Role of nanoparticles in elimination of biofilm produced by pathogenic bacteria

Samina Kousar, Atia Iqbal, Shafqat Rasool, Hafiz M. N. Iqbal
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Abstract

Biofilm is a structured conglomeration of bacteria entrenched in a polymer matrix that is self-produced and contains DNA, polysaccharide, protein, and cause chronic infections. Pseudomonas aeruginosa lung infection is one of the well stated examples of pathogenic biofilms in cystic fibrosis patients. Due to mutating nature of the pathogens high antibiotic resistance will develop that make antibiotic treatment ineffective against repeated infections that are related to indwelling medical devices. Normally it was considered that nanoparticles are not larger than 100 nm, and their development to fight infection has gained popularity over the several decades. Different types of nanoparticles were introduced to treat biofilm infections in which silver nanoparticles were considered to be more efficient than all others. Maximum zone of inhibition in case of silver nanoparticles was found to be 40 mm against S.aureus, whereas maximum zone of inhibition with ZnO nanoparticles was 16 mm against Campylobacter jejuni, while in case of selenium nanoparticles and iron oxide nanoparticles zone of inhibition was time dependent and concentration dependent respectively. The order of antibacterial activity was like that Ag-Np>ZnO>CuO>Fe2O3. In this review article we discussed different biofilm producing pathogens that were isolated from different locations in latest research and to evaluate the role of nanoparticles in eradicating these pathogenic microbes.    
纳米颗粒在消除致病菌产生的生物膜中的作用
生物膜是细菌在聚合物基质中形成的一种结构集合体,它是由细菌自行产生的,含有DNA、多糖、蛋白质,可引起慢性感染。铜绿假单胞菌肺部感染是囊性纤维化患者致病性生物膜的一个很好的例子。由于病原体的突变性质,将产生高抗生素耐药性,使抗生素治疗对与留置医疗器械有关的反复感染无效。通常人们认为纳米颗粒不大于100纳米,几十年来,纳米颗粒在抗感染方面的发展越来越受欢迎。不同类型的纳米颗粒被引入治疗生物膜感染,其中银纳米颗粒被认为比所有其他纳米颗粒更有效。银纳米粒子对金黄色葡萄球菌的最大抑制区为40 mm, ZnO纳米粒子对空肠弯曲杆菌的最大抑制区为16 mm,而硒纳米粒子和氧化铁纳米粒子对空肠弯曲杆菌的最大抑制区分别是时间依赖性和浓度依赖性。抗菌活性的强弱顺序为Ag-Np>ZnO>CuO>Fe2O3。本文综述了最近研究中从不同地点分离的不同产生物膜病原体,并评价了纳米颗粒在根除这些病原微生物中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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