A review on orodispersible drug delivery system

Sonia Iqbal, Hanasul Hanan, Afshan Maqbool, Nasra Munawar
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Abstract

The future of drug delivery holds great promise for orally dispersible dose formulations, which make application simple since no water requirement as compared to conventional solid dosage forms which requires significant volumes of fluids for administration. The objective for development of ODF provides a substitute for pills, syrups, and tablets in treating vomiting as well as nausea, particularly in children. On the basis of transdermal patch delivery system, a novel oral films drug delivery has been introduced. Fast dissolving films disintegrates quickly when come in contact with salivary secretion in the oral mucosa and released the drug fast approximately within 3 mins. ODFs are of different types, like sustained or controlled release, oral patches and fast dissolving films. They can be manufactured using a variety of method including solvent and semi solid casting, hot melt and solid dispersion extrusion, spray drying and rolling. Among them solvent casting method is the most employed method. ODFs comprises of active ingredient, polymer, plasticizer and additives like surfactants, sweetening and coloring agents. ODFs preparation requires hydrophilic polymer which provides quick dissolution in the oral cavity. Hydrophilic polymer act as base for ODFs formulation as they impart mouth feel and mechanical properties of the ODFs also dependent of polymer type. Oral thin-film provide fast drug dissolution precise dosage in a portable, safe, and handy manner that doesn't required water or any special equipment. This review article comprises of different methods for ODFs preparations, ODFs ingredients, ODFs benefits and drawbacks and their packaging.
非分散给药系统的研究进展
口服分散剂量制剂的未来给药前景广阔,与需要大量液体给药的传统固体剂型相比,口服分散剂量制剂不需要水,因此应用简单。开发ODF的目的是为治疗呕吐和恶心,特别是儿童呕吐和恶心提供一种药片、糖浆和片剂的替代品。在透皮贴片给药系统的基础上,介绍了一种新型的口服薄膜给药系统。快溶膜与口腔黏膜唾液分泌物接触后迅速崩解,约在3分钟内快速释药。odf有不同类型,如缓释或控释、口服贴剂和快速溶解薄膜。它们可以使用多种方法制造,包括溶剂和半固态铸造,热熔和固体分散挤出,喷雾干燥和轧制。其中溶剂铸造法是最常用的方法。odf包括活性成分、聚合物、增塑剂和添加剂,如表面活性剂、甜味剂和着色剂。odf的制备需要在口腔中快速溶解的亲水性聚合物。亲水聚合物作为odf配方的基础,因为它们赋予odf的口感和机械性能,这也取决于聚合物类型。口服薄膜提供快速药物溶出,精确剂量,便携,安全,方便,不需要水或任何特殊设备。本文综述了odf的不同制备方法、odf的成分、odf的优缺点及其包装。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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