Journal of Contemporary Pharmacy Practice最新文献_第3页

Formulation and evaluation of fast dissolving films embedded with nanoparticles of mirtazapine hydrochloride 盐酸米氮平纳米颗粒包埋快溶膜的制备与评价

Journal of Contemporary Pharmacy Practice Pub Date : 2022-07-31 DOI: 10.56770//jcp2022612

Afshan Maqbool, M. Aamir, M. Naeem

{"title":"Formulation and evaluation of fast dissolving films embedded with nanoparticles of mirtazapine hydrochloride","authors":"Afshan Maqbool, M. Aamir, M. Naeem","doi":"10.56770//jcp2022612","DOIUrl":"https://doi.org/10.56770//jcp2022612","url":null,"abstract":"Objectives: The goal of this research was to produce fast dissolving film embedded with nanoparticles of mirtazapine hydrochloride. Method: Semisynthetic polymer (HPMC) is used to prepare orodispersible films which is prepared by solvent casting method and nanoparticles were formed by ion gelation method from chitosan and STPP. Fourier transform infrared spectroscopy and scanning electron microscopy demonstrated that all ODF constituents were compatible with one another. Different physico-chemical, mechanical characteristics, morphological examination and in vitro drug release investigations evaluation were used to assess and evaluate ODFs. Results: All formulations have disintegration times of less than 70 seconds. Mirtazapine hydrochloride content consistency in all ODFs ranged from 95.7% to 99.1%. These values revealed that the ODFs were strong and flexible enough. Tensile strength of oral films measured as 10.82±1.8 to 28.31±1.5, and percent elongation was 3.23±0.63 to 10.04±0.27. The ODFs had a smooth surface with uniform distribution of nanoparticles and all constituents, according to scanning electron microscopy. Mirtazapine hydrochloride were released from ODFs 20 to 25 minutes, according to in vitro drug release experiments. After stability tests, no significant differences in physicochemical and mechanical parameters were found in any of the formulations. Conclusion: The formulation of nanoparticles of mirtazapine hydrochloride were successfully developed and embedded on fast dissolving film, which was prepared, in vitro release of film was observed for specific time.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91016209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Comparison of health care delivery system between Pakistan and Singapore 巴基斯坦与新加坡医疗服务体系比较

Journal of Contemporary Pharmacy Practice Pub Date : 2022-01-31 DOI: 10.56770/jcp2021523

Rashida Jabeen, Lal Bux, Sadia Rashid, Rukhsana Kousar

{"title":"Comparison of health care delivery system between Pakistan and Singapore","authors":"Rashida Jabeen, Lal Bux, Sadia Rashid, Rukhsana Kousar","doi":"10.56770/jcp2021523","DOIUrl":"https://doi.org/10.56770/jcp2021523","url":null,"abstract":"Background: Health assumes a noteworthy job in people's life and in reestablishing this, human services arrangement of a country contributes its significant part. As indicated by World Wellbeing Association wellbeing framework is characterized as \"every one of the exercises whose basic role is to advance, reestablish or potentially look after wellbeing\". This paper essentially depicts the medicinal services conveyance arrangement of Pakistan and Singapore, investigation of both the human services frameworks and examines a portion of the suggestions so as to improve social insurance segment of Pakistan. In this paper, examination of medicinal services framework among Pakistan and Singapore is chosen since Global benchmarking loans further trustworthiness to Singapore's fine record. The Financial Specialist Insight Unit (2014) positions its wellbeing framework the subsequent best (after Japan) out of 166 on the planet. Additionally, the Bloomberg Social Insurance Effectiveness File 2017 positions it second best among 55 nations. Objective: Comparison of health care delivery system between Pakistan and Singapore. Methods: Literature review used for study. Through this examination and investigation, we can Improve Human services conveyance arrangement of Pakistan by utilizing apparatuses and methods utilized in Singapore. Study is about Correlation of medicinal services conveyance framework, various difficulties, shortcomings in wellbeing arrangements and suggestions to improve social insurance arrangement of Pakistan. Conclusion: Medicinal services segment is significant for any nation which legitimately influences the economy of nation. On the off chance that there would be solid labor there would be increment in the efficiency and therefore the economy of the nation will likewise observe an expansion that prompts human welfare.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88627060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tuberculosis in geriatric patients 老年患者的结核病

Journal of Contemporary Pharmacy Practice Pub Date : 2022-01-31 DOI: 10.56770/jcp2021524

Hafiza Maryam Mukhtar, Misbah Shaheen, A. Ashraf, Attofa Afzel, Mehr-un-Nisa, H. S. Yaseen

引用次数: 0

Corona virus disease – a short review 冠状病毒病——简要回顾

Journal of Contemporary Pharmacy Practice Pub Date : 2022-01-31 DOI: 10.56770/jcp2021525

Maryam Ghaffar, Ume Habiba, Muhammad Akram Choohan

引用次数: 2

Gastroretentive floating microspheres for the management hypertension based on drug combination of amlodipine /losartan 氨氯地平/氯沙坦联合应用胃保留漂浮微球治疗高血压

Journal of Contemporary Pharmacy Practice Pub Date : 2022-01-31 DOI: 10.56770/jcp2021521

Rubab Ali, Muhammad Naeem Aamir, Nayab Khalid, Muhammad Bilal

{"title":"Gastroretentive floating microspheres for the management hypertension based on drug combination of amlodipine /losartan","authors":"Rubab Ali, Muhammad Naeem Aamir, Nayab Khalid, Muhammad Bilal","doi":"10.56770/jcp2021521","DOIUrl":"https://doi.org/10.56770/jcp2021521","url":null,"abstract":"Background: Hypertension is one of the serious global health issues that affect millions of people and leads to cardiovascular damage if remain untreated. Various antihypertensive drugs have been developed but it is difficult to achieve better control of blood pressure by using mono-therapy so in this research work, combination therapy having sustained effect for the treatment of hypertension was developed. Method: Gastroretentive floating microspheres of amlodipine besylate and losartan potassium were formulated for the purpose of increasing the time of retention of drugs in the upper gastrointestinal tract and ultimately extend drug release. Eudragit RS100 was used as release controlling agent. The method adopted to prepare microspheres was solvent extraction. Formulated microspheres after that tested for assessing flow properties, buoyancy (%), percentage yield, drug release, surface morphology, by FTIR drug and polymer compatibility, size analysis and entrapment efficiency. Release kinetics on cumulative release data were applied. Results: It was observed from the findings that all the formulation remained buoyant in 1.2 pH buffer up to 12 hrs. It was also found that release of drug from formulation was prolonged which indicates sustained effect of dosage form. All the other results were satisfactory and it was also found that entrapment efficiency of formulation increased when concentration of polymer increased. On the basis of results, formulation 1 with 1:1 drug polymer ratio was selected as optimum formulation. Conclusion: It was concluded from the study that gastroretentive floating microspheres could be a one of best approach to extend the release of drug delivery system.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84117242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Preparation and characterization of magnetic nanoparticles loaded with antimicrobial agent 负载抗菌剂的磁性纳米颗粒的制备与表征

Journal of Contemporary Pharmacy Practice Pub Date : 2022-01-31 DOI: 10.56770/jcp2021522

Kanza Amjad, Muhammad Naeem Aamir, Muhammad Akram Choohan, Ume Habiba, Saif Ur Rehman

{"title":"Preparation and characterization of magnetic nanoparticles loaded with antimicrobial agent","authors":"Kanza Amjad, Muhammad Naeem Aamir, Muhammad Akram Choohan, Ume Habiba, Saif Ur Rehman","doi":"10.56770/jcp2021522","DOIUrl":"https://doi.org/10.56770/jcp2021522","url":null,"abstract":"Background: Bacterial infections are an important cause of serious health issues worldwide. Various antibacterial drugs have been developed but they have numerous side effects. Development of drug loaded magnetic nanoparticles will help to achieve targeted drug delivery while sustaining the release of drug. It will also enhance its antibacterial activity by using iron oxide. Method: Drug loaded iron oxide nanoparticles were developed to sustain and enhance the antibacterial activity of drug. Chitosan was used as a polymer. The method adopted to prepare magnetic nanoparticles was co-precipitation. Formulated magnetic nanoparticles were tested for drug release, surface morphology, antibacterial activity and FTIR. Results: It was observed from the findings that both formulations were effectively loaded with drugs. It was also found that the release of drug levofloxacin was sustained over a period of 48 hrs. The SEM results showed the semi spherical nanoparticles effectively loaded with drug. FTIR spectrum revealed characteristic peaks related to functional groups. Raman spectroscopy showed characteristic bands of both drugs and drug loaded iron oxide nanoparticles. Antibacterial assay results showed an enhanced antibacterial activity by using iron oxide nanoparticles Conclusion: It was concluded from the study that magnetic nanoparticles could be one of the best approaches to load antibacterial drugs while sustaining and enhancing their antibacterial activity","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"205 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78511372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gaps in Patient Education on Safe Handling and Disposal of Oral Chemotherapy Drugs: A Pilot Prospective Cohort Survey Study. 关于口服化疗药物安全处理和处置的患者教育差距：一项前瞻性队列调查研究。

Journal of Contemporary Pharmacy Practice Pub Date : 2022-01-01

Sun Yang, Priya Patel, Alexandra Corcoran, Eric Dobberpuhl, Samantha Isidro, Dustin Le, Analise Klassen, Jay Rho, David Tran, Richard Beuttler, Neda Noori Nassr, Katherine Gruenberg, Siu-Fun Wong

{"title":"Gaps in Patient Education on Safe Handling and Disposal of Oral Chemotherapy Drugs: A Pilot Prospective Cohort Survey Study.","authors":"Sun Yang, Priya Patel, Alexandra Corcoran, Eric Dobberpuhl, Samantha Isidro, Dustin Le, Analise Klassen, Jay Rho, David Tran, Richard Beuttler, Neda Noori Nassr, Katherine Gruenberg, Siu-Fun Wong","doi":"","DOIUrl":"","url":null,"abstract":"Background: Oral anticancer chemotherapy (OC) has been misperceived as being safer than intravenous chemotherapy, leading to its increased risk of improper handling and disposal. This survey study assessed the knowledge, practices and attitudes of pharmacists and patients regarding OC handling and disposal, gaps in knowledge and barriers to patient education.Methods: Surveys were developed based on literature review and pilot study validation results. Patients completed a 33-item paper or electronic survey whereas pharmacists completed a 38-item electronic survey. Descriptive statistics and Fisher's exact test computed using the R Project were used for analyses.Results: Pharmacist group (16/25, 62.5%) and patient group (14/29, 48.3%) believed that the oral route is safer than IV. Average overall correct response rates for pharmacist and patient groups were 78.3% and 61.9%, respectively. Significant gaps in knowledge between groups were observed in three sections (p < 0.05). Common barriers to providing patient education were insufficient training (70.8%) and insufficient time (50%).Conclusion: Pharmacist and patient knowledge, awareness and practices of OC safe handling and disposal are suboptimal. Areas of knowledge gaps and barriers to patient education were identified. Enhanced supports are needed to empower pharmacists to assume an active role in patient education on safe handling and disposal of OC.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"70 2","pages":"23-33"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629833/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71482129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a Continuing Pharmacy Education Program on Pharmacologic Interventions for Healthy Pregnancies 健康妊娠药物干预继续药学教育项目的评估

Journal of Contemporary Pharmacy Practice Pub Date : 2021-10-31 DOI: 10.37901/jcphp21-00003

K. Cheung, Agnes Suh, Cydnee Ng, S. Rafie

引用次数: 0

CPESN California Update CPESN加州更新

Journal of Contemporary Pharmacy Practice Pub Date : 2021-10-31 DOI: 10.37901/jcphp21-00ee3

Bruno Tching, Pam Yoshikawa, S. Frausto

引用次数: 0

Direct Pharmacist Prescribing of Emergency Contraception: Findings of an Academic Detailing Intervention Pilot Study 直接药剂师处方紧急避孕药:一项学术详细干预试点研究的结果

Journal of Contemporary Pharmacy Practice Pub Date : 2021-10-31 DOI: 10.37901/jcphp20-00019

M. Nguyen, Niamh O'Grady, S. Rafie, S. Mody, Marisa Hildebrand

{"title":"Direct Pharmacist Prescribing of Emergency Contraception: Findings of an Academic Detailing Intervention Pilot Study","authors":"M. Nguyen, Niamh O'Grady, S. Rafie, S. Mody, Marisa Hildebrand","doi":"10.37901/jcphp20-00019","DOIUrl":"https://doi.org/10.37901/jcphp20-00019","url":null,"abstract":"Purpose This exploratory study tested the effectiveness of an academic detailing (AD) intervention for improving pharmacist emergency contraception (EC) practices compared to a handout intervention in a state where pharmacists can prescribe EC using a statewide protocol. AD is a peer educational outreach designed to encourage evidence-based practices that improve patient outcomes and healthcare costs. Methods In this pilot randomized controlled trial, four community pharmacies in San Diego County, California, received an AD intervention or a control handout intervention regarding pharmacist prescribing of EC. The AD intervention group received a one-hour training from an expert pharmacist regarding EC prescribing and an informational EC handout, while the handout intervention group received only the handout. Participants completed a survey assessing EC practices, knowledge, and attitudes before and after the interventions. Phone interviews were performed one month following the interventions. Participants in the AD intervention group demonstrated greater knowledge of clinical considerations for prescribing ulipristal acetate (UPA) EC and California statewide protocols for pharmacist prescribing of EC compared to the handout intervention. Participants in the AD intervention were also more likely to have begun prescribing EC following the intervention compared to those in the handout intervention, which was observed in both quantitative and qualitative results. Increased prescribing rates in the AD intervention group highlight the utility of AD for implementation of pharmacist services. Training that focuses on the clinical considerations for the EC products and statewide protocol for pharmacists’ prescribing of EC could lead to increased community access to EC in pharmacies and more accurate counseling by pharmacists.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46748011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0