单侧海马硬化症患者大脑半球间灰质体积的不对称变化

IF 1.1 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
S. Mugikura, Naoko Mori, Miyeong Gang, Shigenori Kanno, K. Jin, S. Osawa, Nobukazu Nakasato, Kei Takase
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引用次数: 0

摘要

为了明确单侧海马硬化症(HS)患者大脑半球间灰质体积(GMV)的非对称性变化,我们比较了单侧HS患者和对侧或非单侧HS患者相对于正常人的GMV变化。我们通过引入单侧 HS 每个区域或相关区域的 Z 值(Z-GMV),量化了 HS 患者 GMV 相对于正常人 GMV 的变化。然后,我们评估了非对称下降的区域,即 HS 一侧的 Z-GMV 明显高于对侧或非 HS 一侧的区域。Z-GMV是根据解剖自动标记(AAL)覆盖全脑的每半球58个区域和解剖工具箱覆盖全脑的每半球78个区域这两个模板计算得出的。AAL 中的海马和尾状,海马的 5 个亚区(CA1-3、齿状回和海马-杏仁核-过渡区)和 4 个海马外区,包括杏仁核的 2 个亚区(CM:解剖工具箱中的基底前脑(BF)(Ch4)和丘脑(颞叶)是 LHS 和 RHS 中关于非对称减少区域的常见区域。通过引入 Z-GMV,我们展示了 LHS 和 RHS 中 GMV 不对称下降的区域,并发现海马和海马外区域(包括 BF)是 LHS 和 RHS 中常见的不对称下降区域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interhemispheric asymmetrical change in gray matter volume in patients with unilateral hippocampal sclerosis
To clarify the interhemispheric asymmetrical change in gray matter volume (GMV) in unilateral hippocampal sclerosis (HS), we compared changes in GMV relative to normal subjects between the HS and contralateral or non-HS sides. Forty-five patients with unilateral HS and 30 healthy subjects were enrolled. We quantified changes in GMV in the patients with HS as compared to GMV in the normal subjects by introducing the Z-score (Z-GMV) in each region or region of interest in unilateral HS. Then, we assessed the asymmetrically decreased regions, that is, regions with significantly higher Z-GMV on the HS side than the contralateral or non-HS side. Z-GMV was calculated according to the two templates of 58 regions per hemisphere covering the whole brain by anatomical automatic labeling (AAL) and 78 regions per cerebral hemisphere using the Anatomy Toolbox. Seven and four regions in AAL and 17 and 11 regions in Anatomy Toolbox were asymmetrically decreased in the Left Hand Side (LHS) and Right Hand Side (RHS), respectively. Hippocampus and Caudate in AAL, five subregions of the hippocampus (CA1–3, Dentate Gyrus and hippocampus-amygdala-transition-area and 4 extrahippocampal regions including two subregions in amygdala (CM: Centromedial, SF: Superficial), basal forebrain (BF) (Ch4), and thalamus (temporal) in anatomy toolbox were common among LHS and RHS concerning asymmetrically decreased regions. By introducing Z-GMV, we demonstrated the regions with asymmetrically decreased GMV in LHS and RHS, and found that the hippocampus and extrahippocampal regions, including the BF, were the common asymmetrically decreased regions among LHS and RHS.
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来源期刊
Journal of Clinical Imaging Science
Journal of Clinical Imaging Science RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.00
自引率
0.00%
发文量
65
期刊介绍: The Journal of Clinical Imaging Science (JCIS) is an open access peer-reviewed journal committed to publishing high-quality articles in the field of Imaging Science. The journal aims to present Imaging Science and relevant clinical information in an understandable and useful format. The journal is owned and published by the Scientific Scholar. Audience Our audience includes Radiologists, Researchers, Clinicians, medical professionals and students. Review process JCIS has a highly rigorous peer-review process that makes sure that manuscripts are scientifically accurate, relevant, novel and important. Authors disclose all conflicts, affiliations and financial associations such that the published content is not biased.
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