Journal of Contemporary Pharmacy Practice最新文献

Formulation and evaluation of mucoadhesive fluconazole vaginal tablets 黏附型氟康唑阴道片的研制及评价

Journal of Contemporary Pharmacy Practice Pub Date : 2023-06-30 DOI: 10.56770/jcp2023712

A. Raza, Taiba Waheed, Usama Ikhlaq, Rimsha Farooq, Qasim Raza, Z. Javed, T. Hussain

{"title":"Formulation and evaluation of mucoadhesive fluconazole vaginal tablets","authors":"A. Raza, Taiba Waheed, Usama Ikhlaq, Rimsha Farooq, Qasim Raza, Z. Javed, T. Hussain","doi":"10.56770/jcp2023712","DOIUrl":"https://doi.org/10.56770/jcp2023712","url":null,"abstract":"Objective: Fluconazole is a triazole antifungal agent, and is used to treat fungal infections but because of frequent dosing and undesirable side effects it affects patient compliance. There came the need for a delivery system that can skip first pass metabolism and adhere long enough to treat the infection effectively, that was the aim for this study. Mucoadhesive drug delivery system adheres to mucous membrane and provide prolonged and sustained drug release. Method: Five formulations were formed by granulation method. The granules were then compressed and tablets were formed each of 250mg. Different evaluation parameters were determined like hardness, friability, weight variation, content uniformity, mucoadhesive strength, swelling index, dissolution and compatibility analysis. Results: The hardness (7.2-8.9kg), friability (0.02-0.05%), weight variation (0.1-0.4%), content uniformity (96.9-103%), were all in the pharmacopeial range. Dissolution was determined using rotating paddle apparatus with a phosphate buffer of 6.8 pH. Release kinetics showed that F1, F2, F3 showed Fickian release while F4 showed both Fickian and non Fickian release and F5 showed non Fickian release. Mucoadhesive strength was found to be the highest (46g) in formulation F5. The highest swelling index (70.34%) was shown by formulation F3 at 12h. Differential scanning calorimeter and Fourier transform infrared spectroscopy showed that there is no interaction between excipients. Conclusion: Hence, results showed that fluconazole vaginal tablets can be formed by using these ingredients and formulation F5 was the most optimum formulation.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"120 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90417401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between virulence and antimicrobial resistance to antimicrobial drugs in Klebsiella Pneumoniae 肺炎克雷伯菌毒力与抗菌药物耐药性的相关性研究

Journal of Contemporary Pharmacy Practice Pub Date : 2023-06-30 DOI: 10.56770/jcp.2023715

Nusrat Bibi, Sabahat ., Zahra Kalim, Muhammad Owais, Hafiz Ali Raza, Shaheen Kausar

引用次数: 0

A review on orodispersible drug delivery system 非分散给药系统的研究进展

Journal of Contemporary Pharmacy Practice Pub Date : 2023-06-30 DOI: 10.56770/jcp.2023714

Sonia Iqbal, Hanasul Hanan, Afshan Maqbool, Nasra Munawar

{"title":"A review on orodispersible drug delivery system","authors":"Sonia Iqbal, Hanasul Hanan, Afshan Maqbool, Nasra Munawar","doi":"10.56770/jcp.2023714","DOIUrl":"https://doi.org/10.56770/jcp.2023714","url":null,"abstract":"The future of drug delivery holds great promise for orally dispersible dose formulations, which make application simple since no water requirement as compared to conventional solid dosage forms which requires significant volumes of fluids for administration. The objective for development of ODF provides a substitute for pills, syrups, and tablets in treating vomiting as well as nausea, particularly in children. On the basis of transdermal patch delivery system, a novel oral films drug delivery has been introduced. Fast dissolving films disintegrates quickly when come in contact with salivary secretion in the oral mucosa and released the drug fast approximately within 3 mins. ODFs are of different types, like sustained or controlled release, oral patches and fast dissolving films. They can be manufactured using a variety of method including solvent and semi solid casting, hot melt and solid dispersion extrusion, spray drying and rolling. Among them solvent casting method is the most employed method. ODFs comprises of active ingredient, polymer, plasticizer and additives like surfactants, sweetening and coloring agents. ODFs preparation requires hydrophilic polymer which provides quick dissolution in the oral cavity. Hydrophilic polymer act as base for ODFs formulation as they impart mouth feel and mechanical properties of the ODFs also dependent of polymer type. Oral thin-film provide fast drug dissolution precise dosage in a portable, safe, and handy manner that doesn't required water or any special equipment. This review article comprises of different methods for ODFs preparations, ODFs ingredients, ODFs benefits and drawbacks and their packaging.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"150 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136186175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and evaluation of mucoadhesive fluconazole vaginal tablets 黏附型氟康唑阴道片的研制及评价

Journal of Contemporary Pharmacy Practice Pub Date : 2023-06-30 DOI: 10.56770/jcp.2023712

Ahsan Raza, Taiba Waheed, Usama Ikhlaq, Rimsha Farooq, Qasim Raza, Zeeshan Javed, Talib Hussain

{"title":"Formulation and evaluation of mucoadhesive fluconazole vaginal tablets","authors":"Ahsan Raza, Taiba Waheed, Usama Ikhlaq, Rimsha Farooq, Qasim Raza, Zeeshan Javed, Talib Hussain","doi":"10.56770/jcp.2023712","DOIUrl":"https://doi.org/10.56770/jcp.2023712","url":null,"abstract":"Objective: Fluconazole is a triazole antifungal agent, and is used to treat fungal infections but because of frequent dosing and undesirable side effects it affects patient compliance. There came the need for a delivery system that can skip first pass metabolism and adhere long enough to treat the infection effectively, that was the aim for this study. Mucoadhesive drug delivery system adheres to mucous membrane and provide prolonged and sustained drug release. Method: Five formulations were formed by granulation method. The granules were then compressed and tablets were formed each of 250mg. Different evaluation parameters were determined like hardness, friability, weight variation, content uniformity, mucoadhesive strength, swelling index, dissolution and compatibility analysis. Results: The hardness (7.2-8.9kg), friability (0.02-0.05%), weight variation (0.1-0.4%), content uniformity (96.9-103%), were all in the pharmacopeial range. Dissolution was determined using rotating paddle apparatus with a phosphate buffer of 6.8 pH. Release kinetics showed that F1, F2, F3 showed Fickian release while F4 showed both Fickian and non Fickian release and F5 showed non Fickian release. Mucoadhesive strength was found to be the highest (46g) in formulation F5. The highest swelling index (70.34%) was shown by formulation F3 at 12h. Differential scanning calorimeter and Fourier transform infrared spectroscopy showed that there is no interaction between excipients. Conclusion: Hence, results showed that fluconazole vaginal tablets can be formed by using these ingredients and formulation F5 was the most optimum formulation.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136186178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review on orodispersible drug delivery system 非分散给药系统的研究进展

Journal of Contemporary Pharmacy Practice Pub Date : 2023-06-30 DOI: 10.56770/jcp2023714

Sonia Iqbal, H. Hanan, Afshan Maqbool, Nasra Munawar

{"title":"A review on orodispersible drug delivery system","authors":"Sonia Iqbal, H. Hanan, Afshan Maqbool, Nasra Munawar","doi":"10.56770/jcp2023714","DOIUrl":"https://doi.org/10.56770/jcp2023714","url":null,"abstract":"The future of drug delivery holds great promise for orally dispersible dose formulations, which make application simple since no water requirement as compared to conventional solid dosage forms which requires significant volumes of fluids for administration. The objective for development of ODF provides a substitute for pills, syrups, and tablets in treating vomiting as well as nausea, particularly in children. On the basis of transdermal patch delivery system, a novel oral films drug delivery has been introduced. Fast dissolving films disintegrates quickly when come in contact with salivary secretion in the oral mucosa and released the drug fast approximately within 3 mins. ODFs are of different types, like sustained or controlled release, oral patches and fast dissolving films. They can be manufactured using a variety of method including solvent and semi solid casting, hot melt and solid dispersion extrusion, spray drying and rolling. Among them solvent casting method is the most employed method. ODFs comprises of active ingredient, polymer, plasticizer and additives like surfactants, sweetening and coloring agents. ODFs preparation requires hydrophilic polymer which provides quick dissolution in the oral cavity. Hydrophilic polymer act as base for ODFs formulation as they impart mouth feel and mechanical properties of the ODFs also dependent of polymer type. Oral thin-film provide fast drug dissolution precise dosage in a portable, safe, and handy manner that doesn't required water or any special equipment. This review article comprises of different methods for ODFs preparations, ODFs ingredients, ODFs benefits and drawbacks and their packaging.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91081619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and stability analysis of metformin HCl microcapsules formulated by complex coacervation technique 复凝聚法制备盐酸二甲双胍微胶囊的表征及稳定性分析

Journal of Contemporary Pharmacy Practice Pub Date : 2023-06-30 DOI: 10.56770/jcp.2023711

Faizan Asad, Faiza Fiaz, Amna Sheraz, Ayesha Nabi Ahmed, Irfan Javaid, T. Hussain

{"title":"Characterization and stability analysis of metformin HCl microcapsules formulated by complex coacervation technique","authors":"Faizan Asad, Faiza Fiaz, Amna Sheraz, Ayesha Nabi Ahmed, Irfan Javaid, T. Hussain","doi":"10.56770/jcp.2023711","DOIUrl":"https://doi.org/10.56770/jcp.2023711","url":null,"abstract":"Objective: Metformin hydrochloride possesses a shorter sort of biological half-life of 1.5–1.6 h with having the absolute type of bioavailability that ranges between 50-60%, the moment it is administered orally. Reduced GIT disturbances and low bioavailability can be optimized by developing microencapsulation of metformin that could prove beneficial. Method: Paraffin oil had been used in obtaining specific types of primary emulsions, whereas the material that was used in the coating of microencapsulation had been identified as sodium alginate. In the process of complex coacervation, a substance known as Tween 20 was used as a surfactant in enhancing the stability of W/O/W double emulsion. Five different formulations with different concentrations of sodium alginate were tested. Result: Metformin's microencapsulation inside certain types of optimized atmosphere tends to ensure the specific size of 1 am of microcapsules in a combined form, and encapsulation efficiency reaches up to 84%. FTIR measurements have been used to determine the interaction between drug and polymer. The qualitative analysis result from FTIR ensures that the quality and effectiveness of the drug have been preserved. A calibration curve was used to estimate drug conc. from dissolution samples and kinetic analysis demonstrated anomalous release pattern. The test for drug content yielded ˃95% of concentration. Conclusion: Results extracted tend to tell us that specific complex coacervation that is using sodium alginate in wall material was a viable method that is used in the microencapsulation process of metformin hydrochloride.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84593567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and evaluation of topical piroxicam microemulgel for arthritis 局部吡罗昔康微凝胶治疗关节炎的配方及评价

Journal of Contemporary Pharmacy Practice Pub Date : 2023-06-30 DOI: 10.56770/jcp.2023713

Mehreen Sattar, Somia Sarfraz, Uzma Liaquat, Iqra Shoukat, B. Ahmad, T. Hussain

{"title":"Formulation and evaluation of topical piroxicam microemulgel for arthritis","authors":"Mehreen Sattar, Somia Sarfraz, Uzma Liaquat, Iqra Shoukat, B. Ahmad, T. Hussain","doi":"10.56770/jcp.2023713","DOIUrl":"https://doi.org/10.56770/jcp.2023713","url":null,"abstract":"Background: Piroxicam is an anti-inflammatory, analgesic, and antipyretic drug. Piroxicam is widely used in the management of chronic pain. The objective of this work was to develop and analyze topical Piroxicam microemulgel to improve drug solubility, enhance permeation, reduce GIT side effects reduce the frequency of the drug. Method: The Piroxicam microemulgel was prepared by drawing the pseudo ternary phase picture and water titration procedure. Formulation was prepared by using isopropyl myristate as an oil, Tween 80 as an surfactant, n-butanol as Co-surfactant and water. It was converted to gel by using 1% Carbopol 940 and few drops of ethanolamine. The prepared formulation was characterized for thermodynamic stability, pH, droplet size, viscosity, FTIR,DSC, electrical conductivity, dye solubility drug content, and in-vitro release using a Franz diffusion cell. Result: Microemulgel formulation was thermodynamically stable on visual inspection after being treated with a freeze-thaw cycle and centrifugation. pH of formulation was 6.5. The mean droplet size for ME gel was 100±0.472nm. The viscosity of the microemulgel was 90.4±0.01 cps which showed Newtonian flow. FTIR and DSC studies showed that microemulgel was compatible with its excipients. Electrical conductivity and dye solubility testing confirmed that the microemulgel was O/W. Piroxicam microemulsion gel showed 89.89% drug content and the release rate of piroxicam was 98±8.63% after 48h. It followed the Korsmeyer Pappas model which means it was a hydrogel-based system. Conclusion: Microemulsion gel formulation obtained remarkably inflated skin retention for piroxicam over the piroxicam gel. It might act as a promising vehicle for the topical delivery of poor water-soluble drugs.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"75 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79616783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and evaluation of topical piroxicam microemulgel for arthritis 局部吡罗昔康微凝胶治疗关节炎的配方及评价

Journal of Contemporary Pharmacy Practice Pub Date : 2023-06-30 DOI: 10.56770/jcp2023713

Mehreen Sattar, Somia Sarfraz, Uzma Liaquat, Iqra Shoukat, Bilal Ahmad, Talib Hussain

{"title":"Formulation and evaluation of topical piroxicam microemulgel for arthritis","authors":"Mehreen Sattar, Somia Sarfraz, Uzma Liaquat, Iqra Shoukat, Bilal Ahmad, Talib Hussain","doi":"10.56770/jcp2023713","DOIUrl":"https://doi.org/10.56770/jcp2023713","url":null,"abstract":"Background: Piroxicam is an anti-inflammatory, analgesic, and antipyretic drug. Piroxicam is widely used in the management of chronic pain. The objective of this work was to develop and analyze topical Piroxicam microemulgel to improve drug solubility, enhance permeation, reduce GIT side effects reduce the frequency of the drug. Method: The Piroxicam microemulgel was prepared by drawing the pseudo ternary phase picture and water titration procedure. Formulation was prepared by using isopropyl myristate as an oil, Tween 80 as an surfactant, n-butanol as Co-surfactant and water. It was converted to gel by using 1% Carbopol 940 and few drops of ethanolamine. The prepared formulation was characterized for thermodynamic stability, pH, droplet size, viscosity, FTIR,DSC, electrical conductivity, dye solubility drug content, and in-vitro release using a Franz diffusion cell. Result: Microemulgel formulation was thermodynamically stable on visual inspection after being treated with a freeze-thaw cycle and centrifugation. pH of formulation was 6.5. The mean droplet size for ME gel was 100±0.472nm. The viscosity of the microemulgel was 90.4±0.01 cps which showed Newtonian flow. FTIR and DSC studies showed that microemulgel was compatible with its excipients. Electrical conductivity and dye solubility testing confirmed that the microemulgel was O/W. Piroxicam microemulsion gel showed 89.89% drug content and the release rate of piroxicam was 98±8.63% after 48h. It followed the Korsmeyer Pappas model which means it was a hydrogel-based system. Conclusion: Microemulsion gel formulation obtained remarkably inflated skin retention for piroxicam over the piroxicam gel. It might act as a promising vehicle for the topical delivery of poor water-soluble drugs.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88730988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization and stability analysis of metformin HCl microcapsules formulated by complex coacervation technique 复凝聚法制备盐酸二甲双胍微胶囊的表征及稳定性分析

Journal of Contemporary Pharmacy Practice Pub Date : 2023-06-30 DOI: 10.56770/jcp2023711

Faizan Asad, Faiza Fiaz, Amna Sheraz, Ayesha Nabi Ahmed, Irfan Javaid, Talib Hussain

{"title":"Characterization and stability analysis of metformin HCl microcapsules formulated by complex coacervation technique","authors":"Faizan Asad, Faiza Fiaz, Amna Sheraz, Ayesha Nabi Ahmed, Irfan Javaid, Talib Hussain","doi":"10.56770/jcp2023711","DOIUrl":"https://doi.org/10.56770/jcp2023711","url":null,"abstract":"Objective: Metformin hydrochloride possesses a shorter sort of biological half-life of 1.5–1.6 h with having the absolute type of bioavailability that ranges between 50-60%, the moment it is administered orally. Reduced GIT disturbances and low bioavailability can be optimized by developing microencapsulation of metformin that could prove beneficial. Method: Paraffin oil had been used in obtaining specific types of primary emulsions, whereas the material that was used in the coating of microencapsulation had been identified as sodium alginate. In the process of complex coacervation, a substance known as Tween 20 was used as a surfactant in enhancing the stability of W/O/W double emulsion. Five different formulations with different concentrations of sodium alginate were tested. Result: Metformin's microencapsulation inside certain types of optimized atmosphere tends to ensure the specific size of 1 μm of microcapsules in a combined form, and encapsulation efficiency reaches up to 84%. FTIR measurements have been used to determine the interaction between drug and polymer. The qualitative analysis result from FTIR ensures that the quality and effectiveness of the drug have been preserved. A calibration curve was used to estimate drug conc. from dissolution samples and kinetic analysis demonstrated anomalous release pattern. The test for drug content yielded ˃95% of concentration. Conclusion: Results extracted tend to tell us that specific complex coacervation that is using sodium alginate in wall material was a viable method that is used in the microencapsulation process of metformin hydrochloride.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"90 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81740813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between virulence and antimicrobial resistance to antimicrobial drugs in Klebsiella Pneumoniae 肺炎克雷伯菌毒力与抗菌药物耐药性的相关性研究

Journal of Contemporary Pharmacy Practice Pub Date : 2023-06-30 DOI: 10.56770/jcp2023715

N. Bibi, Sabahat ., Zahra Kalim, M. Owais, H. A. Raza, S. Kausar

引用次数: 0