Journal of Angiotherapy最新文献

{"title":"Pomegranate Juice Attenuates Anti-ulcer in Indomethacin-induced Peptic Ulcer","authors":"","doi":"10.25163/angiotherapy.719364","DOIUrl":"https://doi.org/10.25163/angiotherapy.719364","url":null,"abstract":"Introduction: Pomegranate (Punica granatum L.) is a well-known fruit that grows in tropical and subtropical areas of the world. In this study, we wanted to find out how pomegranate juice (POMJ) affected rats with gastric ulcers caused by standard drugs. Indomethacin is the most common drug causes gastric ulcer also, most of the NSAID drugs have harmful side effects, so studies have focused on finding an alternative natural solution. Methods: In this study, 25 male albino rats were used and were split into four groups of five rats each. These groups were called control, pomegranate, indomethacin, and standard. The examination took one week to complete. Indomethacin saline suspension (100 mg/kg rat weight) caused gastric ulcers. Pomegranate peel juice (5-10%) reduced stomach ulcer area and ulcer index, gastric juice volume, and acidity. Pomegranate juice restores stomach mucus content and tissue at the histological level. Results: Rats that were given indomethacin and then given pomegranate juice were significantly less likely to get a gastric ulcer. It also lowered the ulcer index to 0.7093±0.36 showing that 52.25 % prevention. Conclusion: The study's macroscopical and microscopical results showed that pomegranate juice might be able to reduce the ulceration caused by indomethacin in a rat model. Pomegranate as a protective food supplement against gastric ulcers.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139230064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Plumbago zeylanica on Analgesia and Arthritis","authors":"Subasini Uthirapathy","doi":"10.25163/angiotherapy.719370","DOIUrl":"https://doi.org/10.25163/angiotherapy.719370","url":null,"abstract":"Background: Rheumatoid arthritis is a chronic inflammatory joint condition that causes oxidative damage and inflammation. The current study evaluates the safety and effectiveness of an 85 percent methanolic extract of Plumbago zeylanica (PZ). Methods: The acute toxicity study is used to calculate the LD50 value in the safety profile. The hot plate and tail immersion procedures are both used to examine the analgesic effect in the efficacy profile. Paw edema caused by carrageenan was investigated for its ability to reduce inflammation and complete Freund's adjuvant produced arthritis was tested for anti-arthritic activity. Results: Various phytochemical analyses, including qualitative and quantitative analyses of 85 % methanolic extract and raw materials. The extract exhibits analgesic effects by increasing the reaction time in both the hot plate and tail immersion procedures. In Freund's adjuvant-induced paw edema, the anti-inflammatory activity of methanolic extract is 30.42 % and 16.90 %, respectively. Conclusion: The PZ extract raises the level of antioxidants and lowers the oxidative stress caused by arthritis caused by complete Freund's adjuvant. PZ has a lot of secondary metabolites that can help with pain, inflammation, and free radicals.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139242264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatitis C and atherosclerosis: inflammatory interplay","authors":"","doi":"10.25163/angiotherapy.719361","DOIUrl":"https://doi.org/10.25163/angiotherapy.719361","url":null,"abstract":"Atherosclerosis along with viral hepatitis C are major health problems. Despite the fact that atherosclerosis is usually associated only with blood vessels, and hepatitis C with the liver, these diseases have a number of common features. The pathogenesis of atherosclerosis includes many different mechanisms, one of the central roles among which is inflammation. The importance of inflammation for the development of hepatitis is also difficult to overestimate. The precise mechanisms of action by which HCV stimulates development of atherosclerosis are still being investigated. Both direct and indirect consequences of HCV infection, such as persistent inflammation and impairments in glucose and lipid metabolism, are well known atherogenic conditions. In this review, we have tried to describe the interaction between hepatitis C and atherosclerosis, with a particular focus on inflammation.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"392 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139242459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of Epstein-Barr Virus EBNA-2 Sequence Variation in Nasopharyngeal Carcinoma and Other EBV-Related Tumors","authors":"Lee Wei, Zheng, Rabiatul Basria, S. M. N. Mydin, Adam Azlan, Muhamad Yusri Musa, Rabiatul Zheng, N. BasriaS.M., Adam Mydin, Muhamad Yusri Azlan, Musa","doi":"10.25163/angiotherapy.719352","DOIUrl":"https://doi.org/10.25163/angiotherapy.719352","url":null,"abstract":"Epstein Barr virus (EBV) is a common gamma herpesvirus that has infected over 95% of the worldwide population and is associated with several diseases which includes Hodgkin lymphoma (HL), Burkitt’s lymphoma (BL), nasopharyngeal carcinoma (NPC) and gastric cancer (GC). Epstein Barr virus nuclear antigen 2 (EBNA-2) gene of EBV is pivotal for growth transformation process and EBV type differentiation. Variations of the EBNA-2 gene could affect EBV transformation. Thus, understanding the variations that occur could provide invaluable insights. Variations of the EBNA-2 gene of EBV from different countries and disease associated was identified by comparing the gene with the reference sequence of EBNA2 from EBV isolated from C666-1 with the accession KC617875. Out of 11 samples, KC440851 is the most diverged and distally related sample from the reference sample. Interestingly some disease share similarities within the EBNA-2 gene as in the case of BL and NPC. The divergence of ENBA-2 gene increases with respect to geographical region when compared to reference sample.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"20 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139243715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking Nature’s Treasure Trove: Exploring Microorganisms for Novel Bioactives","authors":"","doi":"10.25163/angiotherapy.719345","DOIUrl":"https://doi.org/10.25163/angiotherapy.719345","url":null,"abstract":"From the marine environment to plants and animals, microorganisms are everywhere. Microbes happen to be a very prominent resource of metabolites and bioactive compounds and in recent times, many therapeutic compounds have been discovered from microbial sources. This review provides an in-depth exploration into the world of microorganisms as a treasure trove of novel bioactives. Different groups of microbes contain unique metabolites and bioactive that might have the potential as therapeutic agents. So, it is very important to screen microbial metabolites to identify, isolate and characterize for potential therapeutic applications. Microbial metabolites are very advantageous in terms of large-scale production and purity of final products. Considering these advantages, research focusing on screening potential microbial bioactive is a very time demanding one. This comprehensive review aims to inspire researchers and stakeholders to further explore and unlock the vast potential of microorganisms for the discovery and development of innovative bioactive compounds.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"11 18","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136226804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing The Protocol For Extraction Of Bioactive Components From Hibiscus Sabdariffa With Potent Antioxidant Activity","authors":"","doi":"10.25163/angiotherapy.719346","DOIUrl":"https://doi.org/10.25163/angiotherapy.719346","url":null,"abstract":"The extract of Hibiscus sabdariffa (HS) also known as roselle from the Malvaceae family is prized for its exceptionally high contents of polyphenols and anthocyanins, the calyces of HS being one of the many sources of natural antioxidants. Considering the numerous health benefits associated with the consumption of such compounds as well its broad application in the food industry, the development of an extraction protocol for such compounds from HS at high yields and antioxidant activity merits scientific relevance. In this study, the optimum conditions to achieve such goals were established by the method of response surface methodology (RSM) using three independent variables: time (30, 165, and 300 min), temperature (50, 70, and 90°C) and ethanol concentration (60, 75 and 90%). A Box-Behnken design (BBD) was utilized to determine the optimum condition that yielded the highest extraction yield and antioxidant activity measured by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical inhibition activity test. The results showed that under optimum conditions [300 min, 70°C in 90% ethanol concentration and 30 min, 70°C in 90% ethanol concentration], a corresponding 48.44% and 87.93% were obtained for the extraction yield and DPPH activity of HS, respectively; hence verifying the suitability of RSM for optimizing the extraction of HS.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"11 17","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136226805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiangiogenic and Anticancer Potential of Supercritical Fluid Extracts from Nutmeg Seeds; In vitro, Ex vivo and In silico studies","authors":"Sawsan S. Al-Rawi, Ahmad Hamdy, Marthad A. Hamde, Dinesh Babu, Mansoureh Nazari, Mohd Omar, Ab Kadir, Aman Shah, Abdul Majid, Amin Malik Shah","doi":"10.25163/angiotherapy.719371","DOIUrl":"https://doi.org/10.25163/angiotherapy.719371","url":null,"abstract":"Background: Angiogenesis is a vital process of forming new blood vessels that occurs during several normal physiological processes. It plays a substantial role in tumor growth and cancer by supplying oxygen and nutrients for the proliferating tumors. Nutmeg, the dried seed of Myristica fragrans, is known for its therapeutic properties. This study aimed to investigate the antiangiogenic and cytotoxic properties of nutmeg extracts derived by Soxhlet and supercritical fluid extraction (SFE) using in-vitro, ex-vivo, and in-silico studies. Method: Nutmeg anticancer property was evaluated against breast cancer cell MCF7 and colon cancer cell HCT116 using MTT in-vitro assay. The antiangiogenic property was investigated using 3D ex-vivo rat aorta assays. The chemical composition of nutmeg extract was characterized using GC/TOF-MS. Subsequently, the main compounds in the nutmeg extract were analyzed against the angiogenesis-associated molecules (COX-1, VEGFA, HIF, and EGF) by molecular docking and were compared with tamoxifen and 5-fluorouracil. Results: The SFE extracts exhibited higher antiangiogenic properties than the Soxhlet (IC50 31µg/mL). Nutmeg SFE extract exhibited higher cytotoxicity towards HCT116 than MCF7 cells. Several active compounds, including myristicin, eugenol, safrole, and α-asarone were identified in the nutmeg SFE extracts using GC/TOF-MS. Molecular docking revealed strong interactions between these compounds and angiogenesis molecular mediators. Particularly, myristicin blocked COX-1, VEGFA, HIF, and EGF enzymes, indicating possible binding interactions. Conclusion: This study highlights the limitless possibilities of nature's offerings in advancing human health. Nutmeg's potential compounds lie in their binding models, which have proven to be powerful tools against cancer and angiogenesis. Myristicin, α-asarone, safrole, and eugenol work synergistically to induce antiangiogenic effects, making nutmeg a promising natural source of angiogenesis inhibitors for future anticancer therapies. The Molecular docking result confirmed that the inhibition of COX-1, VEGF-A, HIF, and EGF by nutmeg compounds offers great potential in the treatment and prevention of various angiogenesis diseases.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"R-22 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139277714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stromal Interaction Molecule-1 (STIM1): Orchestrating Calcium Signaling in Cancer and Hematologic Malignancies","authors":"","doi":"10.25163/angiotherapy.719353","DOIUrl":"https://doi.org/10.25163/angiotherapy.719353","url":null,"abstract":"STIM-1 plays pivotal roles in carcinogenesis via calcium signalling. STIM-1 regulatory functions in malignancies were observed to be significantly implicated resulting in various oncogenic properties. STIM-1 induced oncogenic properties mainly via the store operated calcium entry (SOCE) disruption. Moreover, calcium signalling mediated via STIM-1 could also in synergy with reactive oxygen species (ROS) mediates oncogenic characteristics. This would often lead to induction of pro-survival mechanism in cancer. Understanding STIM-1 lanscape is therefore crucial in contributing to the knowledge on cancer alleviation. This review emphasized on the significance of STIM1 in various cancers including hematologic malignancies and its intricate influence over ROS and various cellular processes.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"80 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135037116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inhibitory Activity of Enzyme Α-Glucosidase Ethanol Extract Combination Of Mareme Plant (Glochidion arborescens (Müll. Arg.) Boerl.) Leaves And Sala Plant (Cynometra ramiflora Linn) Leaves","authors":"","doi":"10.25163/angiotherapy.719344","DOIUrl":"https://doi.org/10.25163/angiotherapy.719344","url":null,"abstract":"Diabetes Mellitus (DM) is still one of the world's major health problems, contributing to many complications leading to increased morbidity and mortality. Different approaches have been performed to enhance the patient's quality of life. Over the past decade, due to a trend in herbal medicines, numerous plants have been claimed to be advantageous in alleviating DM features in pre-clinical research, including Mareme and Sala plants. Mareme and Sala leaves contain flavonoid compounds which are potential as antidiabetic agents. This study aimed to determine the in vitro inhibitory activity of the ethanolic extracts of both plants on the α-glucosidase enzyme that plays a pivotal role in diabetic pathophysiology. The inhibition potential of the combination of Mareme and Sala leaf ethanol extracts and the positive control, namely acarbose, were measured using an ELISA reader at 450 nm based on the formation of p-nitrophenol. The ELISA reader measurements showed that the combination of Mareme leaves and Sala leaf ethanol extract could not inhibit α-glucosidase activity in vitro, indicated by the IC50 calculation of 374.47 ppm. Nevertheless, our research revealed the presence of diverse secondary metabolites, including flavonoids, in both extracts, which could potentially be responsible for further pharmacological activities.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"39 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135041633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge and Self-Management Practice Among Diabetic Patients from the Urban Areas in Bangladesh","authors":"Md. Jubayer Hossain, S. Towhid, Sumona Akter, Muhibullah Shahjahan, Tilottoma Roy, B. Akter, T. A. Nodee","doi":"10.25163/angiotherapy.717340","DOIUrl":"https://doi.org/10.25163/angiotherapy.717340","url":null,"abstract":"This study aims to determine the knowledge of self-management, prognosis, and the quality of daily life among adult patients with Type 1 and Type 2 diabetes in Bangladesh. Settings and Design: A descriptive cross-sectional study was conducted from April 2021 to August 2021 on diabetic patients from Dhaka City and Rangpur City in Bangladesh. A structured questionnaire was used to collect information from the respondents of this study. The data was collected via a phone interview by the researchers of this study. The data was analyzed using Python (Version 3.8), Pandas, ResearchPy (A Python package for research data analysis), and Microsoft Excel 2019. We found that 85% of the participants were aware of Bangladesh National Diabetes Management Guidelines and its recommendations, and males were better informed about diabetes and its management than females. Most participants (68.32%) experienced an onset of diabetic symptoms around 50-60 years of age, and 34.65% of participants were unaware of the type of diabetes they had. 91% were satisfied with the prognosis of their diabetes. However, the frequency of check-ups for hyperglycemia from serum was insufficient (less than once annually) despite the national guidelines’ recommendation for quarterly check-ups. Participants were more eager to check for diabetes-associated symptoms (more than 3 times a year among 80.53%) rather than checking the serum hyperglycemia. Female participants were lenient to take physical exercise to self-manage diabetes. The healthcare centers across Bangladesh need to make the information provided by Bangladesh National Diabetes Management Guidelines more reader-friendly for all socio-economic groups. Broader movements are needed to make patients feel more interested to learning, practicing, and following the guidelines.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139290466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}