Journal of Contemporary Pharmacy Practice最新文献_第10页

Direct Oral Anticoagulant (DOAC) to Warfarin Transitions in a Pharmacist-led Anticoagulation Clinic 药剂师领导的抗凝诊所中直接口服抗凝剂（DOAC）到华法林的转变

Journal of Contemporary Pharmacy Practice Pub Date : 2019-03-01 DOI: 10.37901/jcphp17-00024

A. Woodhouse, M. Burke, A. Misher

{"title":"Direct Oral Anticoagulant (DOAC) to Warfarin Transitions in a Pharmacist-led Anticoagulation Clinic","authors":"A. Woodhouse, M. Burke, A. Misher","doi":"10.37901/jcphp17-00024","DOIUrl":"https://doi.org/10.37901/jcphp17-00024","url":null,"abstract":"Purpose\u0000Patients with non-valvular atrial fibrillation or venous thromboembolism have historically been treated with vitamin-k antagonist therapy; however, due to well-documented limitations, direct oral anticoagulant (DOAC) use has been increasing.(1)(2) The convenience and clinical utility of DOACs is not applicable to all patients, and some must be transitioned to warfarin therapy. Despite practice recommendations, suggestions from package inserts, and clinical trial evidence, there remains a lack of literature describing real-word examples of patient transition from DOACs to warfarin.(3–11)\u0000\u0000Summary\u0000All patients who were transitioned from a DOAC to warfarin from January to December 2016 and were managed by the clinic were included. Patients were excluded if the transition to warfarin did not include ≥ 2 days of DOAC overlap or if DOAC therapy was used as a bridge to surgery or procedure. St. Joseph's/Candler Health System IRB granted expedited approval and waived informed consent. Four elderly, Caucasian patients met the inclusion criteria. Four patients were successfully transitioned from a DOAC to warfarin for their atrial fibrillation, 3 were transitioned from apixaban and 1 was transitioned from rivaroxaban.\u0000\u0000Conclusion\u0000Overall the purpose of this retrospective, observational study was to highlight real-world management of the transition of DOACs to warfarin in an outpatient, pharmacist-led clinic.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45971576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Administration Time and Adherence Rates of Morning vs. Bedtime Dosing of Antihypertensive Medications 抗高血压药物早晨与睡前给药时间和依从率的评价

Journal of Contemporary Pharmacy Practice Pub Date : 2019-03-01 DOI: 10.37901/jcphp18-00010

Laura Perry, Suzanne M Surowiec, Danielle Danso, Omuwa Kerobo, Ashley Anugwom, Kihara Couvertier

{"title":"Evaluation of Administration Time and Adherence Rates of Morning vs. Bedtime Dosing of Antihypertensive Medications","authors":"Laura Perry, Suzanne M Surowiec, Danielle Danso, Omuwa Kerobo, Ashley Anugwom, Kihara Couvertier","doi":"10.37901/jcphp18-00010","DOIUrl":"https://doi.org/10.37901/jcphp18-00010","url":null,"abstract":"Purpose\u0000The primary objective of this study was to evaluate the time of day patients administer antihypertensive medications. Secondary objectives were to evaluate medication adherence rates between morning and bedtime dosing and possible barriers to bedtime administration.\u0000\u0000Methods\u0000A single-center, cross-sectional study using a mixed-methods model containing a retrospective chart review and telephone survey was administered to hypertensive patients at a multidisciplinary, private practice clinic. Patients above the age of 18 with a diagnosis of hypertension were eligible for inclusion. The primary endpoint was the number of patients administering one or more antihypertensive medications at bedtime. Secondary endpoints were medication adherence and potential barriers of adherence to bedtime dosing.\u0000\u0000Results\u0000A total of 139 responses were collected. Most patients (75.5%) administered all antihypertensive medications in the morning, with only 24.5% of patients administering at least one antihypertensive medication at bedtime. Adherence was higher for medications administered in the morning compared to medications administered at bedtime, 87.8% and 79.4%, respectively. Limitations to this study include the single-center design and potential for patient recall and reporting bias when using self-reported data.\u0000\u0000Conclusion\u0000Results of this study suggest that the prevalence of bedtime administration of antihypertensive medications is low. Although self-reported adherence rates were higher with morning dosing compared to bedtime dosing, adherence rates for bedtime dosing were still promising. Future studies should be conducted to expand on existing morbidity and mortality evidence as well as prevalence of and adherence to bedtime dosing of antihypertensive medications.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45532484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Efficacy and Tolerability of non-daily Statin Administration: A Systematic Review of Literature 他汀类药物非日常给药的疗效和耐受性：文献系统综述

Journal of Contemporary Pharmacy Practice Pub Date : 2019-03-01 DOI: 10.37901/jcphp18-00003

Cindy Park, Q. Le

{"title":"Efficacy and Tolerability of non-daily Statin Administration: A Systematic Review of Literature","authors":"Cindy Park, Q. Le","doi":"10.37901/jcphp18-00003","DOIUrl":"https://doi.org/10.37901/jcphp18-00003","url":null,"abstract":"Purpose Current issues regarding biosimilar drug use are reviewed in a two-part article from the perspective of pharmacy practice. Background Statins are known to be safe, but some patients discontinue the therapy due to adverse effects. Given the clinical benefits of statin therapy, it is important to find different strategies to maintain its use. The aims of this systematic review were to summarize and critically appraise evidence of the efficacy, tolerability, and economic evaluation of non-daily statin administration in the past ten years. Methods Literature was searched through Cochrane, Embase, PubMed and Web of Science using relevant search terms. Studies of any size and design published between January 2007 and August 2017 were considered for the assessment of efficacy and tolerability. For economic evaluation, the search was repeated without restriction to the publication year to identify more relevant articles. Results All eleven studies, of which three were randomized controlled trials, supported the use of intermittent statin regimens to lower low-density lipoprotein (LDL) levels in patients with dyslipidemia. Most of the studies reported high tolerability to intermittent statin therapy, ranging from 72.5% to 100%. Economic analysis of four articles showed that the intermittent regimen is cost-saving in terms of cost per 1% LDL reduction. Our systematic review of current evidence suggests that patients with dyslipidemia may reduce their LDL levels with intermittent statin administration. Non-daily administration has other benefits of improved tolerability and lower cost when compared to daily administration.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44940428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keeping It Real in the Era of Bots and Trolls 在机器人和巨魔的时代保持真实

Journal of Contemporary Pharmacy Practice Pub Date : 2019-03-01 DOI: 10.37901/jcphp19-000e1

Gary M Besinque

{"title":"Keeping It Real in the Era of Bots and Trolls","authors":"Gary M Besinque","doi":"10.37901/jcphp19-000e1","DOIUrl":"https://doi.org/10.37901/jcphp19-000e1","url":null,"abstract":"Today it is much harder to distinguish science from science fiction.(1) The advent of social media has created a universe of information made up of equal parts of opinion, facts and false information.(2) The evolutionary shifts in the media environment that have occurred in recent decades have enabled bad actors increasingly to circulate fake news, misinformation, and disinformation(3), with the help of trolls, bots, and respondentdriven algorithms.(4) Internet trolls and bots greatly amplify the message of alternative internet news outlets: Between 9% and 15% of Twitter accounts are estimated to be bots, and Facebook estimates that as many as 60 million bots are currently trolling its platform; in 2016, 20% of all tweets concerning the presidential election came from bots.(3)(5)(6) As a result of these changes over the last 30 years, communication in media and political environments has changed profoundly in ways that degrade effective communication.(4) Rather than process information dispassionately, partisan stakeholders resort to motivated reasoning with the goal of protecting their beliefs and values from external threat. As Iyengar and Massey(4) put it, “As a result, whenever scientific findings clash with a person or group’s political agenda, be it conservative (as with climate science and immigration) or liberal (as with genetically modified foods and vaccination risks), scientists can expect to encounter a targeted campaign of fake news, misinformation, and disinformation in response, no matter how clearly the information is presented or how carefully and convincingly it is framed.”","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44686333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the Impact of Antimicrobial Stewardship Program (ASP) on Unrestricted Use of Meropenem at an Academic Medical Center 学术医疗中心抗菌药物管理计划（ASP）对美罗培南无限制使用的影响评估

Journal of Contemporary Pharmacy Practice Pub Date : 2019-03-01 DOI: 10.37901/jcphp17-00030

Priyam Mithawala, Edo-abasi McGee

{"title":"Evaluation of the Impact of Antimicrobial Stewardship Program (ASP) on Unrestricted Use of Meropenem at an Academic Medical Center","authors":"Priyam Mithawala, Edo-abasi McGee","doi":"10.37901/jcphp17-00030","DOIUrl":"https://doi.org/10.37901/jcphp17-00030","url":null,"abstract":"Objective\u0000The primary objectives were to evaluate the prescriber acceptance rate of Antimicrobial Stewardship Program (ASP) pharmacist recommendation to de-escalate/discontinue meropenem, and estimate the difference in duration of meropenem therapy. The secondary objective was to determine incidence of adverse events in the two groups.\u0000\u0000Methods\u0000It was a retrospective study. All patients admitted to Gwinnett Medical Center and receiving meropenem from January–November 2015 were included in the study. Exclusion criteria were: patients admitted to intensive care unit, one-time dose, infectious disease consultation, and age <18 years. Electronic medical records were reviewed for data collection. The control group consisted of patients from January–July 2015 when there was no ASP pharmacist. The intervention group consisted of patients from August–November 2015 during which period the ASP pharmacist recommended de-escalation/discontinuation of meropenem based on culture and sensitivity results.\u0000\u0000Results\u0000A total of 41 patients were studied, 21 in the control group and 20 in the intervention group. There was no significant difference in baseline characteristics in the two groups and in terms of prior hospitalization or antibiotic use (within 90 days) and documented or suspected MDRO infection at the time of admission. De-escalation/discontinuation was suggested in 16/20 patients in the intervention group (80%), and intervention was accepted in 68%. The mean duration of therapy was significantly decreased in the intervention group (5.6 days vs. 8.1 days, p =0.0175). Two patients had thrombocytopenia (unrelated to meropenem), and none of the patients had seizure.\u0000\u0000Conclusion\u0000Targeted antibiotic review is an effective ASP strategy, which significantly decreases the duration of meropenem therapy.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42647798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative analysis of antibacterial and antioxidant properties of transdermal preparations containing castor oil 含蓖麻油透皮制剂抗菌和抗氧化性能的比较分析

Journal of Contemporary Pharmacy Practice Pub Date : 2019-01-31 DOI: 10.56770/jcp201806

K. Shazadi

{"title":"Comparative analysis of antibacterial and antioxidant properties of transdermal preparations containing castor oil","authors":"K. Shazadi","doi":"10.56770/jcp201806","DOIUrl":"https://doi.org/10.56770/jcp201806","url":null,"abstract":"Medicinal plants play vital role in preservation of healthy human life. In these medicinal plants Ricinus communis has great importance that belongs to the family Euphorbiaceae. It is found all over Pakistan. Castor Oil obtained from this plant is highly useful in Homeopathic, Ayurvedic, and Unani system of medicines as a fertilizer, fungicidal, antibacterial, cathartic and purgative. It also used as a labor pain inducer and as an ingredient in many cosmetics products for preventing wrinkles, fight acne, as a moisturizing ingredient, soothing the sunburn and reduce inflammation of skin. Method: Two types of transdermal patches were formulated, one containing combination of castor oil and acetone emulsion A while other formulation emulsion B was contain castor oil, acetone and antioxidants i.e. Vitamin C and E. Both formulations were evaluated by in vitro for antibacterial and antioxidant activities. Results: The outcomes indicated that transdermal patch containing emulsions A have TPC 136, TFC 59.8, reducing power assay 74%, DPPH 75% of inhibition. Transdermal patch containing emulsion B have TPC 150, TFC 77.23, reducing power assay 51%, DPPH 61.90% of inhibition in vitro antibacterial activity showed that castor oil + acetone emulsion containing patches showed 4 µg/ml MIC for E. coli and 2 µg/ml MIC for S. Aureus. For, vivo testing, these transdermal patches was applied on skin wounds of rabbits to study its wound healing activity. Conclusion: It was concluded that transdermal patch containing emulsions B have more efficacies in wound healing then patches A at the end of 20 days.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82696606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A survey on prescription trends for hypertension in Faisalabad 费萨拉巴德高血压处方趋势调查

Journal of Contemporary Pharmacy Practice Pub Date : 2019-01-31 DOI: 10.56770/jcp201808

Usman Sabir, Syed Ali Farhan, Ali Rashid, Junaid Ahmad, Saba Javed

{"title":"A survey on prescription trends for hypertension in Faisalabad","authors":"Usman Sabir, Syed Ali Farhan, Ali Rashid, Junaid Ahmad, Saba Javed","doi":"10.56770/jcp201808","DOIUrl":"https://doi.org/10.56770/jcp201808","url":null,"abstract":"High blood pressure or hypertension has been called the \"silent killer\", because it often has no warning signs or symptoms, and many people do not even know they have it. Over time, the constant pressure overload causes accumulating damage that eventually becomes more than your circulatory system can handle, often leading to serious health problems. Method: The present study is conducted to observe its prevalence in the city Faisalabad and its prescription trends by using retrospective method. The objective of this was to evaluate trends in prescription drug use among population living in the Faisalabad. Several hospitals in the area were visited for this article which includes DHQ, Allied Hospital, FIC and National hospitals. Results: The study explores which age group people, which gender is more prone towards this ailment. How lifestyle, diet and other factors affect blood pressure Moreover, it tells us how other diseases are interrelated with hypertension. It also provides information about the prescription trends of anti-hypertensive drugs. It elaborate that almost 47% male and 53% female are affected by this disease. Conclusion: Major cause of hypertension in female patients is angina and depression. Moreover, our data suggested that most of the outpatients with hypertension receive monotherapy and most frequently used class of drugs is the CCBs and ARBs. Studies showed that hypertension mostly coexist with heart diseases and other co-morbidities like diabetes. Any how the incidence of hypertension is dependent upon several factors like age, ethnicity, diet, and life style, environmental and physiological factors.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88838629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation and in vitro evaluation of mouth dissolving tablets of levosulpiride 左舒必利口腔溶解片的处方及体外评价

Journal of Contemporary Pharmacy Practice Pub Date : 2019-01-31 DOI: 10.56770/jcp201809

Irfan Sohail, Noman Ahmad, Muhammad Majid, Waqas Nasir, Shan Malik, Tuseef Tahir

引用次数: 0

Nanoemulsion for skin drug delivery 用于皮肤给药的纳米乳

Journal of Contemporary Pharmacy Practice Pub Date : 2019-01-31 DOI: 10.56770/jcp201810

Shams-ul-Hassan, Muhammad Imran khan, Mubashra Gul, Badarqa Tul Ayesha, Maria Gul

{"title":"Nanoemulsion for skin drug delivery","authors":"Shams-ul-Hassan, Muhammad Imran khan, Mubashra Gul, Badarqa Tul Ayesha, Maria Gul","doi":"10.56770/jcp201810","DOIUrl":"https://doi.org/10.56770/jcp201810","url":null,"abstract":"The use of nanoemulsion in augmenting dermal and transdermal effectiveness of drugs has now well established. The development of nanoemulsion based semisolid dosage forms is an active area of present research. However, thickening or liquid-to-semisolid conversion of the nanoemulsions provides opportunities to the formulation scientist to explore novel means of solving instability issues during transformation. Extending knowledge about the explicit role of nature/magnitude of zeta potential, types of emulsifiers and selection of appropriate semisolid bases could place these versatile carriers from laboratory to industrial scale. Nanoemulsions are termed as biphasic (O/W or W/O) or multiple nanoemulsions (W/O/W). Oil phase components include fatty acids (e.g., oleic acid), esters of fatty acids and alcohols (e.g., isopropyl myristate, isopropyl palmitate, ethyl oleate), medium chain triglycerides, triacetin, terpenes (e.g., limonene, menthol, cineole) and other penetration enhancers. Till date several approaches have been employed to develop nanoemulsions (size range 20–200 nm) which are High-energy emulsification and Low-energy emulsification. NanoemulsionS are found effective to treat psoriasis, dermatitis and cancer.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"332 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76587898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescription trend of antidiabetics among physicians and their selection according to lab investigations and physical parameters 医师抗糖尿病药物的处方趋势及根据实验室调查和身体参数的选择

Journal of Contemporary Pharmacy Practice Pub Date : 2019-01-31 DOI: 10.56770/jcp201807

Saba Rafique, Danish Shakoor, Ayesha Amjad, Syeda Zonish Ziadi, Ismat Younus, Maria Manan

{"title":"Prescription trend of antidiabetics among physicians and their selection according to lab investigations and physical parameters","authors":"Saba Rafique, Danish Shakoor, Ayesha Amjad, Syeda Zonish Ziadi, Ismat Younus, Maria Manan","doi":"10.56770/jcp201807","DOIUrl":"https://doi.org/10.56770/jcp201807","url":null,"abstract":"While writing this article we observed 300 prescriptions of patients suffering from a number of different diabetic complications. Patients were from different family backgrounds but most of them belonged to Middle-class. We go through from the prescriptions and also analyzed them from their laboratory values and physical parameters. In the laboratory Investigations, we basically gave importance to Cholesterol level, ALT, Hba1c and creatinine levels .We asked from patients either they are taking their recommended medicines regularly ,we also asked them about the effect of medicines they observed . Most of the people were taking their medicines regularly but some were skipping their doses. After completing our survey we analyzed our data from different perspectives. We determined the generics mostly prescribed and then rank them according to their percentage of usage. After that we analyzed the change in trend of prescriptions due to disturbance in any of the above mentioned lab values. We also observed the changing trend of prescriptions according to their Body Mass Index(BMI) . In the end we gave it a conclusion that some of the classes of anti-diabetics are being prescribed in specific conditions and the rest of them are rarely used.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76330023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0