Journal of Controlled Release最新文献

{"title":"Multi-interfacial microbubbles controlled sequential cavitation for synergistic vascular destruction/chemotherapeutic therapy","authors":"Tiandong Chen ,&nbsp;Chenyi Zhang ,&nbsp;Yanxiao Zhao ,&nbsp;Yakun Wang ,&nbsp;Mingxi Li ,&nbsp;Yang Liu ,&nbsp;Xiao Wang ,&nbsp;Shuangyu Liu ,&nbsp;Dan Mu ,&nbsp;Fang Yang","doi":"10.1016/j.jconrel.2025.114287","DOIUrl":"10.1016/j.jconrel.2025.114287","url":null,"abstract":"<div><div>Microbubbles have emerged as versatile theranostic platforms in biomedicine. In addition to being used as ultrasound contrast agents, capitalizing on cavitation-mediated physical effects, microbubbles now enable targeted drug delivery and precision tumor ablation. In this study, we engineer doxorubicin (DOX)-loaded multi-interfacial microbubbles (DOX-MIMBs) through interfacial self-assembly of hydrophobic mesoporous silica nanoparticles (hMSNs), establishing a hierarchically structured MIMBs with the sustained acoustic activity. Strong affinity between hMSNs and the gas-liquid interface facilitates cavitation effect transmission. Under low intensity ultrasound (&lt;3 W/cm²) irradiation, primary MIMBs collapse generates secondary daughter bubbles that rapidly stabilize <em>via</em> hMSNs-mediated gas-liquid interface reconstruction and are able to cavitate again. This process enables energy-cascaded cavitation-successive bubble generations persisting until acoustic energy dissipation, achieving prolonged cavitation duration <em>versus</em> conventional lipid-shelled microbubbles. The sequential acoustomechanical perturbation generated by DOX-MIMBs induced synergistic tumor therapy: selective vascular destruction for mechanically collapsed immature tumor vasculature and enhanced chemotherapy for wider distribution and deeper penetration of DOX in tumors. Utilizing sequential bubble cavitation-induced shockwave and microstreaming, by integrating tumor vasculature mechanical disruption and deep tumor DOX penetration chemotherapy, DOX-MIMBs achieved tumor volume appropriate 90 % reduction in renal cell carcinoma models. Such elaborated DOX-MIMBs mechano-pharmaceutical delivery system achieve a paradigm shift from systemic drug bombardment to local mechanochemical tumor suppression and provide a powerful strategy for tumor precision therapy.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"388 ","pages":"Article 114287"},"PeriodicalIF":11.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145203244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting polyamine metabolism induces oxidative/carbonyl stress to reinvigorate antitumor immunity in prostate cancer","authors":"Aijing Zhang ,&nbsp;Jianguo Zheng ,&nbsp;Yingying Xu ,&nbsp;Shuai Fu ,&nbsp;Qinglong Du ,&nbsp;Chengyang Zhao ,&nbsp;Yuxiang Meng ,&nbsp;Mengqi Li ,&nbsp;Lin Wang ,&nbsp;Shuliang Wang ,&nbsp;Tongrui Shi ,&nbsp;Chen Yang ,&nbsp;Peihong Jiang ,&nbsp;Yiping Wang ,&nbsp;Zhongwei Zhao ,&nbsp;Zhao Zhang ,&nbsp;Shuo Zhao ,&nbsp;Xin Qin ,&nbsp;Huimin Geng ,&nbsp;Nengwang Yu","doi":"10.1016/j.jconrel.2025.114283","DOIUrl":"10.1016/j.jconrel.2025.114283","url":null,"abstract":"<div><div>Immunotherapy of prostate cancer (PCa) remains challenging due to the immunosuppressive nature of the tumor microenvironment (TME). Oxidative damage enhances immunogenic cell death (ICD) to counteract immunotherapy resistance in PCa, but is limited by tumor antioxidant defenses and single-modality reactive oxygen species (ROS) generation in the TME. Herein, we report an innovative polyamine-based strategy that overproduces hydrogen peroxide and acrolein to simultaneously induce oxidative/carbonyl stress while suppressing endogenous antioxidant systems, thereby synergistically amplifying oxidative/carbonyl damage, which triggers robust ICD and achieves potent antitumor efficacy. Both <em>in vitro</em> and <em>in vivo</em> assays demonstrated that the nanoparticles, modified with a PCa-targeting peptide, could generate acrolein to induce mitochondrial destruction, DNA damage, and accumulate lipid peroxidation. In addition, they enhanced the recruitment of mature dendritic cells and T cells within the TME, thus inhibiting lung metastasis and tumor rechallenge. This work proposes an immunotherapy strategy using polyamine metabolism to induce combined carbonyl and oxidative stress, providing a novel approach for overcoming cold TME resistance in advanced PCa.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"388 ","pages":"Article 114283"},"PeriodicalIF":11.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In situ enrichment and delivery of STING agonists by protamine-modified Salmonella for cancer immunotherapy","authors":"Yanjun Lu ,&nbsp;Zhiyan Li ,&nbsp;Hanxiao Xu ,&nbsp;Qingwei Zeng ,&nbsp;Xudong Zhu ,&nbsp;Kai Chen ,&nbsp;Wenxuan Zheng ,&nbsp;Song Liu ,&nbsp;Wenxian Guan ,&nbsp;Jinhui Wu","doi":"10.1016/j.jconrel.2025.114284","DOIUrl":"10.1016/j.jconrel.2025.114284","url":null,"abstract":"<div><div>Immunotherapy has emerged as a promising therapeutic strategy for cancer. The activation of the stimulator of interferon genes (STING) pathway promotes the polarization of tumor-associated macrophages (TAMs) towards M1 phenotype, with 2′, 3′-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) serving as an inherent activator, which significantly accumulates in the extracellular space of the tumor sites following radiotherapy (RT). However, the electronegativity and hydrophilicity of cGAMP prevent it from crossing the cell membrane into TAMs, hampering subsequent immunotherapy efficacy. Here, positively charged protamine-modified <em>Salmonella</em> (VNP20009), called VNP-protamine (VNP-PRM), were prepared to enrich cGAMP and form a composite bacteria-drug delivery system with the capacity to enter TAMs freely. <em>Via</em> electrostatic interactions between the guanidine groups of protamine and the phosphate groups of cGAMP, VNP-PRM stably enriched cGAMP on their surface and neutralized the electronegativity of cGAMP. The uptake efficiency of cGAMP by TAMs was then significantly enhanced by the active delivery of VNP-PRM, whose inherent motility and cellular invasiveness endowed them with increased potential to bump against and enter the macrophages. Subsequently, the intracellular cGAMP synergized with the immunogenicity of the bacteria to activate the STING pathway and drive M1 polarization, thereby boosting tumor eradication. Therefore, antitumor immunotherapy can be optimized through <em>in situ</em> enrichment and delivery of post-RT cGAMP to TAMs by the engineered bacteria.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"388 ","pages":"Article 114284"},"PeriodicalIF":11.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145194953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-activatable nanovaccines amplify dual-modal ROS for cancer sono-immunotherapy","authors":"Yiming Liu ,&nbsp;Guangzhe Li ,&nbsp;Guibin Wang ,&nbsp;Yang Wang ,&nbsp;Jianlong Su ,&nbsp;Zhihao Wu ,&nbsp;Ruimin Wang ,&nbsp;Xiaomai Zhang ,&nbsp;Jinrong Li ,&nbsp;Guanyi Zhang ,&nbsp;Yuxuan Zhang ,&nbsp;Xu Wang ,&nbsp;Yuanhang Yao ,&nbsp;Mingrui Bai ,&nbsp;Ruoshi Wang ,&nbsp;Lei Wang ,&nbsp;Jingdong Zhang ,&nbsp;Kun Shao","doi":"10.1016/j.jconrel.2025.114285","DOIUrl":"10.1016/j.jconrel.2025.114285","url":null,"abstract":"<div><div>Insufficient reactive oxygen species (ROS), including limited ROS bioactivity and poor accumulation efficiency inside tumor cells, remain a major barrier to the effectiveness of sonodynamic therapy (SDT). Among ROS types, hydroxyl radical (·OH) displays superior killing efficiency compared to singlet oxygen (¹O₂), while diminishing oxygen reliance. Nevertheless, most existing small molecule sonosensitizers exhibit ¹O₂-predominance under ultrasound (US). In this study, we discovered that RB-Biotin, a derivative of the classical ¹O₂ sonosensitizer Rose Bengal (RB), remarkably augmented ·OH production without compromising ¹O₂ yield under US irradiation. The dual-modal ROS generation mechanism was elucidated by computational studies of density functional theory (DFT). RB-Biotin was further loaded onto MnO₂-based nanocarriers to obtain the ultrasound-enabled nanovaccines, BMRP. The MnO₂ scaffold not only transformed the endogenous hydrogen peroxide (H₂O₂) into oxygen to fuel ¹O₂ production by RB-Biotin, but also inhibited ROS depletion by blocking intracellular glutathione (GSH), creating a dual-modal ROS “reservoir” within tumor cells. In a mouse hepatocellular carcinoma (HCC) model, BMRP demonstrated a potent sono-immune therapeutic effect through synergistic dual-modal ROS (¹O₂ and ·OH) amplification and locally released Mn²⁺-favored immune activation, leading to remarkable tumor regression and robust anti-tumor immune responses. This work represents a paradigm shift in SDT by transitioning from mono-modal to dual-modal ROS generation, leveraging the complementary oxidative mechanisms of ¹O₂ and ·OH to improve SDT efficacy. By integrating the strengths of RB-Biotin and MnO₂ nanocarriers, this approach not only overcomes intrinsic limitations of conventional SDT, but also expands the application of ultrasound-driven cancer therapy.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"388 ","pages":"Article 114285"},"PeriodicalIF":11.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145195378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CTLA-4 nanovesicles disrupt dendritic cell-driven CD8 T cell priming for myocardial infarction therapy","authors":"Shengnan Wang ,&nbsp;Mengting Li ,&nbsp;Han Shen ,&nbsp;Wenjing Zhou ,&nbsp;Jiuyuan Sun ,&nbsp;Qingsong Tang ,&nbsp;Hongman Liu ,&nbsp;Wencheng Zhang ,&nbsp;Zhenya Shen ,&nbsp;Weiqian Chen","doi":"10.1016/j.jconrel.2025.114277","DOIUrl":"10.1016/j.jconrel.2025.114277","url":null,"abstract":"<div><div>Myocardial infarction (MI) remains a formidable global health challenge, as current therapies are hindered by excessive inflammation that exacerbates cardiac dysfunction and accelerates disease progression. Cytotoxic T-lymphocyte antigen 4 (CTLA-4) and CD28 are T-lymphocyte receptors with opposing roles in T-cell activation: CD28 binding to CD80/CD86 ligands on dendritic cells (DCs) mediates co-stimulation, whereas CTLA-4 engagement delivers inhibitory signals. In our present study, mannosylated cytotoxic T-lymphocyte antigen 4 (CTLA-4)-presenting small extracellular vesicles (CM@sEVs) were engineered for targeted MI therapy. By disrupting the CD80/86-CD28 costimulatory signaling, these CM@sEVs counteract dendritic cell (DC)-driven CD8⁺ T cell priming, thereby mitigating ischemic immunopathology while supporting myocardial repair. Notably, distinct from existing T-cell modulatory therapies, our CM@sEVs uniquely reshape in vivo T-cell dynamics directly through DC-dependent mechanisms, offering a precise and stable strategy for ischemic cardiomyopathy.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"388 ","pages":"Article 114277"},"PeriodicalIF":11.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buccal microneedle-delivered ferritin nanovaccines induce strong respiratory immunity against Pseudomonas aeruginosa","authors":"Chunting He ,&nbsp;Penghui He ,&nbsp;Lin Ye,&nbsp;Qiaoran Yang,&nbsp;Yuxuan Ye,&nbsp;Yuwei Wang,&nbsp;Zhaofei Guo,&nbsp;Yangsen Ou,&nbsp;Hairui Wang,&nbsp;Yuanhao Zhao,&nbsp;Shuting Bai,&nbsp;Hongjiao Wei,&nbsp;Guangsheng Du,&nbsp;Xun Sun","doi":"10.1016/j.jconrel.2025.114280","DOIUrl":"10.1016/j.jconrel.2025.114280","url":null,"abstract":"<div><div>Mucosal vaccines provide a crucial first-line defense against invading pathogens by inducing secretory IgA (sIgA) at mucosal surfaces. While subunit antigen based mucosal vaccines offer improved safety profiles, their development faces two tremendous challenges: inherently poor mucosal immunogenicity and inefficient antigen delivery across mucosal barriers. Here, we demonstrate ferritin nanovaccine incorporated dissolving microneedles are effective against <em>Pseudomonas aeruginosa</em> (<em>PA</em>) infection via buccal mucosal immunization. The nanovaccine was engineered through conjugating the <em>PA</em> antigen PcrV_NH to ferritin nanoparticles using SpyTag/SpyCatcher system. This microneedles vaccine demonstrated efficient mucosal penetration and recruitment of antigen-presenting cells at the penetration sites. Notably, the used ferritin nanoparticles showed potent mucosal adjuvanticity as indicated by the improved antigen uptake, activation of the antigen-presenting cells and the amplification of the both mucosal and systemic humoral and cellular immune responses. Finally, it induced potent sIgA production in respiratory mucosal secretions and systemic immune responses, providing effective protection against <em>PA</em> pulmonary infection. Our findings establish ferritin nanovaccines combined with microneedles delivery as a promising strategy for developing safe and effective mucosal subunit vaccines.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"388 ","pages":"Article 114280"},"PeriodicalIF":11.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tailored mechano-responsive micelles mimic the iron starvation response and impair pH homeostasis for triggered cancer therapy","authors":"Hongyu Leng ,&nbsp;Yao Li ,&nbsp;Han Wang ,&nbsp;Panyu Du ,&nbsp;Ning Zhao ,&nbsp;Zheng Wang ,&nbsp;Xin Li ,&nbsp;Huikai Li ,&nbsp;Yanjun Zhao","doi":"10.1016/j.jconrel.2025.114279","DOIUrl":"10.1016/j.jconrel.2025.114279","url":null,"abstract":"<div><div>Carbonic anhydrase IX (CAIX) and cysteine desulfurase (NFS1) are a synthetic lethal pair for cancer treatment. The suppression of NFS1 upregulates the iron starvation response and enriches intracellular Fe²⁺, leading to increased lipid peroxidation. However, the potency of the NFS1 inhibitor is compromised by the hypoxic microenvironment. To address this issue, we report a mechano-responsive ferrocene-bearing micelle that mimics the CAIX/NFS1 axis <em>via</em> ultrasound-activated iron release and the co-delivery of SLC-0111, a CAIX inhibitor. Upon ultrasound stimulation, the micelles disassemble in acidic lysosomes, releasing ferrous ions and SLC-0111, triggering intracellular acidification, reactive oxygen species accumulation, and lipid peroxidation. Moreover, the liberation of Fe²⁺ is facilitated by the presence of hydrogen peroxide and further enhanced by mechanical force. SLC-0111 leads to intracellular acidification and synergizes with Fe²⁺ to boost the Fenton reaction. This cascade disrupted redox homeostasis and induced multiple cell death pathways, including ferroptosis, apoptosis, pyroptosis, and necroptosis, in a tumor-selective manner. The <em>in vivo</em> efficacy studies in a 4T1 breast cancer model confirmed potent tumor suppression with minimal systemic toxicity. This work introduces a mechanical force-controlled strategy as a substitute for CAIX/NFS1 synthetic lethality therapy without the interference of oxygen level, holding promise for advancing tumor-specific therapy.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"388 ","pages":"Article 114279"},"PeriodicalIF":11.5,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145189470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging drug delivery strategies for local immunomodulation in atherosclerosis","authors":"Caleb Nunes, Amelia Kramer, Lisa R. Volpatti","doi":"10.1016/j.jconrel.2025.114261","DOIUrl":"https://doi.org/10.1016/j.jconrel.2025.114261","url":null,"abstract":"Atherosclerosis is a leading cause of cardiovascular disease, which is responsible for one in three deaths globally. Characterized by the blocking of arteries, atherosclerosis develops when lipids accumulate in arterial walls and harden into a plaque. When macrophages consume excess modified low-density lipoprotein, they become inflamed and transform into foam cells, which further contribute to plaque development. The standard-of-care for atherosclerosis treatment includes diet and exercise and lipid-lowering therapies such as statins that do not fully address the inflammation that underlies the disease. While many anti-inflammatory therapies have shown promise in vitro and in vivo, their clinical translation has been limited by poor selectivity and off-target effects. This review explores emerging drug delivery strategies designed to improve the precision of anti-inflammatory treatments for atherosclerosis. We highlight nanoparticle-based approaches constructed from lipids, polymers, polysaccharides, metals, and two-dimensional materials, alongside biologic platforms that leverage cell membranes, extracellular vesicles, viruses, and engineered proteins. Finally, we discuss key challenges and considerations for translating these technologies into clinically viable therapies.","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"31 1","pages":""},"PeriodicalIF":10.8,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanoparticles across mucosal barriers: Differentiating mucoadhesion from mucopenetration using single particle tracking","authors":"Matteo Tollemeto ,&nbsp;Lasse H.E. Thamdrup ,&nbsp;Nikos S. Hatzakis ,&nbsp;Claus-Michael Lehr ,&nbsp;Jan van Hest ,&nbsp;Anja Boisen","doi":"10.1016/j.jconrel.2025.114268","DOIUrl":"10.1016/j.jconrel.2025.114268","url":null,"abstract":"<div><div>Mucus is a viscoelastic, selectively permeable barrier that protects epithelial surfaces throughout the body. Its complex structure presents a major challenge for nanoparticle-based drug delivery, requiring a balance between mucoadhesion, to prolong residence time, and mucopenetration, to access underlying tissues. These processes vary by anatomical site due to differences in mucus turnover and composition.</div><div>Current methods often fail to clearly distinguish between mucoadhesion and mucopenetration. Here, we highlight single-particle tracking (SPT) as a powerful approach to address this gap. By capturing the trajectories of individual nanoparticles in mucus, SPT offers high-resolution insight into their diffusion behavior and interaction dynamics. Notably, particle behavior observed in <em>ex vivo</em> mucus has shown good correlation with <em>in vivo</em> outcomes, making SPT a promising tool for translational research.</div><div>Despite its advantages, SPT remains underutilized in mucosal drug delivery, largely due to a lack of standardized protocols and benchmark materials. We advocate for the development of a nanoparticle test set with well-defined surface properties (<em>e.g.</em>, charge, hydrophobicity) and the routine reporting of key parameters such as diffusion coefficients and mean squared displacement. These steps are essential to improve reproducibility, support cross-study comparisons, and accelerate progress in mucosal nanomedicine.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"388 ","pages":"Article 114268"},"PeriodicalIF":11.5,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highly adhesive asynchronous drug-releasing membrane for facial care: Combined anti-acne and anti-inflammatory properties","authors":"Dandan Kang ,&nbsp;Chengyao Xue ,&nbsp;Binli Cai ,&nbsp;Qianqing Fan ,&nbsp;Yang Lu ,&nbsp;Yu Zhang ,&nbsp;Jiaxiang Ye ,&nbsp;Deng-guang Yu ,&nbsp;Wenliang Song","doi":"10.1016/j.jconrel.2025.114260","DOIUrl":"10.1016/j.jconrel.2025.114260","url":null,"abstract":"<div><div>The facial skin of teenagers often suffers from problems such as acne and inflammation. In severe cases, it may even lead to skin ulcers. This not only affects their study and daily life, but also has a negative impact on their physical and mental health. However, conventional hydrocolloid dressings exhibit several limitations, such as poor adhesion in high-tension or contoured facial areas, lack of staged therapeutic functionality, and the inclusion of potentially irritating ingredients. To overcome these challenges, electrospun nanofiber membranes with a core-shell architecture have been developed. The outer shell is composed of polyvinyl alcohol grafted with 3,4-dihydroxyphenylalanine (PVA-DOPA) and is loaded with <em>star</em>-poly(<span>l</span>-lysine) (star-PLs) to exert antibacterial activity against <em>Propionibacterium acnes</em> (<em>P. acnes</em>). The inner core consists of gelatin (GEL) incorporated with tannic acid (TA), which provides sustained antioxidant and anti-inflammatory effects to support tissue repair and mitigate skin aging. The catechol groups in DOPA further enhance the membrane's skin adhesion, especially on complex surfaces such as the chin and nose. In vitro studies confirmed the membrane's hydrophilicity, controlled drug release, and strong antimicrobial performance. Cellular assays and a rat wound healing model validated its bioactivity and therapeutic potential. This work presents a promising strategy for facial skin care via multifunctional nanofiber dressings with strong adhesion and asynchronous drug release.</div></div>","PeriodicalId":15450,"journal":{"name":"Journal of Controlled Release","volume":"388 ","pages":"Article 114260"},"PeriodicalIF":11.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145153604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}