Effect of Plumbago zeylanica on Analgesia and Arthritis

Subasini Uthirapathy
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Abstract

Background: Rheumatoid arthritis is a chronic inflammatory joint condition that causes oxidative damage and inflammation. The current study evaluates the safety and effectiveness of an 85 percent methanolic extract of Plumbago zeylanica (PZ). Methods: The acute toxicity study is used to calculate the LD50 value in the safety profile. The hot plate and tail immersion procedures are both used to examine the analgesic effect in the efficacy profile. Paw edema caused by carrageenan was investigated for its ability to reduce inflammation and complete Freund's adjuvant produced arthritis was tested for anti-arthritic activity. Results: Various phytochemical analyses, including qualitative and quantitative analyses of 85 % methanolic extract and raw materials. The extract exhibits analgesic effects by increasing the reaction time in both the hot plate and tail immersion procedures. In Freund's adjuvant-induced paw edema, the anti-inflammatory activity of methanolic extract is 30.42 % and 16.90 %, respectively. Conclusion: The PZ extract raises the level of antioxidants and lowers the oxidative stress caused by arthritis caused by complete Freund's adjuvant. PZ has a lot of secondary metabolites that can help with pain, inflammation, and free radicals.
板蓝根对镇痛和关节炎的影响
背景:类风湿性关节炎是一种慢性关节炎症,会导致氧化损伤和炎症。本研究评估了含 85% 的板蓝根(PZ)甲醇提取物的安全性和有效性。方法:急性毒性研究用于计算安全性概况中的半数致死剂量。在疗效分析中,热板和尾部浸泡程序都用于检查镇痛效果。对卡拉胶引起的爪水肿进行了研究,以了解其消炎能力;对完全弗氏佐剂引起的关节炎进行了测试,以了解其抗关节炎活性。结果:对 85% 的甲醇提取物和原材料进行了各种植物化学分析,包括定性和定量分析。在热板和尾部浸泡程序中,提取物通过延长反应时间而显示出镇痛效果。在弗氏佐剂诱导的爪水肿中,甲醇提取物的抗炎活性分别为 30.42% 和 16.90%。结论PZ 提取物提高了抗氧化剂的水平,降低了完全弗氏佐剂引起的关节炎所导致的氧化应激。PZ 有很多次生代谢产物,可以帮助缓解疼痛、炎症和自由基。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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