Characterization and stability analysis of metformin HCl microcapsules formulated by complex coacervation technique

Faizan Asad, Faiza Fiaz, Amna Sheraz, Ayesha Nabi Ahmed, Irfan Javaid, T. Hussain
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Abstract

Objective: Metformin hydrochloride possesses a shorter sort of biological half-life of 1.5–1.6 h with having the absolute type of bioavailability that ranges between 50-60%, the moment it is administered orally. Reduced GIT disturbances and low bioavailability can be optimized by developing microencapsulation of metformin that could prove beneficial. Method: Paraffin oil had been used in obtaining specific types of primary emulsions, whereas the material that was used in the coating of microencapsulation had been identified as sodium alginate. In the process of complex coacervation, a substance known as Tween 20 was used as a surfactant in enhancing the stability of W/O/W double emulsion. Five different formulations with different concentrations of sodium alginate were tested. Result: Metformin's microencapsulation inside certain types of optimized atmosphere tends to ensure the specific size of 1 am of microcapsules in a combined form, and encapsulation efficiency reaches up to 84%. FTIR measurements have been used to determine the interaction between drug and polymer. The qualitative analysis result from FTIR ensures that the quality and effectiveness of the drug have been preserved. A calibration curve was used to estimate drug conc. from dissolution samples and kinetic analysis demonstrated anomalous release pattern. The test for drug content yielded ˃95% of concentration. Conclusion: Results extracted tend to tell us that specific complex coacervation that is using sodium alginate in wall material was a viable method that is used in the microencapsulation process of metformin hydrochloride.
复凝聚法制备盐酸二甲双胍微胶囊的表征及稳定性分析
目的:盐酸二甲双胍口服时生物半衰期较短,为1.5 ~ 1.6 h,绝对生物利用度在50 ~ 60%之间。二甲双胍微胶囊化可以减少胃肠道干扰和降低生物利用度。方法:用石蜡油制备特定类型的初乳,用海藻酸钠作为微胶囊包衣材料。在复合凝聚过程中,采用Tween 20作为表面活性剂,提高了W/O/W双乳液的稳定性。试验了五种不同浓度海藻酸钠的配方。结果:二甲双胍在一定优化气氛下的微胶囊化趋向于以组合形式保证微胶囊的比尺寸为1 μ m,胶囊化效率可达84%。FTIR测量已被用于确定药物与聚合物之间的相互作用。FTIR的定性分析结果保证了药物的质量和有效性。用标定曲线估计药物质量。溶出样品和动力学分析显示出异常的释放模式。药物含量测定率为浓度的95%。结论:提取结果倾向于告诉我们,海藻酸钠在壁材中特定复合凝聚是一种可行的方法,可用于盐酸二甲双胍微胶囊化工艺。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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