Journal of Contemporary Pharmacy Practice最新文献

{"title":"Formulation and evaluation of sustained releasedomperidone hydrochloride transdermal patches to treat motion sickness","authors":"M. Asif Jamshaid, Muqarab Abbas, M. Yousaf, Mahnoor Younas, Hajra Muzaffar, Talib Hussain, Rais A. Nawaz","doi":"10.56770/jcp2022621","DOIUrl":"https://doi.org/10.56770/jcp2022621","url":null,"abstract":"Objective: Transdermal route of drug delivery is superior than oral route because it avoids first pass effect, ensures better patient compliance, reduce dosing frequency especially in extended-release formulation and is easy to use. Domperidone HCl is DA2 receptor antagonistic and is used to prevent nausea and vomiting. The objective was to formulate a domperidone HCl extended-release transdermal drug delivery system to treat motion sickness. Methods: Five different formulations were formed using different solvents (methanol and dichloromethane) and polymers (HPMC and Eudragitl-100) by solvent evaporation method. 500mg of domperidone HCl was added in each patch and dibutyl phthalate was added as plasticizer. A 3%  w/v PVA layer was used as backing. All these formulations were evaluated for their physicochemical properties (weight variation, thickness, folding endurance and tensile strength), in-vitro drug release, drug contents determination, any incompatibility between drug and excipients by FTIR and DSC and skin irritation. Results: All formulations exhibited good physicochemical properties and percentage drug release during 24 hours was 79.3%, 97.1%, 96.8%, 74.7% and 59.7% respectively. F-YM showed maximum in-vitro drug release. The optimized formulation (F-YM) followed Korsmeyer Peppas release model with n=0.383 showing that the system was following dissolution dependent drug release. No interaction between drug and excipients was detected by DSC and FTIR. No skin irritation was detected. Conclusion: The extended release transdermal patches of domperidone HCl to treat motion sickness were prepared and formulation F-YM showed optimized behavior with maximum in vitro drug release.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82792143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation techniques, functionalization, and cytotoxicity of magnetic nanoparticles: A review","authors":"Humaira Sultana, Afifa Shafiq, Muhammad Akram Choohan, Khalil Ahmad, Ume Habiba","doi":"10.56770/jcp2022625","DOIUrl":"https://doi.org/10.56770/jcp2022625","url":null,"abstract":"In the relatively new but fast-evolving field of nanomedicine and nanotransport systems, different nanoscale molecules are used to deliver therapeutic agents to precisely targeted sites or potentially function as diagnostic tools. In present review provides up-to-date accurate information on the latest advancements in nanomedicine and nanotechnology DDS through a complete review of nanomaterials discoveries. The potential and difficulties of using nanomedicine to deliver medications from synthetic or natural sources to their intended clinical purposes are also covered. Additionally, we have exclusive data on perspectives and trends in nanomedicine. \u0000 ","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76337836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of 5-fluorouracil controlled release chronotherapeutic drug delivery system (CTDDS) for colorectal cancer","authors":"Hammad Ayaz, Muhammad Ahmad, Mustafa Kazmi, Husnain Ahmed, Talib Hussain, Ishtiaq Jeelani, Ume Habiba, Muhammad Akram Choohan","doi":"10.56770/jcp2022624","DOIUrl":"https://doi.org/10.56770/jcp2022624","url":null,"abstract":"Objective: As most of the drugs disintegrate and dissolve in stomach before reaching the target site and to substitute intravenous (IV) route based chrono modulated chemotherapy, oral colon target drug delivery system was formed. The aim of this study was to design, develop, and evaluate a colon targeted tablet containing 5-Fluorouracil (5-FU) to give a controlled release effect of drug for colonic cancer with a goal to increase the bioavailability and improve the patient compliance. Methods: Varied concentration of different polymers such as Xanthan gum and Eudragit were used to get an optimized formulation of 5-FU tablet. The prepared formulation was evaluated for pre compression and post compression parameters such as hardness, weight, friability and drug content uniformity. The optimized formulation was further evaluated by Fourier Transformed Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), in-vitro dissolution studies, dissolution kinetic modeling and stability analysis. Results: All pre-formulation tests were within range of USP standards. Friability of all tablets was satisfied. The interference of the polymers was ruled out by FTIR. In-vitro release studies of 5-FU tablets in phosphate buffer of pH 7.0 were performed using a modified diffusion cell that resulted sustained release (90.99% to 92.69% after 12h) and kinetic models depicted the combined diffusion and dissolution mechanism of release. The optimized tablets were found having only physical interactions based on DSC. The product was found stable when evaluated using accelerated stability studies. Conclusion: It was concluded from the studies that the colon target tablet of 5-FU prepared by different concentration of polymers were optimized and can be efficiently used to control the rate of drug release to the colon in the belief of improved therapeutic efficacy and tolerability. Therefore, it is a better alternative for intravenous route based chrono modulated chemotherapy.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72768037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation, development and characterization of ibuprofen microemulgel for arthritis","authors":"M. H. T. Bhatti, Sarim Sohail, M. U. Aslam, Hana Ather, T. Hussain, Muhammad Kashif","doi":"10.56770/jcp2022623","DOIUrl":"https://doi.org/10.56770/jcp2022623","url":null,"abstract":"Objective: Microemulgel is composed of aqueous phase, lipophilic phase, along with surfactant and co-surfactant, a suitable gelling agent is also incorporated. The drug Ibuprofen is non-steroidal anti-inflammatory drug. Its oral administration associated with many GIT, hepatic and renal problems. The main objective of the study was to formulate a stable topical microemulgel of ibuprofen in order to achieve the highest bioavailability with least side effects. Method: Pseudo ternary phase diagram was constructed in order to get the suitable concentrations of lipophilic phase, surfactant and co-surfactant. Phase titration method was used to prepare microemulsion, with surfactant and co-surfactant in a ratio of 2:1 respectively, along with gelling agent to form microemulgel. Formulations were evaluated to check appearance, pH, flowability, particle size, drug content, spreadability, drug release and skin irritation. Results: The globule size of microemulsion was 400 nm and zeta potential was -14 mV showing acceptable stability. Formulated emulgel showed good physical characteristics, suitable pH of 6.4 for skin. The drug content was 98.474%. The stability study showed that the ibuprofen was stable in phosphate buffer pH of 6.8. The carbopol 940 as a gelling agent showed high release rate values. The release rate of the optimized formulation, F1 was 94% and it followed Korsmeyer Peppas model (n=0.467). Conclusion: The prepared formulation was cost-effective because of promising highest bioavailability. The results suggest the potential use of developed microemulgel is mainly for topical delivery of ibuprofen, ensuring the safe use.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76664850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation development and characterization of famotidine dry suspension for oral use","authors":"Sajjad Qaisar, Masood-ur-Rehman Aarbi, Shahiq-uz-zaman, Ammar Sadiq, Talha Rafique","doi":"10.56770/jcp2022622","DOIUrl":"https://doi.org/10.56770/jcp2022622","url":null,"abstract":"Famotidine an H2 receptor blocker is generally used to treat ulcers of stomach and intestine. Famotidine is available in liquid suspension that is unstable during shelf life. Degradation of the drug as well as bad smell and color change is major problem in liquid suspension. This problem may be solved by formulating the drug as a dry suspension. We prepared four different formulations of famotidine as dry suspension. Geometric mixing methodology was followed to prepare the formulations. IR-spectroscopy showed no incompatibility between excipients used and API. Tests performed to evaluate formulations include assay, pH, viscosity, flow property, sedimentation volume and re-dispersibility. Among all the developed formulations, F3 was most ideal having excellent flow property, 100% drug assay, optimum viscosity and pH. Other formulations displayed some problems like viscosity of F1 was high that caused difficulty in flow while assay of F2 was 94% and F4 had bitter taste and low pH value. Hence F3 formulation was selected for further studies and kept for six months in stability chamber at accelerated conditions having temperature 40 °C ±2  and 75% ±5 R.H. samples were taken at 0, 1, 2, 3, 4 and 6 months to evaluate stability of the dry formulation. Moreover formulation (F3) was reconstituted with water and placed at accelerated conditions for 28 days to check its stability. Samples were taken at 0, 1, 2, 3, and 4 weeks. Results showed that no change occurred in both dry and reconstituted suspension during stability studies. It can be concluded on the basis of these findings that F3 formulation was stable and can be used in future.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82318304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial assessment of surfaces and air quality in emergency and gynecology operation theater of Bahawal Victoria Hospital","authors":"Saif Ur Rehman, Shumaila Nazuk, Eqaza Javed, Nayab Khalid","doi":"10.56770/jcp2022611","DOIUrl":"https://doi.org/10.56770/jcp2022611","url":null,"abstract":"Background: Microorganisms present in air and on surfaces of operation theaters are the common cause of nosocomial infection in patients. Microbiological assessment of organisms is important to check the quality of environment provided to patients who are already in compromised state. So, this study was conducted to determine the level of bacterial contamination of air, environmental and medical equipment surfaces in operation theatres of Bahawal Victoria Hospital, Bahawalpur. Objective: To determine Microbes of surfaces and air quality in Emergency and Gynecology operation theater of Bahawal Victoria Hospital. Methodology: A descriptive cross-sectional analytical study performed involving 100 samples from air and surfaces of Gynecology and Emergency operation theater of BVH from July 2015 to Dec 2015. Demographic and other clinical data was collected using standardized data collection tools. Culture of air and different sites [floor, walls, basin and equipment) for the microbiological assessment was done by the gold standard method. Culture positive organisms were confirmed by gram staining, microscopy and biochemical tests. Results: Of the100 samples collected from different sites like air, basin, walls, floor and instruments of emergency operation theater and Gynecology Operation Theater most organisms collected from theatres were Staphylococcus aureus followed by E. coli and K. pneumonia respectively. Most organisms were isolated from air, basin, and floor while medical equipment were fully sterilized and their samples show no growth.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87412555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction and comparison of quality and purity of DNA of medicinal plants by CTAB and kit method","authors":"Raheela Jabeen, Ume Habiba, Sana Khalid, Jafir Hussain Shirazi","doi":"10.56770/jcp2022613","DOIUrl":"https://doi.org/10.56770/jcp2022613","url":null,"abstract":"Background: Today is a world of bioengineering. Man is playing with DNA. Extraction and isolation of DNA has become as a key part for the researches of modern times. One needs high quality and increased quantity of DNA for performing several genetic techniques. There are several methods through which DNA can be extracted but the quality of the DNA cannot be compromised. Material methods: In the current research work extraction of DNA from four medicinal important plants Cassia fistula, Saccharum officinarum, Albizzia lebbeck and Cymbopogan citratus was carried out by two methods. One is a manual method that is used for the extraction of DNA from plant source; The CTAB method, and the other is extraction with the help of commercially available kit. Results: Results of the work showed that the high quantity of the DNA was obtained by CTAB method while DNA extracted with the kit was of better quality and purity then CTAB method. Conclusion: In techniques where high quality DNA is required like genetic engineering, micro arrays, extraction of DNA through kit method should be preferred, while in cases where quantity of DNA maters over its quality CTAB method is better to be used and economic.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"168 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76941766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SCN1A gene mutation: A a rising cause of human epilepsy syndrome","authors":"Muhammad Akram Choohan, Ishtiaq Ahmed, S. K. Syed, M. Naeem","doi":"10.56770/jcp2022615","DOIUrl":"https://doi.org/10.56770/jcp2022615","url":null,"abstract":"Epilepsy is found to be very common neurological disorder; it covers a wide range of abnormalities lying within brain. Generation of electrical activity of brain that is action potential and then its proper propagation in central nervous system (CNS) and Peripheral Nervous System (PNS) upto the target site is mandatory for the proper functioning of brain. The human sodium channel (SCN) family plays its critical role in all these neuronal mechanisms. These channels are prone to number of channelopatheis and mutations that are the key point of research and discussion now a day. About 700 mutations of SCN1A gene have been identified. This gene is considered as the commonly mutated gene in human epilepsy. This review is on the structural, functional and pathological aspects of SCN1A gene and its associated channelopathies. This will explore the advances in epilepsy genetics and may help in designing for new therapeutic modalities for treating epileptic patients.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85725704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of nanoparticles in elimination of biofilm produced by pathogenic bacteria","authors":"Samina Kousar, Atia Iqbal, Shafqat Rasool, Hafiz M. N. Iqbal","doi":"10.56770/jcp2022614","DOIUrl":"https://doi.org/10.56770/jcp2022614","url":null,"abstract":"Biofilm is a structured conglomeration of bacteria entrenched in a polymer matrix that is self-produced and contains DNA, polysaccharide, protein, and cause chronic infections. Pseudomonas aeruginosa lung infection is one of the well stated examples of pathogenic biofilms in cystic fibrosis patients. Due to mutating nature of the pathogens high antibiotic resistance will develop that make antibiotic treatment ineffective against repeated infections that are related to indwelling medical devices. Normally it was considered that nanoparticles are not larger than 100 nm, and their development to fight infection has gained popularity over the several decades. Different types of nanoparticles were introduced to treat biofilm infections in which silver nanoparticles were considered to be more efficient than all others. Maximum zone of inhibition in case of silver nanoparticles was found to be 40 mm against S.aureus, whereas maximum zone of inhibition with ZnO nanoparticles was 16 mm against Campylobacter jejuni, while in case of selenium nanoparticles and iron oxide nanoparticles zone of inhibition was time dependent and concentration dependent respectively. The order of antibacterial activity was like that Ag-Np>ZnO>CuO>Fe2O3. In this review article we discussed different biofilm producing pathogens that were isolated from different locations in latest research and to evaluate the role of nanoparticles in eradicating these pathogenic microbes.\u0000 \u0000 ","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84414215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formulation and evaluation of fast dissolving films embedded with nanoparticles of mirtazapine hydrochloride","authors":"Afshan Maqbool, Muhammad Naeem Aamir, Muhammad Naeem","doi":"10.56770/jcp2022612","DOIUrl":"https://doi.org/10.56770/jcp2022612","url":null,"abstract":"Objectives: The goal of this research was to produce fast dissolving film embedded with nanoparticles of mirtazapine hydrochloride. Method: Semisynthetic polymer (HPMC) is used to prepare orodispersible films which is prepared by solvent casting method and nanoparticles were formed by ion gelation method from chitosan and STPP. Fourier transform infrared spectroscopy and scanning electron microscopy demonstrated that all ODF constituents were compatible with one another. Different physico-chemical, mechanical characteristics, morphological examination and in vitro drug release investigations evaluation were used to assess and evaluate ODFs. Results: All formulations have disintegration times of less than 70 seconds. Mirtazapine hydrochloride content consistency in all ODFs ranged from 95.7% to 99.1%. These values revealed that the ODFs were strong and flexible enough. Tensile strength of oral films measured as 10.82±1.8 to 28.31±1.5, and percent elongation was 3.23±0.63 to 10.04±0.27. The ODFs had a smooth surface with uniform distribution of nanoparticles and all constituents, according to scanning electron microscopy. Mirtazapine hydrochloride were released from ODFs 20 to 25 minutes, according to in vitro drug release experiments. After stability tests, no significant differences in physicochemical and mechanical parameters were found in any of the formulations. Conclusion: The formulation of nanoparticles of mirtazapine hydrochloride were successfully developed and embedded on fast dissolving film, which was prepared, in vitro release of film was observed for specific time.","PeriodicalId":15502,"journal":{"name":"Journal of Contemporary Pharmacy Practice","volume":"277 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75028617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}