Stromal Interaction Molecule-1 (STIM1): Orchestrating Calcium Signaling in Cancer and Hematologic Malignancies

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Abstract

STIM-1 plays pivotal roles in carcinogenesis via calcium signalling. STIM-1 regulatory functions in malignancies were observed to be significantly implicated resulting in various oncogenic properties. STIM-1 induced oncogenic properties mainly via the store operated calcium entry (SOCE) disruption. Moreover, calcium signalling mediated via STIM-1 could also in synergy with reactive oxygen species (ROS) mediates oncogenic characteristics. This would often lead to induction of pro-survival mechanism in cancer. Understanding STIM-1 lanscape is therefore crucial in contributing to the knowledge on cancer alleviation. This review emphasized on the significance of STIM1 in various cancers including hematologic malignancies and its intricate influence over ROS and various cellular processes.
基质相互作用分子-1 (STIM1):在癌症和血液恶性肿瘤中协调钙信号
STIM-1通过钙信号传导在癌变中起关键作用。STIM-1在恶性肿瘤中的调节功能被观察到与各种致癌特性有显著关联。STIM-1主要通过储存操作钙进入(SOCE)中断诱导致癌特性。此外,通过STIM-1介导的钙信号也可能与活性氧(ROS)协同介导致癌特性。这通常会导致在癌症中诱导促生存机制。因此,了解STIM-1的结构对于促进癌症缓解至关重要。这篇综述强调了STIM1在包括血液恶性肿瘤在内的各种癌症中的意义,以及它对活性氧和各种细胞过程的复杂影响。
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