Journal of Angiotherapy最新文献

{"title":"Platelet Implication in Atherosclerosis Pathogenesis","authors":"","doi":"10.25163/angiotherapy.819385","DOIUrl":"https://doi.org/10.25163/angiotherapy.819385","url":null,"abstract":"Atherosclerosis is a prevalent cardiovascular disease that leads to serious complications like myocardial infarction and ischemic stroke. Platelets play a pivotal role in thrombosis and contribute to the development of atherosclerosis through interactions with the cellular environment. Consequently, platelets have emerged as a potential therapeutic target. This review explores the normal functioning of platelets and their involvement in atherosclerosis progression, highlighting their participation in inflammatory responses within the arterial wall. Platelets activate and release mediators that promote vascular inflammation and endothelial dysfunction, key features of atherosclerotic plaque formation. They also interact with circulating immune cells, exacerbating the inflammatory milieu and fostering disease progression. Targeting platelets presents a promising approach for therapeutic interventions in atherosclerosis. Antiplatelet agents aim to impede platelet activation and aggregation, reducing thrombosis risk. Novel strategies that target platelet interactions with inflammatory cells and modulate platelet-derived inflammatory mediators are also being investigated. Further research is needed to fully exploit the potential of platelet-targeted therapy. Understanding the precise role of platelets at different stages of atherosclerosis and their interactions with immune cells and the inflammatory milieu will enhance our understanding of disease pathogenesis and guide the development of more effective therapeutic approaches. In conclusion, platelets significantly influence atherosclerosis by contributing to thrombus formation and promoting inflammatory processes. Recognizing platelets as a therapeutic target opens up new possibilities for mitigating the consequences of atherosclerosis and improving patient outcomes.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Toll-Like Receptor 9 (TLR9) in Breast Cancer Risk, Along with Hormonal Effects in Patients Receiving Radiotherapy","authors":"","doi":"10.25163/angiotherapy.819424","DOIUrl":"https://doi.org/10.25163/angiotherapy.819424","url":null,"abstract":"Introduction: Antioxidant enzyme polymorphisms and innate immune receptors have been implicated in the development of various cancer forms. This study aimed to assess the potential association between toll-like receptor 9 (TLR9) polymorphisms and female susceptibility to breast cancer. Methods: Forty female breast cancer patients from Iraq and 20 healthy volunteers were enrolled in the study. Gene polymorphisms of TLR9 rs187084 (1237T/C) were analyzed using real-time polymerase chain reaction (RT-PCR). Additionally, a hormonal study was conducted, comparing breast cancer patients exposed to radiation with a control group. The levels of follicle-stimulating hormone (FSH), estradiol (E2), and progesterone were measured. Results: The analysis revealed a non-significant increase in the prevalence of TLR9 wild TT genotypes among breast cancer patients compared to healthy individuals (72.5% vs. 90%, respectively). Conversely, heterozygous CT genotypes were significantly higher in breast cancer patients compared to healthy women (22.5% vs. 10%, P<0.05). In the hormonal study, breast cancer patients exposed to radiation exhibited a significant increase in FSH levels (2.9 vs. 18.8 IU/ml), a significant decrease in E2 levels (0.232 vs. 0.910 pico/ml), and a significant increase in progesterone levels (0.910 vs. 0.732 nanogram/ml). Conclusion: The study concludes that TLR9 rs187084 (1237T/C) polymorphism variants play crucial roles in the susceptibility of Iraqi females to breast cancer. Furthermore, the observed hormonal disruptions in FSH, E2, and progesterone levels highlight potential contributors to breast cancer development, emphasizing the need for further exploration of genetic and hormonal factors in cancer susceptibility.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Cancer Study of Carvacrol in Hypoxic-Induced Colorectal Cancer Cell","authors":"","doi":"10.25163/angiotherapy.819441","DOIUrl":"https://doi.org/10.25163/angiotherapy.819441","url":null,"abstract":"Introduction: Colorectal cancer presents a complex global health challenge, characterized by complications arising from metastasis development due to rapid proliferation, adaptation to hypoxia, and angiogenesis. Carvacrol, a natural monoterpenoid phenol derived from various plants, has interest for its diverse pharmacological properties, particularly its antitumor effects. Methods: We aimed to assess the inhibitory effect of carvacrol on cell migration and proliferation in the hypoxic colorectal cancer cell line (SW480). Chemical induction of hypoxia using cobalt chloride and serially diluted concentrations of carvacrol (400, 200, 100, 50, 25, and 12.5 µg/ml) were employed to evaluate the cytotoxic effect via the MTT assay. Smaller concentrations (low IC50) were used to examine the impact of carvacrol on SW480 cell migration through a cell migration assay (50, 25, 12.5, and 6.25 µg/ml). Results: The results demonstrated a significant, dose-dependent reduction in both cell proliferation and migration with carvacrol doses. Conclusion: The findings suggest that carvacrol could be useful as an adjuvant therapy and a promising addition for patients with highly metastatic colorectal cancer.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"11 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Hypercholesterolemia is a Significant Risk Factor for Atherogenesis – A Systematic Review","authors":"","doi":"10.25163/angiotherapy.819390","DOIUrl":"https://doi.org/10.25163/angiotherapy.819390","url":null,"abstract":"Background: Cardiovascular diseases, typically associated with older individuals, have been found to have risk factors that can develop during childhood and even fetal development. Maternal hypercholesterolemia, experienced during pregnancy, is one such factor that affects the fetus. This review aims to explore the mechanisms through which maternal hypercholesterolemia can contribute to the development of atherosclerosis and subsequent cardiovascular diseases and events. Methods: To conduct this review, we systematically analyzed existing literature and collected relevant information on the impact of maternal hypercholesterolemia on fetal development and subsequent cardiovascular health. We examined studies that investigated the pathways and mechanisms by which maternal hypercholesterolemia influences atherosclerosis and its related diseases. Results: Our review identified several mechanisms by which maternal hypercholesterolemia can stimulate the development of atherosclerosis and contribute to cardiovascular diseases and events. These mechanisms include alterations in lipid metabolism, oxidative stress, endothelial dysfunction, inflammation, and vascular remodeling. Maternal hypercholesterolemia during pregnancy can lead to lipid abnormalities in the fetus, triggering early atherosclerotic changes that persist into adulthood. These changes may increase the risk of cardiovascular diseases later in life. Conclusion: This review highlights the potential impact of maternal hypercholesterolemia on the development of atherosclerosis and subsequent cardiovascular diseases in offspring. Understanding the mechanisms involved is crucial for developing effective preventive strategies and interventions. By addressing maternal hypercholesterolemia and its effects during pregnancy, healthcare providers can contribute to reducing the burden of cardiovascular diseases in future generations. Further research is needed to elucidate the precise mechanisms and long-term effects, which will aid in developing targeted approaches for early intervention and risk mitigation.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"10 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An In-Depth Analysis of Microorganisms Linked to Various Forms of Hospital-Acquired Infections: A Systematic Review","authors":"","doi":"10.25163/angiotherapy.819381","DOIUrl":"https://doi.org/10.25163/angiotherapy.819381","url":null,"abstract":"Nosocomial infections (NIs) represent one of the serious public health concerns worldwide that are linked with healthcare-associated infections. The present study reviewed the microorganisms associated with various types of NIs. The data search strategy was guided by the PRISMA-P protocol with the utilization of various search engine databases (PubMed, Springer Link, Science Direct, and Google Scholar) and pre-determined keywords. The search retrieved 504 articles from 2014 to 2019. Based on the inclusion and exclusion criteria stated, only a total of 63 articles have been discussed further in this study. The signatures of NIs can be described by microorganisms associated with the transmission route groups (Nosocomial bloodstream infections-BSI, Hospital Acquired Pneumonia-HAP, Catheter-Associated Urinary Tract Infection-CAUTI, Surgical Site Infection-SSI). BSI is the major cause of morbidity and mortality in hospitals. HAP is the most frequently reported case including Ventilator-associated Pneumonia-VAP. Microorganisms such as Acinetobacter Baumannii spp., Escherichia spp., Streptococcus spp., Staphylococcus aureus spp., and Pseudomonas spp. pathogens are commonly associated with NIs. Recently, the healthcare challenge is also associated with Multi-Drug Resistant (MDR) related strains that contribute to a significantly high mortality rate, especially in immune-compromised patients. Hence, the emergence of various nosocomial infections marked the relevant steps and measures that need to be taken with effective precautions.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"2 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Steroid Treatment on Tissue Damage Markers in Diabetic Patients","authors":"","doi":"10.25163/angiotherapy.819442","DOIUrl":"https://doi.org/10.25163/angiotherapy.819442","url":null,"abstract":"Steroid-induced hyperglycemia challenges primary care providers. Understanding and managing these effects are insufficient despite widespread glucocorticoid use. Our study aimed to investigate the impact of steroid treatment on tissue damage markers in diabetic patients. We determined the liver enzymes, blood biochemistry, and interleukins (IL-12, IL-17A, IL-6, and IL1B) before and after steroid treatment. The results revealed a significant increase in creatinine levels among the active patients compared to the control group. The mean concentrations of ALT and ALP in the active patients (on steroids) were 43 ± 3.1 and 112 ± 10.2 U/L, respectively, significantly higher than the active control (24 ± 5.1). Our study also found that IL-12, IL-17A, IL-6, and IL-10 were upregulated 5.2, 16.2, 2.13, and 5.11 times, respectively, compared to the control. The blood sugar levels (RBS) showed positive correlations with Neutrophils (r = 0.81, P = 0.012), IL-12 (r = 0.68, P = 0.028), and IL-6 (r = 0.51, P = 0.03). In conclusion, our research demonstrated the significance of inflammation and tissue damage in the expression patterns associated with type 2 diabetes and its effects.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"21 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis And In-Silico Anti-Cancer Potential of N-Aryl-Keto-Nitrone As A Spin Adducts","authors":"","doi":"10.25163/angiotherapy.819437","DOIUrl":"https://doi.org/10.25163/angiotherapy.819437","url":null,"abstract":"Introduction: This study explores N-Aryl-Keto-Nitrone synthesis and its impact on spin-trapping chemistry, revealing crucial insights into free radicals' roles in diseases. While aldo-nitrones are well-studied, keto-nitrones, especially linear ones, are underexplored as spin traps. Seven novel keto-nitrones are introduced, and their efficacy in capturing carbon-centered radicals is assessed. Methods: Synthesis involves dissolving N-aryl-nitroso compounds in THF, adding NaOH, and introducing dimethyl or diethyl bromo malonate. Thin-layer chromatography monitors the reaction, yielding crude keto-nitrones purified through extraction, drying, and recrystallization. Spin trapping experiments use various radical sources, analyzed by EPR at room temperature. In silico predictions assess ADME properties, P-glycoprotein substrate potential, and molecular docking explores binding orientations with VEGFR2 and EGFR. Results: Diverse N-aryl-keto-nitrones with unique structures and reactivity towards carbon-centered radicals are successfully synthesized. Enhanced interpretability is observed in penta-deuterated compounds N6 and N7. The compounds exhibit varying lipophilicity and resistance to oxidative or reducing agents, broadening their potential applications. In silico predictions show favorable properties, and the compounds demonstrate potential as VEGFR1 downregulators, suggesting applications in disrupting angiogenic signals in cancers. Conclusion: This research advances spin-trapping chemistry by introducing linear keto-nitrones as effective agents. The synthesized compounds demonstrate versatility and impact, with ongoing research focusing on additional applications and refinement for practical use.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"14 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-Brain Connection; IBS linked to Anxiety, Quality of Life, and Academic Performance in Undergraduate Students","authors":"","doi":"10.25163/angiotherapy.819418","DOIUrl":"https://doi.org/10.25163/angiotherapy.819418","url":null,"abstract":"Background: Irritable bowel syndrome (IBS) is a disease that affects the lower gastrointestinal tract. It causes several distressing abdominal symptoms that affect the quality of life, emotional well-being, and academic performance of undergraduate students. Chronic stress affects many processes including immunity and angiogenesis. Our cross-sectional study aimed to identify the prevalence of IBS and its impact on anxiety levels, quality of life, and academic performance among undergraduate students. Method: A total of 357 students (male and female) were randomly selected. IBS prevalence was assessed using Rome III criteria and Birmingham IBS Symptom Questionnaire. Anxiety and quality of life were measured using Beck Anxiety Inventory and IBS-Quality of Life Questionnaire respectively. Results: About 16% of students had IBS with the majority from medical departments. Females had a higher IBS prevalence due to diet, lifestyle, and cultural habits. Students with IBS showed high levels of anxiety, below-average quality of life, low academic performance, and insufficient knowledge of IBS. Interestingly, negative, and positive correlations (p =.000) were found between the demographic variables. However, the anxiety levels and quality of life were significantly correlated. Conclusion: Several factors, such as social characteristics, diet, and posttraumatic stress disorder caused by wars, are significantly correlated with IBS development, and could impact students' lives. Our findings can pave the way for creating preventive measures, including stress management and health education programs, to curb the incidence of IBS and anxiety among undergraduate students. Therefore, appropriate interventions are necessary to address the student’s mental health with IBS and improve their academic and personal lives.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"8 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of Serum Biomarkers in Early Diagnosis of Hepatocellular Carcinoma in Patients with Fisher Groups","authors":"","doi":"10.25163/angiotherapy.819440","DOIUrl":"https://doi.org/10.25163/angiotherapy.819440","url":null,"abstract":"Introduction: This study investigates the relationship between serum biomarkers and the detection of hepatocellular carcinoma (HCC) in different fisher groups in Bangladesh. The research adopts a descriptive and experimental approach to demonstrate the health risks faced by fishermen, including tobacco consumption, polluted drinking water, and insufficient sunlight exposure. Method: We used serum biomarkers such as vitamin D, alpha-fetoprotein (AFP), creatinine (Cr), and hemoglobin A1C (HbA1c) to evaluate their significance in distinguishing between different categories and sexes. Result: We determined a strong and direct correlation between insufficient vitamin D levels and an increased risk of liver cancer. The combination of AFP, vitamin D, and Cr (AFP+Vit-D+Cr) emerges as a highly predictive tool, enhancing diagnostic accuracy and providing a reliable means of identifying hepatocellular carcinoma. Conclusion: The identified correlation showed the significance of addressing lifestyle factors and promoting nutritional support to mitigate the risk of liver cancer among fisher groups. The AFP+Vit-D+Cr combination is a promising diagnostic tool for hepatocellular carcinoma, offering an improved early detection and intervention approach.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"7 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Piperidine-Catalyzation in Protecting Carbonyl Compounds with Implications for Angiogenesis and Inflammation","authors":"","doi":"10.25163/angiotherapy.819343","DOIUrl":"https://doi.org/10.25163/angiotherapy.819343","url":null,"abstract":"Introduction: This study explores the application of piperidine-catalyzed protection, an innovative technique, for safeguarding various carbonyl compounds functioning as acetals in a generic reaction. Specifically, we investigate the catalysis of 2-amino-1,3-propanediol-2-methyl with various aromatic aldehydes, leading to the production of cis and trans-5-methyl-2-(mono or di-substitutions-phenyl)-1,3-dioxane-5-amine. Methods: Identification of all newly formed products is achieved through the utilization of spectroscopic techniques, including IR, 1H-NMR, and 13C-NMR spectroscopy. Molecular interactions and potential therapeutic applications of compounds E1 and E2 are demonstrated with cAMP-specific phosphodiesterase (1zkl) and oxidized purine nucleoside triphosphate hydrolase (5ws7). Detailed structural analyses highlight specific hydrogen bonds, pi-pi stacked interactions, and alkyl contacts formed by these compounds with target proteins. A comprehensive bioinformatics approach involves GO enrichment, STRING protein-protein association networks, KEGG pathway analysis, and Reactome pathways to elucidate biological processes, molecular functions, and cellular components associated with the compounds. Results: Compounds E1 and E2 exhibit diverse enrichment profiles, suggesting their involvement in various signaling cascades, neurotransmission, immune responses, and cancer pathways. Comparative analysis of five compound pairs (A1/A2, B1/B2, C1/C2, D1/D2, E1/E2) reveals subtle distinctions in enrichment patterns, implying unique pharmacological advantages for each pair. Conclusion: This study introduces a separate investigation on piperidine-catalyzed protection of carbonyl groups in aldehydes, presenting a practical approach. Emphasizing the significance of understanding distinct biological signatures, our findings guide therapeutic applications and compound optimization, particularly in the context of anti-cancer therapeutics. The compounds show potential in modulating neuronal function, neurotransmission, cancer mechanisms, and immune responses, suggesting promising avenues for future research and development.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"7 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}