Evaluation of Administration Time and Adherence Rates of Morning vs. Bedtime Dosing of Antihypertensive Medications

Laura Perry, Suzanne M Surowiec, Danielle Danso, Omuwa Kerobo, Ashley Anugwom, Kihara Couvertier
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引用次数: 3

Abstract

Purpose The primary objective of this study was to evaluate the time of day patients administer antihypertensive medications. Secondary objectives were to evaluate medication adherence rates between morning and bedtime dosing and possible barriers to bedtime administration. Methods A single-center, cross-sectional study using a mixed-methods model containing a retrospective chart review and telephone survey was administered to hypertensive patients at a multidisciplinary, private practice clinic. Patients above the age of 18 with a diagnosis of hypertension were eligible for inclusion. The primary endpoint was the number of patients administering one or more antihypertensive medications at bedtime. Secondary endpoints were medication adherence and potential barriers of adherence to bedtime dosing. Results A total of 139 responses were collected. Most patients (75.5%) administered all antihypertensive medications in the morning, with only 24.5% of patients administering at least one antihypertensive medication at bedtime. Adherence was higher for medications administered in the morning compared to medications administered at bedtime, 87.8% and 79.4%, respectively. Limitations to this study include the single-center design and potential for patient recall and reporting bias when using self-reported data. Conclusion Results of this study suggest that the prevalence of bedtime administration of antihypertensive medications is low. Although self-reported adherence rates were higher with morning dosing compared to bedtime dosing, adherence rates for bedtime dosing were still promising. Future studies should be conducted to expand on existing morbidity and mortality evidence as well as prevalence of and adherence to bedtime dosing of antihypertensive medications.
抗高血压药物早晨与睡前给药时间和依从率的评价
目的本研究的主要目的是评估患者服用降压药的时间。次要目的是评估早晨和就寝给药之间的药物依从率以及就寝给药的可能障碍。方法采用单中心、横断面研究,采用包括回顾性图表回顾和电话调查在内的混合方法模型,对一家多学科私人诊所的高血压患者进行研究。年龄在18岁以上且诊断为高血压的患者符合纳入条件。主要终点是睡前服用一种或多种抗高血压药物的患者数量。次要终点是药物依从性和睡前剂量依从性的潜在障碍。结果共收集问卷139份。大多数患者(75.5%)在早晨服用了所有降压药物,只有24.5%的患者在睡前服用了至少一种降压药物。与睡前服药相比,早上服药的依从性更高,分别为87.8%和79.4%。本研究的局限性包括单中心设计和使用自我报告数据时患者回忆和报告偏倚的可能性。结论本研究结果提示,睡前给药降压药物的患病率较低。尽管早晨服药的依从率比睡前服药的依从率高,但睡前服药的依从率仍然很有希望。未来的研究应扩大现有的发病率和死亡率证据,以及睡前服用降压药物的流行和依从性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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