Journal of Angiotherapy最新文献_第2页

Renal and Hepatic Toxicity of Alpha-Cypermethrine Pesticide Used on Agricultural Farmers Living Closed to Tigris river, Iraq 生活在伊拉克底格里斯河附近的农民使用的 Alpha-Cypermethrine 杀虫剂对肾脏和肝脏的毒性

Journal of Angiotherapy Pub Date : 2024-01-21 DOI: 10.25163/angiotherapy.819426

{"title":"Renal and Hepatic Toxicity of Alpha-Cypermethrine Pesticide Used on Agricultural Farmers Living Closed to Tigris river, Iraq","authors":"","doi":"10.25163/angiotherapy.819426","DOIUrl":"https://doi.org/10.25163/angiotherapy.819426","url":null,"abstract":"The study was conducted from October 15, 2021, to February 15, 2022, in Wasit Governorate, Iraq, targeting farmers of different ages exposed to chemical pesticides along the banks of the Tigris River within the administrative borders of the province. The objective of the study was to identify the impact of alpha-cypermethrin on the health condition of farmers during spraying operations. This was achieved by measuring and identifying changes in vital indicators through biochemical tests, specifically kidney functions and liver enzymes. A total of 200 samples were collected for the study and divided into two groups. The first group comprised 150 samples from farmers exposed to the pesticide, categorized into two age groups. The first subgroup included individuals older than 18 (100 samples), and the second included those under 18 (50 samples). The second group, serving as the control, consisted of 50 samples, with 25 individuals over 18 and 25 under 18. Results revealed high significant differences (P≤0.01) in the concentrations of kidney functions (urea and creatinine) and hepatic enzymes (AST, ALT, and ALP) among individuals exposed to the pesticide compared to the concentrations in the non-exposed control group. The study's findings lead to the conclusion that direct exposure to alpha-cypermethrin showed an impact on overall body functions and affected biomarkers, particularly kidney and liver enzyme functions. Moreover, the adverse effects were more pronounced in older farmers exposed to the pesticide than their younger counterparts.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"2 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139610389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Two Forms of C-Reactive Protein and Their Implication for Atherogenesis: Focus on Monomeric Form 两种形式的 C 反应蛋白及其对动脉粥样硬化的影响：关注单体形式

Journal of Angiotherapy Pub Date : 2024-01-21 DOI: 10.25163/angiotherapy.819386

{"title":"Two Forms of C-Reactive Protein and Their Implication for Atherogenesis: Focus on Monomeric Form","authors":"","doi":"10.25163/angiotherapy.819386","DOIUrl":"https://doi.org/10.25163/angiotherapy.819386","url":null,"abstract":"In this review, we discuss the role of C-reactive protein (CRP), a biomarker of inflammation, in the development of atherosclerosis. CRP exists in two forms: the native pentameric form (nCRP) and the non-native form (mCRP), which is formed during inflammatory processes. The article explores the functions of both forms in atherosclerosis. nCRP binds to molecules with uncoated phosphocholine groups and activates the classical complement pathway. It can bind to enzymatically-modified LDL (E-LDL) and ox-LDL, affecting their pro-inflammatory properties and reducing LDL oxidation. nCRP also interacts with endothelial cells and reduces the absorption of acetylated LDL by these cells. In contrast, mCRP, formed in the presence of pathological conditions, exhibits distinct pro-inflammatory characteristics. While the role of nCRP in atherosclerosis remains unclear in animal models, mCRP has been associated with inflammation and is found in atherosclerotic lesions. The study suggests that nCRP may have atheroprotective effects, while mCRP may contribute to the progression of atherosclerosis. Further research is needed to fully understand the complex mechanisms of CRP in atherosclerosis.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Educational Intervention to Improve Adverse Drug Reactions Reporting Among Healthcare Practitioners in Selected Pediatric Hospitals in Iraq 改善伊拉克部分儿科医院医护人员药物不良反应报告的教育干预措施

Journal of Angiotherapy Pub Date : 2024-01-21 DOI: 10.25163/angiotherapy.819392

引用次数: 0

Impact of Various Contraceptive Methods on Immunological Profiles in Women: A Serological Analysis in Diyala Governorate 各种避孕方法对妇女免疫特征的影响：迪亚拉省的血清学分析

Journal of Angiotherapy Pub Date : 2024-01-21 DOI: 10.25163/angiotherapy.819444

{"title":"Impact of Various Contraceptive Methods on Immunological Profiles in Women: A Serological Analysis in Diyala Governorate","authors":"","doi":"10.25163/angiotherapy.819444","DOIUrl":"https://doi.org/10.25163/angiotherapy.819444","url":null,"abstract":"Introduction: Both hormonal and non-hormonal contraception methods are highly effective and used globally. Our study aimed to examine the immune factors in women using contraceptives, providing insights into the complexities involved. Ninety women participated, with 50 using contraceptives (study group) and 40 not using any (control group), all considered healthy individuals. Venous blood samples, drawn using sterile single-use medical syringes, were 5 ml each. Methods: The study used an inclusive approach, employing techniques like Indirect Sandawish ELISA to assess CD4, CD8, IL16, and IL27 levels, and Single Immunodiffusion (SRID) for IgG, IgM, and IgA determination. Results: Analysis revealed significantly higher levels of IgG, IgM, IgA, and IL16 in contraceptive users compared to non-users. However, CD4 and IL27 levels showed a marked reduction in patients compared to healthy controls. Notably, there were no statistically significant differences (P>0.05) in immune variables between different contraceptive types, except for IgA, which was highest in injection users and lowest in oral contraceptive users. Further scrutiny found no significant variations (P>0.05) between immune variable levels and hormonal/non-hormonal contraceptives, except for IL16 (P>0.01). Conclusions: The study concludes that various contraceptive methods (tablets, injections, copper IUDs) lead to increased levels of immunoglobulins (IgG, IgM, IgA). Importantly, changes in contraceptive type (tablets, injections, IUDs) had minimal impact on immune variables, except for increased IgA in injection users. Hormonal or non-hormonal contraceptives showed no noticeable influence on immune indicators, except for IL16, which exhibited a significant increase.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"22 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polycystic Ovarian Syndrome: An Overview with Special Consideration to Its Oral and Pediatric Clinical Manifestations 多囊卵巢综合征：口腔和儿科临床表现概述

Journal of Angiotherapy Pub Date : 2024-01-21 DOI: 10.25163/angiotherapy.819415

{"title":"Polycystic Ovarian Syndrome: An Overview with Special Consideration to Its Oral and Pediatric Clinical Manifestations","authors":"","doi":"10.25163/angiotherapy.819415","DOIUrl":"https://doi.org/10.25163/angiotherapy.819415","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a complex endocrine disorder affecting women of reproductive age. It is characterized by a combination of symptoms including irregular menstrual cycles, excessive androgen production, and the presence of multiple small cysts on the ovaries. This condition affects approximately 5-10% of women worldwide and is considered one of the most common endocrine disorders in women. The exact cause of PCOS is still unclear, but it is believed to involve a combination of genetic and environmental factors. Insulin resistance and hormonal imbalances play a significant role in the development of this syndrome. High levels of insulin can stimulate the ovaries to produce excess androgens, leading to hormonal dysregulation and subsequent complications such as hirsutism (excessive hair growth), acne, and male pattern baldness. PCOS is associated with a wide range of health problems, ranging from infertility and pregnancy complications to an increased risk of metabolic disorders such as type 2 diabetes and cardiovascular diseases. Furthermore, women with PCOS often experience psychological distress, as the visible symptoms, such as weight gain and fertility issues, can significantly impact their self-esteem and quality of life. Early diagnosis is crucial to prevent long-term complications and provide appropriate management. This review highlights an overview of PCOS, its clinical features, diagnosis, and treatment strategies involved.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"21 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin Nanocarriers with a Focus on Cellular Uptake Studies – An Innovative Cancer Therapy 以细胞吸收研究为重点的姜黄素纳米载体--一种创新的癌症疗法

Journal of Angiotherapy Pub Date : 2024-01-21 DOI: 10.25163/angiotherapy.7819388

{"title":"Curcumin Nanocarriers with a Focus on Cellular Uptake Studies – An Innovative Cancer Therapy","authors":"","doi":"10.25163/angiotherapy.7819388","DOIUrl":"https://doi.org/10.25163/angiotherapy.7819388","url":null,"abstract":"Once a dye, curcumin (CUR) has transformed into a versatile therapeutic agent with antioxidative, anti-inflammatory, and anticancer properties. Despite its potent anticancer effects, CUR encounters challenges such as poor solubility and a short circulation half-life. To address this, researchers utilize nanocarriers like nanoparticles, liposomes, and micelles for efficient CUR delivery. With its multifaceted anticancer activity, CUR holds promise as a cancer therapeutic. Recent studies concentrate on crafting nanocarriers tailored for size, charge, and functionalization, offering adaptable tools for combinational cancer therapy. The synergistic combination of CUR with chemotherapy, magnetic nano hyperthermia, or photodynamic therapy amplifies the efficacy of malignancy treatment. The investigation into CUR-loaded nanocarriers, whether used alone or in combination with other modalities, aims to enhance cancer treatment outcomes, highlighting the diverse potential of curcumin in contemporary therapeutic strategies. This research underscores the importance of combinational drug delivery therapies, providing a renewed perspective on the versatile applications of curcumin in modern medicine.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"2 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139610388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Effects of Esomeprazole, Curcumin, Chitosan, and Curcumin-Chitosan Mixture on Ethanol-Induced Gastric Ulcer in Female Rats 埃索美拉唑、姜黄素、壳聚糖和姜黄素-壳聚糖混合物对乙醇诱发的雌性大鼠胃溃疡的治疗效果

Journal of Angiotherapy Pub Date : 2024-01-21 DOI: 10.25163/angiotherapy.819439

{"title":"Therapeutic Effects of Esomeprazole, Curcumin, Chitosan, and Curcumin-Chitosan Mixture on Ethanol-Induced Gastric Ulcer in Female Rats","authors":"","doi":"10.25163/angiotherapy.819439","DOIUrl":"https://doi.org/10.25163/angiotherapy.819439","url":null,"abstract":"Introduction: Gastric ulcer (GU) is a prevalent health issue linked to alcohol consumption, smoking, and physiological stress. This study aims to assess the therapeutic effects of esomeprazole (40 mg), curcumin (40 mg/kg), chitosan (150 mg/kg), and a mixture of curcumin (40 mg/kg) and chitosan (150 mg/kg) on ethanol-induced gastric ulcers in female rats. Method: The study involved 30 female rats with an average weight ranging from 179.1 to 180.3 gm. Rats were divided into two control groups and four treated groups (esomeprazole, curcumin, chitosan, and mixture), each containing 5 rats. Gastric ulcers were induced by orally administering 2 ml of absolute ethanol to All groups, except the negative control, after a 19-hour fasting period. Therapeutic effects were evaluated by assessing gastric juice volume and pH, ulcer index, curative index, and through morphological and histological examination of the stomach. Results: The study revealed a significant decrease (p≤0.05) in body weight percentage change in the curcumin-treated group compared to the positive control. Esomeprazole, chitosan, and the mixture showed mixture showed no significant change (p>0.05). Additionally, esomeprazole, curcumin, chitosan, and the mixture demonstrated a significant decrease (p≤0.05) in ulcer index and gastric juice volume, with a significant increase (p≤0.05) in pH compared to the positive control. Conclusion: In conclusion, esomeprazole, chitosan, and the mixture demonstrated notable protective effects and therapeutic effects by reducing ulcer index and gastric juice volume in ethanol-induced gastric ulcers in female rats.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"8 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimizing Fast-Dissolving Tablets of Ketotifen: Impact of Sodium Bicarbonate and Citric Acid in Formulation and Evaluation 优化酮替芬速溶片剂：碳酸氢钠和柠檬酸对配方和评估的影响

Journal of Angiotherapy Pub Date : 2024-01-21 DOI: 10.25163/angiotherapy.819379

{"title":"Optimizing Fast-Dissolving Tablets of Ketotifen: Impact of Sodium Bicarbonate and Citric Acid in Formulation and Evaluation","authors":"","doi":"10.25163/angiotherapy.819379","DOIUrl":"https://doi.org/10.25163/angiotherapy.819379","url":null,"abstract":"The research aimed to develop and assess fast-dissolving tablets (FDT) of ketotifen, a second-generation noncompetitive H1-receptor blocker, due to its poor oral bioavailability resulting from rapid first-pass effect (~50%) and poor solubility despite excellent permeability within the II-class of the biopharmaceutical classification system (BCS). The methodology involved formulating ketotifen with various excipients, including sodium bicarbonate, citric acid, menthol, polyvinyl pyrrolidone (PVP), aspartame, magnesium stearate, saccharin sodium, and dextrose. The combination of sodium bicarbonate and citric acid served as a fast-disintegrating agent by evolving carbon dioxide. Employing 23 factorial designs, the study assessed the impact of sodium bicarbonate (X1), citric acid (X2), and menthol (X3) on FDT performance. Batch A, exhibiting desirable characteristics, demonstrated weight variation (200±0.53), thickness (3.52±0.12 mm), hardness (2.87±0.23), friability (0.55±0.12), disintegration time (16±3 s), drug content uniformity (99.45±0.23), wetting time (3±1 s), and water absorption ratio (19.23±0.43). The primary contributor to fast tablet disintegration was identified as the high concentration of sodium bicarbonate rather than citric acid. All batches adhered to the Peppas Korsmeyer model, signifying Fickian Diffusion (Higuchi Matrix) as the drug release mechanism. In conclusion, the study underscored the pivotal role of sodium bicarbonate concentration in facilitating rapid tablet disintegration, emphasizing its significance over citric acid concentration.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"12 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Therapeutic Efficacy of Star Anise Oil with (Illicium verum) Nano-Emulsion Formulation 用纳米乳液配方提高八角茴香油的疗效

Journal of Angiotherapy Pub Date : 2024-01-21 DOI: 10.25163/angiotherapy.819383

{"title":"Advancing Therapeutic Efficacy of Star Anise Oil with (Illicium verum) Nano-Emulsion Formulation","authors":"","doi":"10.25163/angiotherapy.819383","DOIUrl":"https://doi.org/10.25163/angiotherapy.819383","url":null,"abstract":"Background. The volatile oil present in star anise (Illicium verum) exhibits efficacy against various health issues such as bronchitis, colds, flu, indigestion, facial paralysis, and intestinal cramps. This study aimed to formulate and assess the nano-emulsion of star anise volatile oil. Method. Star anise volatile oil was extracted from its fruits using the Clevenger apparatus and subsequently purified. The extraction process involved dissolving the extracted oil in dichloromethane, and solvent recycling was performed using a rotavapor. Nano-emulsions were developed through homogenization (8 batches) and ultra-sonication methods (8 batches) with varying surfactant (Tween-80) and co-surfactant (PEG-200, PEG-300) ratios. Characterization involved refractive index, pH, Fourier transform infrared spectroscopy, particle size distribution, zeta potential, drug content, drug release, release kinetics, and stability studies (25°C/60% RH at 1, 2, 3, 4, and 5 weeks). Results. The smallest droplet sizes were observed in batches NE-HH (646.1±71.54 nm) and NE-HS (694±195.48 nm), with the least zeta potential values of -10.4 mV (NE-FH batch) and -5.2 mV (NE-HS batches). The highest drug release percentages were recorded in NE-EH (31.411±1.26%) and NE-ES (34.004±1.74%) batches. Both NE-EH and NE-ES followed the Peppas Korsmeyer model, and the release mechanism was identified as Fickian Diffusion (Higuchi Matrix). Conclusion. The study concludes that nano-emulsions of star anise volatile oil can be successfully prepared using homogenization and ultrasonication methods, demonstrating good stability and prolonged drug release.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"15 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139609859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Dipeptidyl Peptidase-4 (DPP-4) and its potential synthetic derivatives in the management of Diabetes Mellitus 二肽基肽酶-4 (DPP-4) 及其潜在合成衍生物在糖尿病治疗中的应用综述

Journal of Angiotherapy Pub Date : 2024-01-21 DOI: 10.25163/angiotherapy.819417

{"title":"A Review of Dipeptidyl Peptidase-4 (DPP-4) and its potential synthetic derivatives in the management of Diabetes Mellitus","authors":"","doi":"10.25163/angiotherapy.819417","DOIUrl":"https://doi.org/10.25163/angiotherapy.819417","url":null,"abstract":"Dipeptidyl peptidase-4 (DPP-4) inhibitors are a type of oral medication used to treat type 2 diabetes mellitus (T2DM). They have become increasingly popular due to their effectiveness and safety in managing the condition. DPP-4 inhibitors function by inhibiting the enzyme that breaks down the incretin hormones, namely glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP). These medicines efficiently raise the levels of active GLP-1 and GIP by blocking DPP-4 activity. As a result, there is an increase in the production of insulin, a decrease in the release of glucagon, and a lowering of glucose levels after a meal. Multiple clinical trials have conclusively shown that DPP-4 inhibitors effectively lower glycated hemoglobin (HbA1c) levels. Certain studies have even proved their equivalent efficacy to other anti-diabetic medications such as metformin or sulfonylureas. Furthermore, DPP-4 inhibitors possess the benefit of being weight-neutral and exhibiting a little risk of hypoglycemia. These qualities render them a compelling option for patients with type 2 diabetes mellitus who are overweight or susceptible to hypoglycemia episodes. In general, DPP-4 inhibitors are a promising therapeutic choice for the management of type 2 diabetes mellitus (T2DM), offering effective regulation of blood sugar levels with a minimal likelihood of adverse effects. Nevertheless, it is important to acknowledge some restrictions and factors to take into account, including the possibility of heightened susceptibility to pancreatitis, nasopharyngitis, and certain drug-drug combinations. Additional investigation is necessary to completely clarify the long-term safety and potential supplementary advantages of DPP-4 inhibitors.","PeriodicalId":154960,"journal":{"name":"Journal of Angiotherapy","volume":"7 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0