Nanoemulsion for skin drug delivery

Shams-ul-Hassan, Muhammad Imran khan, Mubashra Gul, Badarqa Tul Ayesha, Maria Gul
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Abstract

The use of nanoemulsion in augmenting dermal and transdermal effectiveness of drugs has now well established. The development of nanoemulsion based semisolid dosage forms is an active area of present research. However, thickening or liquid-to-semisolid conversion of the nanoemulsions provides opportunities to the formulation scientist to explore novel means of solving instability issues during transformation. Extending knowledge about the explicit role of nature/magnitude of zeta potential, types of emulsifiers and selection of appropriate semisolid bases could place these versatile carriers from laboratory to industrial scale. Nanoemulsions are termed as biphasic (O/W or W/O) or multiple nanoemulsions (W/O/W). Oil phase components include fatty acids (e.g., oleic acid), esters of fatty acids and alcohols (e.g., isopropyl myristate, isopropyl palmitate, ethyl oleate), medium chain triglycerides, triacetin, terpenes (e.g., limonene, menthol, cineole) and other penetration enhancers. Till date several approaches have been employed to develop nanoemulsions (size range 20–200 nm) which are High-energy emulsification and Low-energy emulsification. NanoemulsionS are found effective to treat psoriasis, dermatitis and cancer.
用于皮肤给药的纳米乳
纳米乳在提高药物的真皮和透皮有效性方面的应用已经得到了很好的证实。基于纳米乳的半固体剂型的开发是目前研究的一个活跃领域。然而,纳米乳液的增稠或液体到半固体的转化为配方科学家提供了探索解决转化过程中不稳定性问题的新方法的机会。进一步了解zeta电位的性质/大小、乳化剂的类型和选择合适的半固体碱的明确作用,可以将这些多功能载体从实验室推向工业规模。纳米乳被称为双相(O/W或W/O)或多相纳米乳(W/O/W)。油相成分包括脂肪酸(如油酸)、脂肪酸和醇的酯(如肉豆蔻酸异丙酯、棕榈酸异丙酯、油酸乙酯)、中链甘油三酯、三乙酸酯、萜烯(如柠檬烯、薄荷醇、桉树脑)和其他渗透增强剂。目前制备纳米乳液的方法主要有高能乳化和低能乳化两种。纳米乳液被发现对治疗牛皮癣、皮炎和癌症有效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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