Effect of Plumbago zeylanica on Analgesia and Arthritis

Background: Rheumatoid arthritis is a chronic inflammatory joint condition that causes oxidative damage and inflammation. The current study evaluates the safety and effectiveness of an 85 percent methanolic extract of Plumbago zeylanica (PZ). Methods: The acute toxicity study is used to calculate the LD50 value in the safety profile. The hot plate and tail immersion procedures are both used to examine the analgesic effect in the efficacy profile. Paw edema caused by carrageenan was investigated for its ability to reduce inflammation and complete Freund's adjuvant produced arthritis was tested for anti-arthritic activity. Results: Various phytochemical analyses, including qualitative and quantitative analyses of 85 % methanolic extract and raw materials. The extract exhibits analgesic effects by increasing the reaction time in both the hot plate and tail immersion procedures. In Freund's adjuvant-induced paw edema, the anti-inflammatory activity of methanolic extract is 30.42 % and 16.90 %, respectively. Conclusion: The PZ extract raises the level of antioxidants and lowers the oxidative stress caused by arthritis caused by complete Freund's adjuvant. PZ has a lot of secondary metabolites that can help with pain, inflammation, and free radicals.