledge of these options will help us better understand conditions, leading to difficult IVC retrieval on insertion, hopefully to minimize the occurrence of these cases, and to better manage cases with difficult IVC filter retrieval to decide the best option for each patient after careful consideration and multidisciplinary discussion with surgeons and patients.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"13 ","pages":"14"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/35/JCIS-13-14.PMC10246343.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9662792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19: Correlation between HRCT findings and clinical prognosis and analysis of parenchymal pattern evolution.","authors":"Stefano Giusto Picchi,&nbsp;Giulia Lassandro,&nbsp;Antonio Corvino,&nbsp;Domenico Tafuri,&nbsp;Martina Caruso,&nbsp;Guido Faggian,&nbsp;Giulio Cocco,&nbsp;Andrea Delli Pizzi,&nbsp;Luigi Gallo,&nbsp;Pasquale Quassone,&nbsp;Andrea Boccatonda,&nbsp;Maria Teresa Minguzzi","doi":"10.25259/JCIS_22_2023","DOIUrl":"https://doi.org/10.25259/JCIS_22_2023","url":null,"abstract":"<p><strong>Objectives: </strong>Severe acute respiratory syndrome - coronavirus 2 (SARS-CoV-2) is a single-stranded positive ribonucleic acid virus of the coronaviridae family. The disease caused by this virus has been named by the World Health Organization coronavirus disease 19 (COVID-19), whose main manifestation is interstitial pneumonia. Aim of this study is to describe the radiological features of SARS-CoV-2 infection in its original form, to correlate the high-resolution computed tomography (HRCT) patterns with clinical findings, prognosis and mortality, and to establish the need for treatment and admission to the intensive care unit.</p><p><strong>Material and methods: </strong>From March 2020 to May 2020, 193 patients (72 F and 121 M) who were swab positive for SARS-CoV-2 were retrospectively selected for our study. These patients underwent HRCT in the clinical suspicion of SARS-CoV-2 interstitial pneumonia.</p><p><strong>Results: </strong>Our results confirm the role of radiology and, in particular, of chest HRCT as a technique with high sensitivity in the recognition of the most peculiar features of COVID-19 pneumonia, in the evaluation of severity of the disease, in the correct interpretation of temporal changes of the radiological picture during the follow-up until the resolution, and in obtaining prognostic information, also to direct the treatment.</p><p><strong>Conclusion: </strong>Chest computed tomography cannot be considered as a substitute for real-time - polymerase chain reaction in the diagnosis of COVID-19, but rather supplementary to it in the diagnostic process as it can detect parenchymal changes at an early stage and even before the positive swab, at least for patients who have been symptomatic for more than 3 days.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"13 ","pages":"10"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b6/84/JCIS-13-10.PMC10159294.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9798999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality assurance for non-contrast CT of the abdomen and pelvis during a period of supply chain disruption leading to iodinated contrast shortage in the emergency department setting.","authors":"Luis Fernando Calimano-Ramirez,&nbsp;Mauricio Hernandez,&nbsp;Anmol Singh,&nbsp;Kazim Ziya Gumus,&nbsp;Wanda Marfori,&nbsp;Mayur K Virarkar,&nbsp;Chandana Lall,&nbsp;Dheeraj Reddy Gopireddy","doi":"10.25259/JCIS_142_2022","DOIUrl":"https://doi.org/10.25259/JCIS_142_2022","url":null,"abstract":"<p><strong>Objectives: </strong>Iodinated contrast media (ICM) shortage crisis due to COVID-19 lockdowns led to a need for alternate imaging protocols consisting of non-contrast computed tomography (CT) for abdominal complaints and related trauma indications in emergency department (ED) settings. This quality assurance study aims to evaluate clinical outcomes of protocol modifications during ICM shortage and identify potential imaging misdiagnosis of acute abdominal complaints and related trauma.</p><p><strong>Material and methods: </strong>The study included 424 ED patients with abdominal pain, falls, or motor vehicle collision (MVC)-related trauma who had non-contrast CT of the abdomen and pelvis in May 2022. We accessed the initial complaint, order indication, non-contrast CT results, any acute or incidental findings, and any follow-up imaging of the same body region with their results. We evaluated their association utilizing Chi-squared tests. We assessed sensitivity, specificity, and positive/negative predictive values using follow-up scan confirmation.</p><p><strong>Results: </strong>Across initial complaint categories, 72.9% of cases were abdominal pain, and 37.3% received positive findings. Only 22.6% of patients had follow-up imaging. Most confirmed original reports were for abdominal pain. We also found three reports of missed findings. There were significant associations between complaint categories and initial non-contrast CT report results (<i>P</i> < 0.001), as well as initial complaint categories and whether the patient received follow-up imaging or not <i>(P</i> < 0.004). No significant associations were found between follow-up imaging results and initial report confirmation. Non-contrast CT had 94% sensitivity and 100% specificity, with positive and negative predictive values 100% and 94%, respectively.</p><p><strong>Conclusion: </strong>Rate of missed acute diagnoses using non-contrast CT for patients presenting to the ED with acute abdominal complaints or related trauma has been low during the recent shortage, but further investigation would be needed to verify and quantify the implications of not routinely giving oral or intravenous contrast in the ED.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"13 ","pages":"8"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7d/98/JCIS-13-8.PMC9990841.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9084373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraluminal arterial transit artifact as a predictor of intracranial large artery stenosis on 3D time of flight MR angiography: Expanding the application of arterial spin labeling MRI in ischemic stroke.","authors":"Sameer Peer,&nbsp;Paramdeep Singh","doi":"10.25259/JCIS_27_2023","DOIUrl":"https://doi.org/10.25259/JCIS_27_2023","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to evaluate the diagnostic value of \"intraluminal arterial transit artifact\" in the prediction of intracranial large artery stenosis and to determine if this finding is predictive of ischemic stroke in the territory of the involved artery.</p><p><strong>Material and methods: </strong>The presence of arterial transit artifact (ATA) within the lumen of an intracranial large vessel was noted on three-dimensional time of flight (3D-TOF) magnetic resonance angiography (MRA) (ATA group). The patients with stenosis but with no ATA (no-ATA group), patients with total occlusion (total occlusion group), and patients with no stenosis/occlusion (normal group) were included in the analysis.</p><p><strong>Results: </strong>There were four groups of patients included in the final analysis, the ATA group (<i>n</i> = 22), the no-ATA group (<i>n</i> = 23), the normal group (<i>n</i> = 25), and the total occlusion group (<i>n</i> = 9). Among patients with any demonstrable stenosis (<i>n</i> = 45), the presence of ATA within the stenotic segment was predictive of stenosis of ≥56% (Sensitivity of 100% [85.2-100, 95% CI], specificity of 100% [86.4-100, 95% CI]), with area under curve of 1.0 (0.92-.0, 95% CI). The presence of intra-arterial ATA signal was significantly associated with ischemic stroke as compared with the no-ATA group (86.36% vs. 26.08%, <i>P</i> = 0.0003). Intraluminal ATA was found to be an independent predictor of infarction in the territory of the involved artery.</p><p><strong>Conclusion: </strong>Intraluminal ATA is predictive of stenosis of at least 56% in the involved artery on 3D-TOF MRA. Intraluminal ATA sign may be an independent predictor of infarction in the territory of the involved artery.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"13 ","pages":"17"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/11/82/JCIS-13-17.PMC10316254.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9803613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ductal carcinoma <i>in situ</i> arises from microglandular adenosis and atypical microglandular adenosis in a young woman.","authors":"Nguyen Thu Huong,&nbsp;Tran-Thi Hue,&nbsp;Nguyen Duy Hung,&nbsp;Nguyen Minh Duc","doi":"10.25259/JCIS_32_2023","DOIUrl":"https://doi.org/10.25259/JCIS_32_2023","url":null,"abstract":"<p><p>Microglandular adenosis (MGA) and atypical microglandular adenosis (AMGA) are intensely rare and distinctive forms of adenosis of the breast, usually occurring in middle-aged women. Carcinoma arising in MGA is an extremely rare subtype of breast carcinoma, and most reported cases are of invasive carcinoma. Ultrasound and magnetic resonance imaging are accurate imaging modalities for diagnosing these abnormalities. Our goal in this article was to report a rare instance of ductal carcinoma <i>in situ</i> (DCIS) arising from MGA and AMGA in a very young Vietnamese woman who presented with a palpable mass in her right breast for 1 month. During clinical examination and imaging, suspected lesions were found and categorized as BI-RADS 4a. The final histopathological findings confirmed DCIS arising from MGA/AMGA. In this patient, the disease was detected and managed early when the lesion was localized in the duct and there were no signs of invasive ductal carcinoma.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"13 ","pages":"15"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/92/d7/JCIS-13-15.PMC10246311.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9964490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging in COVID-19-associated acute invasive fungal rhinosinusitis - Diagnosis and beyond.","authors":"Gayatri Senapathy,&nbsp;Tharani Putta,&nbsp;Srinivas Kishore Sistla","doi":"10.25259/JCIS_46_2023","DOIUrl":"https://doi.org/10.25259/JCIS_46_2023","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;The aim of the study was to evaluate the magnetic resonance imaging (MRI) features of acute invasive fungal rhinosinusitis (AIFRS) at presentation and on follow-up imaging when patients receive treatment with systemic antifungal therapy and surgical debridement.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Material and methods: &lt;/strong&gt;This is a retrospective analysis of imaging data from a cohort of patients diagnosed with AIFRS during the second wave of COVID-19 in single tertiary referral hospital in South India between March 2021 and May 2021 (&lt;i&gt;n&lt;/i&gt; = 68). Final diagnosis was made using a composite reference standard which included a combination of MRI findings, clinical presentation, nasal endoscopy and intraoperative findings, and laboratory proof of invasive fungal infection. Analysis included 62 patients with \"Definite AIFRS\" findings on MRI and another six patients with \"Possible AIFRS\" findings on MRI and laboratory proof of invasive fungal infection. Follow-up imaging was available in 41 patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The most frequent MRI finding was T2 hypointensity in the sinonasal mucosa (94%) followed by mucosal necrosis/loss of contrast-enhancement (92.6%). Extrasinosal inflammation with or without necrosis in the pre-antral fat, retroantral fat, pterygopalatine fossa, and masticator space was seen in 91.1% of the cases. Extrasinosal spread was identified on MRI even when the computed tomography (CT) showed intact bone with normal extrasinosal density. Orbital involvement (72%) was in the form of contiguous spread from either the ethmoid or maxillary sinuses; the most frequent presentation being orbital cellulitis and necrosis, with some cases showing extension to the orbital apex (41%) and inflammation of the optic nerve (32%). A total of 22 patients showed involvement of the cavernous sinuses out of which 10 had sinus thrombosis and five patients had cavernous internal carotid artery involvement. Intracranial extension was seen both in the form of contiguous spread to the pachymeninges over the frontal and temporal lobes (25%) and intra-axial involvement in the form of cerebritis, abscesses, and infarcts (8.8%). Areas of blooming on SWI were noted within the areas of cerebritis and infarcts. Perineural spread of inflammation was seen along the mandibular nerves across foramen ovale in five patients and from the cisternal segment of trigeminal nerve to the root exit zone in pons in three patients. During follow-up, patients with disease progression showed involvement of the bones of skull base, osteomyelitis of the palate, alveolar process of maxilla, and zygoma. Persistent hyperenhancement in the post-operative bed after surgical debridement and resection was noted even in patients with stable disease.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Contrast-enhanced MRI must be performed in all patients with suspected AIFRS as non-contrast MRI fails to demonstrate tissue necrosis and CT fails to demonstrate extrasinosal dis","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"13 ","pages":"23"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/54/JCIS-13-23.PMC10481822.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10245178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic retroperitoneal dedifferentiated liposarcoma: A case report.","authors":"Sara Sorour,&nbsp;Bo Bao,&nbsp;Mitchell Patrick Wilson,&nbsp;Gavin Low","doi":"10.25259/JCIS_48_2023","DOIUrl":"https://doi.org/10.25259/JCIS_48_2023","url":null,"abstract":"<p><p>Liposarcoma is the most common primary retroperitoneal sarcoma in adults. We report the case of an 86-year-old male who presented to the emergency department with frequent falls and unexplained weight loss that was found to have a cystic retroperitoneal dedifferentiated liposarcoma. Initial computed tomography revealed a large heterogeneous complex cystic hypoenhancing lesion in the left retroperitoneum. Subsequent magnetic resonance imaging demonstrates a multilocular cystic mass with microscopic lipid content, diffusion restriction, and enhancing nodular soft-tissue components. Histologic examination of the tissue sample following biopsy is consistent with cystic retroperitoneal dedifferentiated liposarcoma. Further management was not pursued due to the patient's advanced age and frailty.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"13 ","pages":"22"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/20/JCIS-13-22.PMC10481824.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10192014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-energy computed tomography of the abdomen: A reliable trouble-shooter.","authors":"Viswanath Anand Chidambaram,&nbsp;Mindy Chu Ming Choong,&nbsp;Chaitra Dhiraj Goud","doi":"10.25259/JCIS_25_2023","DOIUrl":"https://doi.org/10.25259/JCIS_25_2023","url":null,"abstract":"<p><p>Dual-energy computed tomography (CT) systems have undergone significant evolution and advancements in technology since they came into clinical practice in 2006. The basic principle of dual-energy is comparing the attenuation of different materials when exposed to high and low energy levels. In this article, we provide a brief overview of the basics of dual-energy CT systems, a pictorial review of commonly encountered abdominal conditions, and its role as a trouble-shooter in various diagnostic difficulties.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"13 ","pages":"12"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/79/ea/JCIS-13-12.PMC10159281.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9436001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of 3-Tesla magnetic resonance perfusion and spectroscopy in distinguishing glioblastoma from solitary brain metastasis.","authors":"Nguyen Duy Hung,&nbsp;Le Van Dung,&nbsp;Nguyen Ha Vi,&nbsp;Nguyen-Thi Hai Anh,&nbsp;Le-Thi Hong Phuong,&nbsp;Nguyen Dinh Hieu,&nbsp;Nguyen Minh Duc","doi":"10.25259/JCIS_49_2023","DOIUrl":"https://doi.org/10.25259/JCIS_49_2023","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the value of magnetic resonance perfusion (MR perfusion) and magnetic resonance spectroscopy (MR spectroscopy) in 3.0-Tesla magnetic resonanceimaging (MRI) for differential diagnosis of glioblastoma (GBM) and solitary brain metastasis (SBM).</p><p><strong>Material and methods: </strong>This retrospective study involved 36 patients, including 24 cases of GBM and 12 of SBM diagnosed using histopathology. All patients underwent a 3.0-Tesla MRI examination with pre-operative MR perfusion and MR spectroscopy. We assessed the differences in age, sex, cerebral blood volume (CBV), relative CBV (rCBV), and the metabolite ratios of choline/N-acetylaspartate (Cho/NAA) and Cho/creatine between the GBM and SBM groups using the Mann-Whitney U-test and Chi-square test. The cutoff value, area under the curve, sensitivity, specificity, positive predictive value, and negative predictive value of the significantly different parameters between these two groups were determined using the receiver operating characteristic curve.</p><p><strong>Results: </strong>In MR perfusion, the CBV of the peritumoral region (pCBV) had the highest preoperative predictive value in discriminating GBM from SBM (cutoff: 1.41; sensitivity: 70.83%; and specificity: 83.33%), followed by the ratio of CBV of the solid tumor component to CBV of normal white matter (rCBVt/n) and the ratio of CBV of the pCBV to CBV of normal white matter (rCBVp/n). In MR spectroscopy, the Cho/NAA ratio of the pCBV (pCho/NAA; cutoff: 1.02; sensitivity: 87.50%; and specificity: 75%) and the Cho/NAA ratio of the solid tumor component (tCho/NAA; cutoff: 2.11; sensitivity: 87.50%; and specificity: 66.67%) were significantly different between groups. Moreover, combining these remarkably different parameters increased their diagnostic utility for distinguishing between GBM and SBM.</p><p><strong>Conclusion: </strong>pCBV, rCBVt/n, rCBVp/n, pCho/NAA, and tCho/NAA are useful indices for differentiating between GBM and SBM. Combining these indices can improve diagnostic performance in distinguishing between these two tumors.</p>","PeriodicalId":15512,"journal":{"name":"Journal of Clinical Imaging Science","volume":"13 ","pages":"19"},"PeriodicalIF":0.9,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d6/5e/JCIS-13-19.PMC10408633.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9975726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}